{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:39:19Z","timestamp":1775547559586,"version":"3.50.1"},"reference-count":167,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT) and by Fundo Europeu de Desenvolvimento Regional (FEDER) under the scope of PORTUGAL 2020 and Programa Operacional do Centro (CENTRO 2020)","award":["UIDB\/00709\/2020"],"award-info":[{"award-number":["UIDB\/00709\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/149360\/2019"],"award-info":[{"award-number":["SFRH\/BD\/149360\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["contract of Scientific Employment in the scientific area of Microbiology"],"award-info":[{"award-number":["contract of Scientific Employment in the scientific area of Microbiology"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, responsible for causing relaxing, stimulating or hallucinogenic effects. The consumption of some of these substances is prompted by religious beliefs and cultural reasons, making the legislation very variable or even ambiguous. However, the abusive consumption of these substances can present an enormous risk to the health of the individuals, since their metabolism and effects are not yet fully known. Additionally, NPSs are widely spread over the internet, and their appearance is very fast, which requires the development of sophisticated analytical methodologies, capable of detecting these compounds. Thus, the objective of this work is to review the toxicological aspects, traditional use\/therapeutic potential and the analytical methods developed in biological matrices in twelve plant specimens (Areca catechu, Argyreia nervosa, Ayahuasca, Catha edulis, Datura stramonium, Lophophora williamsii, Mandragora officinarum, Mitragyna speciosa, Piper methysticum Forst, Psilocybe, Salvia divinorum and Tabernanthe iboga).<\/jats:p>","DOI":"10.3390\/molecules26051397","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T11:46:09Z","timestamp":1614944769000},"page":"1397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples"],"prefix":"10.3390","volume":"26","author":[{"given":"Joana","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-6522","authenticated-orcid":false,"given":"\u00c2ngelo","family":"Lu\u00eds","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-8998","authenticated-orcid":false,"given":"Eugenia","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-5977","authenticated-orcid":false,"given":"Ana Paula","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"Laborat\u00f3rio de F\u00e1rmaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilh\u00e3, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"ref_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (2019). EU Drug Markets Report 2019."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.4155\/bio-2020-0148","article-title":"Recent bionalytical methods for the determination of new psychoactive substances in biological specimens","volume":"12","author":"Antunes","year":"2020","journal-title":"Bioanalysis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112945","DOI":"10.1016\/j.jpba.2019.112945","article-title":"Biomedical analysis of New Psychoactive Substances (NPS) of natural origin","volume":"179","author":"Tagliabracci","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/ijpp.12313","article-title":"New psychoactive substances: A public health issue","volume":"25","author":"Guirguis","year":"2017","journal-title":"Int. J. Pharm. Practice"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/jat\/bkx020","article-title":"Hair testing for drugs of abuse and new psychoactive substances in a high-risk population","volume":"41","author":"Salomone","year":"2017","journal-title":"J. Anal. Toxicol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/bcp.14239","article-title":"Evaluation of long-term detection trends of new psychoactive substances in pooled urine from city street portable urinals (London, UK)","volume":"86","author":"Archer","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0140-6736(19)32231-7","article-title":"New psychoactive substances: Challenges for drug surveillance, control, and public health responses","volume":"394","author":"Peacock","year":"2019","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00204-016-1812-x","article-title":"New psychoactive substances: An overview on recent publications on their toxicodynamics and toxicokinetics","volume":"90","author":"Meyer","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/add.13528","article-title":"New psychoactive substances: Driving greater complexity into the drug problem","volume":"112","author":"Sedefov","year":"2017","journal-title":"Addiction"},{"key":"ref_10","unstructured":"United Nations Office on Drugs and Crime (2021, January 28). UNODC Early Warning Advisory (EWA) on New Psychoactive Substances (NPS). Available online: https:\/\/www.unodc.org\/LSS\/Home\/NPS."},{"key":"ref_11","unstructured":"(2021, January 28). European Monitoring Centre for Drugs and Drug The EU Early Warning System on new psychoactive substances (NPS). Available online: https:\/\/www.emcdda.europa.eu\/publications\/topic-overviews\/eu-early-warning-system_en."