{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:17:51Z","timestamp":1777529871127,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b\u2013g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S. aureus.<\/jats:p>","DOI":"10.3390\/molecules22020302","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T12:55:34Z","timestamp":1487249734000},"page":"302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-9128","authenticated-orcid":false,"given":"Mariana","family":"Cardoso","sequence":"first","affiliation":[{"name":"Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal"},{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24020-150, RJ, Brazil"}]},{"given":"Ana","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal"}]},{"given":"Caroline","family":"Moreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24020-150, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-2252","authenticated-orcid":false,"given":"M\u00e1rio","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-8166","authenticated-orcid":false,"given":"Maria","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal"}]},{"given":"David","family":"Da Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24020-150, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-3778","authenticated-orcid":false,"given":"Fernando","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24020-150, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0352-2616","authenticated-orcid":false,"given":"Catarina","family":"Moreirinha","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro 3810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-8664","authenticated-orcid":false,"given":"Adelaide","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biology and CESAM, University of Aveiro, Aveiro 3810-193, Portugal"}]},{"given":"Vitor","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i 24020-150, RJ, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-5126","authenticated-orcid":false,"given":"Jos\u00e9","family":"Cavaleiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and QOPNA, University of Aveiro, Aveiro 3810-193, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ardp.200900162","article-title":"Synthesis of \u03b1- and \u03b2-pyran naphthoquinones as a new class of antitubercular agents","volume":"343","author":"Ferreira","year":"2010","journal-title":"Arch. 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