{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T15:05:31Z","timestamp":1774105531719,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Reference: SFRH\/BD\/149360\/2019"],"award-info":[{"award-number":["Reference: SFRH\/BD\/149360\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Nacional de Gest\u00e3o de Bolsas de Estudo","award":["Presentation Guide Number: 459\/2016"],"award-info":[{"award-number":["Presentation Guide Number: 459\/2016"]}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000019\u2013C4"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000019\u2013C4"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Julbernardia paniculata and Pterocarpus angolensis are two plant species with important application in African traditional medicine, particularly in Angola, in the treatment of several diseases. However, scientific studies concerning these species are scarce. The goal of this work was to know better which medicinal approaches are used by the Hu\u00edla population in Angola by means of ethnobotanical surveys. Furthermore, extracts of both plants were phytochemically characterized. Antioxidant, anti-inflammatory, wound-healing activities, and potential cytotoxicity were also studied. With this study it was possible to verify that 67% of the individuals that use medicinal plants are women, and their main therapeutic uses are the treatment of problems of the digestive system and skin disorders. Barks of J. paniculata and leaves of P. angolensis are the most often used plant parts. Through high-performance liquid chromatography coupled to diode-array detector (HPLC-DAD) and GC-MS it was possible to characterize the chemical composition of the two species, which are rich in phenolic compounds, terpenes, terpenoids, sesquiterpenoids and fatty acids. Both plants showed to possess antioxidant, anti-inflammatory proprieties, and wound-healing activity. To the best of our knowledge, this is the most comprehensive study of these two species and the first ethnobotanical and ethnopharmacological study of medicinal plants from this region of Angola.<\/jats:p>","DOI":"10.3390\/molecules25081828","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:01:39Z","timestamp":1587042099000},"page":"1828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Julbernardia paniculata and Pterocarpus angolensis: From Ethnobotanical Surveys to Phytochemical Characterization and Bioactivities Evaluation"],"prefix":"10.3390","volume":"25","author":[{"given":"Eug\u00e9nia Solange","family":"Santos","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Instituto Superior Polit\u00e9cnico da Hu\u00edla, Universidade Mandume Ya Ndemufayo, Bairro Comercial, Avenida Hoji Ya Henda N. 30, Caixa Postal N. 201, Lubango, Hu\u00edla, Angola"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-6522","authenticated-orcid":false,"given":"\u00c2ngelo","family":"Lu\u00eds","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"given":"Joana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-2895","authenticated-orcid":false,"given":"Tiago","family":"Rosado","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"},{"name":"C4-Cloud Computing Competence Centre, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"given":"Lu\u00edsa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Matem\u00e1tica e Aplica\u00e7\u00f5es (CMA-UBI), Universidade da Beira Interior, Rua Marqu\u00eas d\u2019\u00c1vila e Bolama, 6201-001 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-8998","authenticated-orcid":false,"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"given":"Ana Paula","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2014.08.042","article-title":"Ethnobotany of medicinal plants in district Mastung of Balochistan province-Pakistan","volume":"157","author":"Bibi","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2004.02.015","article-title":"Studies on pharmaceutical ethnobotany in Arrabida Natural Park (Portugal)","volume":"93","author":"Novais","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4314\/mmj.v30i4.2","article-title":"Efficacy of pterocarpus angolensis crude extracts against Candida krusei, Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli","volume":"30","author":"Chipinga","year":"2018","journal-title":"Malawi Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.phymed.2017.09.007","article-title":"Ethnobotanical survey of medicinal plants in northeastern of Algeria","volume":"36","author":"Bouasla","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-8741(03)00270-8","article-title":"An ethnobotanical study of medicinal and aromatic plants in the Natural Park of \u2018Serra de S\u00e3o Mamede\u2019 (Portugal)","volume":"89","author":"Bonet","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(00)00213-0","article-title":"Review on some plants of Indian traditional medicine with antioxidant activity","volume":"71","author":"Scartezzini","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jep.2010.01.017","article-title":"In