{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:41:28Z","timestamp":1771872088503,"version":"3.50.1"},"reference-count":93,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BSAB\/150379\/2019"],"award-info":[{"award-number":["SFRH\/BSAB\/150379\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-030219"],"award-info":[{"award-number":["POCI-01-0145-FEDER-030219"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides\u2014cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, \u03b1-methylcinnamic, and \u03b1-fluorocinnamic acids had a factional inhibitory concentration index (FICI) \u2264 1 for Escherichia coli and Staphylococcus aureus. Several phytochemicals\/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacteria. The most effective combination was LA with allyl cinnamate (2.98 \u00b1 0.76 log CFU\u00b7cm\u22122 reduction) against E. coli. The combination with CTAB was successful for most phytochemicals\/derivatives with a maximum bactericidal efficacy against sessile E. coli when combined with allyl cinnamate (2.20 \u00b1 0.07 log CFU\u00b7cm\u22122 reduction) and for S. aureus when combined with \u03b1-methylcinnamic acid (1.68 \u00b1 0.30 log CFU\u00b7cm\u22122 reduction). This study highlights the potential of phytochemicals and their derivatives to be used in biocide formulations.<\/jats:p>","DOI":"10.3390\/molecules24213918","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T05:18:26Z","timestamp":1572499106000},"page":"3918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-7334","authenticated-orcid":false,"given":"Joana F.","family":"Malheiro","sequence":"first","affiliation":[{"name":"LEPABE, Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"},{"name":"Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales CF10 3NB, UK"},{"name":"CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"given":"Jean-Yves","family":"Maillard","sequence":"additional","affiliation":[{"name":"Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales CF10 3NB, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-2402","authenticated-orcid":false,"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-4398","authenticated-orcid":false,"given":"Manuel","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"LEPABE, Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cofs.2018.09.002","article-title":"Food processing as a risk factor for antimicrobial resistance spread along the food chain","volume":"30","author":"Oniciuc","year":"2019","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s40258-018-0451-1","article-title":"A payer perspective of the hospital inpatient additional care costs of antimicrobial resistance in france: A matched case\u2013control study","volume":"17","author":"Touat","year":"2019","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","unstructured":"European Comission (2019, October 17). EU Action on Antimicrobial Resistance. Available online: https:\/\/ec.europa.eu\/health\/amr\/antimicrobial-resistance_en."},{"key":"ref_5","unstructured":"ECDC\/EMEA (2019, October 30). ECDC\/EMEA Joint Technical Report: The Bacterial Challenge: Time to React. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/ecdcemea-joint-technical-report-bacterial-challenge-time-react."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States--major pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.lwt.2009.12.008","article-title":"A review of current and emergent biofilm control strategies","volume":"43","author":"Vieira","year":"2010","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijfoodmicro.2016.10.021","article-title":"Activity of essential oil-based microemulsions against Staphylococcus aureus biofilms developed on stainless steel surface in different culture media and growth conditions","volume":"241","author":"Campana","year":"2017","journal-title":"Int. J. Food Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0209072","article-title":"An assay for determining the susceptibility of Salmonella isolates to commercial and household biocides","volume":"13","author":"Humayoun","year":"2018","journal-title":"PloS ONE"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/jam.14145","article-title":"Interactions of organic acids with vancomycin-resistant Enterococcus faecium isolated from community wastewater in Texas","volume":"126","author":"Beier","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijantimicag.2018.04.024","article-title":"Plant nutraceuticals as antimicrobial agents in food preservation: Terpenoids, polyphenols and thiols","volume":"52","year":"2018","journal-title":"Int. J. Antimicrob. Ag."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.envres.2018.04.020","article-title":"Efficacy of \u201cHLE\u201d-a multidrug efflux-pump inhibitor-as a disinfectant against surface bacteria","volume":"165","author":"Abriouel","year":"2018","journal-title":"Env. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ijantimicag.2010.08.006","article-title":"Identification of the plasmid-encoded qacA efflux pump gene in meticillin-resistant Staphylococcus aureus (MRSA) strain HPV107, a representative of the MRSA Iberian clone","volume":"36","author":"Costa","year":"2010","journal-title":"Int. J. Antimicrob. Ag."