{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:43:34Z","timestamp":1777992214132,"version":"3.51.4"},"reference-count":200,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nowadays, the food sector is highly concerned with environmental issues and foreseen to develop strategies to reduce waste and losses resulting from activities developed in the food system. An approach is to increment added value to the agro-industrial wastes, which might provide economic growth and environmental protection, contributing to a circular economy. Mushroom by-products represent a disposal problem, but they are also promising sources of important compounds, which may be used due to their functional and nutritional properties. Research has been developed in different fields to obtain value added solutions for the by-products generated during mushroom production and processing. Bioactive compounds have been obtained and applied in the development of nutraceutical and pharmaceutical formulations. Additionally, other applications have been explored and include animal feed, fertilizer, bioremediation, energy production, bio-based materials, cosmetics and cosmeceuticals. The main purpose of this review is to highlight the relevant composition of mushroom by-products and discuss their potential as a source of functional compounds and other applications. Future research needs to explore pilot and industrial scale extraction methods to understand the technological feasibility and the economic sustainability of the bioactive compounds extraction and valorization towards different applications.<\/jats:p>","DOI":"10.3390\/molecules25112672","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T08:49:11Z","timestamp":1591692551000},"page":"2672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Valorization of Mushroom By-Products as a Source of Value-Added Compounds and Potential Applications"],"prefix":"10.3390","volume":"25","author":[{"given":"Filipa","family":"Antunes","sequence":"first","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7576","authenticated-orcid":false,"given":"Sara","family":"Mar\u00e7al","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-3532","authenticated-orcid":false,"given":"Oludemi","family":"Taofiq","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-9649","authenticated-orcid":false,"given":"Alcina","family":"M. M. B. Morais","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-9370","authenticated-orcid":false,"given":"Ana Cristina","family":"Freitas","sequence":"additional","affiliation":[{"name":"CBQF\u2013Centro de Biotecnologia e Qu\u00edmica Fina\u2013Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel","family":"C. F. R. 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Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0308-8146(99)00197-1","article-title":"Beta-glucans in edible mushrooms","volume":"68","author":"Manzi","year":"2000","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bcab.2017.11.011","article-title":"Screening and decolorizing potential of enzymes from spent mushroom composts of six different mushrooms","volume":"13","author":"Nakajima","year":"2018","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5941\/MYCO.2013.41.4.214","article-title":"Efficient Recovery of Lignocellulolytic Enzymes of Spent Mushroom Compost from Oyster Mushrooms, Pleurotus spp., and Potential Use in Dye Decolorization","volume":"41","author":"Lim","year":"2013","journal-title":"Mycobiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jclepro.2013.10.051","article-title":"Current options for the valorization of food manufacturing waste: A review","volume":"65","author":"Mirabella","year":"2014","journal-title":"J. Clean. Prod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1007\/s00253-018-9226-8","article-title":"Mushroom cultivation in the circular economy","volume":"102","author":"Grimm","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00253-012-4446-9","article-title":"Potential uses of spent mushroom substrate and its associated lignocellulosic enzymes","volume":"96","author":"Phan","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"376387","DOI":"10.1155\/2015\/376387","article-title":"Edible mushrooms: Improving human health and promoting quality life","volume":"2015","author":"Valverde","year":"2015","journal-title":"Int. J. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Diego, C.Z., and Pardo-Gim\u00e9nez, A. (2017). Current Overview of Mushroom Production in the World. Edible and Medicinal Mushrooms: Technology and Applications, Wiley Blackwell.","DOI":"10.1002\/9781119149446"},{"key":"ref_10","first-page":"221","article-title":"Submerged Culture of Mushrooms in Bioreactors- Challenges, Current State-of-the-Art, and Future Prospects","volume":"45","author":"Tang","year":"2007","journal-title":"Food Technol. Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1023\/A:1020994628109","article-title":"Medicinal mushrooms: A rapidly developing area of biotechnology for cancer therapy and other bioactivities","volume":"24","author":"Smith","year":"2002","journal-title":"Biotechnol. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.copbio.2014.01.010","article-title":"Bioactive fungal polysaccharides as potential functional ingredients in food and nutraceuticals","volume":"26","author":"Giavasis","year":"2014","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s00253-004-1569-7","article-title":"Modern aspects of mushroom culture technology","volume":"64","year":"2004","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_14","first-page":"209","article-title":"A review of chemical composition and nutritional value of wild-growing and cultivated mushrooms","volume":"93","year":"2012","journal-title":"J. Sci. Food Agric."