{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:45:03Z","timestamp":1778345103240,"version":"3.51.4"},"reference-count":87,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UI\/BD\/151028\/2021"],"award-info":[{"award-number":["UI\/BD\/151028\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04077\/2020"],"award-info":[{"award-number":["UIDB\/04077\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00319\/2020"],"award-info":[{"award-number":["UIDB\/00319\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04436\/2020"],"award-info":[{"award-number":["UIDB\/04436\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Micromachines"],"abstract":"<jats:p>Numerical simulations have revolutionized research in several engineering areas by contributing to the understanding and improvement of several processes, being biomedical engineering one of them. Due to their potential, computational tools have gained visibility and have been increasingly used by several research groups as a supporting tool for the development of preclinical platforms as they allow studying, in a more detailed and faster way, phenomena that are difficult to study experimentally due to the complexity of biological processes present in these models\u2014namely, heat transfer, shear stresses, diffusion processes, velocity fields, etc. There are several contributions already in the literature, and significant advances have been made in this field of research. This review provides the most recent progress in numerical studies on advanced microfluidic devices, such as organ-on-a-chip (OoC) devices, and how these studies can be helpful in enhancing our insight into the physical processes involved and in developing more effective OoC platforms. In general, it has been noticed that in some cases, the numerical studies performed have limitations that need to be improved, and in the majority of the studies, it is extremely difficult to replicate the data due to the lack of detail around the simulations carried out.<\/jats:p>","DOI":"10.3390\/mi12101149","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:30:33Z","timestamp":1632443433000},"page":"1149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Computational Simulations in Advanced Microfluidic Devices: A Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-4746","authenticated-orcid":false,"given":"Violeta","family":"Carvalho","sequence":"first","affiliation":[{"name":"MEtRICs, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"ALGORITMI, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-2654","authenticated-orcid":false,"given":"Raquel O.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center for MicroElectromechanical Systems (CMEMS-UMinho), Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-637X","authenticated-orcid":false,"given":"Rui A.","family":"Lima","sequence":"additional","affiliation":[{"name":"MEtRICs, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"CEFT, R. Dr. Roberto Frias, Faculty of Engineering of the University of Porto (FEUP), 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-3944","authenticated-orcid":false,"given":"Senhorinha","family":"Teixeira","sequence":"additional","affiliation":[{"name":"ALGORITMI, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","unstructured":"Vrana, N.E., Knopf-Marques, H., and Barthes, J. (2020). Simulation of organ-on-a-chip systems. Biomaterials for Organ and Tissue Regeneration, Woodhead Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/bit.25950","article-title":"A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening","volume":"113","author":"Soker","year":"2016","journal-title":"Biotechnol. 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