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Ecol. Agric. For."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2174\/1385272819666150119225952","article-title":"Anti-cancer and Anti-angiogenic Properties of Various Natural Pentacyclic Tri-terpenoids and Some of their Chemical Derivatives","volume":"19","author":"Mokhtari","year":"2015","journal-title":"Curr. Org. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1016\/j.febslet.2006.10.038","article-title":"(2\u03b1,3\u03b2)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells","volume":"580","author":"Centelles","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1055\/s-0029-1186102","article-title":"Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy","volume":"75","author":"Laszczyk","year":"2009","journal-title":"Planta Medica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jprot.2013.02.031","article-title":"Maslinic acid, a triterpenic anti-tumoural agent, interferes with cytoskeleton protein expression in HT29 human colon-cancer cells","volume":"83","author":"Mokhtari","year":"2013","journal-title":"J. Proteom."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Tena, S., Reyes-Zurita, F.J., Diaz-Moralli, S., Vinardell, M.P., Reed, M., Garcia-Garcia, F., Dopazo, J., Lupi\u00e1\u00f1ez, J.A., G\u00fcnther, U., and Cascante, M. (2013). Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin\/+ Mice through Transcriptomic and Metabolomic Reprogramming. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059392"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.biochi.2013.08.017","article-title":"Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells","volume":"95","author":"Medina","year":"2013","journal-title":"Biochimie"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Reyes-Zurita, F.J., Rufino-Palomares, E.E., Garc\u00eda-Salguero, L., Perag\u00f3n, J., Medina, P.P., Parra, A., Cascante, M., and Lupi\u00e1\u00f1ez, J.A. (2016). Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146178"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1158\/0008-5472.CAN-06-3735","article-title":"Betulinic Acid Inhibits Prostate Cancer Growth through Inhibition of Specificity Protein Transcription Factors","volume":"67","author":"Chintharlapalli","year":"2007","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1021\/jf103904b","article-title":"Antiangiogenic Potential of Three Triterpenic Acids in Human Liver Cancer Cells","volume":"59","author":"Lin","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.canlet.2014.01.016","article-title":"Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence","volume":"346","author":"Shanmugam","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bonel-P\u00e9rez, G.C., P\u00e9rez-Jim\u00e9nez, A., Gris-C\u00e1rdenas, I., Parra-P\u00e9rez, A., Lupi\u00e1\u00f1ez, J., Reyes-Zurita, F.J., Siles, E., Csuk, R., Perag\u00f3n, J., and Rufino-Palomares, E.E. (2020). Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0\/G1 Cell Cycle Arrest, ROS Production and AKT\/PI3K Signaling Pathway. Molecules, 25.","DOI":"10.3390\/molecules25184254"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1055\/s-2003-39698","article-title":"Antioxidant Activity of Maslinic Acid, a Triterpene Derivative Obtained from Olea europaea","volume":"69","author":"Montilla","year":"2003","journal-title":"Planta Medica"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/272457","article-title":"Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions","volume":"2015","author":"Mokhtari","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mokhtari, K., P\u00e9rez-Jim\u00e9nez, A., Garc\u00eda-Salguero, L., Lupi\u00e1\u00f1ez, J.A., and Rufino-Palomares, E.E. (2020). Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide. Molecules, 25.","DOI":"10.20944\/preprints202008.0077.v1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cyto.2006.12.007","article-title":"Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells","volume":"36","author":"Yaqoob","year":"2006","journal-title":"Cytokine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00210-009-0399-7","article-title":"Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells","volume":"379","author":"Zhang","year":"2009","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejphar.2011.07.037","article-title":"Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen\u2013glucose deprivation-induced injury","volume":"670","author":"Qian","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/jmf.2012.2191","article-title":"Maslinic Acid Protects Against Isoproterenol-Induced Cardiotoxicity in Albino Wistar Rats","volume":"15","author":"Shaik","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Khathi, A., Serumula, M.R., Myburg, R.B., Van Heerden, F., and Musabayane, C.T. (2013). Effects of Syzygium aromaticum-Derived Triterpenes on Postprandial Blood Glucose in Streptozotocin-Induced Diabetic Rats Following Carbohydrate Challenge. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081632"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.phymed.2016.07.001","article-title":"Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea","volume":"23","author":"Mokhtari","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/14756360701633187","article-title":"Oleanolic acid and related derivatives as medicinally important compounds","volume":"23","author":"Sultana","year":"2008","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejmech.2013.12.049","article-title":"Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents","volume":"74","author":"Parra","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1021\/acs.jnatprod.9b00649","article-title":"Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease","volume":"82","author":"Rivas","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1111\/j.1742-4658.2011.08220.x","article-title":"Multi-targeted activity of maslinic acid as an antimalarial natural compound","volume":"278","author":"Moneriz","year":"2011","journal-title":"FEBS J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cbpc.2007.09.010","article-title":"Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss)","volume":"147","author":"Amores","year":"2008","journal-title":"Comp. Biochem. Physiol. Part. C Toxicol. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1002\/pmic.201000271","article-title":"Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid","volume":"11","year":"2011","journal-title":"Proteomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1365-2095.2011.00933.x","article-title":"Maslinic acid, a natural triterpene, and ration size increased growth and protein turnover of white muscle in gilthead sea bream (Sparus aurata)","volume":"18","year":"2012","journal-title":"Aquac. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.canlet.2008.07.033","article-title":"Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway","volume":"273","author":"Cascante","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Reyes-Zurita, F.J., Pach\u00f3n-Pe\u00f1a, G., Liz\u00e1rraga, D., Rufino-Palomares, E.E., Cascante, M., and Lupi\u00e1\u00f1ez, J.A. (2011). The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-154"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0044-8486(94)90353-0","article-title":"The influence of dietary protein on the kinetics of NADPH production systems in various tissues of rainbow trout (Oncorhynchus mykiss)","volume":"124","author":"Barroso","year":"1994","journal-title":"Aquaculture"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0020-711X(87)90310-7","article-title":"Differential behaviour of glucose 6-phosphate dehydrogenase in two morphological forms of Trypanosoma cruzi","volume":"19","author":"Adroher","year":"1987","journal-title":"Int. J. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00223564","article-title":"Differential energetic metabolism during Trypanosoma cruzi differentiation. II. Hexokinase, phosphofructokinase and pyruvate kinase","volume":"94","author":"Adroher","year":"1990","journal-title":"Mol. Cell. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2095.1996.tb00059.x","article-title":"Long-term nutritional effects on the primary liver and kidney metabolism in rainbow trout (Oncorhynchus mykiss). II. Adaptive response of glucose 6-phosphate dehydrogenase activity to high-carbohydrate\/low-protein and high-fat\/non-carbohydrate diets","volume":"2","year":"1996","journal-title":"Aquac. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1357-2725(01)00050-4","article-title":"Carbohydrate deprivation reduces NADPH-production in fish liver but not in adipose tissue","volume":"33","author":"Barroso","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3600001","article-title":"Structure, function and evolution of glutathione transferases: Implications for classification of non-mammalian members of an ancient enzyme superfamily","volume":"360","author":"Sheehan","year":"2001","journal-title":"Biochem. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1104\/pp.121.3.921","article-title":"Peroxisomal NADP-Dependent Isocitrate Dehydrogenase. Characterization and Activity Regulation during Natural Senescence","volume":"121","author":"Corpas","year":"1999","journal-title":"Plant. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/co500051z","article-title":"Solid-Phase Library Synthesis of Bi-Functional Derivatives of Oleanolic and Maslinic Acids and Their Cytotoxicity on Three Cancer Cell Lines","volume":"16","author":"Parra","year":"2014","journal-title":"ACS Comb. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"93590","DOI":"10.1039\/C6RA18879F","article-title":"The oleanolic acid derivative, 3-O-succinyl-28-O-benzyl oleanolate, induces apoptosis in B16\u2013F10 melanoma cells via the mitochondrial apoptotic pathway","volume":"6","author":"Rivas","year":"2016","journal-title":"RSC Adv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejmech.2016.04.016","article-title":"Semi-synthesis and antiproliferative evaluation of PEGylated pentacyclic triterpenes","volume":"118","author":"Rivas","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fitote.2017.05.006","article-title":"Synthesis and in vitro antiproliferative evaluation of PEGylated triterpene acids","volume":"120","author":"Rivas","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejmech.2018.02.044","article-title":"Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents","volume":"148","author":"Rivas","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Jannus, F., Medina-O\u2019Donnell, M., Rivas, F., D\u00edaz-Ruiz, L., Rufino-Palomares, E.E., Lupi\u00e1\u00f1ez, J.A., Parra, A., and