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.1021\/jf0492565","article-title":"Chitin and Chitosan Value-Added Products from Mushroom Waste","volume":"52","author":"Wu","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.carbpol.2014.07.069","article-title":"Purification, characterization and antitumor activity of polysaccharides from Pleurotus eryngii residue","volume":"114","author":"Ma","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.geoderma.2017.07.033","article-title":"Composition variability of spent mushroom substrates during continuous cultivation, composting process and their effects on mineral nitrogen transformation in soil","volume":"307","author":"Lou","year":"2017","journal-title":"Geoderma"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.lwt.2016.11.043","article-title":"Ultrasound assisted extraction of polysaccharides from mushroom by-products","volume":"77","author":"Walton","year":"2017","journal-title":"LWT"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa, R., Barros, L., Fernandes, A., Sokovic, M., Brachtc, A., Peralta, R.M., and Ferreira, I.C.F.R. (2018). A natural food ingredient based on ergosterol: Optimization of the extraction from Agaricus blazei, evaluation of bioactive properties and incorporation in yogurts. Food Funct., 1465\u20131474.","DOI":"10.1039\/C7FO02007D"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Letti, L.A.J., V\u00edtola, F.M.D., Pereira, G.V.D.M., Karp, S.G., Medeiros, A.B.P., Da Costa, E.S.F., Bissoqui, L., and Soccol, C.R. (2018). Solid-State Fermentation for the Production of Mushrooms. Curr. Dev. Biotechnol. Bioeng., 285\u2013318.","DOI":"10.1016\/B978-0-444-63990-5.00014-1"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pandey, A., Soccol, C.R., and Larroche, C. (2008). Mushroom Production BT. Current Developments in Solid-state Fermentation, Springer.","DOI":"10.1007\/978-0-387-75213-6"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/jsfa.3992","article-title":"Value-added use of mushroom ergothioneine as a colour stabilizer in processed fish meats","volume":"90","author":"Bao","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"671252","DOI":"10.1155\/2013\/671252","article-title":"Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats","volume":"2013","author":"Cheng","year":"2013","journal-title":"Evid. Based. Complement. Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fct.2017.07.051","article-title":"The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits","volume":"108","author":"Taofiq","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-1097(03)00853-X","article-title":"Polysaccharides from the fruit bodies of the basidiomycete Laetiporus sulphureus (Bull.: Fr.) Murr","volume":"230","author":"Alquini","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.foodchem.2016.08.030","article-title":"Chemical and structural characterization of Pholiota nameko extracts with biological properties","volume":"216","author":"Rodrigues","year":"2017","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.carbpol.2013.05.028","article-title":"Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii","volume":"97","author":"Chen","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jff.2017.12.046","article-title":"Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions","volume":"41","author":"Khan","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.foodres.2015.07.044","article-title":"The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives","volume":"76","author":"Taofiq","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.lwt.2011.05.010","article-title":"Antioxidative activities and chemical characterization of polysaccharides extracted from the basidiomycete Schizophyllum commune","volume":"44","author":"Klaus","year":"2011","journal-title":"LWT"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.lwt.2010.02.006","article-title":"A novel alcoholic beverage developed from shiitake stipe extract and cane sugar with various Saccharomyces strains","volume":"43","author":"Lin","year":"2010","journal-title":"LWT"},{"key":"ref_32","first-page":"611","article-title":"Nutritional composition and antioxidant capacity of several edible mushrooms grown in the Southern Vietnam","volume":"19","author":"Hung","year":"2012","journal-title":"Int. Food Res. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biortech.2006.12.012","article-title":"Composition variability of spent mushroom compost in Ireland","volume":"99","author":"Jordan","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jasi\u0144ska, A. (2018). Spent mushroom compost (SMC)\u2013retrieved added value product closing loop in agricultural production. Acta Agrar. Debr., 185\u2013202.","DOI":"10.34101\/actaagrar\/150\/1715"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Diego, C.Z., and Pardo-Gim\u00e9nez, A. (2017). Spent Mushroom Substrate Uses: Technology and Applications. Edible and Medicinal Mushrooms: Technology and Applications, Wiley Blackwell.","DOI":"10.1002\/9781119149446"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Diego, C.Z., and Pardo-Gim\u00e9nez, A. (2017). Mushrooms: Biology and Life Cycle. Edible and Medicinal Mushrooms: Technology and Applications, Wiley Blackwell.","DOI":"10.1002\/9781119149446"},{"key":"ref_37","unstructured":"Marshall, E., and Nair, N.G. (2009). Make money by growing mushrooms."},{"key":"ref_38","unstructured":"Biswas, S., Datta, M., and Ngachan, S.V. (2011). Mushrooms: A Manual for Cultivation, Prentice-Hall of India Pvt. Ltd. [First ed.]."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Alhujaily, A., Yu, H., Zhang, X., and Ma, F. (2018). Highly Efficient and Sustainable Spent Mushroom Waste Adsorbent Based on Surfactant Modification for the Removal of Toxic Dyes. Int. J. Environ. Res. Public Heal., 15.","DOI":"10.3390\/ijerph15071421"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.carbpol.2016.03.071","article-title":"Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes","volume":"146","author":"Lin","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jtice.2016.10.017","article-title":"Chemical characterization and antioxidant activity of polysaccharide extract from spent mushroom substrate of Pleurotus eryngii","volume":"69","author":"He","year":"2016","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/jctb.852","article-title":"Optimization of extraction of bulk enzymes from spent mushroom compost","volume":"78","author":"Singh","year":"2003","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.lwt.2018.01.032","article-title":"Extraction, purification and physicochemical properties of a novel lectin from Laetiporus sulphureus mushroom","volume":"91","author":"Wang","year":"2018","journal-title":"LWT"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ijbiomac.2015.10.016","article-title":"Extraction, characterization and antioxidant activity of polysaccharides of spent mushroom compost of Ganoderma lucidum","volume":"82","author":"Zhang","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ijbiomac.2011.11.016","article-title":"Extraction, purification and antibacterial activities of a polysaccharide from spent mushroom substrate","volume":"50","author":"Zhu","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1615\/IntJMedMushr.v14.i3.10","article-title":"Submerged Cultivation of Medicinal Mushrooms: Bioprocesses and Products (Review) Int","volume":"14","author":"Elisashvili","year":"2012","journal-title":"J. Med. Mushrooms"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1023\/A:1005616516646","article-title":"Production of a liquid inoculum\/spawn of Agaricus bisporus","volume":"22","author":"Friel","year":"2000","journal-title":"Biotechnol. Lett."