{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:56:32Z","timestamp":1776495392064,"version":"3.51.2"},"reference-count":163,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The development of new materials based on hydroxyapatite has undergone a great evolution in recent decades due to technological advances and development of computational techniques. The focus of this review is the various attempts to improve new hydroxyapatite-based materials. First, we comment on the most used processing routes, highlighting their advantages and disadvantages. We will now focus on other routes, less common due to their specificity and\/or recent development. We also include a block dedicated to the impact of computational techniques in the development of these new systems, including: QSAR, DFT, Finite Elements of Machine Learning. In the following part we focus on the most innovative applications of these materials, ranging from medicine to new disciplines such as catalysis, environment, filtration, or energy. The review concludes with an outlook for possible new research directions.<\/jats:p>","DOI":"10.3390\/molecules26113190","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T21:56:44Z","timestamp":1622066204000},"page":"3190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Advanced Materials Based on Nanosized Hydroxyapatite"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-4015","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Rial","sequence":"first","affiliation":[{"name":"Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-0811","authenticated-orcid":false,"given":"Michael","family":"Gonz\u00e1lez-Durruthy","sequence":"additional","affiliation":[{"name":"Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physics and Engineering, Frostburg State University, Frostburg, MD 21532, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-6754","authenticated-orcid":false,"given":"Juan M.","family":"Ruso","sequence":"additional","affiliation":[{"name":"Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1119\/1.1625210","article-title":"An historico-critical account of potential energy: Is PE really real?","volume":"41","author":"Hecht","year":"2003","journal-title":"Phys. Teach."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1098\/rsif.2007.0218","article-title":"Biomimetic materials research: What can we really learn from nature\u2019s structural materials?","volume":"4","author":"Fratzl","year":"2007","journal-title":"J. R. Soc. Interface"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1666\/0094-8373(2001)027<0405:THSOOA>2.0.CO;2","article-title":"The hierarchical structure of organisms: A scale and documentation of a trend in the maximum","volume":"27","author":"McShea","year":"2001","journal-title":"Paleobiology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vallet-Regi, M. (2014). Bio-Ceramics with Clinical Applications, John Wiley & Sons.","DOI":"10.1002\/9781118406748"},{"key":"ref_5","first-page":"403","article-title":"Recent advances in ceramic implants as drug delivery systems for biomedical applications","volume":"3","author":"Colilla","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10904-018-0969-6","article-title":"Thermal behavior, sintering and mechanical characterization of multiple ion-substituted hydroxyapatite bioceramics","volume":"29","author":"Hidouri","year":"2019","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11192-010-0202-z","article-title":"The rate of growth in scientific publication and the decline in coverage provided by Science Citation Index","volume":"84","author":"Larsen","year":"2010","journal-title":"Scientometrics"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"(2009). Boom time for biomaterials. Nat. Mater., 8, 439.","DOI":"10.1038\/nmat2451"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0142-9612(96)80752-6","article-title":"Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models","volume":"17","author":"Ripamonti","year":"1996","journal-title":"Biomaterials"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2591.2011.01886.x","article-title":"Properties and applications of calcium hydroxide in endodontics and dental traumatology","volume":"44","author":"Mohammadi","year":"2011","journal-title":"Int. Endod. J."},{"key":"ref_11","first-page":"217","article-title":"Prospects of hydroxyapatite-based nanomaterials application synthesized by layer-by-layer method for pediatric traumatology and orthopedics","volume":"8","author":"Meleshko","year":"2020","journal-title":"Probl. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41433-019-0571-3","article-title":"Unwrapped hydroxyapatite orbital implants: Our experience in 347 cases","volume":"34","author":"Sobti","year":"2020","journal-title":"Eye"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3390\/jfb6041099","article-title":"Fabrication, Properties and Applications of Dense Hydroxyapatite: A Review","volume":"6","author":"Prakasam","year":"2015","journal-title":"J. Funct. Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0167-577X(02)00539-6","article-title":"A simple route to hydroxyapatite nanofibers","volume":"56","author":"Liu","year":"2002","journal-title":"Mater. