{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:59:48Z","timestamp":1772755188868,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T00:00:00Z","timestamp":1247443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3\u2019,4\u2019,5\u2019-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.<\/jats:p>","DOI":"10.3390\/molecules14072514","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T11:05:36Z","timestamp":1247483136000},"page":"2514-2520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids"],"prefix":"10.3390","volume":"14","author":[{"given":"Antonella","family":"Fais","sequence":"first","affiliation":[{"name":"Dipartimento Scienze Applicate ai Biosistemi, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 Km 0.700 bivio per Sestu, 09042 Monserrato, CA, Italy"}]},{"given":"Marcella","family":"Corda","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Applicate ai Biosistemi, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 Km 0.700 bivio per Sestu, 09042 Monserrato, CA, Italy"}]},{"given":"Benedetta","family":"Era","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Applicate ai Biosistemi, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 Km 0.700 bivio per Sestu, 09042 Monserrato, CA, Italy"}]},{"given":"M. Benedetta","family":"Fadda","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Applicate ai Biosistemi, Universit\u00e0 degli Studi di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 Km 0.700 bivio per Sestu, 09042 Monserrato, CA, Italy"}]},{"given":"Maria Joao","family":"Matos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, CA, Italy"}]},{"given":"Elias","family":"Quezada q","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"},{"name":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, CA, Italy"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Carmen","family":"Picciau","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, CA, Italy"}]},{"given":"Gianni","family":"Podda","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, CA, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-1544","authenticated-orcid":false,"given":"Giovanna","family":"Delogu","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universit\u00e0 degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, CA, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2009,7,13]]},"reference":[{"key":"ref_1","first-page":"221","article-title":"Molecular and active site structure of tyrosinase","volume":"5","author":"Lerch","year":"1987","journal-title":"Life Chem. 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