{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:19:46Z","timestamp":1774937986476,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BII-BIO\/30884\/2017 - POCI-01-0145-FEDER-030884"],"award-info":[{"award-number":["PTDC\/BII-BIO\/30884\/2017 - POCI-01-0145-FEDER-030884"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/ASP-AGR\/29277\/2017- POCI-01-0145-FEDER-029277"],"award-info":[{"award-number":["PTDC\/ASP-AGR\/29277\/2017- POCI-01-0145-FEDER-029277"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/02702\/2017"],"award-info":[{"award-number":["CEECIND\/02702\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/144534\/2019"],"award-info":[{"award-number":["SFRH\/BD\/144534\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The majority of works about vine-canes are focused on the evaluation of their chemical composition and antioxidant potential. To the best of our knowledge, the possible applications of produced extracts in cosmetic formulations have never been explored. The aim of the present study was to evaluate the antioxidant properties of vine-canes subcritical water extracts for use as active ingredients in the cosmetic industry. For that, the phenolic content and antioxidant activity of six vine-cane varieties, namely Alvarinho and Loureiro from the Minho region and Touriga Nacional and Tinta Roriz (TR) from both the Douro and D\u00e3o regions, were evaluated through spectrophotometric and chromatographic methods. All extracts presented similar antioxidant activity and the highest phenolic content was reported for TR variety from the Douro region (33.7 \u00b1 1.9 mg GAE\/g dw). The capacity of vine-cane extracts to capture reactive oxygen species superoxide (O2\u2219\u2212) was also studied, with the highest IC50 value being obtained for Loureiro variety (56.68 \u00b1 2.60 \u00b5g\/mL). Furthermore, no adverse effects on HaCaT and HFF-1 dermal cell lines in concentrations below 100 and 1000 \u03bcg\/mL, respectively, were determined. Finally, Loureiro vine-cane extract was incorporated into a topical formulation, and physical and microbiological properties were within expected values, demonstrating that vine-canes extracts can be successfully incorporated in cosmetic products.<\/jats:p>","DOI":"10.3390\/molecules25132969","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T16:06:54Z","timestamp":1593533214000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vine-Canes as a Source of Value-Added Compounds for Cosmetic Formulations"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9211","authenticated-orcid":false,"given":"Manuela M.","family":"Moreira","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-0041","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"given":"Olena","family":"Dorosh","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-3739","authenticated-orcid":false,"given":"Diana","family":"Pinto","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-3398","authenticated-orcid":false,"given":"Paulo C.","family":"Costa","sequence":"additional","affiliation":[{"name":"REQUIMTE\/UCIBIO, MedTech-Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n\u00ba. 228, 4050-313 Porto, Portugal"}]},{"given":"Jaroslava","family":"\u0160varc-Gaji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 431, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jclepro.2017.08.230","article-title":"Integral valorization of vine pruning residue by sequential autohydrolysis stages","volume":"168","author":"Jesus","year":"2017","journal-title":"J. Cleaner Prod."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dorosh, O., Moreira, M.M., Rodrigues, F., Peixoto, A.F., Freire, C., Morais, S., and Delerue-Matos, C. (2020). Vine-Canes Valorisation: Ultrasound-Assisted Extraction from Lab to Pilot Scale. Molecules, 25.","DOI":"10.3390\/molecules25071739"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.scitotenv.2018.04.035","article-title":"Potential of Portuguese vine shoot wastes as natural resources of bioactive compounds","volume":"634","author":"Moreira","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.indcrop.2019.01.070","article-title":"Bioactive compounds recovery optimization from vine pruning residues using conventional heating and microwave-assisted extraction methods","volume":"132","author":"Jesus","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.indcrop.2016.12.009","article-title":"A potential use of vine-shoot wastes: The antioxidant, antifeedant and phytotoxic activities of their aqueous extracts","volume":"97","author":"Alonso","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.indcrop.2013.06.015","article-title":"Medicago spp. extracts as promising ingredients for skin care products","volume":"49","author":"Rodrigues","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Matos, M.S., Romero-D\u00edez, R., \u00c1lvarez, A., Bronze, M.R., Rodr\u00edguez-Rojo, S., Mato, R.B., Cocero, M.J., and Matias, A.A. (2019). Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential. Antioxidants, 8.","DOI":"10.3390\/antiox8090355"},{"key":"ref_8","unstructured":"Holban, A.M. (2017). Chapter 2\u2014Environment-Friendly Techniques for Extraction of Bioactive Compounds from Fruits A2 - Grumezescu, Alexandru Mihai. Soft Chemistry and Food Fermentation, Academic Press."