},{"key":"ref_48","first-page":"238","article-title":"Cultivation Techniques and Medicinal Properties of Pleurotus spp.","volume":"45","author":"Gregori","year":"2007","journal-title":"Food Technol. Biotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Petre, M., and Petre, V. (2016). Biotechnology of Mushroom Growth Through Submerged Cultivation. Mushroom Biotechnol., 1\u201318.","DOI":"10.1016\/B978-0-12-802794-3.00001-1"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bjm.2016.04.007","article-title":"Production of mycelial biomass by the Amazonian edible mushroom Pleurotus albidus","volume":"47","author":"Teixeira","year":"2016","journal-title":"Brazilian J. Microbiol."},{"key":"ref_51","first-page":"835","article-title":"Comparison between liquid culture and solid culture technologies for edible mushroom spawn production and analysis on their economic benefits","volume":"44","author":"Jingli","year":"2011","journal-title":"China Agric. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s11274-015-1937-8","article-title":"Extracellular polysaccharides from Ascomycota and Basidiomycota: Production conditions, biochemical characteristics, and biological properties","volume":"31","author":"Nowak","year":"2015","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/MBI.S10957","article-title":"Fungal exopolysaccharide: Production, composition and applications","volume":"6","author":"Mahapatra","year":"2013","journal-title":"Microbiol. insights"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00253-002-1076-7","article-title":"Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides","volume":"60","author":"Wasser","year":"2002","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, O.J., Montoya, S., and Vargas, L.M. (2015). Polysaccharide Production by Submerged Fermentation. Polysaccharides, 451\u2013473.","DOI":"10.1007\/978-3-319-16298-0_39"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jsfa.6711","article-title":"Effects of dietary polysaccharides from the submerged fermentation concentrate of Hericium caput-medusae (Bull.:Fr.) Pers. on fat deposition in broilers","volume":"95","author":"Shang","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.carbpol.2015.06.016","article-title":"Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12","volume":"131","author":"Wang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.procbio.2004.02.004","article-title":"Production of polysaccharides of Ganoderma lucidum (CCRC36021) by reusing thin stillage","volume":"40","author":"Hsieh","year":"2005","journal-title":"Process Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1365-2672.2005.02682.x","article-title":"A comparative study on the production of exopolysaccharides between two entomopathogenic fungi Cordyceps militaris and Cordyceps sinensis in submerged mycelial cultures","volume":"99","author":"Kim","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.resconrec.2012.06.005","article-title":"Sustainable management of coffee industry by-products and value addition\u2014A review","volume":"66","author":"Murthy","year":"2012","journal-title":"Resour. Conserv. Recycl."},{"key":"ref_61","unstructured":"Galanakis, C. (2017). Nutraceutical and Functional Food Components, Academic Press."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Vuong, Q. (2017). Utilisation of Bioactive Compounds from Agricultural and Food Waste, CRC Press.","DOI":"10.1201\/9781315151540"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-011-0036-2","article-title":"Recent developments in mushrooms as anti-cancer therapeutics: A review","volume":"2","author":"Patel","year":"2012","journal-title":"3 Biotech"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Puri, M. (2017). Bioactives from Mushroom and Their Application. Food Bioactives: Extraction and Biotechnology Applications, Springer International Publishing.","DOI":"10.1007\/978-3-319-51639-4"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/ecam\/neh107","article-title":"The pharmacological potential of mushrooms","volume":"2","author":"Lindequist","year":"2005","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"ref_66","unstructured":"Giavasis, I. (2014). Polysaccharides Natural Fibers in Food and Nutrition, First Edition, CRC Press."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tifs.2017.05.010","article-title":"Functional foods based on extracts or compounds derived from mushrooms","volume":"66","author":"Reis","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tifs.2020.03.005","article-title":"Recovery of ergosterol and vitamin D2 from mushroom waste - Potential valorization by food and pharmaceutical industries","volume":"99","author":"Papoutsis","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.fct.2013.06.021","article-title":"Laetiporus sulphureus, edible mushroom from Serbia: Investigation on volatile compounds, in vitro antimicrobial activity and in situ control of Aspergillus flavus in tomato paste","volume":"59","author":"Guerzoni","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.carbpol.2009.12.029","article-title":"Extraction, purification, characterization and antitumor activity of polysaccharides from Ganoderma lucidum","volume":"80","author":"Zhao","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jfca.2017.01.016","article-title":"Nutritional composition and nutraceutical properties of the Pleurotus fruiting bodies: Potential use as food ingredient","volume":"58","year":"2017","journal-title":"J. Food Compos. Anal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5937\/savteh1602053D","article-title":"Comprehensive Evaluation of the Antioxidant Activity of six wild edible mushroom species","volume":"5","author":"Dimitrijevic","year":"2016","journal-title":"Adv. Technol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.carbpol.2011.10.018","article-title":"Effects of drying methods on the antioxidant activities of polysaccharides extracted from Ganoderma