{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:44:19Z","timestamp":1776699859162,"version":"3.51.2"},"reference-count":72,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["FCT UID\/QUI\/00062\/2019"],"award-info":[{"award-number":["FCT UID\/QUI\/00062\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["TDC\/QEQQOR\/1273\/2012"],"award-info":[{"award-number":["TDC\/QEQQOR\/1273\/2012"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["SFRH\/BPD\/79521\/2011"],"award-info":[{"award-number":["SFRH\/BPD\/79521\/2011"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnolgia","award":["FCT UID\/QUI\/00062\/2013"],"award-info":[{"award-number":["FCT UID\/QUI\/00062\/2013"]}]},{"name":"Compete-FEDER","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}]},{"name":"Centro 2020 Regional Operational Programme","award":["CENTRO-01-0145-FEDER-000012"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.<\/jats:p>","DOI":"10.3390\/molecules25071607","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T05:55:16Z","timestamp":1585893316000},"page":"1607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3201-0081","authenticated-orcid":false,"given":"Ana T. P. C.","family":"Gomes","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Rosa","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-4895","authenticated-orcid":false,"given":"Carlos F.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Jo\u00e3o P. C.","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"CQE, Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-8166","authenticated-orcid":false,"given":"Maria G. P. M. S.","family":"Neves","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-3778","authenticated-orcid":false,"given":"Fernando de C. da","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Niter\u00f3i, RJ 24020-150, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-766X","authenticated-orcid":false,"given":"V\u00edtor F.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Tecnologia Farmac\u00eautica, Faculdade de Farm\u00e1cia, Universidade Federal Fluminense, Niter\u00f3i, RJ 24241-000, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-5126","authenticated-orcid":false,"given":"Jos\u00e9 A. S.","family":"Cavaleiro","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/acs.chemrev.6b00361","article-title":"Porphyrinoids for chemical sensor applications","volume":"117","author":"Paolesse","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Costa, L.D., Costa, J.I.T., and Tome, A.C. (2016). Porphyrin macrocycle modification: Pyrrole ring-contracted or -expanded porphyrinoids. Molecules, 21.","DOI":"10.3390\/molecules21030320"},{"key":"ref_3","unstructured":"D\u2019Souza, F., and Ito, O. (2012). Tetrapyrrole\u2013nanocarbon hybrids: Self-assembly and photoinduced electron transfer. 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