{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:23:00Z","timestamp":1769264580920,"version":"3.49.0"},"reference-count":67,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/128817\/2017"],"award-info":[{"award-number":["SFRH\/BD\/128817\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The development of coastal regions has contributed to the intensification of environmental contamination, which can accumulate in aquatic biota, such as shrimps. These crustaceans, besides being delicious and being a good source of nutrients, can also accumulate environmental pollutants. Amongst others, these include organochlorine pesticides (OCPs), organophosphorus pesticides (OPPs), brominated flame retardants (BFRs), polychlorinated biphenyls (PCBs) and synthetic musks (SMs). These pollutants, classified as endocrine disruptors, are related to adverse effects in humans and since one of the major routes of exposition is ingestion, this is a cause for concern regarding their presence in food. The aim of the present study was to quantify the presence of environmental pollutants in shrimp samples and in the water from their habitat along the northwest Portuguese coast. In seawater samples, only two OCPs (lindane and DDD) and one BFR (BTBPE) were detected, and in shrimp samples, one OCP (DDD) and three SMs (HHCB, AHTN and ketone) were found. Bioaccumulation and the risk assessment of dietary exposure of SMs in shrimp samples were investigated. It was observed that all shrimp samples analyzed significantly presented bioaccumulation of the three SMs found. Concentrations of SMs detected in shrimp samples do not present a health risk for the adult Portuguese population.<\/jats:p>","DOI":"10.3390\/molecules26195774","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:30:33Z","timestamp":1632443433000},"page":"5774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Validation and Evaluation of Selected Organic Pollutants in Shrimp and Seawater Samples from the NW Portuguese Coast"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-3822","authenticated-orcid":false,"given":"Maria Luz","family":"Maia","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"},{"name":"Center for Research in Health Technologies and Information Systems, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]},{"given":"Concei\u00e7\u00e3o","family":"Calhau","sequence":"additional","affiliation":[{"name":"Center for Research in Health Technologies and Information Systems, 4200-450 Porto, Portugal"},{"name":"Nutri\u00e7\u00e3o e Metabolismo, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3472-849X","authenticated-orcid":false,"given":"Valentina Fernandes","family":"Domingues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV-GRAQ, Instituto Superior de Engenharia do Porto, Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.envpol.2003.08.039","article-title":"Latitudinal and seasonal capacity of the surface oceans as a reservoir of polychlorinated biphenyls","volume":"128","author":"Jurado","year":"2004","journal-title":"Environ. Pollut."},{"key":"ref_2","unstructured":"(2021, March 05). EU Directive 2013\/39\/EU of the European Parliament and of the Council of 12 August 2013 Amending Directives 2000\/60\/EC and 2008\/105\/EC as Regards Priority Substances in the Field of Water Policy. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2013:226:0001:0017:en:PDF."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1177\/0960327110396535","article-title":"Impact of pesticides residue and heavy metals on lipids and fatty acids composition of some seafoods of Red Sea (KSA)","volume":"30","author":"Moselhy","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/ejlt.201200081","article-title":"The effects of season on fat and fatty acids contents of shrimp and prawn species","volume":"115","author":"Ayas","year":"2013","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_5","first-page":"1487","article-title":"Shrimps\u2014A nutritional perspective","volume":"104","author":"Dayal","year":"2013","journal-title":"Curr. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s00128-012-0561-7","article-title":"Seasonal variation of polychlorinated biphenyls and organochlorine pesticide levels of sea and cultured farm fish in the Samsun Region of Turkey","volume":"88","author":"Aksoy","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2016.02.156","article-title":"Rapid determination of organochlorine pesticides in fish using selective pressurized liquid extraction and gas chromatography\u2013mass spectrometry","volume":"205","author":"Choi","year":"2016","journal-title":"Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-019-09521-z","article-title":"Endocrine disrupting chemicals: Exposure, effects on human health, mechanism of action, models for testing and strategies for prevention","volume":"21","author":"Yilmaz","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_9","unstructured":"(2009). EPA Persistent Organic Pollutants: A Global Issue, A Global Response."},{"key":"ref_10","unstructured":"(2021, April 04). Stockholm Convention Protecting Human Health and the Environment from Persistent Organic Pollutants. Gen\u00e8ve, Switzerland. Available online: http:\/\/www.pops.int\/TheConvention\/Overview\/tabid\/3351\/Default.aspx."