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jac\/49.1.11","article-title":"Biocide abuse and antimicrobial resistance--a cause for concern?","volume":"49","author":"Fraise","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/08927014.2011.626899","article-title":"Resistance of bacterial biofilms to disinfectants: A review","volume":"27","author":"Bridier","year":"2011","journal-title":"Biofouling"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chotigarpa, R., Na Lampang, K., Pikulkaew, S., Okonogi, S., Ajariyakhajorn, K., and Mektrirat, R. (2018). Inhibitory effects and killing kinetics of lactic acid rice gel against pathogenic bacteria causing bovine mastitis. Sci. Pharm., 86.","DOI":"10.3390\/scipharm86030029"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1089\/mdr.2018.0183","article-title":"Are the hands of veterinary staff a reservoir for antimicrobial-resistant bacteria? A randomized study to evaluate two hand hygiene rubs in a veterinary hospital","volume":"24","author":"Espadale","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijfoodmicro.2018.05.012","article-title":"Tomato type and post-treatment water rinse affect efficacy of acid washes against Salmonella enterica inoculated on stem scars of tomatoes and product quality","volume":"280","author":"Fan","year":"2018","journal-title":"Int. J. Food Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1128\/JCM.39.11.3999-4004.2001","article-title":"Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus","volume":"39","author":"Bjorland","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2166\/wh.2007.009b","article-title":"Quaternary ammonium compounds: An alternative disinfection method for fresh produce wash water","volume":"5","author":"Chaidez","year":"2007","journal-title":"J. Water Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/mdr.2009.0120","article-title":"Does the wide use of quaternary ammonium compounds enhance the selection and spread of antimicrobial resistance and thus threaten our health?","volume":"16","author":"Hegstad","year":"2010","journal-title":"Microb. Drug Resist."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9755\/ejfa.v24i1.10592","article-title":"Synergistic effect of copper and lactic acid against Salmonella and Escherichia coli O157:H7: A review","volume":"24","author":"Gyawali","year":"2012","journal-title":"Emir. J. Food Agric."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0202100","article-title":"Interactions of organic acids with Campylobacter coli from swine","volume":"13","author":"Beier","year":"2018","journal-title":"PloS ONE"},{"key":"ref_24","first-page":"43","article-title":"Bacterial hazards in fresh and fresh-cut produce: Sources and control","volume":"Volume 4","author":"Beier","year":"2008","journal-title":"Preharvest and Postharvest Food Safety: Contemporary Issues and Future Directions"},{"key":"ref_25","first-page":"5","article-title":"Types of microbicidal and microbistatic agents","volume":"Volume 2","author":"Fraise","year":"2012","journal-title":"Russell, Hugo and Ayliffe\u2019s: Principles and Practice of Disinfection, Preservation and Sterilization"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(99)00072-0","article-title":"Preservative agents in foods. Mode of action and microbial resistance mechanisms","volume":"50","author":"Brul","year":"1999","journal-title":"Int. J. Food Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijfoodmicro.2009.12.019","article-title":"Contemporary strategies in combating microbial contamination in food chain","volume":"141","author":"Rajkovic","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/CMR.12.1.147","article-title":"Antiseptics and disinfectants: Activity, action, and resistance","volume":"12","author":"McDonnell","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.watres.2004.09.018","article-title":"Action of a cationic surfactant on the activity and removal of bacterial biofilms formed under different flow regimes","volume":"39","author":"Pereira","year":"2005","journal-title":"Water Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ecoenv.2017.04.028","article-title":"Toxicity of quaternary ammonium compounds (QACs) as single compounds and mixtures to aquatic non-target microorganisms: Experimental data and predictive models","volume":"142","author":"Gallet","year":"2017","journal-title":"Ecotoxicol. Env. Saf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1365-2672.92.5s1.5.x","article-title":"Biofilms in vitro and in vivo: Do singular mechanisms imply cross-resistance?","volume":"92","author":"Gilbert","year":"2002","journal-title":"J. Appl. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.1365-2672.92.5s1.3.x","article-title":"Bacterial target sites for biocide action","volume":"92","author":"Maillard","year":"2002","journal-title":"J. Appl. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/08927014.2016.1220550","article-title":"Phytochemical profiling as a solution to palliate disinfectant limitations","volume":"32","author":"Malheiro","year":"2016","journal-title":"Biofouling"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/08927014.2016.1232402","article-title":"Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms","volume":"32","author":"Abreu","year":"2016","journal-title":"Biofouling"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Borges, A., Abreu, A.C., Dias, C., Saavedra, M.J., Borges, F., and Sim\u00f5es, M. (2016). New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms. Molecules, 21.","DOI":"10.3390\/molecules21070877"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.3390\/molecules17043989","article-title":"Essential oils in combination and their antimicrobial properties","volume":"17","author":"Bassole","year":"2012","journal-title":"Molecules"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ferro, T.A.F., Souza, E.B., Suarez, M.A.M., Rodrigues, J.F.S., Pereira, D.M.S., Mendes, S.J.F., Gonzaga, L.F., Machado, M.C.A.M., Bomfim, M.R.Q., and Calixto, J.B. (2019). Topical application of cinnamaldehyde promotes faster healing of skin wounds infected with Pseudomonas aeruginosa. Molecules, 24.","DOI":"10.3390\/molecules24081627"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.micres.2016.12.003","article-title":"Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity","volume":"196","author":"Barbieri","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on plant antimicrobials: A mechanistic viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rsif.2016.0650","article-title":"Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms","volume":"14","author":"Chan","year":"2017","journal-title":"J. R. Soc. Interface"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.00630-18","article-title":"Gold nanoparticle-conjugated cinnamic acid exhibits antiacanthamoebic and antibacterial properties","volume":"62","author":"Anwar","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lwt.2018.04.018","article-title":"Antimicrobial and antibiofilm effects of trans-cinnamic acid nanoemulsion and its potential application on lettuce","volume":"94","author":"Letsididi","year":"2018","journal-title":"LWT"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-018-0559-1","article-title":"Innovative drugs, chemicals, and enzymes within the animal production chain","volume":"49","author":"Hassan","year":"2018","journal-title":"Vet. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1039\/c2np20035j","article-title":"Plants as sources of new antimicrobials and resistance-modifying agents","volume":"29","author":"Abreu","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53915","DOI":"10.1039\/C5RA05840F","article-title":"Fine-tuning of the hydrophobicity of caffeic acid: Studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli","volume":"5","author":"Andrade","year":"2015","journal-title":"Rsc. Adv."},{"key":"ref_46","first-page":"108","article-title":"Mechanisms of bacterial resistance to microbicides","volume":"Volume 6","author":"Fraise","year":"2012","journal-title":"Russell, Hugo and Ayliffe\u2019s: Principles and Practice of Disinfection, Preservation and Sterilization"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0964-8305(03)00044-1","article-title":"Disinfectant resistance mechanisms, cross-resistance, and co-resistance","volume":"51","author":"Chapman","year":"2003","journal-title":"Int. Biodeter. Biodegr."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Fraise, A., Maillard, J.Y., and Sattar, S. (2012). Hand hygiene. Russell, Hugo and Ayliffe\u2019s: Principles and Practice of Disinfection, Preservation and Sterilization, Blackwell Publishing.","DOI":"10.1002\/9781118425831"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ibiod.2018.06.003","article-title":"Evaluation of cinnamaldehyde and cinnamic acid derivatives in microbial growth control","volume":"141","author":"Malheiro","year":"2018","journal-title":"Int. Biodeter. Biodegr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.diagmicrobio.2014.03.002","article-title":"Evaluation of the best method to assess antibiotic potentiation by phytochemicals against Staphylococcus aureus","volume":"79","author":"Abreu","year":"2014","journal-title":"Diagn. Micr. Infec. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1472-765X.2002.01198.x","article-title":"Inactivation of Listeria monocytogenes\/Flavobacterium spp. biofilms using chlorine: Impact of substrate, pH, time and concentration","volume":"35","author":"Bremer","year":"2002","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/inp.e2741","article-title":"Selection and use of disinfectants","volume":"34","author":"Maillard","year":"2012","journal-title":"Practice."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0195-6701(99)90421-8","article-title":"Choosing disinfectants","volume":"43","author":"Fraise","year":"1999","journal-title":"J. Hosp. Infect."