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1021\/acsami.8b20703","article-title":"Ultralong Hydroxyapatite Nanowire-Based Filter Paper for High-Performance Water Purification","volume":"11","author":"Zhang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1023\/A:1020585800572","article-title":"Hydroxyapatite and hydroxyapatite-based ceramics","volume":"38","author":"Orlovskii","year":"2002","journal-title":"Inorg. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1039\/C5NR05262A","article-title":"Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization","volume":"8","author":"Zhao","year":"2016","journal-title":"Nanoscale"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25848","DOI":"10.1021\/acsami.6b10089","article-title":"Synthesis of hydroxyapatite substrates: Bridging the gap between model surfaces and enamel","volume":"8","author":"Zeitz","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.matdes.2011.08.011","article-title":"Sintering behavior of hydroxyapatite prepared from different routes","volume":"34","author":"Ramesh","year":"2012","journal-title":"Mater. Des."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0142-9612(00)00332-X","article-title":"Water-based sol\u2013gel synthesis of hydroxyapatite: Process development","volume":"22","author":"Liu","year":"2001","journal-title":"Biomaterials"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/BF02706339","article-title":"Synthesis, characterization and gas sensing property of hydroxyapatite ceramic","volume":"28","author":"Mahabole","year":"2005","journal-title":"Bull. Mater. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.matpr.2020.05.536","article-title":"Synthesis method of hydroxyapatite: A review","volume":"29","author":"Haq","year":"2020","journal-title":"Mater. Today Proc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1680\/bbn.14.00010","article-title":"Comparison of techniques for the synthesis of hydroxyapatite","volume":"4","author":"Cox","year":"2015","journal-title":"Bioinspired Biomim. Nanobiomater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0142-9612(01)00229-0","article-title":"Synthesis of hydroxyapatite via mechanochemical treatment","volume":"23","author":"Rhee","year":"2002","journal-title":"Biomaterials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/S0142-9612(00)00257-X","article-title":"Mechanochemical synthesis of nanocrystalline hydroxyapatite from CaO and CaHPO4","volume":"22","author":"Yeong","year":"2001","journal-title":"Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/S0142-9612(01)00295-2","article-title":"Structural evolution of sol\u2013gel-derived hydroxyapatite","volume":"23","author":"Liu","year":"2002","journal-title":"Biomaterials"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/j.1151-2916.2001.tb00970.x","article-title":"Gel-to-Ceramic Conversion during Hydroxyapatite Synthesis","volume":"84","author":"Hsieh","year":"2001","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S1516-14391999000200003","article-title":"Influence of process conditions on hydroxyapatite crystallinity obtained by direct crystallization","volume":"2","author":"Seckler","year":"1999","journal-title":"Mater. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0955-2219(96)00215-4","article-title":"A new synthesis of hydroxyapatite","volume":"17","author":"Weng","year":"1997","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0167-577X(00)00157-9","article-title":"Extrusion of hydroxyapatite to clinically significant shapes","volume":"46","author":"Velayudhan","year":"2000","journal-title":"Mater. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180962","DOI":"10.1098\/rsos.180962","article-title":"Wet chemical synthesis of nanocrystalline hydroxyapatite flakes: Effect of pH and sintering temperature on structural and morphological properties","volume":"5","author":"Karthik","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1016\/j.ceramint.2018.02.201","article-title":"Wet chemical precipitation synthesis of hydroxyapatite (HA) powders","volume":"44","author":"Yilmaz","year":"2018","journal-title":"Ceram. Int."},{"key":"ref_33","first-page":"448","article-title":"Properties of hydroxyapatite synthesize by wet chemical method","volume":"14","author":"Ramesh","year":"2013","journal-title":"J. Ceram. Process. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1021\/acsnano.6b07239","article-title":"Large-Scale Automated Production of Highly Ordered Ultralong Hydroxyapatite Nanowires and Construction of Various Fire-Resistant Flexible Ordered Architectures","volume":"10","author":"Chen","year":"2016","journal-title":"ACS Nano"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1590\/0366-69132019653742706","article-title":"A brief review on hydroxyapatite production and use in biomedicine","volume":"65","author":"Gomes","year":"2019","journal-title":"Cer\u00e2mica"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1359\/jbmr.1997.12.1.111","article-title":"Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: In vivo studies in the distal radius using high resolution magnetic resonance imaging","volume":"12","author":"Majumdar","year":"1997","journal-title":"J. Bone Mineral. