{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:56:51Z","timestamp":1768719411884,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbiology Research"],"abstract":"<jats:p>Objective: This review evaluated chlorhexidine (CHX)\u2019s beneficial effect as an antibacterial substance on periodontopathogenic bacteria, which can influence the preservation of periodontal tissues and biomaterials. Methods: A search was performed in the PubMed\/MedLine, B-On, ScienceDirect, and Cochrane Library databases. In vitro studies published between 1 January 2000 and 31 December 2023 in the English language were included; studies that did not correlate the sensitivity of collagenolytic microorganisms to CHX and observational and in vivo studies were excluded. The Quality Assessment Tool for In Vitro Studies (QUIN) evaluated the risk of bias. Results: Eight studies were included; six assessed the inhibitory effect of CHX on the activity of various bacteria associated with periodontitis and collagen degradation; two studies evaluated the same effect only for P. gingivalis. All the studies had an evaluation percentage above 70%, representing a low bias risk. Conclusions: There is a relationship between collagen degradation and the microorganisms in periodontal diseases. CHX showed efficacy against various microorganisms, inhibiting their growth and cell viability. CHX demonstrated significant implications for preventing and treating infections associated with collagen degradation.<\/jats:p>","DOI":"10.3390\/microbiolres15040164","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:26:08Z","timestamp":1732706768000},"page":"2435-2454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sensitivity of Collagenolytic Periopathogenic Microorganisms to Chlorhexidine Solution: A Comprehensive Review of In Vitro Studies"],"prefix":"10.3390","volume":"15","author":[{"given":"Bruno","family":"Barbosa","sequence":"first","affiliation":[{"name":"FP-I3ID, FCS, Fernando Pessoa University, 4249-004 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-6721","authenticated-orcid":false,"given":"Filipe","family":"Castro","sequence":"additional","affiliation":[{"name":"FP-I3ID, FCS, Fernando Pessoa University, 4249-004 Porto, Portugal"},{"name":"Department of Periodontology, University of Seville, 41009 Seville, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-8331","authenticated-orcid":false,"given":"Jorge","family":"Pereira","sequence":"additional","affiliation":[{"name":"FP-I3ID, FCS, Fernando Pessoa University, 4249-004 Porto, Portugal"}]},{"given":"Maria","family":"Catarino","sequence":"additional","affiliation":[{"name":"FP-I3ID, FCS, Fernando Pessoa University, 4249-004 Porto, Portugal"}]},{"given":"Jaime","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Independent Researcher, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-4390","authenticated-orcid":false,"given":"Gustavo Vicentis Oliveira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Missouri School of Dentistry & Oral Health, A.T. Still University, St. Louis, MO 63104, USA"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.14219\/jada.archive.2005.0256","article-title":"The National Institute of Dental and Craniofacial Research: Research for the practicing dentist","volume":"136","author":"Pihlstrom","year":"2005","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","article-title":"Periodontitis in U.S. adults: National Health and Nutrition Examination Survey 2009\u20132014","volume":"149","author":"Eke","year":"2018","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_3","unstructured":"National Institutes of Health (2024, January 03). Oral Health in America: Advances and Challenges. 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Care"}],"container-title":["Microbiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7481\/15\/4\/164\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:40:47Z","timestamp":1760114447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7481\/15\/4\/164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["microbiolres15040164"],"URL":"https:\/\/doi.org\/10.3390\/microbiolres15040164","relation":{},"ISSN":["2036-7481"],"issn-type":[{"value":"2036-7481","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]}}}