{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:33:12Z","timestamp":1761823992945,"version":"build-2065373602"},"reference-count":87,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BBB-BQB\/3494\/2014","SPRH\/BD\/52431\/2013"],"award-info":[{"award-number":["PTDC\/BBB-BQB\/3494\/2014","SPRH\/BD\/52431\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI119762","AI121349","NS091263"],"award-info":[{"award-number":["AI119762","AI121349","NS091263"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Measles virus (MV) infection is re-emerging, despite the availability of an effective vaccine. The mechanism of MV entry into a target cell relies on coordinated action between the MV hemagglutinin (H) receptor binding protein and the fusion envelope glycoprotein (F) which mediates fusion between the viral and cell membranes. Peptides derived from the C-terminal heptad repeat (HRC) of F can interfere with this process, blocking MV infection. As previously described, biophysical properties of HRC-derived peptides modulate their antiviral potency. In this work, we characterized a MV peptide fusion inhibitor conjugated to 25-hydroxycholesterol (25HC), a cholesterol derivative with intrinsic antiviral activity, and evaluated its interaction with membrane model systems and human blood cells. The peptide (MV<\/jats:p>","DOI":"10.3390\/molecules22111869","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T12:48:31Z","timestamp":1509454111000},"page":"1869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-182X","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Gomes","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Nuno","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Matteo","family":"Porotto","sequence":"additional","affiliation":[{"name":"Center for Host-Pathogen Interaction, Columbia University Medical Center, 701 W. 168th St., New York, NY 10032, USA"},{"name":"Department of Pediatrics, Columbia University Medical Center, 701 W. 168th St., New York, NY 10032, USA"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/v7020699","article-title":"Morbillivirus infections: An introduction","volume":"7","author":"Duprex","year":"2015","journal-title":"Viruses"},{"key":"ref_2","unstructured":"(2017, July 10). 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