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1148\/radiology.168.3.3043546","article-title":"Bone marrow imaging","volume":"168","author":"Vogler","year":"1988","journal-title":"Radiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mser.2007.05.001","article-title":"Bone structure and formation: A new perspective","volume":"58","author":"Olszta","year":"2007","journal-title":"Mater. Sci. Eng. R Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1016\/j.biomaterials.2003.10.007","article-title":"A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering","volume":"25","author":"Tadic","year":"2004","journal-title":"Biomaterials"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10047-005-0292-1","article-title":"Bone tissue engineering with porous hydroxyapatite ceramics","volume":"8","author":"Yoshikawa","year":"2005","journal-title":"J. Artif. Organs"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.stam.2006.11.017","article-title":"Porous hydroxyapatite for artificial bone applications","volume":"8","author":"Sopyan","year":"2007","journal-title":"Sci. Technol. Adv. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.carbon.2017.02.013","article-title":"Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering","volume":"116","author":"Nie","year":"2017","journal-title":"Carbon"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.msec.2018.07.020","article-title":"3D porous collagen\/functionalized multiwalled carbon nanotube\/chitosan\/hydroxyapatite composite scaffolds for bone tissue engineering","volume":"92","author":"Efe","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0142-9612(95)98272-G","article-title":"Influence of porosity on the mechanical resistance of hydroxyapatite ceramics under compressive stress","volume":"16","author":"Schaeverbeke","year":"1995","journal-title":"Biomaterials"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0142-9612(00)00030-2","article-title":"Osteoconduction at porous hydroxyapatite with various pore configurations","volume":"21","author":"Chang","year":"2000","journal-title":"Biomaterials"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1016\/j.biomaterials.2006.07.007","article-title":"Enhanced bone ingrowth into hydroxyapatite with interconnected pores by Electrical Polarization","volume":"27","author":"Itoh","year":"2006","journal-title":"Biomaterials"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0142-9612(95)91127-K","article-title":"Do porous calcium hydroxyapatite ceramics cause porosis in bone? A bone densitometry and biomechanical study on cortical bones of rabbits","volume":"16","author":"Korkusuz","year":"1995","journal-title":"Biomaterials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17059","DOI":"10.1038\/boneres.2017.59","article-title":"Bone biomaterials and interactions with stem cells","volume":"5","author":"Gao","year":"2017","journal-title":"Bone Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0142-9612(95)98858-B","article-title":"Chemistry and sintering behaviour of thin hydroxyapatite ceramics with controlled porosity","volume":"16","author":"Arita","year":"1995","journal-title":"Biomaterials"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0142-9612(94)90193-7","article-title":"Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues","volume":"15","author":"Klein","year":"1994","journal-title":"Biomaterials"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0955-2219(99)00131-4","article-title":"Manufacture of macroporous calcium hydroxyapatite bioceramics","volume":"19","author":"Tas","year":"1999","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.msec.2013.09.036","article-title":"PCL-coated hydroxyapatite scaffold derived from cuttlefish bone: Morphology, mechanical properties and bioactivity","volume":"34","author":"Milovac","year":"2014","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"015010","DOI":"10.1088\/2057-1976\/aa54f5","article-title":"Mechanochemical synthesis of nanocrystalline hydroxyapatite from Mercenaria clam shells and phosphoric acid","volume":"3","author":"Pal","year":"2017","journal-title":"Biomed. Phys. Eng. Express"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1016\/j.ceramint.2012.11.050","article-title":"Synthesis of nanocrystalline hydroxyapatite by precipitation using hen\u2019s eggshell","volume":"39","author":"Goloshchapov","year":"2013","journal-title":"Ceram. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1166\/jnn.2015.9489","article-title":"Synthesis and characterization of collagen scaffolds reinforced by eggshell derived hydroxyapatite for tissue engineering","volume":"15","author":"Padmanabhan","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.colsurfb.2010.10.006","article-title":"Flower-like agglomerates of hydroxyapatite crystals formed on an egg-shell membrane","volume":"82","author":"Zhang","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1016\/j.ceramint.2014.10.153","article-title":"In situ preparation of iron oxide nanoparticles in natural hydroxyapatite\/chitosan matrix for bone tissue engineering application","volume":"41","author":"Heidari","year":"2015","journal-title":"Ceram. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s11665-016-2086-4","article-title":"Influence of Fe3O4 nanoparticles in hydroxyapatite scaffolds on proliferation of primary human fibroblast cells","volume":"25","author":"Aghaie","year":"2016","journal-title":"J. Mater. Eng. Perform."