lucidum","volume":"87","author":"Fan","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.3390\/molecules17044373","article-title":"Chemical characteristics and antioxidant properties of crude water soluble polysaccharides from four common edible mushrooms","volume":"17","author":"He","year":"2012","journal-title":"Molecules"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.foodchem.2014.05.110","article-title":"Antioxidant and antibacterial activities of sulphated polysaccharides from Pleurotus eryngii and Streptococcus thermophilus ASCC 1275","volume":"165","author":"Li","year":"2014","journal-title":"Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.foodchem.2015.10.113","article-title":"Characterization, antioxidative and bifidogenic effects of polysaccharides from Pleurotus eryngii after heat treatments","volume":"197","author":"Li","year":"2016","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijbiomac.2018.01.132","article-title":"Extraction optimization, characterization, antioxidant and immunomodulatory activities of a novel polysaccharide from the wild mushroom Paxillus involutus","volume":"112","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bcdf.2013.01.001","article-title":"Current development of polysaccharides from Ganoderma: Isolation, structure and bioactivities","volume":"1","author":"Nie","year":"2013","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.carbpol.2017.12.009","article-title":"Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review","volume":"183","author":"Yu","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"D\u00edaz Reinoso, B., and Dom\u00ednguez Gonz\u00e1lez, H. (2017). Introduction. Water Extr. Bioact. Compd., 1\u201350.","DOI":"10.1016\/B978-0-12-809380-1.00001-2"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1295\/polymj.30.838","article-title":"Chemical Structure of the Water-Insoluble Polysaccharide Isolated from the Fruiting Body of Ganoderma lucidum","volume":"30","author":"Chen","year":"1998","journal-title":"Polym. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.carbpol.2011.05.031","article-title":"Structure and chain conformation of water-soluble heteropolysaccharides from Ganoderma lucidum","volume":"86","author":"Wang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijbiomac.2010.03.019","article-title":"Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity","volume":"47","author":"Huang","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.foodchem.2018.06.045","article-title":"Potential of chitosan from mushroom waste to enhance quality and storability of fresh-cut melons","volume":"268","author":"Poverenov","year":"2018","journal-title":"Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.carbpol.2017.03.010","article-title":"Vitamin D-fortified chitosan films from mushroom waste","volume":"167","author":"Chiou","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.carbpol.2007.04.010","article-title":"Purification, characterization and biological activity on hepatocytes of a polysaccharide from Flammulina velutipes mycelium","volume":"70","author":"Pang","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijbiomac.2018.01.196","article-title":"Preparation, characterization and antioxidant activity of polysaccharide from spent Lentinus edodes substrate","volume":"112","author":"Zhu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lwt.2016.05.049","article-title":"Antioxidant and cytotoxicites of Pleurotus eryngii residue polysaccharides obtained by ultrafiltration","volume":"73","author":"Ma","year":"2016","journal-title":"LWT"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ifset.2018.02.004","article-title":"A novel biodegradable film from edible mushroom (F. velutipes) by product: Microstructure, mechanical and barrier properties associated with the fiber morphology","volume":"47","author":"Wang","year":"2018","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/molecules19010022","article-title":"Physicochemical Characteristics and Anti-Inflammatory Activities of Antrodan, a Novel Glycoprotein Isolated from Antrodia cinnamomea Mycelia","volume":"19","author":"Chiu","year":"2014","journal-title":"Molecules"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.foodchem.2009.03.073","article-title":"Protective effect of selenium-polysaccharides from the mycelia of Coprinus comatus on alloxan-induced oxidative stress in mice","volume":"117","author":"Yu","year":"2009","journal-title":"Food Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijbiomac.2013.10.025","article-title":"Purification and partial characterization of a novel anti-tumor glycoprotein from cultured mycelia of Grifola frondosa","volume":"62","author":"Cui","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ijbiomac.2015.08.043","article-title":"A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity","volume":"81","author":"Wang","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1080\/14786419.2014.898145","article-title":"Bioactive metabolites from the mycelia of the basidiomycete Hericium erinaceum","volume":"28","author":"Lu","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.intimp.2014.05.015","article-title":"Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization","volume":"21","author":"Xu","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.foodchem.2010.12.090","article-title":"Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus","volume":"127","author":"Xu","year":"2011","journal-title":"Food Chem."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Ahmad, R., Muniandy, S., Shukri, N., Alias, S., Hamid, A., Yusoff, W., Senafi, S., and Daud, F. (2014). Antioxidant Properties and Glucan Compositions of Various Crude Extract from Lentinus squarrosulus Mycelial Culture. Adv. Biosci. Biotechnol., 805\u2013814.","DOI":"10.4236\/abb.2014.510094"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2008-2231-21-5","article-title":"Isolation and characterization of exopolysaccharide with immunomodulatory activity from fermentation broth of Morchella conica","volume":"21","author":"Su","year":"2013","journal-title":"DARU"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.intimp.2006.04.002","article-title":"Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans","volume":"6","author":"Sarangi","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.carbpol.2004.01.005","article-title":"Molecular weight and anti-tumor activity of the water-soluble polysaccharides isolated by hot water and ultrasonic treatment from the sclerotia and mycelia of Pleurotus tuber-regium","volume":"56","author":"Zhang","year":"2004","journal-title":"Carbohydr. Polym."