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Due to their size, they are likely to cause deleterious effects. In this study, we assessed the effects of MPs obtained from two commercially available plastics (PP and PET) in the polychaeta Hediste diversicolor after different periods (4 and 28 days). Toxic effects were assessed by measuring burrowing and spontaneous activities, phase I (CYP1A1, 1A2, and 3A4) activities), conjugation metabolism (GSTs), and antioxidant defense (CAT). Behavioral traits and phase I activities were nonresponsive to the presence of both plastics and for the two durations of exposure, indicating that these organisms are not affected by exposure to MPs and do not metabolize them. Conjugation metabolism was inhibited, which may be explained by the MPs\u2019 capability of inhibiting certain enzymes. CAT activity was increased in animals acutely exposed to PP and decreased in animals chronically exposed to PET. This study shows that PP- and PET-MPs do not cause adverse effects on H. diversicolor.<\/jats:p>","DOI":"10.3390\/microplastics4030046","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:37:23Z","timestamp":1753861043000},"page":"46","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Commercially Available Plastics on Estuarine Sediment Dweller Polychaeta Hediste diversicolor"],"prefix":"10.3390","volume":"4","author":[{"given":"David","family":"Daniel","sequence":"first","affiliation":[{"name":"Centro de Estudos do Ambiente e do Mar (CESAM), Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-7160","authenticated-orcid":false,"given":"Jo\u00e3o Pinto","family":"da Costa","sequence":"additional","affiliation":[{"name":"Centro de Estudos do Ambiente e do Mar (CESAM), Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Departamento de Qu\u00edmica, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-646X","authenticated-orcid":false,"given":"Ana Violeta","family":"Gir\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia de Materiais e Cer\u00e2mica, CICECO, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]},{"given":"Bruno","family":"Nunes","sequence":"additional","affiliation":[{"name":"Centro de Estudos do Ambiente e do Mar (CESAM), Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"},{"name":"Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1007\/s10924-018-1214-7","article-title":"Biological Recycling of Polyethylene Terephthalate: A Mini-Review","volume":"26","author":"Koshti","year":"2018","journal-title":"J. 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