{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:25:20Z","timestamp":1773721520505,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China;Natural Science Foundation of Guangxi Province","award":["21261002, 31660251, 31860245 and 31960203;2018GXNSFAA138024, 2018GXNSFAA281019 and 2017GXNSFAA198010"],"award-info":[{"award-number":["21261002, 31660251, 31860245 and 31960203;2018GXNSFAA138024, 2018GXNSFAA281019 and 2017GXNSFAA198010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Six new zinc(II) complexes were prepared by the reaction of ZnBr2 or ZnI2 with 4\u2032-(substituted-phenyl)-2,2\u2032:6\u2032,2\u2032\u2032-terpyridine compounds, bearing p-methylsulfonyl (L1), p-methoxy (L2) and p-methyl (L3), which were characterized by elemental analysis, FT-IR, NMR and single crystal X-ray diffraction. The antiproliferative properties against Eca-109, A549 and Bel-7402 cell lines and the cytotoxicity test on RAW-264.7 of these compounds were monitored using a CCK-8 assay, and the studies indicate that the complexes show higher antiproliferative activities than cisplatin. The interactions of these complexes with CT-DNA and proteins (BSA) were studied by UV-Vis, circular dichroism (CD) and fluorescent spectroscopy, respectively. The results indicate that the interaction of these zinc(II) complexes with CT-DNA is achieved through intercalative binding, and their strong binding affinity to BSA is fulfilled through a static quenching mechanism. The simulation of the complexes with the CT-DNA fragment and BSA was studied by using molecular docking software. It further validates that the complexes interact with DNA through intercalative binding mode and that they have a strong interaction with BSA.<\/jats:p>","DOI":"10.3390\/molecules25153459","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:15:38Z","timestamp":1596111338000},"page":"3459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis, Characterization, Photoluminescence, Molecular Docking and Bioactivity of Zinc (II) Compounds Based on Different Substituents"],"prefix":"10.3390","volume":"25","author":[{"given":"Rongping","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"},{"name":"National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China"}]},{"given":"Jinzhang","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}]},{"given":"Jiahe","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}]},{"given":"Xing","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-6157","authenticated-orcid":false,"given":"Dengfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China"}]},{"given":"Lixia","family":"Pan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530004, Guangxi, China"}]},{"given":"Tisan","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-7764","authenticated-orcid":false,"given":"Zhen","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2017.12.003","article-title":"Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy","volume":"56","author":"Baig","year":"2019","journal-title":"Semin. Cancer Boil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2011","journal-title":"Oncogene"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"22657","DOI":"10.1002\/jcp.28832","article-title":"Deregulation of lncRNA-AC078883.3 and microRNA-19a is involved in the development of chemoresistance to cisplatin via modulating signaling pathway of PTEN\/AKT","volume":"234","author":"Xing","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: Molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110752","DOI":"10.1016\/j.jinorgbio.2019.110752","article-title":"Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes","volume":"198","author":"Karges","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: The first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorganic Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0277-5379(91)90549-S","article-title":"Neurotoxic side-effects of cisplatin","volume":"27","author":"Hamers","year":"1991","journal-title":"Eur. J. Cancer Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1021\/acs.inorgchem.9b03562","article-title":"Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands","volume":"59","author":"Munteanu","year":"2020","journal-title":"Inorg. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ejmech.2018.08.037","article-title":"Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis","volume":"157","author":"Huang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cbpa.2007.11.013","article-title":"New trends for metal complexes with anticancer activity","volume":"12","author":"Bruijnincx","year":"2008","journal-title":"Curr. Opin. Chem. Boil."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1367-5931(03)00081-4","article-title":"New metal complexes as potential therapeutics","volume":"7","author":"Zhang","year":"2003","journal-title":"Curr. Opin. Chem. Boil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1871520619666181224121004","article-title":"Current Perspectives in the Application of Medicinal Plants Against Cancer: Novel Therapeutic Agents","volume":"19","author":"Gezici","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","article-title":"Cisplatin: A review of toxicities and therapeutic applications","volume":"6","author":"Barabas","year":"2008","journal-title":"Vet. Comp. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0010-8545(00)82029-9","article-title":"Transition metal complexes in cancer chemotherapy","volume":"12","author":"Cleare","year":"1974","journal-title":"Co-Ord. Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","article-title":"Novel metals and metal complexes as platforms for cancer therapy","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_18","unstructured":"Farrell, N. (2012). Transition Metal Complexes as Drugs and Chemotherapeutic Agents, Kluwer Academic."