{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T19:08:51Z","timestamp":1769886531565,"version":"3.49.0"},"reference-count":227,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T00:00:00Z","timestamp":1219881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Spiroketals are widely found as substructures of many naturally occurring compounds from diverse sources including plants, animals as well as microbes. Naturally occurring spiroketals are biologically active and most of them are chiral molecules. This article aims at reviewing the asymmetric synthesis of biologically active spiroketals for last 10 years (1998-2007).<\/jats:p>","DOI":"10.3390\/molecules13081942","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T12:22:15Z","timestamp":1219926135000},"page":"1942-2038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Asymmetric Synthesis of Naturally Occuring Spiroketals"],"prefix":"10.3390","volume":"13","author":[{"given":"B. Rama","family":"Raju","sequence":"first","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India"}]},{"given":"Anil K.","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India"}]}],"member":"1968","published-online":{"date-parts":[[2008,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1021\/cr00097a015","article-title":"Chemistry of spiroketals","volume":"89","author":"Perron","year":"1989","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2174\/1385272033372969","article-title":"Strategies in spiroketal synthesis revisited: Recent applications and advances","volume":"7","author":"Mead","year":"2003","journal-title":"Curr. Org. 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