vitro antimicrobial activity of extracts and compounds of some selected medicinal plants from Cameroon","volume":"128","author":"Mbosso","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","first-page":"946","article-title":"Antimicrobial natural products","volume":"2","author":"Soares","year":"2013","journal-title":"Formatex"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0266467416000584","article-title":"Biotic interactions, climate and disturbance underlie the distribution of two Julbernardia tree species in miombo woodlands of Africa","volume":"33","author":"Chidumayo","year":"2016","journal-title":"J. Trop. Ecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0031-9422(00)88861-5","article-title":"4,5-Dihydrpxypipecolic acids in the seed of Julbernardia, Isoberlinia and Brachystegia","volume":"15","author":"Shewry","year":"1976","journal-title":"Phytochemistry"},{"key":"ref_11","first-page":"157","article-title":"Bark removal for medicinal use predisposes indigenous forest trees to wood degradation in Zambia","volume":"69","author":"Chungu","year":"2007","journal-title":"South. Hemisph. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Abubakar, M., and Majinda, R. (2016). GC-MS Analysis and Preliminary Antimicrobial Activity of Albizia adianthifolia (Schumach) and Pterocarpus angolensis (DC). Medicines, 3.","DOI":"10.3390\/medicines3010003"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4067\/S0717-92002015000100011","article-title":"Mozambiques\u2019s charcoals: Anatomy of nine native species","volume":"36","author":"Afonso","year":"2015","journal-title":"Bosque"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3923\/pjbs.2007.627.631","article-title":"The Characteristics and Economic Importance of Pterocarpus angulensis in D. C. Botswana","volume":"10","author":"Lumbile","year":"2007","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2989\/20702620.2018.1531278","article-title":"Land-use impacts on the composition and diversity of the Baikiaea\u2013Guibourtia\u2013Pterocarpus woodlands of north-western Zimbabwe","volume":"81","author":"Chichinye","year":"2019","journal-title":"South. For. J. For. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.sajb.2018.02.117","article-title":"The ethnobotany of Pterocarpus angolensis DC.: A reflection of rural Venda speaking community of Gundani in Limpopo Province, South Africa","volume":"115","author":"Sadiki","year":"2018","journal-title":"South Afr. J. Bot."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1179\/136485909X435111","article-title":"Crude extracts of, and purified compounds from, Pterocarpus angolensis, and the essential oil of Lippia javanica: Their in vitro cytotoxicities and activities against selected bacteria and Entamoeba histolytica","volume":"103","author":"Samie","year":"2009","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111668","DOI":"10.1016\/j.indcrop.2019.111668","article-title":"Evaluation of antimicrobial activity of Pterocarpus extracts","volume":"140","author":"Cai","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zininga, T., Anokwuru, C., Sigidi, M., Tshisikhawe, M., Ramaite, I., Traor\u00e9, A., Heinrich, H., Shondai, A., and Potgieter, N. (2017). Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function. Molecules, 22.","DOI":"10.3390\/molecules22081224"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jep.2012.06.048","article-title":"Trifolium species-derived substances and extracts\u2014Biological activity and prospects for medicinal applications","volume":"143","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jsfa.8600","article-title":"Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: A review","volume":"98","author":"Dhakad","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1080\/14786419.2017.1303698","article-title":"In vitro antibacterial, antifungal and antioxidant activities of Eucalyptus spp. leaf extracts related to phenolic composition","volume":"31","author":"Elansary","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/14786419.2010.488232","article-title":"Antioxidant activities, total phenolics and HPLC analyses of the phenolic compounds of extracts from common Mediterranean plants","volume":"25","author":"Rababah","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2005.09.002","article-title":"Antimicrobial activity of flavonoids","volume":"26","author":"Cushnie","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_25","first-page":"6428","article-title":"Stumps of Eucalyptus globulus as a Source of Antioxidant and Antimicrobial Polyphenols","volume":"19","author":"Neiva","year":"2014","journal-title":"Molecules"},{"key":"ref_26","unstructured":"U.S. Food and Drug Administration (2020, January 15). Guidance for Industry: Bioanalytical Method Validation, Available online: https:\/\/www.fda.gov\/downloads\/drugs\/guidances\/ucm368107.