{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:40:41Z","timestamp":1777621241133,"version":"3.51.4"},"reference-count":273,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of severity and the persistence of infections are worsened when microorganisms form biofilms. Therefore, efforts are being applied to develop new drugs not as vulnerable as the current ones to bacterial resistance mechanisms, and also able to target bacteria in biofilms. Natural products, especially those obtained from plants, have proven to be outstanding compounds with unique properties, making them perfect candidates for these much-needed therapeutics. This review presents the current knowledge on the potentialities of plant products as antibiotic adjuvants to restore the therapeutic activity of drugs. Further, the difficulties associated with the use of the existing antibiotics in the treatment of biofilm-related infections are described. To counteract the biofilm resistance problems, innovative strategies are suggested based on literature data. Among the proposed strategies, the use of phytochemicals to inhibit or eradicate biofilms is highlighted. An overview on the use of phytochemicals to interfere with bacterial quorum sensing (QS) signaling pathways and underlying phenotypes is provided. The use of phytochemicals as chelating agents and efflux pump inhibitors is also reviewed.<\/jats:p>","DOI":"10.3390\/molecules21070877","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T10:06:19Z","timestamp":1467713179000},"page":"877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":241,"title":["New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-6805","authenticated-orcid":false,"given":"Anabela","family":"Borges","sequence":"first","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"},{"name":"CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s\/n, Porto 4169-007, Portugal"},{"name":"CECAV-Veterinary and Animal Science Research Center, Department of Veterinary Science, University of Tr\u00e1s-os-Montes e Alto Douro, Apartado 1013, Vila Real 5001-801, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-866X","authenticated-orcid":false,"given":"Ana","family":"Abreu","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"},{"name":"CECAV-Veterinary and Animal Science Research Center, Department of Veterinary Science, University of Tr\u00e1s-os-Montes e Alto Douro, Apartado 1013, Vila Real 5001-801, Portugal"}]},{"given":"Carla","family":"Dias","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"},{"name":"CECAV-Veterinary and Animal Science Research Center, Department of Veterinary Science, University of Tr\u00e1s-os-Montes e Alto Douro, Apartado 1013, Vila Real 5001-801, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-4965","authenticated-orcid":false,"given":"Maria","family":"Saavedra","sequence":"additional","affiliation":[{"name":"CECAV-Veterinary and Animal Science Research Center, Department of Veterinary Science, University of Tr\u00e1s-os-Montes e Alto Douro, Apartado 1013, Vila Real 5001-801, Portugal"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s\/n, Porto 4169-007, Portugal"}]},{"given":"Manuel","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s\/n, Porto 4200-465, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.3390\/ijms10083371","article-title":"Chemical diversity and defence metabolism: How plants cope with pathogens and ozone pollution","volume":"10","author":"Iriti","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/nph.12797","article-title":"Abiotic and biotic stress combinations","volume":"203","author":"Suzuki","year":"2014","journal-title":"New Phytol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/35081193","article-title":"Co-evolution and plant resistance to natural enemies","volume":"411","author":"Rausher","year":"2001","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/35081161","article-title":"Plant pathogens and integrated defence responses to infection","volume":"411","author":"Dangl","year":"2001","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.4161\/psb.21663","article-title":"Mechanisms of plant defense against insect herbivores","volume":"7","author":"War","year":"2012","journal-title":"Plant Signal. Behav."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.3390\/ijms140510242","article-title":"Plant defense against insect herbivores","volume":"14","author":"Zagrobelny","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2307\/3869817","article-title":"Two classes of plant antibiotics: Phytoalexins versus \u201cphytoanticipins\u201d","volume":"6","author":"VanEtten","year":"1994","journal-title":"Plant Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.3390\/ijms10083400","article-title":"Plant antimicrobial agents and their effects on plant and human pathogens","volume":"10","author":"Mitchell","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jfda.2015.06.010","article-title":"Antioxidant and antidiabetic activities of 11 herbal plants from Hyrcania region, Iran","volume":"24","author":"Dehghan","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/039463201402700301","article-title":"Review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants","volume":"27","author":"Akram","year":"2014","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1300\/J044v11n01_01","article-title":"Important secondary metabolites and essential oils of species within the Anthemideae (Asteraceae)","volume":"11","author":"Yonekura","year":"2005","journal-title":"J. Herbs Spices Med. Plants"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrd3975","article-title":"Platforms for antibiotic discovery","volume":"12","author":"Lewis","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/AAC.46.10.3133-3141.2002","article-title":"Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials","volume":"46","author":"Tegos","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","article-title":"Molecular mechanisms of antibiotic resistance","volume":"13","author":"Blair","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tim.2013.11.001","article-title":"The role of aquatic ecosystems as reservoirs of antibiotic resistance","volume":"22","author":"Marti","year":"2014","journal-title":"Trends Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1476-5381.2011.01250.x","article-title":"Novel classes of antibiotics or more of the same?","volume":"163","author":"Coates","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1128\/AAC.00919-08","article-title":"Geraniol restores antibiotic activities against multidrug-resistant isolates from Gram-negative species","volume":"53","author":"Lorenzi","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.addr.2005.04.005","article-title":"Clinical impact and relevance of antibiotic resistance","volume":"57","author":"French","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Walsh, F. (2013). Investigating antibiotic resistance in non-clinical environments. Front. Microbiol., 4.","DOI":"10.3389\/fmicb.2013.00019"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1155157","article-title":"Bacteria subsisting on antibiotics","volume":"320","author":"Dantas","year":"2008","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fiamegos, Y.C., Kastritis, P.L., Exarchou, V., Han, H., Bonvin, A.M.J.J., Vervoort, J., Lewis, K., Hamblin, M.R., and Tegos, G.P. (2011). Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018127"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"Holmes","year":"2016","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cell.2007.03.004","article-title":"Molecular mechanisms of antibacterial multidrug resistance","volume":"128","author":"Alekshun","year":"2007","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/medicina47030019","article-title":"Antibiotic resistance mechanisms of clinically important bacteria","volume":"47","author":"Giedraitiene","year":"2011","journal-title":"Medicina"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s12038-008-0077-9","article-title":"Emerging antibiotic resistance in bacteria with special reference to India","volume":"33","author":"Raghunath","year":"2008","journal-title":"J. Biosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/CMR.00043-12","article-title":"Adaptive and mutational resistance: Role of porins and efflux pumps in drug resistance","volume":"25","author":"Fernandez","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"Delcour","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","article-title":"Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria","volume":"19","author":"Piddock","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/c0cc05111j","article-title":"Molecular mechanisms of antibiotic resistance","volume":"47","author":"Wright","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/dkg050","article-title":"The importance of efflux pumps in bacterial antibiotic resistance","volume":"51","author":"Webber","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1128\/AAC.00580-10","article-title":"LmrS Is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus","volume":"54","author":"Floyd","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Hu, R.M., Liao, S.T., Huang, C.C., Huang, Y.W., and Yang, T.C. (2012). An inducible fusaric acid tripartite efflux pump contributes to the fusaric acid resistance in Stenotrophomonas maltophilia. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051053"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.gene.2012.02.008","article-title":"Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae","volume":"498","author":"Ogawa","year":"2012","journal-title":"Gene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/cbic.201000067","article-title":"Antibiotic resistance by enzyme inactivation: From mechanisms to solutions","volume":"11","author":"Wright","year":"2010","journal-title":"ChemBioChem"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01857.x","article-title":"Defining an extended-spectrum beta-lactamase","volume":"14","author":"Livermore","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.tim.2011.09.005","article-title":"The emerging NDM carbapenemases","volume":"19","author":"Nordmann","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/fmb.12.130","article-title":"Carbapenemase-producing Enterobacteriaceae: Now that the storm is finally here, how will timely detection help us fight back?","volume":"8","author":"Voulgari","year":"2013","journal-title":"Future Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1574-6976.2011.00268.x","article-title":"Multiresistant Gram-negative bacteria: The role of high-risk clones in the dissemination of antibiotic resistance","volume":"35","author":"Woodford","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-Lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMra041359","article-title":"Mechanisms of disease: The new beta-lactamases","volume":"352","author":"Jacoby","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of beta-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.mib.2005.08.014","article-title":"The threat of antibiotic resistance in Gram-negative pathogenic bacteria: Beta-lactams in peril!","volume":"8","author":"Thomson","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AAC.39.6.1211","article-title":"A functional classification scheme for beta-lactamases and its correlation with molecular-structure","volume":"39","author":"Bush","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1128\/AAC.48.7.2347-2349.2004","article-title":"Update of the standard numbering scheme for class B beta-lactamases","volume":"48","author":"Garau","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_46","first-page":"22","article-title":"Mechanisms of antibiotic resistance in Pseudomonas aeruginosa","volume":"95","author":"Lambert","year":"2002","journal-title":"J. R. Soc. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1099\/jmm.0.052555-0","article-title":"Global spread of antibiotic resistance: The example of New Delhi metallo-beta-lactamase (NDM)-mediated carbapenem resistance","volume":"62","author":"Johnson","year":"2013","journal-title":"J. Med. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.8.4.557","article-title":"Beta-lactamases in laboratory and clinical resistance","volume":"8","author":"Livermore","year":"1995","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.48.1.1-14.2004","article-title":"Growing group of extended-spectrum beta-lactamases: The CTX-M enzymes","volume":"48","author":"Bonnet","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tim.2006.07.008","article-title":"The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter","volume":"14","author":"Livermore","year":"2006","journal-title":"Trends Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: A clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_52","first-page":"11","article-title":"Antibiotic resistance mechanisms in bacteria: Biochemical and genetic aspects","volume":"46","author":"Dzidic","year":"2008","journal-title":"Food Technol. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/CMR.15.4.647-679.2002","article-title":"Interactions among strategies associated with bacterial infection: Pathogenicity, epidemicity, and antibiotic resistance","volume":"15","author":"Martinez","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/bmj.317.7159.657","article-title":"The origins and molecular basis of antibiotic resistance","volume":"317","author":"Hawkey","year":"1998","journal-title":"Br. Med. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0966-842X(01)02175-8","article-title":"The emergence and evolution of methicillin-resistant Staphylococcus aureus","volume":"9","author":"Hiramatsu","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.2174\/0929867322666150530210522","article-title":"Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents","volume":"22","author":"Borges","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1078\/1438-4221-00196","article-title":"Mechanisms of antibiotic resistance in bacterial biofilms","volume":"292","author":"Stewart","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_58","first-page":"135","article-title":"Antibiotic resistance of bacteria in biofilms","volume":"358","author":"Stewart","year":"2001","journal-title":"Antibiot. Resist. Bact. Biofilms"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/35037627","article-title":"Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms","volume":"407","author":"Singh","year":"2000","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.mib.2013.06.013","article-title":"Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies","volume":"16","author":"Reffuveille","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1365-2672.2010.04756.x","article-title":"Biofilm formation and the food industry, a focus on the bacterial outer surface","volume":"109","author":"Van","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2110-5820-1-19","article-title":"Hacking into bacterial biofilms: A new therapeutic challenge","volume":"1","author":"Bordi","year":"2011","journal-title":"Ann. Intensive Care"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","article-title":"Riddle of biofilm resistance","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1128\/AAC.44.3.640-646.2000","article-title":"A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms","volume":"44","author":"Brooun","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/jac\/dkn044","article-title":"Increased mutability of Pseudomonas aeruginosa in biofilms","volume":"61","author":"Driffield","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0958-1669(03)00036-3","article-title":"Gene transfer occurs with enhanced efficiency in biofilms and induces enhanced stabilisation of the biofilm structure","volume":"14","author":"Molin","year":"2003","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijantimicag.2009.12.011","article-title":"Antibiotic resistance of bacterial biofilms","volume":"35","author":"Hoiby","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: Survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: Microbial life on surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1128\/AAC.38.9.2125","article-title":"Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms","volume":"38","author":"Suci","year":"1994","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1139\/m92-201","article-title":"Disparate efficacy of tobramycin on Ca(2+)-, Mg(2+)-, and HEPES-treated Pseudomonas aeruginosa biofilms","volume":"38","author":"Hoyle","year":"1992","journal-title":"Can. J. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.blo.0000175714.68624.74","article-title":"Biofilms and antimicrobial resistance","volume":"437","author":"Patel","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1128\/CMR.15.2.155-166.2002","article-title":"Bacterial adhesion: Seen any good biofilms lately?","volume":"15","author":"Dunne","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/jac\/27.2.177","article-title":"Susceptibility of Pseudomonas aeruginosa and Escherichia coli biofilms towards ciprofloxacin: Effect of specific growth rate","volume":"27","author":"Evans","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/jac\/30.6.791","article-title":"Growth-rate-independent killing by ciprofloxacin of biofilm-derived Staphylococcus epidermidis; evidence for cell-cycle dependency","volume":"30","author":"Duguid","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/jac\/30.6.803","article-title":"Effect of biofilm culture upon the susceptibility of Staphylococcus epidermidis to tobramycin","volume":"30","author":"Duguid","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_79","first-page":"267","article-title":"Persister cells and the riddle of biofilm survival","volume":"70","author":"Lewis","year":"2005","journal-title":"Biochemesrty"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1097(03)00856-5","article-title":"Persister cells and tolerance to antimicrobials","volume":"230","author":"Keren","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Malik, A., Grohmann, E., and Akhtar, R. (2013). Environmental Deterioration and Human Health: Natural and Anthropogenic Determinants, Springer Science & Business Media.","DOI":"10.1007\/978-94-007-7890-0"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Berglund, B. (2015). Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect. Ecol. Epidemiol., 5.","DOI":"10.3402\/iee.v5.28564"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2672.1997.tb03590.x","article-title":"Isolation and characterization of coliforms from glacial ice and water in Canada\u2019s High Arctic","volume":"82","author":"Dancer","year":"1997","journal-title":"J. Appl. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.mib.2010.08.005","article-title":"Antibiotic resistance in the environment: A link to the clinic?","volume":"13","author":"Wright","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","article-title":"Call of the wild: Antibiotic resistance genes in natural environments","volume":"8","author":"Allen","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1126\/science.1120800","article-title":"Sampling the antibiotic resistome","volume":"311","author":"McGrann","year":"2006","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1220761","article-title":"The shared antibiotic resistome of soil bacteria and human pathogens","volume":"337","author":"Forsberg","year":"2012","journal-title":"Science"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1462-2920.2004.00664.x","article-title":"Uncultured soil bacteria are a reservoir of new antibiotic resistance genes","volume":"6","author":"Riesenfeld","year":"2004","journal-title":"Environ. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1128\/AEM.01763-09","article-title":"Metagenomic analysis of apple orchard soil reveals antibiotic resistance genes encoding predicted bifunctional proteins","volume":"76","author":"Donato","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1128\/AEM.00323-10","article-title":"Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics","volume":"76","author":"Lang","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00248-008-9431-6","article-title":"Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface","volume":"57","author":"Brown","year":"2008","journal-title":"Microb. Ecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijmm.2015.11.004","article-title":"Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options","volume":"306","author":"Chatterjee","year":"2016","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1073\/pnas.0800072105","article-title":"Antibiotic-resistant soil bacteria in transgenic plant fields","volume":"105","author":"Sanguin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/1874285801408010006","article-title":"Essential oils, a new horizon in combating bacterial antibiotic resistance","volume":"8","author":"Yap","year":"2014","journal-title":"Open Microbiol. J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/1060028014556652","article-title":"\u03b2-lactam\/\u03b2-lactamase inhibitor combinations: From then to now","volume":"49","author":"Toussaint","year":"2015","journal-title":"Ann. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.febslet.2011.04.054","article-title":"Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria","volume":"585","author":"Bolla","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbapap.2008.12.011","article-title":"Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria","volume":"1794","author":"Amaral","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/157489112799829710","article-title":"Bacterial efflux pumps involved in multidrug resistance and their inhibitors: Rejuvinating the antimicrobial chemotherapy","volume":"7","author":"Bhardwaj","year":"2012","journal-title":"Recent Pat. Antiinfect. Drug Discov."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1017\/S1462399410001766","article-title":"Antibiotic adjuvants: Multicomponent anti-infective strategies","volume":"13","author":"Kalan","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/157489109787236256","article-title":"Inhibitors of multidrug resistant efflux systems in bacteria","volume":"4","author":"Zechini","year":"2009","journal-title":"Recent Pat. Antiinfect. Drug Discov."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.2174\/0929867323666160304150522","article-title":"Current advances in developing inhibitors of bacterial multidrug efflux pumps","volume":"23","author":"Mahmood","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: Diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.biochi.2005.04.012","article-title":"Bacterial efflux systems and efflux pumps inhibitors","volume":"87","author":"Marquez","year":"2005","journal-title":"Biochimie"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbrc.2014.05.090","article-title":"Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations","volume":"453","author":"Sun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: A continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1055\/s-0030-1250606","article-title":"Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition","volume":"77","author":"Ettefagh","year":"2011","journal-title":"Planta Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ja.2012.27","article-title":"Thoughts and facts about antibiotics: Where we are now and where we are heading","volume":"65","author":"Berdy","year":"2012","journal-title":"J. Antibiot."