{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:23:33Z","timestamp":1769855013223,"version":"3.49.0"},"reference-count":93,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,17]],"date-time":"2018-06-17T00:00:00Z","timestamp":1529193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-OE\/QUI\/UI0674\/2013"],"award-info":[{"award-number":["PEst-OE\/QUI\/UI0674\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Madeira 14-20 Program","award":["M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000008"]}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o, Tecnologia e Inova\u00e7\u00e3o","award":["M1420-01-0145-FEDER-000005 Centro de Qu\u00edmica da Madeira - CQM+ (Madeira 14-20 Program)"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005 Centro de Qu\u00edmica da Madeira - CQM+ (Madeira 14-20 Program)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Here and for the first time, we show that the organometallic compound [Ru(\u03b75-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(\u03b75-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(\u03b75-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma cell lines (A2780cisR cells). Also, RuCp and the prepared metallodendrimers are active against human mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.<\/jats:p>","DOI":"10.3390\/molecules23061471","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T10:57:11Z","timestamp":1529319431000},"page":"1471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(\u03b75-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells"],"prefix":"10.3390","volume":"23","author":[{"given":"Marisol","family":"Gouveia","sequence":"first","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-2278","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Figueira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ScilifeLab, Ume\u00e5 University, KBC-Building, Linnaeus v\u00e4g 6, 90736 Ume\u00e5, Sweden"}]},{"given":"Manuel G.","family":"Jardim","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]},{"given":"Rita","family":"Castro","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]},{"given":"Helena","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-8419","authenticated-orcid":false,"given":"Kari","family":"Rissanen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Jyvaskyla, P.O. Box. 35, FI-40014 Jyv\u00e4skyl\u00e4, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-1953","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal"},{"name":"School of Materials Science and Engineering\/Center for Nano Energy Materials, Northwestern Polytechnical University, Xi\u2019an 710072, China"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ruddon, R.W. (2007). Cancer Biology, Oxford University Press. [4th ed.].","DOI":"10.1093\/oso\/9780195175448.001.0001"},{"key":"ref_2","unstructured":"Hesketh, R. (2013). 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