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fphar.2017.00252","article-title":"Characterization and Anti-Inflammatory Potential of an Exopolysaccharide from Submerged Mycelial Culture of Schizophyllum commune","volume":"8","author":"Du","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Scarpari, M., Reverberi, M., Parroni, A., Scala, V., Fanelli, C., Pietricola, C., Zjalic, S., Maresca, V., Tafuri, A., and Ricciardi, M.R. (2017). Tramesan, a novel polysaccharide from Trametes versicolor. Structural characterization and biological effects. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171412"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jbiotec.2006.06.013","article-title":"Production of exopolysaccharides by submerged mycelial culture of a mushroom Tremella fuciformis","volume":"127","author":"Cho","year":"2006","journal-title":"J. Biotechnol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bcdf.2018.02.005","article-title":"Fractionation, characterization and antioxidant activity of exopolysaccharide from fermentation broth of a Xylaria nigripes","volume":"16","author":"Chang","year":"2018","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10856-015-5461-z","article-title":"Isolation of chitosan from Ganoderma lucidum mushroom for biomedical applications","volume":"26","author":"Ospina","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.fct.2008.04.030","article-title":"Wild and commercial mushrooms as source of nutrients and nutraceuticals","volume":"46","author":"Barros","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.fct.2012.02.013","article-title":"Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: A comparative study between in vivo and in vitro samples","volume":"50","author":"Reis","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1039\/C7FO00515F","article-title":"Development of nutraceutical formulations based on the mycelium of Pleurotus ostreatus and Agaricus bisporus","volume":"8","author":"Cardoso","year":"2017","journal-title":"Food Funct."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1007\/s12010-013-0133-2","article-title":"Stimulatory Effect of Different Lignocellulosic Materials for Phenolic Compound Production and Antioxidant Activity from Inonotus obliquus in Submerged Fermentation","volume":"169","author":"Zhu","year":"2013","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s12010-015-1642-y","article-title":"Stimulatory Agents Simultaneously Improving the Production and Antioxidant Activity of Polyphenols from Inonotus obliquus by Submerged Fermentation","volume":"176","author":"Xu","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.biortech.2008.05.002","article-title":"Accumulation of antioxidant phenolic constituents in submerged cultures of Inonotus obliquus","volume":"100","author":"Zheng","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodchem.2017.03.026","article-title":"Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties","volume":"230","author":"Souilem","year":"2017","journal-title":"Food Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1039\/C5FO00465A","article-title":"Bioactive formulations prepared from fruiting bodies and submerged culture mycelia of the Brazilian edible mushroom Pleurotus ostreatoroseus Singer","volume":"6","author":"Calhelha","year":"2015","journal-title":"Food Funct."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jff.2014.06.008","article-title":"Enhancement of the antioxidant capacity of chickpeas by solid state fermentation with Cordyceps militaris SN-18","volume":"10","author":"Xiao","year":"2014","journal-title":"J. Funct. Foods"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00217-015-2580-1","article-title":"Phenolic composition and antioxidant properties of Pleurotus ostreatus and Pleurotus eryngii enriched with selenium and zinc","volume":"242","author":"Gasecka","year":"2016","journal-title":"Eur. Food Res. Technol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1055\/s-0035-1568274","article-title":"Rosmarinic Acid - Pharmaceutical and Clinical Aspects","volume":"82","author":"Amoah","year":"2016","journal-title":"Planta Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jep.2015.07.030","article-title":"Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the \u03b2-catenin pathway in colorectal cancer","volume":"173","author":"Kang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.micpath.2017.01.019","article-title":"Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps","volume":"104","author":"Tintino","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ifset.2013.01.007","article-title":"Sterol enriched fractions obtained from Agaricus bisporus fruiting bodies and by-products by compressed fluid technologies (PLE and SFE)","volume":"18","author":"Palanisamy","year":"2013","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tifs.2017.06.012","article-title":"The emerging use of mycosterols in food industry along with the current trend of extended use of bioactive phytosterols","volume":"67","author":"Peralta","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3892\/ijo.2016.3391","article-title":"Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells","volume":"48","author":"Shimizu","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jbiosc.2014.05.022","article-title":"Stimulated production of steroids in Inonotus obliquus by host factors from birch","volume":"118","author":"Wang","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/14786410902751009","article-title":"Beneficial effects of the ethanol extract from the dry matter of a culture broth of Inonotus obliquus in submerged culture on the antioxidant defence system and regeneration of pancreatic \u03b2 -cells in experimental diabetes in mice","volume":"24","author":"Xu","year":"2010","journal-title":"Nat. Prod. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/molecules18011150","article-title":"Bioassay-Guided Isolation of DPP-4 Inhibitory Fractions from Extracts of Submerged Cultured of Inonotus obliquus","volume":"18","author":"Geng","year":"2013","journal-title":"Molecules"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fbp.2016.06.006","article-title":"Optimization of microwave-assisted extraction of ergosterol from Agaricus bisporus L. by-products using response surface methodology","volume":"100","author":"Heleno","year":"2016","journal-title":"Food Bioprod. Process."