Reyes-Zurita, F.J. (2020). A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells. Biomolecules, 10.","DOI":"10.3390\/biom10101375"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1021\/acs.jnatprod.1c00128","article-title":"Synthesis and Biological Activity of Triterpene\u2013Coumarin Conjugates","volume":"84","author":"Rivas","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/697390","article-title":"Recent Progress of Propolis for Its Biological and Chemical Compositions and Its Botanical Origin","volume":"2013","author":"Toreti","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wezgowiec, J., Wieczynska, A., Wieckiewicz, W., Kulbacka, J., Saczko, J., Pachura, N., Wieckiewicz, M., Gancarz, R., and Wilk, K.A. (2020). Polish Propolis\u2014Chemical Composition and Biological Effects in Tongue Cancer Cells and Macrophages. Molecules, 25.","DOI":"10.3390\/molecules25102426"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nguyen, N.H., Pham, Q.T., Luong, T.N.H., Le, H.K., and Vo, V.G. (2020). Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati). Biomolecules, 10.","DOI":"10.3390\/biom10020201"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Nguyen, N.H., Ta, Q.T.H., Pham, Q.T., Luong, T.N.H., Phung, V.T., Duong, T.H., and Vo, V.G. (2020). Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells. Molecules, 25.","DOI":"10.3390\/molecules25122912"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ptr.2023","article-title":"Moringa oleifera: A food plant with multiple medicinal uses","volume":"21","author":"Anwar","year":"2006","journal-title":"Phytother. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Luetragoon, T., Sranujit, R.P., Noysang, C., Thongsri, Y., Potup, P., Suphrom, N., Nuengchamnong, N., and Usuwanthim, K. (2020). Anti-Cancer Effect of 3-Hydroxy-\u03b2-Ionone Identified from Moringa oleifera Lam. Leaf on Human Squamous Cell Carcinoma 15 Cell Line. Molecules, 25.","DOI":"10.3390\/molecules25163563"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Jabeen, A., Sharma, A., Gupta, I., Kheraldine, H., Vranic, S., Al Moustafa, A.-E., and Al Farsi, H.F. (2020). Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells. Molecules, 25.","DOI":"10.3390\/molecules25184240"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Roda, E., De Luca, F., Locatelli, C.A., Ratto, D., Di Iorio, C., Savino, E., Bottone, M.G., and Rossi, P. (2020). From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases. Molecules, 25.","DOI":"10.3390\/molecules25225400"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Huang, X.F., Sheu, G.T., Chang, K.F., Huang, Y.C., Hung, P.H., and Tsai, N.M. (2020). Pogostemon cablin Triggered ROS-Induced DNA Damage to Arrest Cell Cycle Progression and Induce Apoptosis on Human Hepatocellular Carcinoma In Vitro and In Vivo. Molecules, 25.","DOI":"10.3390\/molecules25235639"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Rotondo, R., Oliva, M.A., Staffieri, S., Castaldo, S., Giangaspero, F., and Arcella, A. (2020). Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth. Molecules, 25.","DOI":"10.3390\/molecules25245843"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Vilari\u00f1o, M., Garc\u00eda-Sanmart\u00edn, J., Ochoa-Callejero, L., L\u00f3pez-Rodr\u00edguez, A., Blanco-Urgoiti, J., and Mart\u00ednez, A. (2020). Macrocybin, a Natural Mushroom Triglyceride, Reduces Tumor Growth In Vitro and In Vivo Through Caveolin-Mediated Interference with the Actin Cytoskeleton. Molecules, 25.","DOI":"10.1101\/2020.12.10.418863"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Grymel, M., Pastuch-Gawo\u0142ek, G., Lalik, A., Zawojak, M., Boczek, S., Krawczyk, M., and Erfurt, K. (2020). Glycoconjugation of Betulin Derivatives Using Copper-Catalyzed 1,3-Dipolar Azido-Alkyne Cycloaddition Reaction and a Preliminary Assay of Cytotoxicity of the Obtained Compounds. Molecules, 25.","DOI":"10.3390\/molecules25246019"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ferraz da Costa, D.C., Rangel, L.P., Quarti, J., Santos, R.A., Silva, J.L., and Fialho, E. (2020). Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy. Molecules, 25.","DOI":"10.3390\/molecules25153531"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Muniyandi, K., George, B., Parimelazhagan, T., and Abrahamse, H. (2020). Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer. Molecules, 25.","DOI":"10.3390\/molecules25184102"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Verebov\u00e1, V., Bene\u0161, J., and Stani\u010dov\u00e1, J. (2020). Biophysical Characterization and Anticancer Activities of Photosensitive Phytoanthraquinones Represented by Hypericin and Its Model Compounds. Molecules, 25.","DOI":"10.3390\/molecules25235666"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Hoenke, S., Serbian, I., Deigner, H.P., and Csuk, R. (2020). Mitocanic Di- and Triterpenoid Rhodamine B Conjugates. Molecules, 25.","DOI":"10.3390\/molecules25225443"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/15\/4701\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:39:47Z","timestamp":1760164787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/15\/4701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":63,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["molecules26154701"],"URL":"https:\/\/doi.org\/10.3390\/molecules26154701","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]}}}