{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:20:10Z","timestamp":1775276410298,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.<\/jats:p>","DOI":"10.3390\/molecules15010270","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T04:04:25Z","timestamp":1263355465000},"page":"270-279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins"],"prefix":"10.3390","volume":"15","author":[{"given":"El\u00edas","family":"Quezada","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Sciences, University Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-1544","authenticated-orcid":false,"given":"Giovanna","family":"Delogu","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy"}]},{"given":"Carmen","family":"Picciau","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Gianni","family":"Podda","sequence":"additional","affiliation":[{"name":"Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Sciences, University Porto, 4169-007 Porto, Portugal"}]},{"given":"Ver\u00f3nica","family":"Garc\u00eda-Morales","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Dolores","family":"Vi\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Francisco","family":"Orallo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2010,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/0929867053507315","article-title":"Simple coumarins and analogues in medicinal chemistry: Occurrence, synthesis and biological activity","volume":"12","author":"Borges","year":"2005","journal-title":"Curr. 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Mechanisms of cardiovascular protection by resveratrol","volume":"7","author":"Hao","year":"2004","journal-title":"Med. Food"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bmcl.2005.10.013","article-title":"Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids","volume":"16","author":"Vilar","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1248\/cpb.35.1796","article-title":"Synthesis of coumarins by Nucleophilic Denitrocyclization Reaction","volume":"35","author":"Oda","year":"1987","journal-title":"Chem. Pharm. Bull."},{"key":"ref_11","first-page":"1159","article-title":"A novel one-step synthesis of 3-phenyl-, 4-methyl-3-phenyl- and 3-phenyl-4-styrylcoumarins using DCC-DMSO","volume":"35B","author":"Hans","year":"1996","journal-title":"Indian J. 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(49054371), JP Pat."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/1\/270\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T22:01:09Z","timestamp":1760220069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/15\/1\/270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,12]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,1]]}},"alternative-id":["15010270"],"URL":"https:\/\/doi.org\/10.3390\/molecules15010270","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,12]]}}}