{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:02:39Z","timestamp":1761490959907,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chirality is a geometric property associated with the asymmetry of tridimensional features that accompanies our daily life at macroscopic as well as microscopic molecular levels [...]<\/jats:p>","DOI":"10.3390\/molecules25071713","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T05:31:16Z","timestamp":1586496676000},"page":"1713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-730X","authenticated-orcid":false,"given":"Maria Elizabeth","family":"Tiritan","sequence":"first","affiliation":[{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal"},{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Edif\u00edcio do Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4050-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-1409","authenticated-orcid":false,"given":"Madalena","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Edif\u00edcio do Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4050-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0940-9163","authenticated-orcid":false,"given":"Carla","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia da Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental (CIIMAR), Edif\u00edcio do Terminal de Cruzeiros do Porto de Leix\u00f5es, Av. General Norton de Matos s\/n, 4050-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-57878-y","article-title":"Development of a cognitive function marker based on D-amino acid proportions using new chiral tandem LC-MS\/MS systems","volume":"10","author":"Kimura","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Teixeira, J., Tiritan, M.E., Pinto, M., and Fernandes, C. (2019). Chiral Stationary Phases for Liquid Chromatography: Recent Developments. Molecules, 24.","DOI":"10.3390\/molecules24050865"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Fernandes, C., Carraro, M.L., Ribeiro, J., Ara\u00fajo, J., Tiritan, M.E., and Pinto, M. (2019). Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies. Molecules, 24.","DOI":"10.3390\/molecules24040791"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Uwai, Y. (2018). Enantioselective Drug Recognition by Drug Transporters. Molecules, 23.","DOI":"10.3390\/molecules23123062"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gogoi, A., Mazumder, N., Konwer, S., Ranawat, H., Chen, N.-T., and Zhuo, G.-Y. (2019). Enantiomeric Recognition and Separation by Chiral Nanoparticles. Molecules, 24.","DOI":"10.3390\/molecules24061007"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Xuan, J., and Feng, Y. (2019). Enantiomeric Tartaric Acid Production Using cis-Epoxysuccinate Hydrolase: History and Perspectives. Molecules, 24.","DOI":"10.3390\/molecules24050903"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Da Silva, A.R., Dos Santos, D.A., Paixao, M.W., and Corr\u00eaa, A.G. (2019). Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines. Molecules, 24.","DOI":"10.3390\/molecules24030630"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ibrahim, D., and Ghanem, A. (2019). On the Enantioselective HPLC Separation Ability of Sub-2 \u00b5m Columns: Chiralpak\u00ae IG-U and ID-U. Molecules, 24.","DOI":"10.3390\/molecules24071287"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fouad, A., Shaykoon, M., Ibrahim, S.M., El-Adl, S.M., and Ghanem, A. (2019). Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography. Molecules, 24.","DOI":"10.3390\/molecules24050833"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kne\u017eevi\u0107, A., Novak, J., and Vinkovi\u0107, V. (2019). New Brush-Type Chiral Stationary Phases for Enantioseparation of Pharmaceutical Drugs. Molecules, 24.","DOI":"10.3390\/molecules24040823"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Shiau, L.-D. (2018). Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization. Molecules, 23.","DOI":"10.3390\/molecules23112901"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bodoki, A.E., Iacob, B.-C., Gliga, L.E., Oprean, S.L., Spivak, D.A., Gariano, N.A., and Bodoki, E. (2018). Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting. Molecules, 23.","DOI":"10.3390\/molecules23081875"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Peng, Y., Feng, C., Rohani, S., and He, Q.S. (2018). Improved Resolution of 4-Chloromandelic Acid and the Effect of Chlorine Interactions Using (R)-(+)-Benzyl-1-Phenylethylamine as a Resolving Agent. Molecules, 23.","DOI":"10.3390\/molecules23123354"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Xiong, F., Yang, B.-B., Zhang, J., and Li, L. (2018). Enantioseparation, Stereochemical Assignment and Chiral Recognition Mechanism of Sulfoxide-Containing Drugs. Molecules, 23.","DOI":"10.3390\/molecules23102680"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Brancatelli, G., Dalcanale, E., Pinalli, R., and Geremia, S. (2018). Probing the Structural Determinants of Amino Acid Recognition: X-Ray Studies of Crystalline Ditopic Host-Guest Complexes of the Positively Charged Amino Acids, Arg, Lys, and His with a Cavitand Molecule. Molecules, 23.","DOI":"10.3390\/molecules23123368"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chebrouk, F., Madani, K., Cherfaoui, B., Boukenna, L., Valega, M., Mendes, R.F., Paz, F.A.A., Bachari, K., Talhi, O., and Silva, A.M.S. (2019). Hemi-Synthesis of Chiral Imine, Benzimidazole and Benzodiazepines from Essential Oil of Ammodaucus leucotrichus subsp. leucotrichus. Molecules, 24.","DOI":"10.3390\/molecules24050975"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Long, S., Resende, D.I.S.P., Kijjoa, A., Silva, A.M.S., Fernandes, R., Xavier, C.P.R., Vasconcelos, M.H., Sousa, M.E., and Pinto, M. (2019). Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects. Molecules, 24.","DOI":"10.3390\/molecules24030534"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Poryvai, A., Vojtylov\u00e1-Jurkovi\u010dov\u00e1, T., \u0160mahel, M., Kolderov\u00e1, N., Tom\u00e1\u0161kov\u00e1, P., S\u00fdkora, D., and Kohout, M. (2019). Determination of Optical Purity of Lactic Acid-Based Chiral Liquid Crystals and Corresponding Building Blocks by Chiral High-Performance Liquid Chromatography and Supercritical Fluid Chromatography. Molecules, 24.","DOI":"10.3390\/molecules24061099"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Petronijevic, E., and Sibilia, C. (2019). Enhanced Near-Field Chirality in Periodic Arrays of Si Nanowires for Chiral Sensing. Molecules, 24.","DOI":"10.3390\/molecules24050853"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, B.-J., Duan, A.-H., Zhang, J.-H., Xie, S.-M., Cao, Q.-E., and Yuan, L.-M. (2019). An Enantioselective Potentiometric Sensor for 2-Amino-1-Butanol Based on Chiral Porous Organic Cage CC3-R. Molecules, 24.","DOI":"10.3390\/molecules24030420"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/7\/1713\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:16:39Z","timestamp":1760174199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/7\/1713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["molecules25071713"],"URL":"https:\/\/doi.org\/10.3390\/molecules25071713","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}