{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:18:45Z","timestamp":1777375125409,"version":"3.51.4"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MAR-BIO\/4694\/2014"],"award-info":[{"award-number":["PTDC\/MAR-BIO\/4694\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Polymeric nanoparticles based on fucoidan and chitosan were developed to deliver quercetin as a novel functional food. Through the polyelectrolyte self-assembly method, fucoidan\/chitosan (F\/C) nanoparticles were obtained with three different weight ratios (1\/1, 3\/1, and 5\/1). The content of quercetin in the fucoidan\/chitosan nanoparticles was in the range 110 \u00b1 3 to 335 \u00b1 4 mg\u00b7mL\u22121, with the increase of weight ratio of fucoidan to chitosan in the nanoparticle. Physicochemically stable nanoparticles were obtained with a particle size within the 300\u2013400 nm range and surface potential higher than +30 mV for the 1F\/1C ratio nanoparticle and around \u221230 mV for the 3F\/1C and 5F\/1C ratios nanoparticles. The 1F\/1C ratio nanoparticle became larger and more unstable as the pH increased from 2.5 to 7.4, while the 3F\/1C and 5F\/1C nanoparticles retained their initial characteristics. This result indicates that the latter nanoparticles were stable along the gastrointestinal tract. The quercetin-loaded fucoidan\/chitosan nanoparticles showed strong antioxidant activity and controlled release under simulated gastrointestinal environments (in particular for the 3F\/1C and 5F\/1C ratios), preventing quercetin degradation and increasing its oral bioavailability.<\/jats:p>","DOI":"10.3390\/molecules24020346","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T11:26:55Z","timestamp":1547810815000},"page":"346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["Application of pH-Responsive Fucoidan\/Chitosan Nanoparticles to Improve Oral Quercetin Delivery"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-3187","authenticated-orcid":false,"given":"Ana Isabel","family":"Barbosa","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-5877","authenticated-orcid":false,"given":"Sofia A.","family":"Costa Lima","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Salette","family":"Reis","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, J.K., and Weng, M.S. 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