{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:00:56Z","timestamp":1761238856763,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["LISBOA-01-0145-FEDER-030988","contract under DL No. 57\/2016 regulation"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-030988","contract under DL No. 57\/2016 regulation"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI-OUT\/30988\/2017","SFRH\/BD\/100029\/2014","contracts under DL No. 57\/2016 regulation and CEECIND program","UIDB\/04567\/2020","UIDP\/04567\/2020","UID\/QUI\/00100\/2019","UIDP\/00100\/2020","UIDB\/00100\/2020"],"award-info":[{"award-number":["PTDC\/QUI-OUT\/30988\/2017","SFRH\/BD\/100029\/2014","contracts under DL No. 57\/2016 regulation and CEECIND program","UIDB\/04567\/2020","UIDP\/04567\/2020","UID\/QUI\/00100\/2019","UIDP\/00100\/2020","UIDB\/00100\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli, Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant.<\/jats:p>","DOI":"10.3390\/molecules26071904","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T22:09:01Z","timestamp":1616969341000},"page":"1904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry"],"prefix":"10.3390","volume":"26","author":[{"given":"S\u00edlvia","family":"Quaresma","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"}]},{"given":"Paula C.","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal"},{"name":"Associa\u00e7\u00e3o do Instituto Superior T\u00e9cnico para a Investiga\u00e7\u00e3o e Desenvolvimento (IST-ID), Av. Rovisco Pais, 1049-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7992-8343","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Bioci\u00eancias e Tecnologias da Sa\u00fade (CBIOS), Universidade Lus\u00f3fona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal"},{"name":"Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy, Universidade de Lisboa (UL), Av. 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Rovisco Pais, 1049-003 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"ref_1","first-page":"6","article-title":"The curious characteristics of pyrazinamide: A review","volume":"7","author":"Zhang","year":"2003","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/jac\/dkh042","article-title":"Iron enhances the antituberculous activity of pyrazinamide","volume":"53","author":"Somoskovi","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_3","unstructured":"Cavalcante, S., Chakaya, J.M., Egwaga, S.M., Gie, R., Gondrie, P., Harries, A.D., Hopewell, P., Kumar, B., Weezenbeck, K.L.-v., and Mase, S. (2010). Treatment of tuberculosis: Guidelines, World Health Organization. [4th ed.]."},{"key":"ref_4","unstructured":"(2021, January 15). 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