},{"key":"ref_55","first-page":"258","article-title":"Molecular descriptor based on a molar refractivity partition using Randic-type graph-theoretical invariant","volume":"5","author":"Carrasco","year":"2002","journal-title":"J. Pharm. Pharmaceut. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/ci020378b","article-title":"On the role of polarizability in chemical\u2212biological interactions","volume":"43","author":"Hansch","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.2042-7158.1983.tb02877.x","article-title":"Inhibition of prostaglandin E2 release by salicylates, benzoates and phenols: A quantitative structure-activity study","volume":"35","author":"Habicht","year":"1983","journal-title":"J. Pharm Pharm."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijfoodmicro.2010.12.001","article-title":"Antifumonisin activity of natural phenolic compounds: A structure\u2013property\u2013activity relationship study","volume":"145","author":"Dambolena","year":"2011","journal-title":"Int. J. Food Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s10910-009-9552-2","article-title":"Molecular modeling of wine polyphenols","volume":"46","author":"Rastija","year":"2009","journal-title":"J. Math. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijfoodmicro.2009.07.031","article-title":"Cell membrane damage induced by phenolic acids on wine lactic acid bacteria","volume":"135","author":"Campos","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1046\/j.1365-2672.2003.01923.x","article-title":"Membrane damage to bacteria caused by single and combined biocides","volume":"94","author":"Johnston","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jsfa.2424","article-title":"Application of the Weibull model to describe inactivation of Listeria monocytogenes and Escherichia coli by citric and lactic acid at different temperatures","volume":"86","author":"Virto","year":"2006","journal-title":"J. Sci. Food Agr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0168-1605(95)00056-9","article-title":"Salmonella, Campylobacter and Escherichia coli 0157:H7 decontamination techniques for the future","volume":"28","author":"Corry","year":"1995","journal-title":"Int. J. Food Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1365-2672.2011.05141.x","article-title":"Structure\u2013function relationships of the antibacterial activity of phenolic acids and their metabolism by lactic acid bacteria","volume":"111","author":"Schieber","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1111\/jam.14097","article-title":"Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates","volume":"125","author":"Yilmaz","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-0711-4-20","article-title":"Antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori","volume":"4","author":"Ali","year":"2005","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1128\/AEM.02164-13","article-title":"Marked synergistic bactericidal effects and mode of action of medium-chain fatty acids in combination with organic acids against Escherichia coli O157:H7","volume":"79","author":"Kim","year":"2013","journal-title":"Appl. Env. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodcont.2014.06.034","article-title":"Antibacterial mechanism of lactic acid on physiological and morphological properties of Salmonella Enteritidis, Escherichia coli and Listeria monocytogenes","volume":"47","author":"Wang","year":"2015","journal-title":"Food Control."},{"key":"ref_69","first-page":"1","article-title":"L-Lactic acid\u2014A safe antimicrobial for home- and personal care formulations","volume":"141","author":"Boomsma","year":"2015","journal-title":"Sofw. J."},{"key":"ref_70","first-page":"317","article-title":"Chemical methods for decontamination of meat and poultry","volume":"Volume 24","author":"Beier","year":"2008","journal-title":"Preharvest and Postharvest Food Safety: Contemporary Issues and Future Directions"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1128\/AEM.66.5.2001-2005.2000","article-title":"Lactic acid permeabilizes Gram-negative bacteria by disrupting the outer membrane","volume":"66","author":"Alakomi","year":"2000","journal-title":"Appl. Env. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/mr.59.2.201-222.1995","article-title":"Mechanisms of membrane toxicity of hydrocarbons","volume":"59","author":"Sikkema","year":"1995","journal-title":"Microbiol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1016\/j.bmc.2016.05.028","article-title":"Tetrodecamycin: An unusual and interesting tetronate antibiotic","volume":"24","author":"Gverzdys","year":"2016","journal-title":"Bioorgan. Med. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/acs.jmedchem.6b00788","article-title":"Covalent modifiers: A chemical perspective on the reactivity of \u03b1,\u03b2-unsaturated carbonyls with thiols via hetero-Michael addition reactions","volume":"60","author":"Jackson","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2166\/wst.2003.0286","article-title":"Monitoring cell detachment by surfactants in a parallel plate flow chamber","volume":"47","author":"Azeredo","year":"2003","journal-title":"Water Sci. Technol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ibiod.2013.04.001","article-title":"Effect of low concentrations of synthetic surfactants on polycyclic aromatic hydrocarbons (PAH) biodegradation","volume":"83","author":"Rodrigues","year":"2013","journal-title":"Int. Biodeter. Biodegr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1365-2672.2010.04912.x","article-title":"Antimicrobial cationic surfactant, cetyltrimethylammonium bromide, induces superoxide stress in Escherichia coli cells","volume":"110","author":"Nakata","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1094\/PDIS-11-10-0839","article-title":"Cationic surfactants: Potential surface disinfectants to manage Agrobacterium tumefaciens biovar 1 contamination of grafting tools","volume":"96","author":"Yakabe","year":"2011","journal-title":"Plant. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.mgene.2014.10.002","article-title":"CTAB-mediated, single-step preparation of competent Escherichia coli, Bifidobacterium sp. and Kluyveromyces lactis cells","volume":"2","author":"Rajagopal","year":"2014","journal-title":"Meta Gene"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1128\/AAC.00138-07","article-title":"Outbreaks associated with contaminated antiseptics and disinfectants","volume":"51","author":"Weber","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10406","DOI":"10.1021\/acs.jafc.7b04344","article-title":"Chemistry, antimicrobial mechanisms, and antibiotic activities of cinnamaldehyde against pathogenic bacteria in animal feeds and human foods","volume":"65","author":"Friedman","year":"2017","journal-title":"J. Agr. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Garcia-Salinas, S., Elizondo-Castillo, H., Arruebo, M., Mendoza, G., and Irusta, S. (2018). Evaluation of the antimicrobial activity and a cytotoxicity of different components of natural origin present in essential oils. Molecules, 23.","DOI":"10.1101\/325639"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1128\/AEM.70.10.5750-5755.2004","article-title":"Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei","volume":"70","author":"Gill","year":"2004","journal-title":"Appl. Env. Microbiol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Soto-Hernandez, M., Palma-Tenango, M., and Garcia-Mateos, M.d.R. (2017). Phenolic compounds: Functional properties, impact of processing and bioavailability. Phenolic Compounds: Biological Activity, IntechOpen.","DOI":"10.5772\/63693"},{"key":"ref_85","first-page":"48","article-title":"Antimicrobials in higher plants: Classification, mode of action and bioactivities","volume":"4","author":"Singh","year":"2017","journal-title":"Chem. Biol. Lett."},{"key":"ref_86","unstructured":"Rutala, W.A., Weber, D.J., and HICPAC (2008). Guideline for Disinfection and Sterilization in Healthcare Facilities, Centers for Disease Control (CDC)."},{"key":"ref_87","unstructured":"BS EN 1276:2009 (2010). Chemical Disinfectants and Antiseptics\u2014Quantitative suspension test for the Evaluation of Bactericidal Activity of Chemical Disinfectants and Antiseptics Used in Food, Industrial, Domestic and Institutional Areas\u2014Test Method and Requirements (Phase 2, Step 1), Kenya Bureau of Standards."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jep.2011.06.039","article-title":"Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase","volume":"137","author":"Chan","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/jac\/dkr028","article-title":"Physiological changes induced by the quaternary ammonium compound benzyldimethyldodecylammonium chloride on Pseudomonas fluorescens","volume":"66","author":"Ferreira","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jobm.200610224","article-title":"Potential of the adhesion of bacteria isolated from drinking water to materials","volume":"47","author":"Oliveira","year":"2007","journal-title":"J. Basic Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0001-8686(87)80008-8","article-title":"Monopolar surfaces","volume":"28","author":"Chaudhury","year":"1987","journal-title":"Adv. Colloid. Interface. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/la00082a018","article-title":"Additive and nonadditive surface tension components and the interpretation of contact angles","volume":"4","author":"Good","year":"1988","journal-title":"Langmuir"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0021-9797(89)90345-7","article-title":"Estimation of the polar parameters of the surface tension of liquids by contact angle measurements on gels","volume":"128","author":"Ju","year":"1989","journal-title":"J. Colloid. Interf. Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/21\/3918\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:30:37Z","timestamp":1760189437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/24\/21\/3918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":93,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["molecules24213918"],"URL":"https:\/\/doi.org\/10.3390\/molecules24213918","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]}}}