{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:22:29Z","timestamp":1773015749988,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2012\/07\/B\/ST5\/00885"],"award-info":[{"award-number":["2012\/07\/B\/ST5\/00885"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/29\/B\/ST5\/01418"],"award-info":[{"award-number":["2018\/29\/B\/ST5\/01418"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LISBOA-01-0145-FEDER-029697"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-029697"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IST-ID\/086\/2018"],"award-info":[{"award-number":["IST-ID\/086\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018647","name":"RUDN University","doi-asserted-by":"publisher","award":["Program 5-100"],"award-info":[{"award-number":["Program 5-100"]}],"id":[{"id":"10.13039\/501100018647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(\u00b5-PTA)2(\u00b53-PTA)2(\u00b54-pma)(H2O)2]n\u00b76nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (\u00b5-PTA, \u00b53-PTA, and \u00b54-pma4\u2212). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity.<\/jats:p>","DOI":"10.3390\/molecules25092119","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T06:41:20Z","timestamp":1588660880000},"page":"2119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-8629","authenticated-orcid":false,"given":"Sabina W.","family":"Jaros","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroc\u0142aw, Poland"}]},{"given":"Jaros\u0142aw","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Wroc\u0142aw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroc\u0142aw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6694-2872","authenticated-orcid":false,"given":"Barbara","family":"Ba\u017can\u00f3w","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Wroc\u0142aw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroc\u0142aw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4296-3174","authenticated-orcid":false,"given":"Dominik","family":"Poradowski","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Biostructure, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-549X","authenticated-orcid":false,"given":"Aleksander","family":"Chr\u00f3szcz","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Biostructure, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-6888","authenticated-orcid":false,"given":"Dmytro S.","family":"Nesterov","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049\u2013001 Lisbon, Portugal"},{"name":"Research Institute of Chemistry, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., 117198 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-5280","authenticated-orcid":false,"given":"Alexander M.","family":"Kirillov","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049\u2013001 Lisbon, Portugal"},{"name":"Research Institute of Chemistry, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., 117198 Moscow, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-6012","authenticated-orcid":false,"given":"Piotr","family":"Smole\u0144ski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroc\u0142aw, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shen, M., Forghani, F., Kong, X., Liu, D., Ye, X., Chen, S., and Ding, T. (2020). Antibacterial applications of metal\u2013organic frameworks and their composites. Comp. Rev. Food Sci. Food Saf., 1\u201323.","DOI":"10.1111\/1541-4337.12515"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/cmi.12590","article-title":"Cryptococcal therapies and drug targets: The old, the new and the promising","volume":"18","author":"Coelho","year":"2016","journal-title":"Cell Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/14787210.2019.1635009","article-title":"Broad-Spectrum Antiviral Agents: A Crucial Pandemic Tool","volume":"17","author":"Adalja","year":"2019","journal-title":"Expert. Rev. Anti-infect. 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