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1039\/C4TB01862A","article-title":"Porous hollow microspheres of amorphous calcium phosphate: Soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery","volume":"3","author":"Ding","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.saa.2015.01.039","article-title":"Opuntia ficus indica peel derived pectin mediated hydroxyapatite nanoparticles: Synthesis, spectral characterization, biological and antimicrobial activities","volume":"141","author":"Gopi","year":"2015","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1039\/C5TB01036E","article-title":"A potential mechanism for amino acid-controlled crystal growth of hydroxyapatite","volume":"3","author":"Wang","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"125991","DOI":"10.1016\/j.jcrysgro.2020.125991","article-title":"Dual function of poly(acrylic acid) on controlling amorphous mediated hydroxyapatite crystallization","volume":"557","author":"Jiang","year":"2021","journal-title":"J. Cryst. Growth"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1007\/s10853-011-6113-4","article-title":"Biomimetic formation of crystalline bone-like apatite layers on spongy materials templated by bile salts aggregates","volume":"47","author":"Verdinelli","year":"2012","journal-title":"J. Mater. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2007.03.018","article-title":"Fabrication and characterization of PLGA\/HAp composite scaffolds for delivery of BMP-2 plasmid DNA","volume":"120","author":"Nie","year":"2007","journal-title":"J. Control. Release"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1021\/cg800641s","article-title":"In Situ Growth Kinetics of Hydroxyapatite on Electrospun Poly(dl-lactide) Fibers with Gelatin Grafted","volume":"8","author":"Cui","year":"2008","journal-title":"Cryst. Growth Des."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40145-020-0415-4","article-title":"High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing","volume":"10","author":"Yao","year":"2021","journal-title":"J. Adv. Ceram."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1151-2916.2003.tb03279.x","article-title":"Novel method to manufacture porous hydroxyapatite by dual-phase mixing","volume":"86","author":"Li","year":"2003","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"124185","DOI":"10.1016\/j.matchemphys.2020.124185","article-title":"Three-dimensional nano-hydroxyapatite sodium silicate glass composite scaffold for bone tissue engineering-A new fabrication process at a near-room temperature","volume":"260","author":"Lakrat","year":"2021","journal-title":"Mater. Chem. Phys."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"110828","DOI":"10.1016\/j.msec.2020.110828","article-title":"Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance","volume":"111","author":"Kermani","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0142-9612(97)00081-1","article-title":"Processing of hydroxyapatite via microemulsion and emulsion routes","volume":"18","author":"Lim","year":"1997","journal-title":"Biomaterials"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jpln.19390120109","article-title":"Zur Kenntnis der Phosphate I: \u00dcber Hydroxylapatit","volume":"12","author":"Rathje","year":"1939","journal-title":"Bodenkd. Pflanz."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.vacuum.2017.06.008","article-title":"Facile synthesis and characterization of hydroxyapatite particles for high value nanocomposites and biomaterials","volume":"146","author":"Miculescu","year":"2017","journal-title":"Vacuum"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Mitran, V., Ion, R., Miculescu, F., Necula, M.G., Mocanu, A.-C., Stan, G.E., Antoniac, I.V., and Cimpean, A. (2018). Osteoblast Cell Response to Naturally Derived Calcium Phosphate-Based Materials. Materials, 11.","DOI":"10.3390\/ma11071097"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1021\/acs.cgd.9b00887","article-title":"Formation of hydroxyapatite via transformation of amorphous calcium phosphate in the presence of alginate additives","volume":"19","author":"Ucar","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"ref_75","first-page":"748","article-title":"Controlled Anisotropic Growth of Hydroxyapatite by Additive-Free Hydrothermal Synthesis","volume":"2","author":"Sans","year":"2020","journal-title":"Cryst. Growth Des."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2174\/1568026611313050006","article-title":"MIANN models in medicinal, physical and organic chemistry","volume":"13","author":"Arrasate","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/1389200215666140908101604","article-title":"Matrix trace operators: From spectral moments of molecular graphs and complex networks to perturbations in synthetic reactions, micelle nanoparticles, and drug ADME processes","volume":"15","author":"Arrasate","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1021\/acs.langmuir.5b03074","article-title":"Self-assembled binary nanoscale systems: Multioutput model with lfer-covariance perturbation theory and an experimental\u2013computational study of nagdc-ddab micelles","volume":"31","author":"Messina","year":"2015","journal-title":"Langmuir"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1021\/bm050549w","article-title":"Effects of Fluorinated and Hydrogenated Surfactants on Human Serum Albumin at Different pHs","volume":"7","author":"Prieto","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.ijbiomac.2020.07.044","article-title":"Mapping the underlying mechanisms of fibrinogen benzothiazole drug interactions using computational and experimental approaches","volume":"163","author":"Scanavachi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0301-4622(01)00196-X","article-title":"Adsorption of an amphiphilic penicillin onto human serum albumin: Characterisation of the complex","volume":"92","author":"Ruso","year":"2001","journal-title":"Biophys. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"114667","DOI":"10.1016\/j.molliq.2020.114667","article-title":"Exploring the conformational binding mechanism of fibrinogen induced by interactions with penicillin \u03b2-lactam antibiotic drugs","volume":"324","author":"Rial","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"110017","DOI":"10.1016\/j.msec.2019.110017","article-title":"Molecular dynamics simulation of the adsorption behavior of two different drugs on hydroxyapatite and Zn-doped hydroxyapatite","volume":"105","author":"Shang","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00170-015-6989-2","article-title":"A new computational intelligence approach in formulation of functional relationship of open porosity of the additive manufacturing process","volume":"80","author":"Garg","year":"2015","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"ref_85","first-page":"e00516","article-title":"Ensemble learning prediction of transmittance at different wavenumbers in natural hydroxyapatite","volume":"9","author":"Okafor","year":"2020","journal-title":"Sci. Afr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1016\/j.ceramint.2020.12.026","article-title":"Structural features modeling of substituted hydroxyapatite nanopowders as bone fillers via machine learning","volume":"47","author":"Yu","year":"2021","journal-title":"Ceram. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1021\/ac103336h","article-title":"Classification of protein binding in hydroxyapatite chromatography: Synergistic interactions on the molecular scale","volume":"83","author":"Hou","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"154706","DOI":"10.1063\/1.5025329","article-title":"Optoelectronics and defect levels in hydroxyapatite by first-principles","volume":"148","author":"Avakyan","year":"2018","journal-title":"J. Chem. Phys."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cplett.2004.08.006","article-title":"Surface energetics of hydroxyapatite: A DFT study","volume":"396","author":"Zhu","year":"2004","journal-title":"Chem. Phys. Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16457","DOI":"10.1039\/C6CP00474A","article-title":"Hydroxyapatite substituted by transition metals: Experiment and theory","volume":"18","author":"Zilm","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"20331","DOI":"10.1039\/C5CP01986A","article-title":"The Interplay of manganese and nitrate in hydroxyapatite nanoparticles as revealed by pulsed EPR and DFT","volume":"17","author":"Gafurov","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"15899","DOI":"10.1016\/j.ceramint.2017.08.164","article-title":"Temperature dependent structural and vibrational properties of hydroxyapatite: A theoretical and experimental study","volume":"43","author":"Kebiroglu","year":"2017","journal-title":"Ceram. Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.msec.2005.01.011","article-title":"Controlled drug delivery from porous hydroxyapatite grafts: An experimental and theoretical approach","volume":"25","author":"Palazzo","year":"2005","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"8385","DOI":"10.1039\/b914379c","article-title":"Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals","volume":"19","author":"Iafisco","year":"2009","journal-title":"J. Mater. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.msec.2019.04.037","article-title":"Noble microfluidic system for bioceramic nanoparticles engineering","volume":"102","author":"Rial","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/ie9005436","article-title":"High throughput methodology for continuous preparation of hydroxyapatite nanoparticles in a microporous tube-in-tube microchannel reactor","volume":"49","author":"Yang","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fbioe.2019.00168","article-title":"3D microfluidic bone tumor microenvironment comprised of hydroxyapatite\/fibrin composite","volume":"7","author":"Ahn","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1039\/C5LC00698H","article-title":"Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix","volume":"15","year":"2015","journal-title":"Lab. A Chip"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/10408347.2016.1169912","article-title":"Microfluidic synthesis of nanoparticles and their biosensing applications","volume":"46","author":"Boken","year":"2016","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/acsabm.9b00853","article-title":"Microfluidic methods for fabrication and engineering of nanoparticle drug delivery systems","volume":"3","author":"Zhang","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1021\/acs.langmuir.0c02408","article-title":"Dual Stimuli-Responsive Pickering Emulsions from Novel Magnetic Hydroxyapatite Nanoparticles and Their Characterization Using a Microfluidic Platform","volume":"37","author":"Mendiratta","year":"2021","journal-title":"Langmuir"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.nano.2015.04.005","article-title":"Enhanced osteogenic differentiation of stem cells via microfluidics synthesized nanoparticles","volume":"11","author":"Hajrezaei","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"126072","DOI":"10.1016\/j.colsurfa.2020.126072","article-title":"Sr2+ adsorbents produced by microfluidics","volume":"613","author":"Ding","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2016.10.040","article-title":"Electrospinning versus microfluidic spinning of functional fibers for biomedical applications","volume":"114","author":"Cheng","year":"2017","journal-title":"Biomaterials"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cej.2012.11.014","article-title":"Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems","volume":"215","author":"Castro","year":"2013","journal-title":"Chem. Eng. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"117768","DOI":"10.1016\/j.lfs.2020.117768","article-title":"Microfluidic fabrication of alendronate-loaded chitosan nanoparticles for enhanced osteogenic differentiation of stem cells","volume":"254","author":"Moradikhah","year":"2020","journal-title":"Life Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ces.2013.01.002","article-title":"Process intensification and optimization for hydroxyapatite nanoparticles production","volume":"100","author":"Castro","year":"2013","journal-title":"Chem. Eng. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.msec.2007.04.005","article-title":"Surface modification of nanophase hydroxyapatite with chitosan","volume":"28","author":"Wilson","year":"2008","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/adfm.200600361","article-title":"Biomimetic Hydroxyapatite\u2013Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties","volume":"17","author":"Palazzo","year":"2007","journal-title":"Adv. Funct. Mater."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0142-9612(00)00279-9","article-title":"Poly (lactide-co-glycolide)\/hydroxyapatite delivery of BMP-2-producing cells: A regional gene therapy approach to bone regeneration","volume":"22","author":"Laurencin","year":"2001","journal-title":"Biomaterials"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1016\/j.biomaterials.2003.11.038","article-title":"Combination of porous hydroxyapatite and cationic liposomes as a vector for BMP-2 gene therapy","volume":"25","author":"Ono","year":"2004","journal-title":"Biomaterials"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1016\/j.bbagen.2013.07.020","article-title":"Manipulating the bioactivity of hydroxyapatite nano-rods structured networks: Effects on mineral coating morphology and growth kinetic","volume":"1830","author":"Gravina","year":"2013","journal-title":"Biochim. Biophys. Acta (Bba) Gen. Subj."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.colsurfb.2016.05.019","article-title":"Biomimetic fiber mesh scaffolds based on gelatin and hydroxyapatite nano-rods: Designing intrinsic skills to attain bone reparation abilities","volume":"145","author":"Sartuqui","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11443","DOI":"10.1016\/j.ceramint.2020.02.001","article-title":"Ion-doped hydroxyapatite: An impasse or the road to follow?","volume":"46","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"15698","DOI":"10.1021\/acsami.7b02241","article-title":"Manipulation of Mg2+\u2013Ca2+ switch on the development of bone mimetic hydroxyapatite","volume":"9","author":"Ruso","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"17277","DOI":"10.1039\/C9NR01236B","article-title":"Self-fluorescent antibiotic MoOx\u2013hydroxyapatite: A nano-theranostic platform for bone infection therapies","volume":"11","author":"Placente","year":"2019","journal-title":"Nanoscale"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"124081","DOI":"10.1016\/j.colsurfa.2019.124081","article-title":"Synthesis and characterization of silver nanoparticles-doped hydroxyapatite\/alginate microparticles with promising cytocompatibility and antibacterial properties","volume":"585","author":"Zhou","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.colcom.2019.01.001","article-title":"Ultrasound-assisted synthesis and characterization of heparin-coated Eu3+ doped hydroxyapatite luminescent nanoparticles","volume":"29","author":"Xing","year":"2019","journal-title":"Colloid Interface Sci. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1021\/acs.cgd.9b00831","article-title":"Mineralization of layer-by-layer ultrathin films containing microfluidic-produced hydroxyapatite nanorods","volume":"19","author":"Rial","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jcis.2020.03.086","article-title":"Development and characterisation of bilayered periosteum-inspired composite membranes based on sodium alginate-hydroxyapatite nanoparticles","volume":"572","author":"Silva","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1021\/la049182r","article-title":"Complexation between dodecyl sulfate surfactant and zein protein in solution","volume":"20","author":"Ruso","year":"2004","journal-title":"Langmuir"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jcis.2011.06.010","article-title":"Fibrinogen stability under surfactant interaction","volume":"362","author":"Hassan","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jcis.2017.01.047","article-title":"Albumin-mediated deposition of bone-like apatite onto nano-sized surfaces: Effect of surface reactivity and interfacial