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nchembio.2003","article-title":"Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence","volume":"12","author":"Chen","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"ref_110","first-page":"1147","article-title":"Use of bioactive plant products in combination with standard antibiotics: Implications in antimicrobial chemotherapy","volume":"3","author":"Aiyegoro","year":"2009","journal-title":"J. Med. Plants Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: Approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1039\/c2np20035j","article-title":"Plants as sources of new antimicrobials and resistance-modifying agents","volume":"29","author":"Abreu","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"ref_113","first-page":"2886","article-title":"The challenges of overcoming antibiotic resistance: Plant extracts as potential sources of antimicrobial and resistance modifying agents","volume":"6","author":"Sibanda","year":"2007","journal-title":"Afr. J. Biotechnol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1590\/S0074-02762006000400007","article-title":"Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases","volume":"101","author":"Betoni","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"556","DOI":"10.7150\/ijbs.6.556","article-title":"Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro","volume":"6","author":"Jayaraman","year":"2010","journal-title":"Int. J. Biol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1089\/mdr.2014.0252","article-title":"Combinatorial activity of flavonoids with antibiotics against drug-resistant Staphylococcus aureus","volume":"21","author":"Abreu","year":"2015","journal-title":"Microb. Drug Res."},{"key":"ref_117","first-page":"464","article-title":"Mechanisms of antibiotic resistance","volume":"23","author":"Hoffman","year":"2001","journal-title":"Compendium"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jac\/dkl460","article-title":"Bacterial efflux pump inhibitors from natural sources","volume":"59","author":"Stavri","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2217\/fmb.12.68","article-title":"Plant-derived antimicrobial compounds: Alternatives to antibiotics","volume":"7","author":"Savoia","year":"2012","journal-title":"Future Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijantimicag.2010.10.027","article-title":"Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria","volume":"37","author":"Garvey","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0378-8741(01)00411-1","article-title":"Screening of antibiotic resistant inhibitors from local plant materials against two different strains of Staphylococcus aureus","volume":"79","author":"Darwish","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.micres.2006.06.010","article-title":"In vitro efficacy of bioactive extracts of 15 medicinal plants against ES\u03b2L-producing multidrug-resistant enteric bacteria","volume":"162","author":"Ahmad","year":"2007","journal-title":"Microbiol. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-14-258","article-title":"Antibiotic-potentiation activities of four Cameroonian dietary plants against multidrug-resistant Gram-negative bacteria expressing efflux pumps","volume":"14","author":"Touani","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Barreto, H.M., Coelho, K.M.R.N., Ferreira, J.H.L., dos Santos, B.H.C., de Abreu, A.P.L., Coutinho, H.D.M., da Silva, R.A.C., de Sousa, T.O., Cit\u00f3, A.M.D.G.L., and Lopes, J.A.D. (2015). Enhancement of the antibiotic activity of aminoglycosides by extracts from Anadenanthera colubrine (Vell.) Brenan var. cebil against multi-drug resistant bacteria. Nat. Prod. Res., 1\u20134.","DOI":"10.1080\/14786419.2015.1049177"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.eujim.2014.03.011","article-title":"Effect of Lippia origanoides H.B.K. essential oil in the resistance to aminoglycosides in methicillin resistant Staphylococcus aureus","volume":"6","author":"Barreto","year":"2014","journal-title":"Eur. J. Integr. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.indcrop.2015.03.058","article-title":"Antimicrobial, antibiotic potentiating activity and phytochemical profile of essential oils from exotic and endemic medicinal plants of Mauritius","volume":"71","author":"Mahomoodally","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-015-0726-0","article-title":"Antibacterial and antibiotic resistance modifying activity of the extracts from Alanblackia gabonensis, Combretum molle and Gladiolus quartinianus against Gram-negative bacteria including multi-drug resistant phenotypes","volume":"15","author":"Fankam","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-015-0944-5","article-title":"In vitro antibacterial and antibiotic-potentiation activities of the methanol extracts from Beilschmiedia acuta, Clausena anisata, Newbouldia laevis and Polyscias fulva against multidrug-resistant Gram-negative bacteria","volume":"15","author":"Tankeo","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/jam.12348","article-title":"Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria","volume":"116","author":"Alves","year":"2014","journal-title":"J. Appl. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrd4000","article-title":"Applying insights from biofilm biology to drug development - can a new approach be developed?","volume":"12","author":"Bjarnsholt","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1517\/13543776.2010.505923","article-title":"New antibiotic agents and approaches to treat biofilm-associated infections","volume":"20","author":"Lynch","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1574-695X.2010.00665.x","article-title":"Prevention and control of biofilm-based medical-device-related infections","volume":"59","author":"Francolini","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/b821648g","article-title":"Understanding antimicrobial activities of phytochemicals against multidrug resistant bacteria and biofilms","volume":"26","author":"Bennett","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.coph.2013.07.004","article-title":"Biologically inspired strategies for combating bacterial biofilms","volume":"13","author":"Blackledge","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/MMBR.00013-14","article-title":"Biofilm-related infections: Bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics","volume":"78","author":"Lebeaux","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ijos.2014.65","article-title":"Strategies for combating bacterial biofilm infections","volume":"7","author":"Wu","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2013\/150653","article-title":"Innovative strategies to overcome biofilm resistance","volume":"2013","author":"Taraszkiewicz","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.tim.2013.08.005","article-title":"Small molecules are natural triggers for the disassembly of biofilms","volume":"21","author":"Steinberg","year":"2013","journal-title":"Trends Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.addr.2005.04.007","article-title":"Biofilms and antibiotic therapy: Is there a role for combating bacterial resistance by the use of novel drug delivery systems?","volume":"57","author":"Smith","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1381612820666140905123529","article-title":"Strategies for antimicrobial drug delivery to biofilm","volume":"21","author":"Martin","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/MMBR.00046-12","article-title":"Exploiting quorum sensing to confuse bacterial pathogens","volume":"77","author":"LaSarre","year":"2013","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrd3013","article-title":"Anti-virulence strategies to combat bacteria-mediated