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jsfa.3809","article-title":"Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus","volume":"90","author":"Lu","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fitote.2014.12.005","article-title":"Triterpenoids from Inonotus obliquus and their antitumor activities","volume":"101","author":"Zhao","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lau, F., Abdullah, N., Aminudin, N., Lee, H.B., Yap, K.C., and Sabaratnam, V. (2014). The Potential of Mycelium and Culture Broth of Lignosus rhinocerotis as Substitutes for the Naturally Occurring Sclerotium with Regard to Antioxidant Capacity, Cytotoxic Effect, and Low-Molecular-Weight Chemical Constituents. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102509"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0960-8524(95)00153-0","article-title":"The recovery of lignocellulose-degrading enzymes from spent mushroom compost","volume":"54","author":"Ball","year":"1995","journal-title":"Bioresour. Technol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00284-009-9546-0","article-title":"Degradation of Polycyclic Aromatic Hydrocarbons by Crude Extracts from Spent Mushroom Substrate and its Possible Mechanisms","volume":"60","author":"Li","year":"2010","journal-title":"Curr. Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.procbio.2008.12.010","article-title":"Recovery of laccase from the residual compost of Agaricus bisporus in aqueous two-phase systems","volume":"44","year":"2009","journal-title":"Process Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF02931456","article-title":"Detection and recovery of hydrolytic enzymes from spent compost of four mushroom species","volume":"50","author":"Ko","year":"2005","journal-title":"Folia Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijbiomac.2016.09.048","article-title":"Biochemical characterization of a novel fibrinolytic enzyme from Cordyceps militaris","volume":"94","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jfca.2015.02.005","article-title":"Vitamin D2 content and antioxidant properties of fruit body and mycelia of edible mushrooms by UV-B irradiation","volume":"42","author":"Huang","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1016\/j.procbio.2016.08.032","article-title":"Industrial by-products from white-rot fungi production. Part I: Generation of enzyme preparations and chemical, protein biochemical and molecular biological characterization","volume":"51","author":"Schimpf","year":"2016","journal-title":"Process Biochem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1111\/1750-3841.14186","article-title":"Layer-by-Layer Alginate and Fungal Chitosan Based Edible Coatings Applied to Fruit Bars","volume":"83","author":"Chiou","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"845","DOI":"10.5713\/ajas.2006.845","article-title":"Spent Wheat Straw Compost of Agaricus bisporus Mushroom as Ruminant Feed","volume":"19","author":"Fazaeli","year":"2006","journal-title":"Asian-Australas J. Anim. Sci."},{"key":"#cr-split#-ref_138.1","unstructured":"Regulation EC (2009). No 1069\/2009 of the European Parliament and the Council of 21 October 2009 laying down health rules as regards animal by-products and derived products not intended for human consumption and repealing Regulation"},{"key":"#cr-split#-ref_138.2","unstructured":"(EC) No 1774\/2002 (Animal by-products Regulation), Official Journal of the European Union."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5851\/kosfa.2012.32.2.133","article-title":"Effect of Substitution of Fermented King Oyster Mushroom By-Products Diet on Pork Quality during Storage","volume":"32","author":"Chu","year":"2012","journal-title":"Food Sci. Anim. Resour."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1111\/jfpp.12185","article-title":"Conventional and Novel Applications of Edible Mushrooms in Today\u2019s Food Industry","volume":"38","author":"Moon","year":"2013","journal-title":"J. Food Process. Preserv."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/S1806-92902016000600001","article-title":"Effects of spent mushroom compost meal on growth performance and meat characteristics of grower geese","volume":"45","author":"Chang","year":"2016","journal-title":"Rev. Bras. Zootec."},{"key":"ref_142","first-page":"178","article-title":"Assessing Spent Mushroom Substrate as a Replacement to Wheat Bran in the Diet of Broilers","volume":"4","author":"Foluke","year":"2014","journal-title":"Am. Int. J. Contemp. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fsi.2017.09.002","article-title":"Effects of Cordyceps militaris spent mushroom substrate and Lactobacillus plantarum on mucosal, serum immunology and growth performance of Nile tilapia (Oreochromis niloticus)","volume":"70","author":"Hoseinifar","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jenvman.2017.03.038","article-title":"Stabilisation of spent mushroom substrate for application as a plant growth-promoting organic amendment","volume":"196","author":"Paula","year":"2017","journal-title":"J. Environ. Manag."},{"key":"ref_145","unstructured":"Kato, Y., Koyama, M., Fukushima, Y., and Nakagaki, T. (2016). Topic: Energy Recovery from Mushroom Culture Waste and the Use of Its Ash as Fertilizer. Energy Technology Roadmaps of Japan: Future Energy Systems Based on Feasible Technologies Beyond 2030, Springer."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"\u00dcnal, M. (2015). The utilization of spent mushroom compost applied at different rates in tomato (Lycopersiconesculentum mill.) seedling production. Emir. J. Food Agric., 27.","DOI":"10.9755\/ejfa.2015-05-206"},{"key":"ref_147","first-page":"78","article-title":"Applicable properties of the bio-fertilizer spent mushroom substrate in organic systems as a byproduct from the cultivation of Pleurotus spp.","volume":"4","author":"Owaid","year":"2017","journal-title":"Inf. Process. Agric."},{"key":"ref_148","first-page":"683","article-title":"Evaluation of casing materials made from spent mushroom substrate and coconut fibre pith for use in production of Agaricus bisporus (Lange) Imbach","volume":"4","year":"2008","journal-title":"Spanish J. Agric. Res."