hydration","volume":"494","author":"Gravina","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1021\/acs.langmuir.7b03573","article-title":"Structural and kinetic visualization of the protein corona on bioceramic nanoparticles","volume":"34","author":"Rial","year":"2018","journal-title":"Langmuir"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2174\/1568026618666180810151539","article-title":"Mechanical properties of composite hydrogels for tissue engineering","volume":"18","author":"Rial","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Rial, R., Liu, Z., and Ruso, J.M. (2020). Soft actuated hybrid hydrogel with bioinspired complexity to control mechanical flexure behavior for tissue engineering. Nanomaterials, 10.","DOI":"10.3390\/nano10071302"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/jcis.1999.6300","article-title":"Influence of Molecular Structure on the Ideality of Mixing in Micelles Formed in Binary Mixtures of Surface-Active Drugs","volume":"216","author":"Taboada","year":"1999","journal-title":"J. Colloid Interface Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1021\/la9912904","article-title":"Interaction between Penicillins and Human Serum Albumin: A \u03b6-Potential Study","volume":"16","author":"Taboada","year":"2000","journal-title":"Langmuir"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/la990538m","article-title":"Interaction between Penicillins and Human Serum Albumin: A Thermodynamic Study of Micellar-like Clusters on a Protein","volume":"16","author":"Taboada","year":"2000","journal-title":"Langmuir"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e1504","DOI":"10.1002\/wnan.1504","article-title":"Recent progress on fabrication and drug delivery applications of nanostructured hydroxyapatite","volume":"10","author":"Mondal","year":"2018","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"101131","DOI":"10.1016\/j.jddst.2019.101131","article-title":"3D hydroxyapatite scaffold for bone regeneration and local drug delivery applications","volume":"53","author":"Mondal","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.msec.2019.01.098","article-title":"Adsorption\/desorption study of antibiotic and anti-inflammatory drugs onto bioactive hydroxyapatite nano-rods","volume":"99","author":"Benedini","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0021-9517(03)00217-3","article-title":"A heterogeneous Ru\u2013hydroxyapatite catalyst for mild racemization of alcohols","volume":"219","author":"Wuyts","year":"2003","journal-title":"J. Catal."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1021\/ie0711731","article-title":"Synthesis of biogasoline from ethanol over hydroxyapatite catalyst","volume":"47","author":"Tsuchida","year":"2008","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.apcatb.2011.07.009","article-title":"Copper loaded hydroxyapatite catalyst for selective catalytic reduction of nitric oxide with ammonia","volume":"107","author":"Tounsi","year":"2011","journal-title":"Appl. Catal. B Environ."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"45420","DOI":"10.1039\/C7RA08781K","article-title":"High efficiency and stability of Au\u2013Cu\/hydroxyapatite catalyst for the oxidation of carbon monoxide","volume":"7","author":"Guo","year":"2017","journal-title":"RSC Adv."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.apsusc.2017.11.218","article-title":"Use of micrometric latex beads to improve the porosity of hydroxyapatite obtained by chemical coprecipitation method","volume":"436","author":"Webler","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.enconman.2015.04.012","article-title":"Biodiesel production from palm oil using active and stable K doped hydroxyapatite catalysts","volume":"98","author":"Chen","year":"2015","journal-title":"Energy Convers. Manag."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/BF00353102","article-title":"An evaluation of hydroxyapatite-based filters for removal of heavy metal ions from aqueous solutions","volume":"31","author":"Reichert","year":"1996","journal-title":"J. Mater. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2320\/matertrans.44.1133","article-title":"Control of crystal orientation of hydroxyapatite by imposition of a high magnetic field","volume":"44","author":"Inoue","year":"2003","journal-title":"Mater. Trans."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Zhang, C., Uchikoshi, T., Liu, L., Kikuchi, M., and Ichinose, I. (2020). Effect of Surface Modification with TiO2 Coating on Improving Filtration Efficiency of Whisker-Hydroxyapatite (HAp) Membrane. Coatings, 10.","DOI":"10.3390\/coatings10070670"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"17198","DOI":"10.1021\/acssuschemeng.9b03793","article-title":"Nanofiltration Filter Paper Based on Ultralong Hydroxyapatite Nanowires and Cellulose Fibers\/Nanofibers","volume":"7","author":"Zhang","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ceramint.2005.10.014","article-title":"Preparation and properties of hydroxyapatite filters for microbial filtration","volume":"33","author":"Yang","year":"2007","journal-title":"Ceram. Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/bit.10388","article-title":"Purification of a functional gene therapy vector derived from Moloney murine leukaemia virus using membrane filtration and ceramic hydroxyapatite chromatography","volume":"80","author":"Kuiper","year":"2002","journal-title":"Biotechnol. Bioeng."