disease","volume":"9","author":"Rasko","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1128\/AAC.05919-11","article-title":"Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing","volume":"56","author":"Jakobsen","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/08927014.2013.852542","article-title":"Evaluation of the effects of selected phytochemicals on quorum sensing inhibition and in vitro cytotoxicity","volume":"30","author":"Borges","year":"2014","journal-title":"Biofouling"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/08927014.2013.776546","article-title":"Mini-review: Molecular mechanisms of antifouling compounds","volume":"29","author":"Qian","year":"2013","journal-title":"Biofouling"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1128\/AEM.05992-11","article-title":"Food as a source for quorum sensing inhibitors: Iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa","volume":"78","author":"Jakobsen","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1021\/ja5110798","article-title":"Small molecule disruption of quorum sensing cross-regulation in Pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes","volume":"137","author":"Welsh","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biotechadv.2012.10.004","article-title":"Quorum sensing inhibitors: An overview","volume":"31","author":"Kalia","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1126\/science.280.5361.295","article-title":"The involvement of cell-to-cell signals in the development of a bacterial biofilm","volume":"280","author":"Davies","year":"1998","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.bioeng.10.061807.160536","article-title":"Bacterial quorum sensing: Signals, circuits, and implications for biofilms and disease","volume":"10","author":"Jayaraman","year":"2008","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1098\/rstb.2007.2046","article-title":"Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens","volume":"362","author":"Bjarnsholt","year":"2007","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1517\/13543770903222293","article-title":"Quorum sensing inhibitors: A patent overview","volume":"19","author":"Pan","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"575","DOI":"10.12998\/wjcc.v3.i7.575","article-title":"Role of quorum sensing in bacterial infections","volume":"3","author":"Maeda","year":"2015","journal-title":"World J. Clin. Cases"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.fitote.2007.03.009","article-title":"Dietary phytochemicals as quorum sensing inhibitors","volume":"78","author":"Vattem","year":"2007","journal-title":"Fitoterapia"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijmm.2006.02.005","article-title":"Quorum-sensing inhibitors as anti-pathogenic drugs","volume":"296","author":"Rasmussen","year":"2006","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000320185","article-title":"Evaluation of anti-quorum-sensing activity of edible plants and fruits through inhibition of the N-acyl-homoserine lactone system in Chromobacterium violaceum and Pseudomonas aeruginosa","volume":"56","author":"Musthafa","year":"2010","journal-title":"Chemotherapy"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jmii.2009.10.001","article-title":"Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity","volume":"44","author":"Koh","year":"2011","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.arcmed.2011.12.002","article-title":"Antiquorum sensing and antibiofilm potential of Capparis spinosa","volume":"42","author":"Palani","year":"2011","journal-title":"Arch. Med. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1055\/s-0030-1250145","article-title":"Quorum sensing inhibitors of Staphylococcus aureus from Italian medicinal plants","volume":"77","author":"Quave","year":"2011","journal-title":"Planta Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/08927014.2011.647308","article-title":"Anti-biofilm activity of Salvadora persica on cariogenic isolates of Streptococcus mutans: In vitro and molecular docking studies","volume":"28","author":"Murugan","year":"2012","journal-title":"Biofouling"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Hasan, S., Danishuddin, M., Adil, M., Singh, K., Verma, P.K., and Khan, A.U. (2012). Efficacy of E. officinalis on the cariogenic properties of Streptococcus mutans: A novel and alternative approach to suppress quorum-sensing mechanism. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040319"},{"key":"ref_162","first-page":"110","article-title":"Effect of biologically synthesised silver nanoparticles on Staphylococcus aureus biofilm quenching and prevention of biofilm formation","volume":"6","author":"Masurkar","year":"2012","journal-title":"Int. J. Pharm. Bio. Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1055\/s-0032-1315042","article-title":"Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"78","author":"Cech","year":"2012","journal-title":"Planta Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3109\/13880209.2013.764330","article-title":"Antibiofilm and quorum sensing inhibitory activity of Achyranthes aspera on cariogenic Streptococcus mutans: An in vitro and in silico study","volume":"51","author":"Murugan","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.arcmed.2013.10.004","article-title":"Amphypterygium adstringens anacardic acid mixture inhibits quorum sensing-controlled virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa","volume":"44","year":"2013","journal-title":"Arch. Med. Res."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Damte, D., Gebru, E., Lee, S.-J., Suh, J.-W., and Park, S.-C. (2013). Evaluation of anti-quorum sensing activity of 97 indigenous plant extracts from Korea through bioreporter bacterial strains Chromobacterium violaceum and Pseudomonas aeruginosa. J. Microb. Biochem. Technol., 2013.","DOI":"10.4172\/1948-5948.1000098"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Sarabhai, S., Sharma, P., and Capalash, N. (2013). Ellagic acid derivatives from Terminalia chebula Retz. downregulate the expression of quorum sensing genes to attenuate Pseudomonas aeruginosa PAO1 virulence. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053441"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1099\/mic.0.064378-0","article-title":"Endemic Malagasy Dalbergia species inhibit quorum sensing in Pseudomonas aeruginosa PAO1","volume":"159","author":"Rasamiravaka","year":"2013","journal-title":"Microbiology"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S2221-1691(13)60185-9","article-title":"Inhibition of quorum sensing in Chromobacterium violaceum by Syzygium cumini L. and Pimenta dioica L.","volume":"3","author":"Vasavi","year":"2013","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/1348-0421.12150","article-title":"Anti-quorum sensing activity of Psidium guajava L. flavonoids against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1","volume":"58","author":"Vasavi","year":"2014","journal-title":"Microbiol. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jmii.2014.03.012","article-title":"Anti-quorum sensing activity of flavonoid-rich fraction from Centella asiatica L. against Pseudomonas aeruginosa PAO1","volume":"49","author":"Vasavi","year":"2014","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0974-8490.147220","article-title":"Anti-quorum sensing potential of Adenanthera pavonina","volume":"7","author":"Vasavi","year":"2015","journal-title":"Pharmacogn. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.foodcont.2014.02.001","article-title":"Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation","volume":"42","author":"Zhang","year":"2014","journal-title":"Food Control"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0033-1360337","article-title":"Inhibition of bacterial quorum sensing and biofilm formation by extracts of neotropical rainforest plants","volume":"80","author":"Ta","year":"2014","journal-title":"Planta Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/1462-2920.12441","article-title":"New properties of wheat bran: Anti-biofilm activity and interference with bacteria quorum-sensing systems","volume":"16","author":"Halkes","year":"2014","journal-title":"Environ. Microbiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1590\/0037-8682-0065-2015","article-title":"Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa","volume":"48","author":"Kazemian","year":"2015","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jphp.12397","article-title":"Antimicrobial properties of Kalanchoe blossfeldiana: A focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation","volume":"67","author":"Sarkar","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_178","unstructured":"Rahman, M.R.T., Lou, Z., Yu, F., Wang, P., and Wang, H. (2015). Anti-quorum sensing and anti-biofilm activity of Amomum tsaoko (Amommum tsao-ko Crevost et Lemarie) on foodborne pathogens. Saudi J. Biol. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Salini, R., and Pandian, S.K. (2015). Interference of quorum sensing in urinary pathogen Serratia marcescens by Anethum graveolens. Pathog. Dis., 73.","DOI":"10.1093\/femspd\/ftv038"},{"key":"ref_180","first-page":"80","article-title":"Anti-quorum sensing activity of some commonly used traditional indian spices","volume":"7","author":"Mutungwa","year":"2015","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Quave, C.L., Lyles, J.T., Kavanaugh, J.S., Nelson, K., Parlet, C.P., Crosby, H.A., Heilmann, K.P., and Horswill, A.R. (2015). Castanea sativa (European chestnut) leaf extracts rich in ursene and oleanene derivatives block Staphylococcus aureus virulence and pathogenesis without detectable resistance. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136486"},{"key":"ref_182","first-page":"903","article-title":"The investigation of inhibiting quorum sensing and methicillin-resistant Staphylococcus aureus biofilm formation from Liriodendron hybrid","volume":"28","author":"Tan","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1039\/C4RA11939H","article-title":"Development and characterization of a novel Swarna-based herbo-metallic colloidal nano-formulation - inhibitor of Streptococcus mutans quorum sensing","volume":"5","author":"Singh","year":"2015","journal-title":"RSC Adv."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Hasan, S., Danishuddin, M., and Khan, A.U. (2015). Inhibitory effect of Zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies. BMC Microbiol., 15.","DOI":"10.1186\/s12866-014-0320-5"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2217\/fmb.15.107","article-title":"Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids","volume":"10","author":"Bhargava","year":"2015","journal-title":"Future Microbiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/2016\/5823013","article-title":"Broad spectrum anti-quorum sensing activity of tannin-rich crude extracts of indian medicinal plants","volume":"2016","author":"Shukla","year":"2016","journal-title":"Scientifica"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-015-0348-8","article-title":"Piper betle leaf extract affects the quorum sensing and hence virulence of Pseudomonas aeruginosa PAO1","volume":"6","author":"Datta","year":"2016","journal-title":"3 Biotech"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.indcrop.2016.01.037","article-title":"Antioxidant, antimicrobial and anti-quorum sensing activities of Rubus rosaefolius phenolic extract","volume":"84","author":"Oliveira","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Bezek, K., Kurin\u010di\u010d, M., Knauder, E., Klan\u010dnik, A., Raspor, P., Bucar, F., and Smole Mo\u017eina, S. (2016). Attenuation of adhesion, biofilm formation and quorum sensing of Campylobacter jejuni by Euodia ruticarpa. Phytother. Res.","DOI":"10.1002\/ptr.5658"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/molecules15020780","article-title":"Evaluation of enoyl-acyl carrier protein reductase inhibitors as Pseudomonas aeruginosa quorum-quenching reagents","volume":"15","author":"Yang","year":"2010","journal-title":"Molecules"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/AEM.01059-09","article-title":"Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1","volume":"76","author":"Vandeputte","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1271\/bbb.100499","article-title":"The inhibitory effects of catechins on biofilm formation by the periodontopathogenic bacterium, Eikenella corrodens","volume":"74","author":"Matsunaga","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.phymed.2010.03.015","article-title":"Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection","volume":"17","author":"Song","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2011.00787.x","article-title":"Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation","volume":"62","author":"Wu","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.00045-11","article-title":"Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo","volume":"55","author":"Brackman","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1099\/jmm.0.024166-0","article-title":"Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm","volume":"60","author":"Ding","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/jac\/dks002","article-title":"Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model","volume":"67","author":"Christensen","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.foodres.2011.10.022","article-title":"Antibiofilm and quorum sensing inhibitory potential of Cuminum cyminum and its secondary metabolite methyl eugenol against Gram negative bacterial pathogens","volume":"45","author":"Packiavathy","year":"2012","journal-title":"Food Res. Int."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10822-012-9599-1","article-title":"Computational discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of Pseudomonas aeruginosa","volume":"26","author":"Annapoorani","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1007\/s00253-013-4704-5","article-title":"Prevention of quorum-sensing-mediated biofilm development and virulence factors production in Vibrio spp. by curcumin","volume":"97","author":"Packiavathy","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.foodchem.2012.08.002","article-title":"Inhibition of biofilm development of uropathogens by curcumin\u2014An anti-quorum sensing agent from Curcuma longa","volume":"148","author":"Packiavathy","year":"2014","journal-title":"Food Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.phymed.2014.01.001","article-title":"Glycosylflavonoids from Cecropia pachystachya Tr\u00e9cul are quorum sensing inhibitors","volume":"21","author":"Costa","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ibiod.2013.06.011","article-title":"The effects of ferulic and salicylic acids on Bacillus cereus and Pseudomonas fluorescens single- and dual-species biofilms","volume":"86","author":"Lemos","year":"2014","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Chang, C.-Y., Krishnan, T., Wang, H., Chen, Y., Yin, W.-F., Chong, Y.-M., Tan, L.Y., Chong, T.M., and Chan, K.-G. (2014). Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target. Sci. Rep., 4.","DOI":"10.1038\/srep07245"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.foodchem.2014.03.039","article-title":"Synthesis and quorum sensing inhibitory activity of key phenolic compounds of ginger and their derivatives","volume":"159","author":"Murthy","year":"2014","journal-title":"Food Chem."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Kim, H.-S., Lee, S.-H., Byun, Y., and Park, H.-D. (2015). 