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10337-015-2846-6","article-title":"Development of a Multiresidue Method for the Analysis of 33 Organochlorine Pesticide Residues in Fatty and High Water Content Foods","volume":"78","author":"Chung","year":"2015","journal-title":"Chromatographia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.toxrep.2019.06.004","article-title":"Genetic polymorphisms as determinants of pesticide toxicity: Recent advances","volume":"6","author":"Teodoro","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_13","unstructured":"(2021, March 09). EU Regulation (EC) No 1107\/2009 of the European Parliament and of the Council of 21 October 2009 Concerning the Placing of Plant Protection Products on the Market and Repealing Council Directives 79\/117\/EEC and 91\/414\/EEC. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2009:309:0001:0050:EN:PDF."},{"key":"ref_14","unstructured":"(2021, March 08). EU Directive 2003\/11\/EC of the European Parliament and of the Council of 6 February 2003 Amending for the 24th time Council Directive 76\/769\/EEC Relating to Restrictions on the Marketing and Use of Certain Dangerous Substances and Preparations (pentabromodip). Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2003:042:0045:0046:EN:PDF."},{"key":"ref_15","unstructured":"(2021, March 08). EU Directive 2002\/95\/EC of the European Parliament and of the Council of 27 January 2003 on the Restriction of the Use of Certain Hazardous Substances in Electrical and Electronic Equipment. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2003:037:0019:0023:en:PDF."},{"key":"ref_16","unstructured":"(2021, March 08). EU Directive 2011\/65\/EU of the European Parliament and of the Council of 8 June 2011 on the Restriction of the Use of Certain Hazardous Substances in Electrical and Electronic Equipment. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2011:174:0088:0110:EN:PDF."},{"key":"ref_17","unstructured":"(2021, March 08). European Court of Justice 2008\/C 116\/02. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:C:2008:116:0002:0003:EN:PDF."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1021\/es503427r","article-title":"Evaluation and Interconversion of Various Indicator PCB Schemes for \u03a3PCB and dioxin-like PCB toxic equivalent levels in fish","volume":"49","author":"Gandhi","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103725","DOI":"10.1016\/j.jfca.2020.103725","article-title":"A novel analytical method for determining total polychlorinated biphenyl concentrations in fish and shellfish using a simple and rapid clean-up followed by GC-MS\/MS","volume":"96","author":"Tsutsumi","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11443","DOI":"10.1021\/acs.est.0c03632","article-title":"Polychlorinated Biphenyls in Food","volume":"54","author":"Saktrakulkla","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_21","unstructured":"(2021, March 10). EU Council Directive 96\/591EC of 16 September 1996 on the Disposal of Polychlorinated Biphenyls and Polychlorinated Terphenyls (PCB\/PCT). Available online: https:\/\/eur-lex.europa.eu\/legal-cotent\/EN\/TXT\/PDF\/?uri=CELEX:31996L0059&from=EN."},{"key":"ref_22","unstructured":"UNEP (2021, March 09). The 12 Initial POPs under the Stockholm Convention. Available online: http:\/\/chm.pops.int\/TheConvention\/ThePOPs\/The12InitialPOPs\/tabid\/296\/Default.aspx."},{"key":"ref_23","unstructured":"Agudo, A., Aronson, K.J., Bonefeld-Jorgensen, E.C., Cocco, P., Cogliano, V., Cravedi, J.P., Esch, H., Fiedler, H., Glauert, H.P., and Guo, Y.-L.L. (2016). Polychlorinated Biphenyls and Polybrominated Biphenyls, IARC Publications."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-069X-13-14","article-title":"Human exposure to nitro musks and the evaluation of their potential toxicity: An overview","volume":"13","author":"Taylor","year":"2014","journal-title":"Environ. Health"},{"key":"ref_25","unstructured":"(2021, March 08). EU Regulation (EC) No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on Cosmetic Products. Available online: https:\/\/ec.europa.eu\/health\/sites\/default\/files\/endocrine_disruptors\/docs\/cosmetic_1223_2009_regulation_en.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00204-016-1849-x","article-title":"Pesticides: An update of human exposure and toxicity","volume":"91","author":"Mostafalou","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fct.2017.05.003","article-title":"Potential contribution of insecticide exposure and development of obesity and type 2 diabetes","volume":"105","author":"Xiao","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.envres.2017.06.035","article-title":"Neurotoxicity of fragrance compounds: A review","volume":"158","author":"Pinkas","year":"2017","journal-title":"Environ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2013.12.064","article-title":"Health consequences of exposure to brominated flame retardants: A systematic review","volume":"106","author":"Kim","year":"2014","journal-title":"Chemosphere"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e04870","DOI":"10.1016\/j.heliyon.2020.e04870","article-title":"Organochlorine pesticides, brominated flame retardants, synthetic musks and polycyclic aromatic hydrocarbons in shrimps. An overview of occurrence and its implication on human exposure","volume":"6","author":"Maia","year":"2020","journal-title":"Heliyon"},{"key":"ref_31","unstructured":"(2021, January 28). EU Document on Analytical Quality Control and Method Validation Procedures for Pesticides Residues Analysis in Food and Feed. Available online: https:\/\/www.eurl-pesticides.eu\/userfiles\/file\/EurlALL\/AqcGuidance_SANTE_2019_12682.pdf."