{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:21:43Z","timestamp":1776500503372,"version":"3.51.2"},"reference-count":26,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and\/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 \u00b1 0.06 \u00b5M) and it was also  showed to be a potent AChEI (IC50 = 31.0 \u00b1 0.09 \u00b5M) when compared to galantamine (IC50 = 211.8 \u00b1 9.5 \u00b5M).<\/jats:p>","DOI":"10.3390\/molecules19068317","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T11:22:58Z","timestamp":1403176978000},"page":"8317-8333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Xanthenedione Derivatives, New Promising Antioxidant and Acetylcholinesterase Inhibitor Agents"],"prefix":"10.3390","volume":"19","author":[{"given":"Ana","family":"Seca","sequence":"first","affiliation":[{"name":"DCTD, University of Azores, Rua M\u00e3e de Deus, Ponta Delgada 9501-801, Portugal"},{"name":"Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago,  Aveiro 3810-193, Portugal"}]},{"given":"Stephanie","family":"Leal","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago,  Aveiro 3810-193, Portugal"}]},{"given":"Diana","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago,  Aveiro 3810-193, Portugal"}]},{"given":"Maria","family":"Barreto","sequence":"additional","affiliation":[{"name":"DCTD, University of Azores, Rua M\u00e3e de Deus, Ponta Delgada 9501-801, Portugal"},{"name":"CIRN, University of Azores, Ponta Delgada 9501-801, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Campus de Santiago,  Aveiro 3810-193, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12223-013-0239-5","article-title":"Role of oxidative stress in infectious diseases. 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