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Sci. Rep., 5.","DOI":"10.1038\/srep08656"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fitote.2015.02.002","article-title":"Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa","volume":"102","author":"Kumar","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fitote.2013.06.017","article-title":"Zingerone inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1","volume":"90","author":"Kumar","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.phymed.2014.10.006","article-title":"Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria","volume":"22","author":"Gilabert","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.micpath.2015.01.010","article-title":"Quorum quenching activity of Syzygium cumini (L.) Skeels and its anthocyanin malvidin against Klebsiella pneumoniae","volume":"79","author":"Gopu","year":"2015","journal-title":"Microb. Pathog."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1038\/srep20321","article-title":"The Quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release","volume":"6","author":"Brackman","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s12038-013-9385-9","article-title":"Influence of clove oil on certain quorum-sensing-regulated functions and biofilm of Pseudomonas aeruginosa and Aeromonas hydrophila","volume":"38","author":"Husain","year":"2013","journal-title":"J. Biosci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/08905436.2014.932287","article-title":"Quorum sensing inhibitory and anti-biofilm activity of essential oils and their in vivo efficacy in food systems","volume":"28","author":"Vittal","year":"2014","journal-title":"Food Biotechnol."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Kalia, M., Yadav, V.K., Singh, P.K., Sharma, D., Pandey, H., Narvi, S.S., and Agarwal, V. (2015). Effect of cinnamon oil on quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas aeruginosa. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135495"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Husain, F.M., Ahmad, I., Khan, M.S., Ahmad, E., Tahseen, Q., Khan, M.S., and Alshabib, N.A. (2015). Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00420"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1007\/s00253-016-7313-2","article-title":"Clove bud oil reduces kynurenine and inhibits pqs A gene expression in P. aeruginosa","volume":"100","author":"Jayalekshmi","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10529-012-1126-x","article-title":"Eugenol inhibits quorum sensing at sub-inhibitory concentrations","volume":"35","author":"Zhou","year":"2013","journal-title":"Biotechnol. Lett."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Burt, S.A., Ojo-Fakunle, V.T.A., Woertman, J., and Veldhuizen, E.J.A. (2014). The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093414"},{"key":"ref_219","first-page":"32","article-title":"Biofilm prevention and control by dietary phytochemicals","volume":"Volume 1","year":"2013","journal-title":"Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1099\/mic.0.27463-0","article-title":"Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent","volume":"151","author":"Bjarnsholt","year":"2005","journal-title":"Microbiology"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1099\/mic.0.27955-0","article-title":"Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections","volume":"151","author":"Bjarnsholt","year":"2005","journal-title":"Microbiology"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10658-007-9232-7","article-title":"Control of plant diseases by natural products: Allicin from garlic as a case study","volume":"121","author":"Slusarenko","year":"2008","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1286-4579(99)80003-3","article-title":"Antimicrobial properties of allicin from garlic","volume":"1","author":"Ankri","year":"1999","journal-title":"Microbes Infect."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fcimb.2013.00090","article-title":"Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: Correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence","volume":"3","author":"Porcheron","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1073\/pnas.0504266102","article-title":"Iron and Pseudomonas aeruginosa biofilm formation","volume":"102","author":"Banin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2958.1998.00797.x","article-title":"Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: A genetic analysis","volume":"28","author":"Kolter","year":"1998","journal-title":"Mol. Microbiol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/417552a","article-title":"A component of innate immunity prevents bacterial biofilm development","volume":"417","author":"Singh","year":"2002","journal-title":"Nature"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1099\/mic.0.2006\/004911-0","article-title":"Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa","volume":"153","author":"Yang","year":"2007","journal-title":"Microbiology"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1128\/JB.01473-07","article-title":"Influence of quorum sensing and iron on twitching motility and biofilm formation in Pseudomonas aeruginosa","volume":"190","author":"Patriquin","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1128\/JB.187.23.8211-8215.2005","article-title":"Iron-responsive regulation of biofilm formation in Staphylococcus aureus involves fur-dependent and fur-independent mechanisms","volume":"187","author":"Johnson","year":"2005","journal-title":"J. Bacteriol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.chembiol.2005.05.007","article-title":"Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa","volume":"12","author":"Musk","year":"2005","journal-title":"Chem. Biol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"272086","DOI":"10.1155\/2013\/272086","article-title":"The effect of gold and iron-oxide nanoparticles on biofilm-forming pathogens","volume":"2013","author":"Sathyanarayanan","year":"2013","journal-title":"ISRN Microbiol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/QCO.0b013e32830634d8","article-title":"The role of chelators in preventing biofilm formation and catheter-related bloodstream infections","volume":"21","author":"Raad","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_234","first-page":"49","article-title":"Influence of calcium ions on the mechanical properties of a model biofilm of mucoid Pseudomonas aeruginosa","volume":"43","author":"Flemming","year":"2001","journal-title":"Wood Sci. Technol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s00253-002-1044-2","article-title":"Role of electrostatic interactions in cohesion of bacterial biofilms","volume":"59","author":"Chen","year":"2002","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1128\/AAC.00463-10","article-title":"Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation","volume":"54","author":"Liu","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1128\/AEM.72.3.2064-2069.2006","article-title":"Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm","volume":"72","author":"Banin","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000048495","article-title":"Chelating agents","volume":"47","author":"Bergan","year":"2001","journal-title":"Chemotherapy"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1099\/jmm.0.004416-0","article-title":"Iron-binding compounds impair Pseudomonas aeruginosa biofilm formation, especially under anaerobic conditions","volume":"58","author":"Che","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/ndt\/gfp651","article-title":"Reduction of biofilm formation with trisodium citrate in haemodialysis catheters: A randomized controlled trial","volume":"25","author":"Bosma","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jinorgbio.2011.02.003","article-title":"In vitro analysis of iron chelating activity of flavonoids","volume":"105","author":"Bovicelli","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_242","first-page":"8","article-title":"Natural iron sequestering agents: Their roles in nature and therapeutic potential","volume":"7","author":"Jayasinghe","year":"2015","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.4155\/fmc.09.121","article-title":"Synthetic and natural iron chelators: Therapeutic potential and clinical use","volume":"1","author":"Hatcher","year":"2009","journal-title":"Future Med. Chem."