{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:22:49Z","timestamp":1777443769692,"version":"3.51.4"},"reference-count":165,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI-QFI\/29236\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QFI\/29236\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["MDM-2016-0618"],"award-info":[{"award-number":["MDM-2016-0618"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019124","name":"Diputaci\u00f3n Foral de Gipuzkoa","doi-asserted-by":"publisher","award":["Gipuzkoa Fellows Program"],"award-info":[{"award-number":["Gipuzkoa Fellows Program"]}],"id":[{"id":"10.13039\/501100019124","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Higher Education and Scientific Research of Tunisia","award":["Grants for stays in Portugal and Spain"],"award-info":[{"award-number":["Grants for stays in Portugal and Spain"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medical strategy is also being explored in this field. Up to three strategies for the use of DNA as target have been studied in our research lines during the last few years: (1) the intercalation of phenanthroline derivatives with duplex DNA; (2) the interaction of metal complexes containing phenanthroline with G-quadruplexes; and (3) the activity of Mo polyoxometalates and other Mo-oxo species as artificial phosphoesterases to catalyze the hydrolysis of phosphoester bonds in DNA. We demonstrate some promising computational results concerning the favorable interaction of these small molecules with DNA that could correspond to cytotoxic effects against tumoral cells and microorganisms. Therefore, our results open the door for the pharmaceutical and medical applications of the compounds we propose.<\/jats:p>","DOI":"10.3390\/molecules26164737","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:35:32Z","timestamp":1628156132000},"page":"4737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes"],"prefix":"10.3390","volume":"26","author":[{"given":"\u00c1ngel","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-7328","authenticated-orcid":false,"given":"Nuno A. G.","family":"Bandeira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Iker","family":"Ortiz de Luzuriaga","sequence":"additional","affiliation":[{"name":"CIC nanoGUNE BRTA, Tolosa Hiribidea 76, Euskadi, 20018 Donostia-San Sebasti\u00e1n, Spain"},{"name":"Polimero eta Material Aurreratuak, Fisika, Kimika eta Teknologia Saila, Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV\/EHU), Paseo Manuel de Lardizabal 3, 20018 Donostia-San Sebasti\u00e1n, Spain"}]},{"given":"Frederico F.","family":"Martins","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Sawssen","family":"Elleuchi","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Inorganique, LR17ES07, Facult\u00e9 de Sciences de Sfax, Universit\u00e9 de Sfax, Sfax 3000, Tunisia"}]},{"given":"Khaled","family":"Jarraya","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Inorganique, LR17ES07, Facult\u00e9 de Sciences de Sfax, Universit\u00e9 de Sfax, Sfax 3000, Tunisia"}]},{"given":"Jose","family":"Lanuza","sequence":"additional","affiliation":[{"name":"Polimero eta Material Aurreratuak, Fisika, Kimika eta Teknologia Saila, Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV\/EHU), Paseo Manuel de Lardizabal 3, 20018 Donostia-San Sebasti\u00e1n, Spain"},{"name":"Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, 20018 Donostia-San Sebasti\u00e1n, Spain"}]},{"given":"Xabier","family":"Lopez","sequence":"additional","affiliation":[{"name":"Polimero eta Material Aurreratuak, Fisika, Kimika eta Teknologia Saila, Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV\/EHU), Paseo Manuel de Lardizabal 3, 20018 Donostia-San Sebasti\u00e1n, Spain"},{"name":"Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, 20018 Donostia-San Sebasti\u00e1n, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-3569","authenticated-orcid":false,"given":"Maria Jos\u00e9","family":"Calhorda","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Adri\u00e0","family":"Gil","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias, BioISI-Biosystems and Integrative Sciences Institute, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"},{"name":"CIC nanoGUNE BRTA, Tolosa Hiribidea 76, Euskadi, 20018 Donostia-San Sebasti\u00e1n, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Scheffler, R.W., and Strasser, B.J. 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