},{"key":"ref_149","first-page":"13","article-title":"Recycling of Spent Mushroom Substrate for the Production of Oyster Mushroom","volume":"5","author":"Ashrafi","year":"2014","journal-title":"Res. Biotechnol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.scitotenv.2018.03.366","article-title":"Removal of emerging contaminants using spent mushroom compost","volume":"634","author":"Chang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0045-6535(03)00492-2","article-title":"Removal of biocide pentachlorophenol in water system by the spent mushroom compost of Pleurotus pulmonarius","volume":"52","author":"Law","year":"2003","journal-title":"Chemosphere"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0045-6535(03)00493-4","article-title":"Use of spent mushroom compost to bioremediate PAH-contaminated samples","volume":"52","author":"Lau","year":"2003","journal-title":"Chemosphere"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1080\/09593330.2017.1422546","article-title":"Role of multiple substrates (spent mushroom compost, ochre, steel slag, and limestone) in passive remediation of metal-containing acid mine drainage","volume":"40","author":"Molahid","year":"2018","journal-title":"Environ. Technol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.biortech.2018.06.078","article-title":"Spent substrate of Ganodorma lucidum as a new bio-adsorbent for adsorption of three typical dyes","volume":"266","author":"Wu","year":"2018","journal-title":"Bioresour. Technol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Lichtfouse, E., Schwarzbauer, J., and Robert, D. (2005). Bioremediation for the Decolorization of Textile Dyes \u2014 A Review BT-Environmental Chemistry: Green Chemistry and Pollutants in Ecosystems, Springer.","DOI":"10.1007\/b137751"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ecoenv.2018.04.003","article-title":"Lignolytic mushroom Lenzites elegans WDP2: Laccase production, characterization, and bioremediation of synthetic dyes","volume":"158","author":"Pandey","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1590\/S1517-83822014000300039","article-title":"Bioremediation of dyes by fungi isolated from contaminated dye effluent sites for bio-usability","volume":"45","author":"Rani","year":"2014","journal-title":"Braz. J. Microbiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s12257-013-0663-z","article-title":"Decolorization of triphenylmethane dyes by wild mushrooms","volume":"19","author":"Kim","year":"2014","journal-title":"Biotechnol. Bioprocess Eng."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00253-002-1109-2","article-title":"Purification and characterization of an extracellular laccase from the edible mushroom Lentinula edodes, and decolorization of chemically different dyes","volume":"60","author":"Nagai","year":"2002","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biochi.2018.02.015","article-title":"An extracellular yellow laccase from white rot fungus Trametes sp. F1635 and its mediator systems for dye decolorization","volume":"148","author":"Wang","year":"2018","journal-title":"Biochimie"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jenvman.2010.10.047","article-title":"Use of spent substrate after Pleurotus pulmonarius cultivation for the treatment of chlorothalonil containing wastewater","volume":"92","year":"2011","journal-title":"J. Environ. Manag."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s13762-016-1100-6","article-title":"Biosorption of heavy metals by organic carbon from spent mushroom substrates and their raw materials","volume":"13","author":"Frutos","year":"2016","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/02757540.2014.976209","article-title":"Removal of textile dyes from aqueous solutions by biosorption on mushroom stump wastes","volume":"31","author":"Demierege","year":"2015","journal-title":"Chem. Ecol."},{"key":"ref_164","unstructured":"Crini, G., and Lichtfouse, E. (2018). Mushroom Biomass and Spent Mushroom Substrate As Adsorbent to Remove Pollutants. Green Adsorbents for Pollutant Removal, Springer."},{"key":"ref_165","first-page":"139","article-title":"The use of spent mushroom substrate in the production of thermal energy in terms of a circular economy","volume":"5","author":"Padolecchia","year":"2018","journal-title":"P-ESEM"},{"key":"ref_166","first-page":"157","article-title":"Use of spent mushroom compost in sustainable fruit production","volume":"12","author":"Uzun","year":"2004","journal-title":"J. Fruit Ornam. Plant Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"493","DOI":"10.5713\/ajas.2011.10333","article-title":"Recycling of Fermented Sawdust-based Oyster Mushroom Spent Substrate as a Feed Supplement for Postweaning Calves","volume":"24","author":"Kim","year":"2011","journal-title":"Asian-Australasian J. Anim. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/jf020932h","article-title":"Biodegradation of Oak (Quercus alba) Wood during Growth of the Shiitake Mushroom (Lentinula edodes):\u2009 A Molecular Approach","volume":"51","author":"Vane","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12223-016-0457-8","article-title":"Spent mushroom substrate of Pleurotus pulmonarius: A source of easily hydrolyzable lignocellulose","volume":"61","author":"Castoldi","year":"2016","journal-title":"Folia Microbiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.biortech.2007.07.003","article-title":"Evaluation of waste mushroom logs as a potential biomass resource for the production of bioethanol","volume":"99","author":"Lee","year":"2008","journal-title":"Bioresour. Technol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"14245","DOI":"10.1016\/j.ijhydene.2011.06.102","article-title":"Hydrogen production from mushroom farm waste with a two-step acid hydrolysis process","volume":"36","author":"Li","year":"2011","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biortech.2017.11.088","article-title":"Methane production and characteristics of the microbial community in the co-digestion of spent mushroom substrate with dairy manure","volume":"250","author":"Luo","year":"2018","journal-title":"Bioresour. Technol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1080\/09593330.2013.827746","article-title":"Butanol fermentation","volume":"34","author":"Montoya","year":"2013","journal-title":"Environ. Technol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1038\/s41598-019-40840-y","article-title":"Continuous Butanol Fermentation of Dilute Acid-Pretreated De-oiled Rice Bran by Clostridium acetobutylicum YM1","volume":"9","author":"Kadier","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.renene.2016.04.048","article-title":"Butanol production from organosolv treated spent mushroom substrate integrated with in situ biodiesel extraction","volume":"96","author":"Zhu","year":"2016","journal-title":"Renew. Energy"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.esd.2019.03.002","article-title":"Mushroom cultivation and biogas production: A sustainable reuse of organic resources","volume":"50","author":"Mayer","year":"2019","journal-title":"Energy Sustain. Dev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.fct.2019.03.045","article-title":"Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies","volume":"127","author":"Taofiq","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Wu, Y., Choi, M.