},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Lin, M.-H., Shu, J.-C., Huang, H.-Y., and Cheng, Y.-C. (2012). Involvement of iron in biofilm formation by Staphylococcus aureus. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034388"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/biof.110","article-title":"Iron chelation by cranberry juice and its impact on Escherichia coli growth","volume":"37","author":"Lin","year":"2011","journal-title":"Biofactors"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1016\/j.bmcl.2014.09.009","article-title":"Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy","volume":"24","author":"Abouelhassan","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1038\/srep19267","article-title":"Calcium-chelating alizarin and other anthraquinones inhibit biofilm formation and the hemolytic activity of Staphylococcus aureus","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1128\/AAC.01287-12","article-title":"Chelator-based catheter lock solutions in eradicating organisms in biofilm","volume":"57","author":"Raad","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/jac\/dkv044","article-title":"In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections","volume":"70","author":"Lebeaux","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1128\/AAC.47.11.3580-3585.2003","article-title":"In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces","volume":"47","author":"Raad","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tips.2014.06.007","article-title":"Siderophore\u2013drug complexes: Potential medicinal applications of the \u2018Trojan horse\u2019strategy","volume":"35","author":"Sloderbach","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4161\/viru.23724","article-title":"Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm","volume":"4","author":"Soto","year":"2013","journal-title":"Virulence"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1074\/jbc.R115.707257","article-title":"The role of efflux and physiological adaptation in biofilm tolerance and resistance","volume":"291","author":"Coenye","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Folsom, J.P., Richards, L., Pitts, B., Roe, F., Ehrlich, G.D., Parker, A., Mazurie, A., and Stewart, P.S. (2010). Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis. BMC Microbiol., 10.","DOI":"10.1186\/1471-2180-10-294"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1128\/AAC.00433-15","article-title":"Contribution of stress responses to antibiotic tolerance in Pseudomonas aeruginosa biofilms","volume":"59","author":"Stewart","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1128\/JB.187.14.4707-4719.2005","article-title":"The Burkholderia pseudomallei BpeAB-OprB efflux pump: Expression and impact on quorum sensing and virulence","volume":"187","author":"Chan","year":"2005","journal-title":"J. Bacteriol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"132.3","DOI":"10.4049\/jimmunol.192.Supp.132.3","article-title":"Multi-drug resistance efflux pumps confer additional resistance against host innate immune defense via induction of genes for biofilm formation and virulence (MPF3P. 803)","volume":"192","author":"Gupta","year":"2014","journal-title":"J. Immunol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijantimicag.2014.12.005","article-title":"Multidrug efflux pumps contribute to Escherichia coli biofilm maintenance","volume":"45","author":"Yamasaki","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1128\/JB.01655-07","article-title":"Involvement of a novel efflux system in biofilm-specific resistance to antibiotics","volume":"190","author":"Zhang","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molmed.2005.06.006","article-title":"Inhibitors of efflux pumps in Gram-negative bacteria","volume":"11","author":"Masi","year":"2005","journal-title":"Trends Mol. Med."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4265\/bio.16.69","article-title":"Roles of multidrug efflux pumps on the biofilm formation of Escherichia coli K-12","volume":"16","author":"Matsumura","year":"2011","journal-title":"Biocontrol Sci."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/jac\/dks228","article-title":"Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm","volume":"67","author":"Baugh","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1128\/AAC.02872-15","article-title":"Modulation of membrane influx and efflux in Escherichia coli sequence type 131 has an impact on bacterial motility, biofilm formation, and virulence in a Caenorhabditis elegans model","volume":"60","author":"Pantel","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cbic.201300701","article-title":"Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa","volume":"15","author":"Moore","year":"2014","journal-title":"ChemBioChem"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"128","DOI":"10.15414\/jmbfs.2014.4.2.128-131","article-title":"Effects of psychotropic drugs as bacterial efflux pump inhibitors on quorum sensing regulated behaviors","volume":"4","author":"Aybey","year":"2014","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.1128\/jb.175.22.7363-7372.1993","article-title":"Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon","volume":"175","author":"Poole","year":"1993","journal-title":"J. Bacteriol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/apm.12455","article-title":"Effect of iron on expression of efflux pump (adeABC) and quorum sensing (luxI, luxR) genes in clinical isolates of Acinetobacter baumannii","volume":"123","author":"Modarresi","year":"2015","journal-title":"APMIS"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1128\/AEM.01310-08","article-title":"Inactivation of efflux pumps abolishes bacterial biofilm formation","volume":"74","author":"Kvist","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jac\/dkt420","article-title":"Inhibition of multidrug efflux as a strategy to prevent biofilm formation","volume":"69","author":"Baugh","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_270","first-page":"764","article-title":"Identification of natural compounds which inhibit biofilm formation in clinical isolates of Klebsiella pneumoniae","volume":"51","author":"Magesh","year":"2013","journal-title":"Indian J. Exp. Biol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/cmdc.201500179","article-title":"A phytochemical\u2013halogenated quinoline combination therapy strategy for the treatment of pathogenic bacteria","volume":"10","author":"Abouelhassan","year":"2015","journal-title":"ChemMedChem"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12088-015-0558-0","article-title":"Potential emergence of multi-quorum sensing inhibitor resistant (MQSIR) bacteria","volume":"56","author":"Koul","year":"2016","journal-title":"Indian J. Microbiol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00248-013-0316-y","article-title":"Evolution of resistance to quorum-sensing inhibitors","volume":"68","author":"Kalia","year":"2014","journal-title":"Microb. Ecol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/7\/877\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:25:29Z","timestamp":1760210729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/21\/7\/877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":273,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7]]}},"alternative-id":["molecules21070877"],"URL":"https:\/\/doi.org\/10.3390\/molecules21070877","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}