{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:10:58Z","timestamp":1778037058240,"version":"3.51.4"},"reference-count":243,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER - Fundo Europeu de Desenvolvimento Regional","award":["POCI-01-0145-FEDER-028744"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028744"]}]},{"name":"FEDER - Fundo Europeu de Desenvolvimento Regional","award":["POCI-01-0145-FEDER-032431"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032431"]}]},{"name":"FCT - Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/BTMMAT\/28744\/2017"],"award-info":[{"award-number":["PTDC\/BTMMAT\/28744\/2017"]}]},{"name":"FCT - Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/129855\/2017"],"award-info":[{"award-number":["SFRH\/BD\/129855\/2017"]}]},{"name":"FCT - Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["IF\/00296\/2015"],"award-info":[{"award-number":["IF\/00296\/2015"]}]},{"name":"FCT - Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/CTM-COM\/32431\/2017"],"award-info":[{"award-number":["PTDC\/CTM-COM\/32431\/2017"]}]},{"name":"Ag\u00eancia para o Desenvolvimento e Coes\u00e3o and Ministerio de Hacienda, Direcci\u00f3n General de Fondos Europeos for Interreg V-A Spain-Portugal (POCTEP)\/FEDER","award":["0245_IBEROS_1_E"],"award-info":[{"award-number":["0245_IBEROS_1_E"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and\/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.<\/jats:p>","DOI":"10.3390\/molecules25040978","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T03:21:16Z","timestamp":1582773676000},"page":"978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-1370","authenticated-orcid":false,"given":"Mariana I.","family":"Neves","sequence":"first","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"INEB-Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"FEUP-Faculdade de Engenharia da Universidade do Porto, Departamento de Engenharia Metal\u00fargica e de Materiais, Rua Dr Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"given":"Marco","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"INEB-Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"}]},{"given":"Lorenzo","family":"Moroni","sequence":"additional","affiliation":[{"name":"MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ET Maastricht, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-8724","authenticated-orcid":false,"given":"Ricardo M.P.","family":"da Silva","sequence":"additional","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"INEB-Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"}]},{"given":"Cristina C.","family":"Barrias","sequence":"additional","affiliation":[{"name":"i3S-Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"INEB-Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pomin, V.H., and Mulloy, B. 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