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1039\/C5AN00797F","article-title":"An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)","volume":"140","author":"Smith","year":"2015","journal-title":"Analyst"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"750","DOI":"10.2174\/1570159X14666161031144427","article-title":"Herbal Highs: Review on Psychoactive Effects and Neuropharmacology","volume":"15","author":"Graziano","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jchromb.2019.06.014","article-title":"Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil","volume":"1124","author":"Souza","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jep.2015.02.010","article-title":"Areca catechu L. (Arecaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"164","author":"Peng","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13556210020091437","article-title":"Global epidemiology of areca nut usage","volume":"7","author":"Gupta","year":"2002","journal-title":"Addict. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Papke, R.L., Horenstein, N.A., and Stokes, C. (2015). Nicotinic Activity of Arecoline, the Psychoactive Element of \u201cBetel Nuts\u201d, Suggests a Basis for Habitual Use and Anti-Inflammatory Activity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140907"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/08039488.2011.605172","article-title":"Potential action of betel alkaloids on positive and negative symptoms of schizophrenia: A review","volume":"66","author":"Coppola","year":"2012","journal-title":"Nord. J. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/0140-6736(92)90732-I","article-title":"Betel-nut chewing and asthma","volume":"339","author":"Taylor","year":"1992","journal-title":"Lancet"},{"key":"ref_20","first-page":"103","article-title":"Areca Nut Chewing Complicated with Non-Obstructive and Obstructive ST Elevation Myocardial Infarction","volume":"32","author":"Chen","year":"2016","journal-title":"Acta Cardiol. Sin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/ptr.6665","article-title":"Areca catechu\u2014From farm to food and biomedical applications","volume":"34","author":"Salehi","year":"2020","journal-title":"Phyther. Res."},{"key":"ref_22","first-page":"35","article-title":"Antilipidemic activity of arecanut, Areca catechu L.: A valuable herbal medicine","volume":"5","author":"Sarpangala","year":"2017","journal-title":"Int. J. Herb. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/369479","article-title":"Natural antioxidant activity of commonly consumed plant foods in India: Effect of domestic processing","volume":"369479","author":"Sreeramulu","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.seizure.2012.02.010","article-title":"Four types of traditional Chinese medicine inducing epileptic seizures","volume":"21","author":"Wu","year":"2012","journal-title":"Seizure"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5530\/ax.2011.1.6","article-title":"Antioxidant activity and the effect of different parts of areca catechu extracts on Glutathione-S-Transferase activity in vitro","volume":"1","author":"Hamsar","year":"2011","journal-title":"Free Radic. Antioxid."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/jat\/34.6.325","article-title":"Quantification of blood betel quid alkaloids and urinary 8-hydroxydeoxyguanosine in humans and their association with betel chewing habits","volume":"34","author":"Wu","year":"2010","journal-title":"J. Anal. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/rcm.1140","article-title":"Quantification of arecoline (Areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography\/electrospray quadrupole mass spectrometry","volume":"17","author":"Pichini","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/02791072.2016.1264647","article-title":"Betel Nut Chewing in Iron Age Vietnam? Detection of Areca catechu Alkaloids in Dental Enamel","volume":"49","author":"Krais","year":"2017","journal-title":"J. Psychoact. Drugs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/10826084.2019.1630442","article-title":"Chemical Markers for Short- and Long-Term Areca Nut Exposure","volume":"55","author":"Franke","year":"2020","journal-title":"Subst. Use Misuse"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/jat\/bkv077","article-title":"Quantification of salivary arecoline, arecaidine and N-methylnipecotic acid levels in volunteers by liquid chromatography-tandem mass spectrometry","volume":"39","author":"Lee","year":"2015","journal-title":"J. Anal. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/rcm.3137","article-title":"Liquid chromatography\/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk","volume":"21","author":"Pellegrini","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1002\/rcm.2183","article-title":"Determination of arecoline (areca nut alkaloid) and nicotine in hair by high-performance liquid chromatography\/electrospray quadrupole mass spectrometry","volume":"19","author":"Marchei","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2307\/1222581","article-title":"A synopsis of Ipomoea (Convolvulaceae) in the Americas","volume":"45","author":"Austin","year":"1996","journal-title":"Taxon"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.forsciint.2015.02.011","article-title":"Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high","volume":"249","author":"Paulke","year":"2015","journal-title":"Forensic Sci. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/jps.2600620409","article-title":"Ergoline alkaloidal constituents of hawaiian baby wood rose, argyreia nervosa (Burm. f.) bojer","volume":"62","author":"Chao","year":"1973","journal-title":"J. Pharm. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2527\/1999.774942x","article-title":"Alkaloid binding and activation of D2 dopamine receptors in cell culture","volume":"77","author":"Larson","year":"1999","journal-title":"J. Anim. Sci."},{"key":"ref_37","first-page":"34","article-title":"Argyreia speciosa Linn. f.: Phytochemistry, pharmacognosy and pharmacological studies","volume":"2","author":"Modi","year":"2010","journal-title":"J. Pharmacogn. Phyther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01217830","article-title":"Microchemical investigations of medicinal plants. XIV\u2014Identification of the alkaloids in the leaves of Ipomoea violacea using preparative thin layer chromatography and solid probe mass spectrometry","volume":"65","author":"Weber","year":"1976","journal-title":"Mikrochim. Acta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00216-012-6121-5","article-title":"Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds","volume":"Volume 404","author":"Paulke","year":"2012","journal-title":"Proceedings of the Analytical and Bioanalytical Chemistry"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sim\u00e3o, A.Y., Gon\u00e7alves, J., Duarte, A.P., Barroso, M., Crist\u00f3v\u00e3o, A.C., and Gallardo, E. (2019). Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review. Medicines, 6.","DOI":"10.3390\/medicines6040106"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cbi.2018.08.001","article-title":"Exposure to ayahuasca induces developmental and behavioral alterations on early life stages of zebrafish","volume":"293","author":"Andrade","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1360-0443.2006.01652.x","article-title":"Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids","volume":"102","author":"Gable","year":"2007","journal-title":"Addiction"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ramachandran, P., Zhang, N., McLaughlin, W.B., Luo, Y., Handy, S., Duke, J.A., Vasquez, R., and Ottesen, A. (2018). Sequencing the vine of the soul: Full chloroplast genome sequence of Banisteriopsis caapi. Genome Announc., 6.","DOI":"10.1128\/genomeA.00203-18"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1177\/0269881116652578","article-title":"The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging","volume":"30","author":"Balthazar","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1590\/1516-4446-2015-1701","article-title":"Antidepressive and anxiolytic effects of ayahuasca: A systematic literature review of animal and human studies","volume":"38","author":"Crippa","year":"2016","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1124\/jpet.103.049882","article-title":"Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics","volume":"306","author":"Riba","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/hbm.21381","article-title":"Seeing with the eyes shut: Neural basis of enhanced imagery following ayahuasca ingestion","volume":"33","author":"Ribeiro","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00213-006-0358-7","article-title":"Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant","volume":"186","author":"Riba","year":"2006","journal-title":"Psychopharmacology"},{"key":"ref_49","first-page":"1","article-title":"The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro","volume":"7","author":"Feilding","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fpsyt.2017.00152","article-title":"Novel psychoactive substances-recent progress on neuropharmacological mechanisms of action for selected drugs","volume":"8","author":"Hassan","year":"2017","journal-title":"Front. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/jat\/20.6.492","article-title":"Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca","volume":"20","author":"Callaway","year":"1996","journal-title":"J. Anal. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, J., Lu\u00eds, \u00c2., Gradillas, A., Garc\u00eda, A., Restolho, J., Fern\u00e1ndez, N., Domingues, F., Gallardo, E., and Duarte, A.P. (2020). Ayahuasca Beverages: Phytochemical Analysis and Biological Properties. Antibiotics, 9.","DOI":"10.3390\/antibiotics9110731"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sim\u00e3o, A.Y., Gon\u00e7alves, J., Gradillas, A., Garc\u00eda, A., Restolho, J., Fern\u00e1ndez, N., Rodilla, J.M., Barroso, M., Duarte, A.P., and Crist\u00f3v\u00e3o, A.C. (2020). Evaluation of the Cytotoxicity of Ayahuasca Beverages. Molecules, 25.","DOI":"10.3390\/molecules25235594"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/1516-4446-2014-1496","article-title":"Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: A preliminary report","volume":"37","author":"Sanches","year":"2015","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/JCP.0000000000000436","article-title":"Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression a SPECT study","volume":"36","author":"Sanches","year":"2016","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jep.2007.04.012","article-title":"Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members","volume":"112","author":"Santos","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00005053-199602000-00004","article-title":"Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil","volume":"184","author":"Grob","year":"1996","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/15733998113099990003","article-title":"Ayahuasca-assisted therapy for addiction: Results from a preliminary observational study in Canada","volume":"6","author":"Thomas","year":"2013","journal-title":"Curr. Drug Abus. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.physbeh.2015.01.032","article-title":"Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice","volume":"142","author":"Santos","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/02791072.2005.10399792","article-title":"Ayahuasca in adolescence: A preliminary psychiatric assessment","volume":"37","author":"Grob","year":"2005","journal-title":"J. Psychoact. Drugs"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/02791072.2009.10400530","article-title":"A six-month prospective evaluation of personality traits, psychiatric symptoms and quality of life in Ayahuasca-Na\u00efve Subjects","volume":"41","author":"Barbosa","year":"2009","journal-title":"J. Psychoact. Drugs"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/bmc.1657","article-title":"Methodology for determining major constituents of ayahuasca and their metabolites in blood","volume":"26","author":"McIlhenny","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1570-0232(02)00397-5","article-title":"Determination of N, N-dimethyltryptamine and \u03b2-carboline alkaloids in human plasma following oral administration of Ayahuasca","volume":"779","author":"Yritia","year":"2002","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.4155\/bio.12.124","article-title":"Determination of dimethyltryptamine and \u03b2-carbolines (ayahuasca alkaloids) in plasma samples by LC-MS\/MS","volume":"4","author":"Oliveira","year":"2012","journal-title":"Bioanalysis"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/bmc.1551","article-title":"Methodology for and the determination of the major constituents and metabolites of the amazonian botanical medicine ayahuasca in human urine","volume":"25","author":"Mcilhenny","year":"2011","journal-title":"Biomed. Chromatogr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/dta.1685","article-title":"Metabolism and urinary disposition of N,N-dimethyltryptamine after oral and smoked administration: A comparative study","volume":"7","author":"Riba","year":"2015","journal-title":"Drug Test. Anal."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jpba.2014.08.006","article-title":"Ultra-high-pressure liquid chromatography tandem mass spectrometry determination of hallucinogenic drugs in hair of psychedelic plants and mushrooms consumers","volume":"100","author":"Pichini","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.pnpbp.2007.12.033","article-title":"A review of the neuropharmacological properties of khat","volume":"32","author":"Feyissa","year":"2008","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.2042-7158.1986.tb04571.x","article-title":"Metabolism of cathinone to (\u2212)-norephedrine and (\u2212)-norpseudoephedrine","volume":"38","author":"Brenneisen","year":"1986","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jchromb.2011.02.010","article-title":"Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography-electrospray tandem mass spectrometry","volume":"879","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jms.1132","article-title":"Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS\/MS with electrospray ionization","volume":"42","author":"Beyer","year":"2007","journal-title":"J. Mass Spectrom."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/clinchem\/48.10.1715","article-title":"Excretion and Detection of Cathinone, Cathine, and Phenylpropanolamine in Urine after Kath Chewing","volume":"48","author":"Toennes","year":"2002","journal-title":"Clin. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/chromsci\/bmw082","article-title":"A GC-MS Method for Detection and Quantification of Cathine, Cathinone, Methcathinone and Ephedrine in Oral Fluid","volume":"54","author":"Mohamed","year":"2016","journal-title":"J. Chromatogr. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchromb.2016.03.001","article-title":"Determination of \u201cnew psychoactive substances\u201d in postmortem matrices using microwave derivatization and gas chromatography-mass spectrometry","volume":"1020","author":"Margalho","year":"2016","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_75","first-page":"92","article-title":"Determination of New Psychoactive Substances in Whole Blood Using Microwave Fast Derivatization and Gas Chromatography\/Mass Spectrometry","volume":"44","author":"Margalho","year":"2020","journal-title":"J. Anal. Toxicol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0361-1124(76)80254-7","article-title":"Anticholinergic poisoning from Jimson weed","volume":"5","author":"Mahler","year":"1976","journal-title":"J. Am. Coll. Emerg. Physicians"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jen.2010.07.018","article-title":"Herbal hallucinations: Common abuse situations seen in the emergency department","volume":"36","author":"Oerther","year":"2010","journal-title":"J. Emerg. Nurs."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1080\/15287390600631284","article-title":"Jimsonweed (Datura stramonium) exposures in Texas, 1998\u20132004","volume":"69","author":"Forrester","year":"2006","journal-title":"J. Toxicol. Environ. Health Part A Curr. Issues"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12016-013-8370-2","article-title":"Alternative drugs of abuse","volume":"46","author":"Sutter","year":"2014","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/15563651003630672","article-title":"Aspects of datura poisoning and treatment","volume":"48","author":"Krenzelok","year":"2010","journal-title":"Clin. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/jama.1972.03200190029007","article-title":"Stramonium intoxication: Review of symptomatology in 212 cases","volume":"221","author":"Gowdy","year":"1972","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0361-1124(77)80035-X","article-title":"Jimson seed poisoning\u2014A new hallucinogen on the horizon","volume":"6","author":"Levy","year":"1977","journal-title":"J. Am. Coll. Emerg. Physicians"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.phytochem.2005.07.016","article-title":"Substances isolated from Mandragora species","volume":"66","author":"Dembitsky","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/10826080701772363","article-title":"Between prohibitions: Patterns and meanings of magic mushroom use in the UK","volume":"43","author":"Riley","year":"2008","journal-title":"Subst. Use Misuse"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.fitote.2010.05.013","article-title":"New withanolides from mandragora officinarum: First report of withanolides from the Genus Mandragora","volume":"81","author":"Suleiman","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1001\/archinte.1997.00440380117012","article-title":"Mandrake Toxicity","volume":"157","author":"Frasca","year":"1997","journal-title":"Arch. Intern. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2605.1982.tb00229.x","article-title":"Meiotic and synaptonemal complex studies in a 14\/21 translocation carrier","volume":"5","author":"Vidal","year":"1982","journal-title":"Int. J. Androl."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/jssc.200800128","article-title":"Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC","volume":"31","author":"Pietsch","year":"2008","journal-title":"J. Sep. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jchromb.2014.10.028","article-title":"Screening approach by ultra-high performance liquid chromatography-tandem mass spectrometry for the blood quantification of thirty-four toxic principles of plant origin. Application to forensic toxicology","volume":"975","author":"Carlier","year":"2015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0379-0738(02)00302-X","article-title":"Quantitative analysis of tropane alkaloids in biological materials by gas chromatography-mass spectrometry","volume":"130","author":"Namera","year":"2002","journal-title":"Forensic Sci. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jchromb.2009.03.004","article-title":"A multi-component LC-MS\/MS method for detection of ten plant-derived psychoactive substances in urine","volume":"877","author":"Beck","year":"2009","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.lfs.2005.09.005","article-title":"Hallucinogenic botanicals of America: A growing need for focused drug education and research","volume":"78","author":"Halpern","year":"2005","journal-title":"Life Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/15563650903586745","article-title":"Peyote and mescaline exposures: A 12-year review of a statewide poison center database","volume":"48","author":"Carstairs","year":"2010","journal-title":"Clin. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2016.05.022","article-title":"Effects of low dose ibogaine on subjective mood state and psychological performance","volume":"189","author":"Forsyth","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuropharm.2011.01.017","article-title":"Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens","volume":"61","author":"Halberstadt","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0010-440X(62)80024-8","article-title":"Mescaline, lysergic acid diethylamide and psilocybin: Comparison of clinical syndromes, effects on color perception and biochemical measures","volume":"3","author":"Hollister","year":"1962","journal-title":"Compr. Psychiatry"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.drugalcdep.2011.10.029","article-title":"Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers","volume":"123","author":"Johnson","year":"2012","journal-title":"Drug Alcohol Depend."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0006-3223(92)90059-9","article-title":"Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research","volume":"32","author":"Hermle","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0010-440X(64)80030-4","article-title":"Clinical syndromes and biochemical alterations following mescaline, lysergic acid diethylamide, psilocybin and a combination of the three psychotomimetic drugs","volume":"5","author":"Hollister","year":"1964","journal-title":"Compr. Psychiatry"},{"key":"ref_100","first-page":"184","article-title":"Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions","volume":"12","author":"Pereira","year":"2018","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/02791072.2015.1012610","article-title":"Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia","volume":"47","author":"Singh","year":"2015","journal-title":"J. Psychoact. Drugs"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainresbull.2016.05.004","article-title":"Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature","volume":"126","author":"Singh","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jep.2017.03.020","article-title":"A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth: Implications for products sold as kratom","volume":"202","author":"Brown","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.drugpo.2009.12.003","article-title":"The informal use of ketum (Mitragyna speciosa) for opioid withdrawal in the northern states of peninsular Malaysia and implications for drug substitution therapy","volume":"21","author":"Vicknasingam","year":"2010","journal-title":"Int. J. Drug Policy"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1360-0443.2008.02209.x","article-title":"Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)","volume":"103","author":"Boyer","year":"2008","journal-title":"Addiction"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Cinosi, E., Martinotti, G., Simonato, P., Singh, D., Demetrovics, Z., Roman-Urrestarazu, A., Bersani, F.S., Vicknasingam, B., Piazzon, G., and Li, J.H. (2015). Following \u201cthe Roots\u201d of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries. Biomed Res. Int., 2015.","DOI":"10.1155\/2015\/968786"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00414-015-1279-y","article-title":"The pharmacology and toxicology of kratom: From traditional herb to drug of abuse","volume":"130","author":"Warner","year":"2016","journal-title":"Int. J. Leg. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainresbull.2016.03.015","article-title":"Neurobiology of Kratom and its main alkaloid mitragynine","volume":"126","author":"Suhaimi","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jep.2012.03.009","article-title":"Mitragyna speciosa use in the northern states of Malaysia: A cross-sectional study","volume":"141","author":"Ahmad","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Meireles, V., Rosado, T., Barroso, M., Soares, S., Gon\u00e7alves, J., Lu\u00eds, \u00c2., Caramelo, D., Sim\u00e3o, A., Fern\u00e1ndez, N., and Duarte, A. (2019). Mitragyna speciosa: Clinical, Toxicological Aspects and Analysis in Biological and Non-Biological Samples. Medicines, 6.","DOI":"10.3390\/medicines6010035"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-0028-1099840","article-title":"The Mitragyna species of Asia. XV. The alkaloids from the bark of Mitragyna parvifolia (Roxb.) Korth and a possible biogenetic route for the oxindole alkaloids","volume":"17","author":"Shellard","year":"1969","journal-title":"Planta Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2155-6105.1000214","article-title":"Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source","volume":"6","author":"Ujvary","year":"2015","journal-title":"J. Addict. Res. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neubiorev.2012.11.012","article-title":"From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction","volume":"37","author":"Hassan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2017.05.059","article-title":"Opioid receptors mediate the acquisition, but not the expression of mitragynine-induced conditioned place preference in rats","volume":"332","author":"Yusoff","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Lu, J., Wei, H., Wu, J., Jamil, M.F.A., Tan, M.L., Adenan, M.I., Wong, P., and Shim, W. (2014). Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115648"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.lfs.2005.04.042","article-title":"Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens","volume":"78","author":"Matsumoto","year":"2005","journal-title":"Life Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jep.2011.04.011","article-title":"Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E 2 production induced by lipopolysaccharide in RAW264.7 macrophage cells","volume":"136","author":"Utar","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.phymed.2010.08.011","article-title":"Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression","volume":"18","author":"Moklas","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s13181-010-0079-5","article-title":"Seizure and Coma Following Kratom (Mitragynina speciosa Korth) Exposure","volume":"6","author":"Nelsen","year":"2010","journal-title":"J. Med. Toxicol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/NPM-1863","article-title":"Natural drugs, not so natural effects: Neonatal abstinence syndrome secondary to \u201ckratom\u201d","volume":"12","author":"Davidson","year":"2019","journal-title":"J. Neonatal. Perinat. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ab.2017.12.021","article-title":"Method validation in quantitative analysis of phase I and phase II metabolites of mitragynine in human urine using liquid chromatography-tandem mass spectrometry","volume":"543","author":"Lee","year":"2018","journal-title":"Anal. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jchromb.2018.02.010","article-title":"Identification of five Mitragyna alkaloids in urine using liquid chromatography-quadrupole\/time of flight mass spectrometry","volume":"1080","author":"Basiliere","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/jat\/bks073","article-title":"Analysis of Mitragynine and Metabolites in Human Urine for Detecting the Use of the Psychoactive Plant Kratom","volume":"36","author":"Le","year":"2012","journal-title":"J. Anal. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4236\/detection.2016.43009","article-title":"A Mass Spectrometric Study of Kratom Compounds by Direct Infusion Electrospray Ionization Triple Quadrupole Mass Spectrometry","volume":"4","author":"Fu","year":"2016","journal-title":"Detection"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Pantano, F., Tittarelli, R., Mannocchi, G., Zaami, S., Ricci, S., Giorgetti, R., Terranova, D., Busard\u00f2, F., and Marinelli, E. (2016). Hepatotoxicity Induced by \u201cthe 3Ks\u201d: Kava, Kratom and Khat. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040580"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.dld.2011.01.018","article-title":"Herbal hepatotoxicity by kava: Update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits","volume":"43","author":"Teschke","year":"2011","journal-title":"Dig. Liver Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jchromb.2003.09.055","article-title":"Testing for kavain in human hair using gas chromatography-tandem mass spectrometry","volume":"798","author":"Villain","year":"2003","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1051\/ata\/2013044","article-title":"Chromatographic hair analysis for natural kavalactones and their metabolites. A preliminary study","volume":"25","author":"Tarbah","year":"2013","journal-title":"Ann. Toxicol. Anal."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Wang, Y., Eans, S.O., Stacy, H.M., Narayanapillai, S.C., Sharma, A., Fujioka, N., Haddad, L., McLaughlin, J., Avery, B.A., and Xing, C. (2018). A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197940"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1570-0232(03)00046-1","article-title":"Kinetics of kavain and its metabolites after oral application","volume":"789","author":"Tarbah","year":"2003","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pharmthera.2004.03.003","article-title":"Hallucinogens and dissociative agents naturally growing in the United States","volume":"102","author":"Halpern","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrn2884","article-title":"The neurobiology of psychedelic drugs: Implications for the treatment of mood disorders","volume":"11","author":"Vollenweider","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/pgmj.57.671.571","article-title":"Sequelae of a \u201cmagic mushroom banquet.\u201d","volume":"57","author":"Harries","year":"1981","journal-title":"Postgrad. Med. J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1177\/0269881106065859","article-title":"Effects of psilocybin on time perception and temporal control of behaviour in humans","volume":"21","author":"Wittmann","year":"2007","journal-title":"J. Psychopharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00213-011-2358-5","article-title":"Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects","volume":"218","author":"Griffiths","year":"2011","journal-title":"Psychopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Vargas, A.S., Lu\u00eds, \u00c2., Barroso, M., Gallardo, E., and Pereira, L. (2020). Psilocybin as a New Approach to Treat Depression and Anxiety in the Context of Life-Threatening Diseases\u2014A Systematic Review and Meta-Analysis of Clinical Trials. Biomedicines, 8.","DOI":"10.3390\/biomedicines8090331"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/dta.1400","article-title":"Magic truffles or Philosopher\u2019s stones: A legal way to sell psilocybin?","volume":"5","author":"Pellegrini","year":"2013","journal-title":"Drug Test. Anal."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jchromb.2003.08.030","article-title":"Optimized glucuronide hydrolysis for the detection of psilocin in human urine samples","volume":"796","author":"Kamata","year":"2003","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11419-006-0006-2","article-title":"Direct detection of serum psilocin glucuronide by LC\/MS and LC\/MS\/MS: Time-courses of total and free (unconjugated) psilocin concentrations in serum specimens of a \u201cmagic mushroom\u201d user","volume":"24","author":"Kamata","year":"2006","journal-title":"Forensic Toxicol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0378-8741(83)90004-1","article-title":"Ethnopharmacology of ska Mar\u00eda Pastora (Salvia divinorum, Epling AND J\u00e1tiva-M.)","volume":"7","author":"Paul","year":"1983","journal-title":"J. Ethnopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/rcm.2288","article-title":"Determination of salvinorins and divinatorins inSalvia divinorum leaves by liquid chromatography\/multistage mass spectrometry","volume":"20","author":"Medana","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1073\/pnas.182234399","article-title":"Salvinorin A: A potent naturally occurring nonnitrogenous \u03ba opioid selective agonist","volume":"99","author":"Roth","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/15321819.2017.1324797","article-title":"An immunochromatographic assay for rapid etection of salvinorin A","volume":"38","author":"Paudel","year":"2017","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1021\/np400358n","article-title":"Development of an Enzyme Immunoassay Using a Monoclonal Antibody against the Psychoactive Diterpenoid Salvinorin, A","volume":"76","author":"Paudel","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.biopsych.2007.07.020","article-title":"Involvement of \u03ba-Opioid and Endocannabinoid System on Salvinorin A-Induced Reward","volume":"63","author":"Braida","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2009.00230.x","article-title":"Potential anxiolytic\u2014And antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents","volume":"157","author":"Braida","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00213-010-1836-5","article-title":"Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens","volume":"210","author":"Ebner","year":"2010","journal-title":"Psychopharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/ibd.21873","article-title":"Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors","volume":"18","author":"Fichna","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/00004714-200112000-00025","article-title":"Antidepressant effects of the herb salvia divinorum: A case report [12]","volume":"21","author":"Hanes","year":"2001","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/B978-0-12-420118-7.00012-3","article-title":"Salvinorin A analogs and other kappa-opioid receptor compounds as treatments for cocaine abuse","volume":"69","author":"Kivell","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pbb.2005.12.011","article-title":"Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist","volume":"83","author":"McCurdy","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1213\/ANE.0b013e31823a5d36","article-title":"Salvinorin a pretreatment preserves cerebrovascular autoregulation after brain hypoxic\/ischemic injury via extracellular signal-regulated kinase\/mitogen-activated protein kinase in piglets","volume":"114","author":"Su","year":"2012","journal-title":"Anesth. Analg."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainres.2016.02.024","article-title":"Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats","volume":"1637","author":"Xin","year":"2016","journal-title":"Brain Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00213-004-2087-0","article-title":"Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: Agonist actions at kappa opioid receptors","volume":"179","author":"Zhang","year":"2005","journal-title":"Psychopharmacology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phytochem.2017.02.001","article-title":"A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics","volume":"137","author":"Cruz","year":"2017","journal-title":"Phytochemistry"},{"key":"ref_156","first-page":"175","article-title":"Salvia Divinorum: Beyond Its Therapeutic Uses","volume":"Volume 1","author":"Villalobos","year":"2020","journal-title":"Salvia: Chemistry and Effects"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.chroma.2011.09.056","article-title":"Analysis of Salvinorin A in plants, water, and urine using solid-phase microextraction-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry","volume":"1226","author":"Barnes","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/jat\/32.6.417","article-title":"The Detection and Quantitative Analysis of the Psychoactive Component of Salvia divinorum, Salvinorin A, in Human Biological Fluids Using Liquid Chromatography-Mass Spectrometry*","volume":"32","author":"McDonough","year":"2008","journal-title":"J. Anal. Toxicol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/rcm.1970","article-title":"Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography\/mass spectrometry after Salvia divinorum smoking","volume":"19","author":"Pichini","year":"2005","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.4155\/bio.13.18","article-title":"Analysis of Salvinorin A in urine using microextraction in packed syringe and GC-MS\/MS","volume":"5","author":"Moreno","year":"2013","journal-title":"Bioanalysis"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chroma.2013.07.031","article-title":"A validated procedure for detection and quantitation of salvinorin a in pericardial fluid, vitreous humor, whole blood and plasma using solid phase extraction and gas chromatography-mass spectrometry","volume":"1304","author":"Margalho","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1556-4029.2011.02008.x","article-title":"Fatalities Temporally Associated with the Ingestion of Ibogaine","volume":"57","author":"Alper","year":"2012","journal-title":"J. Forensic Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jep.2012.06.039","article-title":"Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga","volume":"143","author":"Jamnik","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0099-9598(01)56005-8","article-title":"Ibogaine: A review","volume":"56","author":"Alper","year":"2001","journal-title":"Alkaloids Chem. Biol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0099-9598(01)56006-X","article-title":"Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener","volume":"56","author":"Glick","year":"2001","journal-title":"Alkaloids Chem. Biol."},{"key":"ref_166","first-page":"71","article-title":"Pharmacodynamics and therapeutic applications of iboga and ibogaine","volume":"6","author":"Goutarel","year":"1993","journal-title":"Psychedelic Monogr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jchromb.2005.06.018","article-title":"Quantitation of ibogaine and 12-hydroxyibogamine in human plasma by liquid chromatography with fluorimetric detection","volume":"822","author":"Larroque","year":"2005","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/5\/1397\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:33:25Z","timestamp":1760160805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/5\/1397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":167,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26051397"],"URL":"https:\/\/doi.org\/10.3390\/molecules26051397","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]}}}