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fpls.2016.00019","article-title":"Cannabis sativa: The Plant of the Thousand and One Molecules","volume":"7","author":"Andre","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pnpbp.2012.04.017","article-title":"Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids","volume":"39","author":"Seely","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0308-8146(03)00151-1","article-title":"Antioxidant activity and total phenolic content of Iranian Ocimum accessions","volume":"83","author":"Javanmardi","year":"2003","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.foodchem.2011.07.127","article-title":"Estimation of antiradical properties of antioxidants using DPPH assay: A critical review and results","volume":"130","author":"Mishra","year":"2012","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00217-010-1333-4","article-title":"Influence of some experimental variables and matrix components in the determination of antioxidant properties by \u03b2-carotene bleaching assay: Experiments with BHT used as standard antioxidant","volume":"231","author":"Dawidowicz","year":"2010","journal-title":"Eur. Food Res. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.foodchem.2014.04.004","article-title":"In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans","volume":"161","author":"Moro","year":"2014","journal-title":"Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S976","DOI":"10.1016\/S2221-1691(12)60346-3","article-title":"Antioxidant and in vitro anti-inflammatory activities of Mimusops elengi leaves","volume":"2","author":"Kar","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.carbpol.2018.02.003","article-title":"Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites","volume":"189","author":"Ziora","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cjtee.2018.10.004","article-title":"The wound healing potential of collagen peptides derived from the jellyfish Rhopilema esculentum","volume":"22","author":"Felician","year":"2019","journal-title":"Chin. J. Traumatol. Engl. Ed."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaim.2016.11.007","article-title":"Studies on wound healing potential of polyherbal formulation using in vitro and in vivo assays","volume":"8","author":"Talekar","year":"2017","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"957","DOI":"10.5650\/jos.ess18005","article-title":"Wound Healing Study of Eucalyptus Essential Oil Containing Nanoemulsion in Rat Model","volume":"67","author":"Alam","year":"2018","journal-title":"J. Oleo Sci."},{"key":"ref_38","unstructured":"Province Profile (2020, February 26). Governo de Angola, Available online: http:\/\/www.huila.gov.ao\/InformacoesProvinciais.aspx?tipo=Perfil."},{"key":"ref_39","first-page":"203","article-title":"Efficacy of Aqueous and Methanol Extracts of Some Medicinal Plants for Potential Antibacterial Activity","volume":"29","author":"Parekh","year":"2005","journal-title":"Turk. J. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1039\/C5FO00510H","article-title":"Nutrient values and bioactivities of the extracts from three fern species in China: A comparative assessment","volume":"6","author":"Qi","year":"2015","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.phytochem.2006.01.014","article-title":"An unusual glucoside from Cleistanthus gracilis","volume":"67","author":"Pinho","year":"2006","journal-title":"Phytochemistry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.fitote.2012.03.019","article-title":"Anti-Helicobacter pylori activity of Terminalia macroptera root","volume":"83","author":"Silva","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JBR-170168","article-title":"Phytochemical characterization, and evaluation of rheological and antioxidant properties of commercially available juices of berries","volume":"8","author":"Sousa","year":"2018","journal-title":"J. Berry Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2008.06.026","article-title":"Antioxidant activity index (AAI) by the 2,2-diphenyl-1-picrylhydrazyl method","volume":"112","author":"Scherer","year":"2009","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ffj.3498","article-title":"Star anise (Illicium verum Hook. f.) essential oil: Antioxidant properties and antibacterial activity against Acinetobacter baumannii","volume":"34","author":"Sousa","year":"2019","journal-title":"Flavour Fragr. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.4103\/0973-1296.127331","article-title":"Antimicrobial, antibiofilm and cytotoxic activities of Hakea sericea Schrader extracts","volume":"10","author":"Breitenfeld","year":"2014","journal-title":"Pharm. Mag."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/8\/1828\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:09:13Z","timestamp":1760364553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/8\/1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["molecules25081828"],"URL":"https:\/\/doi.org\/10.3390\/molecules25081828","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]}}}