{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:49:04Z","timestamp":1767826144403,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>(1) Background: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children &lt; 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013\u20132020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. (3) Results: We found a total of 75 children, 44 with K. kingae and 31 with pyogenic infections (mostly MSSA, S. pneumoniae and S. pyogenes). K. kingae affected younger children with low or absent fever, low inflammatory markers and a favourable prognosis. In the univariate analyses, fever, septic look, CRP and ESR at admission and CRP at 48 h were significantly lower in K. kingae SA. In the multivariate analyses, age &gt; 6 months \u2264 2 years, apyrexy and CRP \u2264 100 mg\/L were significative, with an overall predictive positive value of 86.5%, and 88.4% for K. kingae. For this model, ROC curves were capable of differentiating (AUC 0.861, 95% CI 0.767\u20130.955) K. kingae SA from typical pathogens. (4) Conclusions: Age &gt; 6 months \u2264 2 years, apyrexy and PCR \u2264 100 mg\/L were the main predictive factors to distinguish K. kingae from pyogenic SA &lt; 5 years. These data need to be validated in a larger study.<\/jats:p>","DOI":"10.3390\/microorganisms10061233","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:25:11Z","timestamp":1655443511000},"page":"1233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Portuguese Children"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-8473","authenticated-orcid":false,"given":"Catarina","family":"Gouveia","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-045 Lisbon, Portugal"},{"name":"Nova Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, 1169-056 Lisbon, Portugal"}]},{"given":"Ana","family":"Subtil","sequence":"additional","affiliation":[{"name":"NOVA National School of Public Health, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, 1600-560 Lisbon, Portugal"},{"name":"CEMAT, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal"}]},{"given":"Susana","family":"Norte","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Unit, \u00c1rea de Pediatria, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-050 Lisbon, Portugal"}]},{"given":"Joana","family":"Arcangelo","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Unit, \u00c1rea de Pediatria, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-050 Lisbon, Portugal"}]},{"given":"Madalena Almeida","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Department of Clinical Pathology, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-050 Lisbon, Portugal"}]},{"given":"Rita","family":"Corte-Real","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Department of Clinical Pathology, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-050 Lisbon, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, 1600-609 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-4870","authenticated-orcid":false,"given":"Helena","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"Nova Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, 1169-056 Lisbon, Portugal"},{"name":"NOVA National School of Public Health, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, 1600-560 Lisbon, Portugal"}]},{"given":"Delfin","family":"Tavares","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Unit, \u00c1rea de Pediatria, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio Lisboa Central, 1169-050 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2217\/fmb.12.144","article-title":"30 Years of Study of Kingella kingae: Post Tenebras, Lux","volume":"8","author":"Ceroni","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_2","first-page":"w13971","article-title":"Osteoarticular Infections in Young Children: What Has Changed over the Last Years?","volume":"144","author":"Ceroni","year":"2014","journal-title":"Swiss Med. 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