},{"key":"ref_145","first-page":"2300","article-title":"Application of the hydroxyapatite crystallization-filtration process to recover phosphorus from wastewater effluents","volume":"81","author":"Chang","year":"2020","journal-title":"Water Sci. Technol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"17482","DOI":"10.1039\/C7TA03870D","article-title":"Flexible hydroxyapatite ultralong nanowire-based paper for highly efficient and multifunctional air filtration","volume":"5","author":"Xiong","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"121139","DOI":"10.1016\/j.jhazmat.2019.121139","article-title":"Hydroxyapatite, a multifunctional material for air, water and soil pollution control: A review","volume":"383","author":"Ibrahim","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"07B313","DOI":"10.1063\/1.3561149","article-title":"Poly (caprolactone) based magnetic scaffolds for bone tissue engineering","volume":"109","author":"Gloria","year":"2011","journal-title":"J. Appl. Phys."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jmmm.2015.01.075","article-title":"Microemulsion synthesis and magnetic properties of hydroxyapatite-encapsulated nano CoFe2O4","volume":"382","author":"Foroughi","year":"2015","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.jmmm.2008.12.027","article-title":"Magnetic properties of Co-ferrite-doped hydroxyapatite nanoparticles having a core\/shell structure","volume":"321","author":"Petchsang","year":"2009","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.materresbull.2010.09.010","article-title":"Temperature dependence of magnetic property and photocatalytic activity of Fe3O4\/hydroxyapatite nanoparticles","volume":"45","author":"Liu","year":"2010","journal-title":"Mater. Res. Bull."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jmmm.2010.11.080","article-title":"Synthesis and hyperthermia property of hydroxyapatite\u2013ferrite hybrid particles by ultrasonic spray pyrolysis","volume":"323","author":"Inukai","year":"2011","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.actbio.2009.09.017","article-title":"A novel route in bone tissue engineering: Magnetic biomimetic scaffolds","volume":"6","author":"Bock","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.actbio.2011.09.032","article-title":"Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite","volume":"8","author":"Tampieri","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/cm4007298","article-title":"Magnetic Bioactive and Biodegradable Hollow Fe-Doped Hydroxyapatite Coated Poly(l-lactic) Acid Micro-nanospheres","volume":"25","author":"Iafisco","year":"2013","journal-title":"Chem. Mater."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.proeng.2013.05.116","article-title":"Systematic analysis of injectable materials and 3D rapid prototyped magnetic scaffolds: From CNS applications to soft and hard tissue repair\/regeneration","volume":"59","author":"Russo","year":"2013","journal-title":"Procedia Eng."},{"key":"ref_157","first-page":"1","article-title":"Hyperthermia induced in magnetic scaffolds for bone tissue engineering","volume":"50","author":"Sandri","year":"2014","journal-title":"IEEE Trans. Magn."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Sprio, S., Campodoni, E., Sandri, M., Preti, L., Keppler, T., M\u00fcller, F.A., Pugno, N.M., and Tampieri, A. (2018). A graded multifunctional hybrid scaffold with superparamagnetic ability for periodontal regeneration. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113604"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1021\/acs.langmuir.8b02602","article-title":"Interaction of folic acid with nanocrystalline apatites and extension to methotrexate (antifolate) in view of anticancer applications","volume":"34","author":"Sarda","year":"2018","journal-title":"Langmuir"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"20180236","DOI":"10.1098\/rsif.2018.0236","article-title":"A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: Potential application for cardiovascular diseases","volume":"15","author":"Marrella","year":"2018","journal-title":"J. R. Soc. Interface"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.2217\/nnm-2018-0372","article-title":"Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain","volume":"14","author":"Adamiano","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"111410","DOI":"10.1016\/j.msec.2020.111410","article-title":"Bio-inspired polymeric iron-doped hydroxyapatite microspheres as a tunable carrier of rhBMP-2","volume":"119","author":"Mumcuoglu","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Sridharan, B., Devarajan, N., Jobanputra, R., Gowd, G.S., Anna, I.M., Ashokan, A., Nair, S., and Koyakutty, M. (2021). nCP: Fe Nanocontrast Agent for Magnetic Resonance Imaging-Based Early Detection of Liver Cirrhosis and Hepatocellular Carcinoma. Acs Appl. Bio Mater.","DOI":"10.1021\/acsabm.1c00001"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3190\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:08:19Z","timestamp":1760162899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/11\/3190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":163,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["molecules26113190"],"URL":"https:\/\/doi.org\/10.3390\/molecules26113190","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]}}}