{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:58:49Z","timestamp":1771952329708,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cerrado biome represents an area with great biodiversity. Some of its plants have significant ethnopharmacological uses, with specific purposes. Croton urucurana Baill., for instance, was previously acknowledged for its anti-hemorrhagic, anti-inflammatory, antiseptic, healing, and potentially antifungal and entomopathogenic actions. Nevertheless, the compounds supporting these empirical applications are still unknown. Accordingly, this work was designed to achieve a complete characterization of the phenolic profile of different botanical tissues obtained from C. urucurana, and also to verify how different operational conditions (different drying temperatures and extraction conditions) affect that profile. All samples were further characterized by HPLC\u2013DAD\u2013ESI\/MSn, and results were compared by advanced chemometric tools. In general, the drying temperatures that maximize the extraction yield of specific individual phenolic compounds were established. Likewise, it was possible to verify that samples extracted with the hydroethanolic solution allowed higher phenolic yields, either in individual compounds (except (epi)catechin-di-O-gallate) or total phenolics. The identification of the best operational conditions and phenolic profiles associated with each C. urucurana botanical part contributes to enabling their use in food or pharmaceutical-related applications.<\/jats:p>","DOI":"10.3390\/molecules25092032","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T01:24:18Z","timestamp":1588123458000},"page":"2032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phenolic Profile of Croton urucurana Baill. Leaves, Stems and Bark: Pairwise Influence of Drying Temperature and Extraction Solvent"],"prefix":"10.3390","volume":"25","author":[{"given":"J\u00e1liston J\u00falio","family":"Lopes Alves","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300\u2013253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio de P\u00f3s-colheita de Produtos Vegetais, Instituto Federal Goiano\u2014Campus Rio Verde, 75.901\u2013970 Rio Verde, Goi\u00e1s, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-7814","authenticated-orcid":false,"given":"Maria In\u00eas","family":"Dias","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300\u2013253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-0990","authenticated-orcid":false,"given":"Jo\u00e3o C. M.","family":"Barreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300\u2013253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300\u2013253 Bragan\u00e7a, Portugal"}]},{"given":"Osvaldo","family":"Resende","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de P\u00f3s-colheita de Produtos Vegetais, Instituto Federal Goiano\u2014Campus Rio Verde, 75.901\u2013970 Rio Verde, Goi\u00e1s, Brazil"}]},{"given":"Ana Carolina","family":"Ribeiro Aguiar","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de P\u00f3s-colheita de Produtos Vegetais, Instituto Federal Goiano\u2014Campus Rio Verde, 75.901\u2013970 Rio Verde, Goi\u00e1s, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel C. F. R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300\u2013253 Bragan\u00e7a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"ref_1","first-page":"78","article-title":"Uso e diversidade de plantas medicinais no Quilombo Olho D\u2019agua dos Pires, Esperantina, Piau\u00ed","volume":"8","author":"Franco","year":"2006","journal-title":"Rev. Bras. Plantas Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1590\/S0102-695X2003000300024","article-title":"Levantamento etnobot\u00e2nico das plantas medicinais do cerrado utilizadas pela popula\u00e7\u00e3o de Moss\u00e2medes (GO)","volume":"13","author":"Paula","year":"2003","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1590\/S0100-40422002000300016","article-title":"Plantas medicinais: A necessidade de estudos multidisciplinares","volume":"25","author":"Maciel","year":"2002","journal-title":"Quim. Nova"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/S0102-33062006000100013","article-title":"Uso de plantas medicinais na regi\u00e3o de Alto Para\u00edso de Goi\u00e1s, GO, Brasil","volume":"20","author":"Souza","year":"2006","journal-title":"Acta Bot\u00e2nica Bras."},{"key":"ref_5","first-page":"25","article-title":"Avalia\u00e7\u00e3o da atividade antibacteriana de Croton urucurana","volume":"10","author":"Soldera","year":"2013","journal-title":"Rev. Context. Sa\u00fade"},{"key":"ref_6","first-page":"331","article-title":"Mortalidade e comprometimento do desenvolvimento de Zabrotes subfasciatus Boh. (Coleoptera: Chrysomelidae), induzido pelo extrato de sangra d\u2019\u00e1gua Croton urucurana Baill (Euphorbiaceae)","volume":"5","author":"Silva","year":"2014","journal-title":"Comun. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2007.06.009","article-title":"Dragon\u2019s blood from Croton urucurana (Baill.) attenuates visceral nociception in mice","volume":"113","author":"Rao","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_8","first-page":"B-253","article-title":"Phytochemical screening of eight traditionally used ethnomedicinal plants from Akola district (MS) India","volume":"1","author":"Koche","year":"2010","journal-title":"Int. J. Pharma Bio Sci."},{"key":"ref_9","first-page":"609","article-title":"Clerodane diterpenes from bark of Croton urucurana baillon","volume":"24","author":"Pizzolatti","year":"2013","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1590\/S1983-40632014000100005","article-title":"Modelagem matem\u00e1tica e difusividade efetiva de folhas de aroeira durante a secagem","volume":"44","author":"Goneli","year":"2014","journal-title":"Pesqui. Agropecu. Trop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/S0103-84782012000400006","article-title":"Cover crops and their effects on the biomass yield of Serjania marginata plants","volume":"42","author":"Tabaldi","year":"2012","journal-title":"Ci\u00eancia Rural"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1590\/1983-084X\/12_071","article-title":"Predi\u00e7\u00e3o de modelos sobre a cin\u00e9tica de secagem de folhas de Ziziphus joazeiro Mart","volume":"17","author":"Sousa","year":"2015","journal-title":"Rev. Bras. Plantas Med."},{"key":"ref_13","first-page":"427","article-title":"Extraction and isolation of phenolic compounds","volume":"864","author":"Sarker","year":"2012","journal-title":"Natural Products Isolation. Methods in Molecular Biology (Methods and Protocols)\u2014Chapter 17"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s40415-014-0115-9","article-title":"Flavonoids and antioxidant potential of nine Argentinian species of Croton (Euphorbiaceae)","volume":"38","author":"Furlan","year":"2015","journal-title":"Rev. Bras. Bot."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jep.2016.02.051","article-title":"Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark","volume":"183","author":"Cordeiro","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/pca.727","article-title":"Approach to the study of C-glycosyl flavones by ion trap HPLC-PAD-ESI\/MS\/MS: Application to seeds of quince (Cydonia oblonga)","volume":"14","author":"Ferreres","year":"2003","journal-title":"Phytochem. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jff.2015.04.044","article-title":"A bioactive formulation based on Fragaria vesca L. vegetative parts: Chemical characterisation and application in \u03ba-carrageenan gelatin","volume":"16","author":"Dias","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Escobar-Avello, D., Lozano-Castell\u00f3n, J., Mardones, C., P\u00e9rez, A.J., Sa\u00e9z, V., Riquelme, S., Von Baer, D., and Vallverd\u00fa-Queralt, A. (2019). Phenolic profile of grape canes: Novel compounds identified by LC-ESI-LTQ-orbitrap-MS. Molecules, 24.","DOI":"10.3390\/molecules24203763"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.indcrop.2016.04.065","article-title":"Phenolic profile and antioxidant activity of Coleostephus myconis (L.) Rchb.f.: An underexploited and highly disseminated species","volume":"89","author":"Bessada","year":"2016","journal-title":"Ind. Crops Prod."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/9\/2032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:23:56Z","timestamp":1760361836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/9\/2032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["molecules25092032"],"URL":"https:\/\/doi.org\/10.3390\/molecules25092032","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]}}}