{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:29:00Z","timestamp":1760984940126,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell line. In this paper, we present a structure-activity relationship study focused on the apolar dioxolane derivatives of 20-hydroxyecdysone. Semi-synthesis and bioactivity of a total of 32 ecdysteroids, including 20 new compounds, is presented, supplemented with their complete 1H- and 13C-NMR signal assignment.<\/jats:p>","DOI":"10.3390\/molecules181215255","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T12:32:12Z","timestamp":1386678732000},"page":"15255-15275","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Synthesis and Structure-Activity Relationships of Novel Ecdysteroid Dioxolanes as MDR Modulators in Cancer"],"prefix":"10.3390","volume":"18","author":[{"given":"Ana","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, University of Szeged, D\u00f3m t\u00e9r 9, Szeged 6720, Hungary"},{"name":"Unidade de Parasitologia e Microbiologia M\u00e9dica, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua da Junqueira 100, Lisbon 1349-008, Portugal"}]},{"given":"J\u00f3zsef","family":"Cs\u00e1bi","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, E\u00f6tv\u00f6s u. 6,  Szeged 6720, Hungary"}]},{"given":"Attila","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"Ubichem Research Ltd., Illatos \u00fat 33, Budapest H-1097, Hungary"}]},{"given":"Di\u00e1na","family":"Kitka","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, University of Szeged, D\u00f3m t\u00e9r 9, Szeged 6720, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-1295","authenticated-orcid":false,"given":"Leonard","family":"Amaral","sequence":"additional","affiliation":[{"name":"Center for Malaria and Other Tropical Diseases (CMDT), Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua da Junqueira 100, Lisbon 1349-008, Portugal"}]},{"given":"J\u00f3zsef","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, University of Szeged, D\u00f3m t\u00e9r 9, Szeged 6720, Hungary"}]},{"given":"Andr\u00e1s","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gell\u00e9rt t\u00e9r 4, Budapest H-1111, Hungary"}]},{"given":"G\u00e1bor","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gell\u00e9rt t\u00e9r 4, Budapest H-1111, Hungary"}]},{"given":"Attila","family":"Hunyadi","sequence":"additional","affiliation":[{"name":"Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, E\u00f6tv\u00f6s u. 6,  Szeged 6720, Hungary"}]}],"member":"1968","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Burdette, W.B. (1974). Invertebrate Endocrinology and Hormonal Heterophylly, Springer.","key":"ref_1","DOI":"10.1007\/978-3-642-65769-6"},{"key":"ref_2","first-page":"183","article-title":"Hormonally mediated insect-plant relationships: Arthropod populations associated with ecdysteroid-containing plant, Leuzea carthamoides (Asteraceae)","volume":"94","author":"Zeleny","year":"1997","journal-title":"Eur J. Entomol."},{"key":"ref_3","first-page":"271","article-title":"A strategy for the identification of ecdysteroid receptor agonists and antagonists from plants","volume":"92","author":"Dinan","year":"1995","journal-title":"Eur. J. Entomol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2174\/092986710791163911","article-title":"Phytoecdysteroids and vitamin D analogues\u2014Similarities in structure and mode of action","volume":"17","author":"Hunyadi","year":"2010","journal-title":"Curr. Med. 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Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1073\/pnas.85.12.4486","article-title":"A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells","volume":"85","author":"Pastan","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7386","DOI":"10.1073\/pnas.88.16.7386","article-title":"Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection","volume":"88","author":"Choi","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/12\/15255\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:51:14Z","timestamp":1760219474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/18\/12\/15255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":13,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,12]]}},"alternative-id":["molecules181215255"],"URL":"https:\/\/doi.org\/10.3390\/molecules181215255","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}