{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:26:32Z","timestamp":1760243192874,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 \u00b0C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN4S with Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+ and Pb2+ metal ions were further performed under the same experimental conditions. The results demonstrated that this compound has a higher selectivity and thermodynamic stability for Hg2+ and Cu2+, followed by Ni2+. The UV-visible-near IR spectroscopies and magnetic moment data for the Co(II) and Ni(II) complexes indicated a tetragonal distorted coordination geometry for both metal centres. The value of magnetic moment and the X-band EPR spectra of the Cu(II) complex are consistent with a distorted square pyramidal geometry.<\/jats:p>","DOI":"10.3390\/molecules19010550","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T11:24:06Z","timestamp":1388748246000},"page":"550-567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy"],"prefix":"10.3390","volume":"19","author":[{"given":"Nuno","family":"Torres","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Sandrina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Ana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CBIOS, Universidade Lus\u00f3fona Research Center in Biosciences & Health Technologies, Campo Grande 376, Lisboa 1749-024, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-2386","authenticated-orcid":false,"given":"J.","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Maria","family":"De Brito","sequence":"additional","affiliation":[{"name":"CQE, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa 1049-001, Portugal"},{"name":"DQB, Faculdade de Ci\u00eancias, Universidade de Lisboa, Campo Grande, Lisboa 1749-001, Portugal"}]},{"given":"Nuno","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Matilde","family":"Castro","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Judite","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]},{"given":"Maria","family":"Cabral","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1018457305212","article-title":"The carcinogenicity of metals in humans","volume":"8","author":"Hayes","year":"1997","journal-title":"Cancer Cause. 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