-H., Li, J., Yang, H., and Shin, H.-J. (2016). Mushroom Cosmetics: The Present and Future. Cosmetics, 3.","DOI":"10.3390\/cosmetics3030022"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-010-0043-3","article-title":"Fungi\u2014An unusual source for cosmetics","volume":"43","author":"Hyde","year":"2010","journal-title":"Fungal Divers."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jep.2013.03.055","article-title":"In vivo and in vitro anti-inflammatory activity of Lentinus polychrous extract","volume":"147","author":"Fangkrathok","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"519","DOI":"10.5897\/AJMR2013.6271","article-title":"Inhibition of melanogenesis in murine melanoma cells by Agaricus brasiliensis methanol extract and anti-reactive oxygen species (ROS) activity","volume":"8","author":"Huang","year":"2014","journal-title":"African J. Microbiol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11046-008-9128-x","article-title":"Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms","volume":"166","author":"Chien","year":"2008","journal-title":"Mycopathologia"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1039\/C8FO02461H","article-title":"Agaricus blazei Murrill from Brazil: An ingredient for nutraceutical and cosmeceutical applications","volume":"10","author":"Taofiq","year":"2019","journal-title":"Food Funct."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"13070","DOI":"10.1038\/s41598-017-13295-2","article-title":"Morphology and mechanics of fungal mycelium","volume":"7","author":"Islam","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1166\/jbns.2017.1440","article-title":"Mycelium composites: A review of engineering characteristics and growth kinetics","volume":"11","author":"Jones","year":"2017","journal-title":"J. Bionanosci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"41292","DOI":"10.1038\/srep41292","article-title":"Advanced Materials from Fungal Mycelium: Fabrication and Tuning of Physical Properties","volume":"7","author":"Haneef","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1038\/s41598-018-23171-2","article-title":"Hydrophobin gene deletion and environmental growth conditions impact mechanical properties of mycelium by affecting the density of the material","volume":"8","author":"Appels","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"4017030","DOI":"10.1061\/(ASCE)MT.1943-5533.0001866","article-title":"Physical and Mechanical Properties of Fungal Mycelium-Based Biofoam","volume":"29","author":"Yang","year":"2017","journal-title":"J. Mater. Civ. Eng."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.matdes.2018.11.027","article-title":"Fabrication factors influencing mechanical, moisture- and water-related properties of mycelium-based composites","volume":"161","author":"Appels","year":"2019","journal-title":"Mater. Des."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1016\/j.matpr.2017.09.211","article-title":"Sustainable packaging applications from mycelium to substitute polystyrene: A review","volume":"5","author":"Abhijith","year":"2018","journal-title":"Mater. Today Proc."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.enbuild.2014.05.005","article-title":"Development of better insulation bricks by adding mushroom compost wastes","volume":"80","author":"Velasco","year":"2014","journal-title":"Energy Build."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Kim, Y., and Ruedy, D. (2019). Mushroom Packages An Ecovative Approach in Packaging Industry. Handbook of Engaged Sustainability, Springer.","DOI":"10.1007\/978-3-319-53121-2_27-1"},{"key":"ref_193","unstructured":"EC (1924). Regulation (EC) No 1924\/2006 of the European Parliament and of the Council on Nutrition and Health Claims Made on Foods, Official Journal of the European Union."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Sadler, M.J. (2014). 2-Authorised EU health claims for barley and oat beta-glucans. Sadler Nutrients and Food Ingredients with Authorised EU Health Claims, Woodhead Publishing.","DOI":"10.1016\/B978-1-78242-382-9.00016-5"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2010). Scientific Opinion on the safety of \u201cLentinus edodes extract\u201d (Lentinex\u00ae) as a Novel Food ingredient. EFSA J., 8, 1685.","DOI":"10.2903\/j.efsa.2010.1685"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2011). Scientific Opinion on the substantiation of health claims related to chitosan and reduction in body weight (ID 679, 1499), maintenance of normal blood LDL-cholesterol concentrations (ID 4663), reduction of intestinal transit time (ID 4664) and reduction. EFSA J., 9, 2214.","DOI":"10.2903\/j.efsa.2011.2214"},{"key":"ref_197","unstructured":"EC (2010). Regulation (EU) No 376\/2010 of 3 May 2010 Amending Regulation (EC) No 983\/2009 on the Authorisation and Refusal of Authorisation of Certain Health Claims Made on Food and Referring to the Reduction of Disease Risk and to Children\u2019s Development and Health, Official Journal of the European Union."},{"key":"#cr-split#-ref_198.1","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012). Scientific Opinion on the substantiation of a health claim related to 3 g\/day plant sterols\/stanols and lowering blood LDL-cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation"},{"key":"#cr-split#-ref_198.2","unstructured":"(EC) No 1924\/2006. EFSA J., 10, 2693."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/11\/2672\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:36:58Z","timestamp":1760175418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/11\/2672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":200,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["molecules25112672"],"URL":"https:\/\/doi.org\/10.3390\/molecules25112672","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]}}}