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jinorgbio.2017.06.002","article-title":"Recent development of transition metal complexes with in vivo antitumor activity","volume":"177","author":"Liang","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_20","first-page":"127","article-title":"Essential trace elements and their vital roles in human body","volume":"5","author":"Mohssan","year":"2017","journal-title":"Indian J. Adv. Chem. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-005-0009-5","article-title":"Zinc: A multipurpose trace element","volume":"80","author":"Stefanidou","year":"2005","journal-title":"Arch. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10488","DOI":"10.1039\/C8DT04924F","article-title":"Synthesis, characterization, photoluminescence, anti-tumor activity, DFT calculations and molecular docking with proteins of zinc(ii) halogen substituted terpyridine compounds","volume":"48","author":"Liang","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110790","DOI":"10.1016\/j.jinorgbio.2019.110790","article-title":"Synthesis, characterization, anti-tumor activity, photo-luminescence and BHb\/HHb\/Hsp90 molecular docking of zinc(II) hydroxyl-terpyridine complexes","volume":"201","author":"Huang","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejmech.2017.04.007","article-title":"Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives","volume":"142","author":"Lazarevic","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jinorgbio.2009.11.002","article-title":"Synthesis, structural characterization and antiproliferative and toxic bio-activities of copper(II) and nickel(II) citronellal N4-ethylmorpholine thiosemicarbazonates","volume":"104","author":"Bisceglie","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1038\/ncomms4462","article-title":"Ligand substitutions between ruthenium\u2013cymene compounds can control protein versus DNA targeting and anticancer activity","volume":"5","author":"Adhireksan","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jphotobiol.2017.06.035","article-title":"Bio-affinity of copper(II) complexes with nitrogen and oxygen donor ligands: Synthesis, structural studies and in vitro DNA and HSA interaction of copper(II) complexes","volume":"174","author":"Jain","year":"2017","journal-title":"J. Photochem. Photobiol. B Boil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jphotobiol.2018.10.006","article-title":"Synthesis, theoretical, spectroscopic and electrochemical DNA binding investigations of 1, 3, 4-thiadiazole derivatives of ibuprofen and ciprofloxacin: Cancer cell line studies","volume":"189","author":"Farooqi","year":"2018","journal-title":"J. Photochem. Photobiol. B Boil."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Liedtke, K.R., Freund, E., Hermes, M., Oswald, S., Heidecke, C.D., Partecke, L.I., and Bekeschus, S. (2020). Gas plasma-conditioned ringer\u2019s lactate enhances the cytotoxic activity of cisplatin and gemcitabine in pancreatic cancer in vitro and in ovo. Cancers, 12.","DOI":"10.3390\/cancers12010123"},{"key":"ref_30","first-page":"1663","article-title":"Cisplatin and platinum drugs at the molecular level. (Review)","volume":"10","author":"Boulikas","year":"2003","journal-title":"Oncol. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.07.041","article-title":"Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu(II) complexes of vitamin B6 derivative","volume":"102","author":"Annaraj","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jinorgbio.2010.03.002","article-title":"Synthesis, characterization, solid-state photo-luminescence and anti-tumor activity of zinc (II) 4\u2032-phenyl-terpyridine compounds","volume":"104","author":"Ma","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00775-020-01763-6","article-title":"Study on the substitution effects of zinc benzoate terpyridine complexes on photoluminescence, antiproliferative potential and DNA binding properties","volume":"25","author":"Jiang","year":"2020","journal-title":"JBIC J. Boil. Inorg. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Li, J., Liu, R., Jiang, J., Liang, X., Huang, L., Huang, G., Chen, H., Pan, L., and Ma, Z. (2019). Zinc(II) Terpyridine Complexes: Substituent Effect on Photoluminescence, Antiproliferative Activity, and DNA Interaction. Molecules, 24.","DOI":"10.3390\/molecules24244519"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1039\/DT9840001349","article-title":"Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; The crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2\u2019-yl)-2,6-dithiaheptane]copper(II) perchlorate","volume":"11","author":"Addison","year":"1984","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ejmech.2012.08.001","article-title":"Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA\/BSA binding, radical scavenging and cytotoxicity","volume":"55","author":"Sathyadevi","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1021\/ic2020308","article-title":"Effect of N(4)-Phenyl Substitution in 2-Oxo-1,2-dihydroquinoline-3-carbaldehyde Semicarbazones on the Structure, DNA\/Protein Interaction, and Antioxidative and Cytotoxic Activity of Cu(II) Complexes","volume":"50","author":"Bhuvanesh","year":"2011","journal-title":"Inorg. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103010","DOI":"10.1016\/j.bioorg.2019.103010","article-title":"Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin","volume":"89","author":"Wani","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/bio.2546","article-title":"Comparison of the binding behavior of FCCP with HSA and HTF as determined by spectroscopic and molecular modeling techniques","volume":"29","author":"Moghaddam","year":"2013","journal-title":"Luminescence"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111599","DOI":"10.1016\/j.ejmech.2019.111599","article-title":"Potential anticancer agent for selective damage to mitochondria or lysosomes: Naphthalimide-modified fluorescent biomarker half-sandwich iridium (III) and ruthenium (II) complexes","volume":"181","author":"Ma","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.saa.2014.02.048","article-title":"DNA- and BSA-binding studies and anticancer activity against human breast cancer cells (MCF-7) of the zinc(II) complex coordinated by 5,6-diphenyl-3-(2-pyridyl)-1,2,4-triazine","volume":"127","author":"Anjomshoa","year":"2014","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109914","DOI":"10.1016\/j.msec.2019.109914","article-title":"Engineered borate ester conjugated protein-polymer nanoconjugates for pH-responsive drug delivery","volume":"104","author":"Zhou","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.saa.2014.06.105","article-title":"Experimental and molecular modeling studies of the interaction of the polypyridyl Fe(II) and Fe(III) complexes with DNA and BSA","volume":"134","author":"Behnamfar","year":"2015","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"96121","DOI":"10.1039\/C6RA18803F","article-title":"Design, synthesis, characterization, cytotoxicity, molecular docking and analysis of binding interactions of novel acetylacetonatopalladium(ii) alanine and valine complexes with CT-DNA and BSA","volume":"6","author":"Heydari","year":"2016","journal-title":"RSC Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molliq.2017.04.020","article-title":"Deciphering the interaction of procaine with bovine serum albumin and elucidation of binding site: A multi spectroscopic and molecular docking study","volume":"236","author":"Ali","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jphotobiol.2016.09.025","article-title":"Binding interaction of ramipril with bovine serum albumin (BSA): Insights from multi-spectroscopy and molecular docking methods","volume":"164","author":"Shi","year":"2016","journal-title":"J. Photochem. Photobiol. B Boil."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.saa.2017.10.017","article-title":"Deciphering the complexation process of a fluoroquinolone antibiotic, levofloxacin, with bovine serum albumin in the presence of additives","volume":"191","author":"Kaur","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Alsaeedi, M.S., Babgi, B.A., Hussien, M., Abdellattif, M.H., and Humphrey, M.G. (2020). DNA-Binding and Anticancer Activity of Binuclear Gold(I) Alkynyl Complexes with a Phenanthrenyl Bridging Ligand. Molecules, 25.","DOI":"10.3390\/molecules25051033"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.colsurfb.2018.12.050","article-title":"DNA G-quadruplexes binding and antitumor activity of palladium aryl oxime ligand complexes encapsulated in either albumin or algal cellulose nanoparticles","volume":"176","author":"Esfahani","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug\u2013DNA interactions and their study by UV\u2013Visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B Boil."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1039\/C8CS00157J","article-title":"Molecular methods for assessment of non-covalent metallodrug\u2013DNA interactions","volume":"48","author":"Kellett","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1039\/C4DT02733G","article-title":"Binding of copper(ii) polypyridyl complexes to DNA and consequences for DNA-based asymmetric catalysis","volume":"44","author":"Draksharapu","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111592","DOI":"10.1016\/j.ejmech.2019.111592","article-title":"Novel 4-quinoline-thiosemicarbazone derivatives: Synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition","volume":"182","author":"Ribeiro","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1039\/C5NJ03439F","article-title":"Effects of N, N-heterocyclic ligands on the in vitro cytotoxicity and DNA interactions of copper (II) chloride complexes from amidino-O-methylurea ligands","volume":"40","author":"Meenongwa","year":"2016","journal-title":"New. J. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12551-016-0247-1","article-title":"Software for molecular docking: A review","volume":"9","author":"Pagadala","year":"2017","journal-title":"Biophys. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jphotochem.2018.02.001","article-title":"Synthesis, solvatochromism, photochemistry, DNA binding, photocleavage, cytotoxicity and molecular docking studies of a ruthenium(II) complex bearing photoactive subunit","volume":"356","author":"Mariappan","year":"2018","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00044-016-1764-y","article-title":"Binding of anti-Trypanosoma natural products from African flora against selected drug targets: A docking study","volume":"26","author":"Ibezim","year":"2017","journal-title":"Med. Chem. Res."},{"key":"ref_58","unstructured":"CrysAlis PRO (2012). Agilent, Agilent Technologies."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect. C Struct. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2007","journal-title":"Acta Crystallogr. Sect. A Found. Crystallogr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1107\/S0021889899006020","article-title":"WinGX suite for small-molecule single-crystal crystallography","volume":"32","author":"Farrugia","year":"1999","journal-title":"J. Appl. Crystallogr."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/15\/3459\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:52:46Z","timestamp":1760176366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/15\/3459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":61,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["molecules25153459"],"URL":"https:\/\/doi.org\/10.3390\/molecules25153459","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]}}}