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.indcrop.2017.05.034","article-title":"Antioxidant and antimicrobial activities of extracts obtained from the refining of autohydrolysis liquors of vine shoots","volume":"107","author":"Eibes","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/jf903441d","article-title":"Extraction of Phenolic Acids by Alkaline Hydrolysis from the Solid Residue Obtained after Prehydrolysis of Trimming Vine Shoots","volume":"58","author":"Max","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.indcrop.2018.10.020","article-title":"Subcritical water extraction of stilbenes from grapevine by-products: A new green chemistry approach","volume":"126","author":"Gabaston","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.indcrop.2017.11.015","article-title":"Subcritical water extraction as an environmentally-friendly technique to recover bioactive compounds from traditional Serbian medicinal plants","volume":"111","author":"Barroso","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/jctb.5468","article-title":"A new source for developing multi-functional products: Biological and chemical perspectives on subcritical water extracts of Sambucus ebulus L.","volume":"93","author":"Zengin","year":"2018","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.supflu.2018.04.019","article-title":"Subcritical water extraction of antioxidants from mountain germander (Teucrium montanum L.)","volume":"138","author":"Morais","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tifs.2019.11.018","article-title":"Recent advances in the extraction of bioactive compounds with subcritical water: A review","volume":"95","author":"Zhang","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.foodchem.2018.06.070","article-title":"Wine industry by-product: Full polyphenolic characterization of grape stalks","volume":"268","author":"Teixeira","year":"2018","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.supflu.2017.05.020","article-title":"Valorization of white wine grape pomace through application of subcritical water: Analysis of extraction, hydrolysis, and biological activity of the extracts obtained","volume":"128","author":"Pedras","year":"2017","journal-title":"J. Supercrit. Fluids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.17221\/19\/2018-CJFS","article-title":"Antioxidant activity and phenolic content of organic and conventional vine cane extracts","volume":"36","author":"Gharwalova","year":"2018","journal-title":"Czech. J. Food Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Apak, R., Gorinstein, S., B\u00f6hm, V., Schaich, K., \u00d6zy\u00fcrek, M., and G\u00fc\u00e7l\u00fc, K. (2013). Methods of measurement and evaluation of natural antioxidant capacity\/activity (IUPAC Technical Report). Pure Appl. Chem., 85.","DOI":"10.1351\/PAC-REP-12-07-15"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.foodchem.2018.03.113","article-title":"Hardy kiwifruit leaves (Actinidia arguta): An extraordinary source of value-added compounds for food industry","volume":"259","author":"Almeida","year":"2018","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pinto, D., Braga, N., Rodrigues, F., and Oliveira, M.B.P.P. (2017). Castanea sativa Bur: An Undervalued By-Product but a Promising Cosmetic Ingredient. Cosmetics, 4.","DOI":"10.3390\/cosmetics4040050"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/03639045.2015.1088865","article-title":"Exploring the antioxidant potentiality of two food by-products into a topical cream: Stability, in vitro and in vivo evaluation","volume":"42","author":"Rodrigues","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.foodchem.2015.12.083","article-title":"Determination of phenolic compounds content and antioxidant activity in skin, pulp, seed, cane and leaf of five native grape cultivars in West Azerbaijan province, Iran","volume":"199","author":"Farhadi","year":"2016","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.foodres.2014.07.021","article-title":"Evaluation of grape (Vitis vinifera L.) stems from Portuguese varieties as a resource of (poly)phenolic compounds: A comparative study","volume":"65","author":"Barros","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.foodchem.2018.05.050","article-title":"Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells","volume":"265","author":"Pastene","year":"2018","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126298","DOI":"10.1016\/j.foodchem.2020.126298","article-title":"Ohmic heating polyphenolic extracts from vine pruning residue with enhanced biological activity","volume":"316","author":"Jesus","year":"2020","journal-title":"Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/03639045.2015.1035279","article-title":"Application of Coffee Silverskin in cosmetic formulations: Physical\/antioxidant stability studies and cytotoxicity effects","volume":"42","author":"Rodrigues","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.indcrop.2017.04.038","article-title":"Valorization of apple tree wood residues by polyphenols extraction: Comparison between conventional and microwave-assisted extraction","volume":"104","author":"Moreira","year":"2017","journal-title":"Ind. Crops Prod."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/13\/2969\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:44:08Z","timestamp":1760175848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/13\/2969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,28]]},"references-count":28,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["molecules25132969"],"URL":"https:\/\/doi.org\/10.3390\/molecules25132969","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,28]]}}}