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Nagyov\u00e1, S., and T\u00f6lgyessy, P. (2019). Validation including uncertainty estimation of a GC-MS\/MS method for determination of selected halogenated priority substances in fish using rapid and efficient lipid removing sample preparation. Foods, 8.","DOI":"10.3390\/foods8030101"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.scitotenv.2015.05.049","article-title":"Determination of a broad spectrum of pharmaceuticals and endocrine disruptors in biofilm from a waste water treatment plant-impacted river","volume":"540","author":"Huerta","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/es010211j","article-title":"The air-sea equilibrium and time trend of hexachlorocyclohexanes in the Atlantic Ocean between the Arctic and Antarctica","volume":"36","author":"Lakaschus","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1071\/EN12065","article-title":"Currently used pesticides, hexachlorobenzene and hexachlorocyclohexanes in the air and seawater of the German Bight (North Sea)","volume":"9","author":"Zhong","year":"2012","journal-title":"Environ. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13967","DOI":"10.1021\/es403494b","article-title":"Concentrations, fluxes, and residence time of PBDEs across the tropical Atlantic Ocean","volume":"47","author":"Lohmann","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111639","DOI":"10.1016\/j.marpolbul.2020.111639","article-title":"Legacy and novel flame retardants in water and sediment from highly industrialized bays of Korea: Occurrence, source tracking, decadal time trend, and ecological risks","volume":"160","author":"Lee","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/es071432d","article-title":"Polychlorinated biphenyls (PCBs) in air and seawater of the Atlantic Ocean: Sources, trends and processes","volume":"42","author":"Gioia","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chroma.2019.01.013","article-title":"Simultaneous determination of synthetic musks and UV-filters in water matrices by dispersive liquid-liquid microextraction followed by gas chromatography tandem mass-spectrometry","volume":"1590","author":"Ramos","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.envpol.2019.05.133","article-title":"Environmental risks associated with contaminants of legacy and emerging concern at European aquaculture areas","volume":"252","author":"Aminot","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.marpolbul.2004.02.024","article-title":"Levels and profiles of PCBs and OCPs in marine benthic species from the Belgian North Sea and the Western Scheldt Estuary","volume":"49","author":"Voorspoels","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.envint.2012.06.017","article-title":"Persistent organic pollutants in the Scheldt estuary: Environmental distribution and bioaccumulation","volume":"48","author":"Covaci","year":"2012","journal-title":"Environ. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4315\/0362-028X-70.3.706","article-title":"Polychlorinated Biphenyls and Organochlorine Pesticides in Seafood from the Gulf of Naples (Italy)","volume":"70","author":"Ferrante","year":"2007","journal-title":"J. Food Prot."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.envpol.2004.12.008","article-title":"Flame retardants, surfactants and organotins in sediment and mysid shrimp of the Scheldt estuary (The Netherlands)","volume":"136","author":"Verslycke","year":"2005","journal-title":"Environ. Pollut."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1021\/es803558r","article-title":"Halogenated Contaminants in Farmed Salmon, Trout, Tilapia, Pangasius, and Shrimp","volume":"43","author":"Swart","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.envres.2017.11.015","article-title":"UV-filters and musk fragrances in seafood commercialized in Europe Union: Occurrence, risk and exposure assessment","volume":"161","author":"Cunha","year":"2018","journal-title":"Environ. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.envres.2015.04.007","article-title":"Exposure of the population of Catalonia (Spain) to musk fragrances through seafood consumption: Risk assessment","volume":"143","author":"Pocurull","year":"2015","journal-title":"Environ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/1047322X.1990.10389587","article-title":"Estimation of Average Concentration in the Presence of Nondetectable Values","volume":"5","author":"Hornung","year":"1990","journal-title":"Appl. Occup. Environ. Hyg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"40664","DOI":"10.1007\/s11356-020-10068-9","article-title":"Seasonal variations on trace element bioaccumulation and trophic transfer along a freshwater food chain in Argentina","volume":"27","author":"Griboff","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.scitotenv.2017.10.117","article-title":"Personal care products in wild fish in two main Chinese rivers: Bioaccumulation potential and human health risks","volume":"621","author":"Yao","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jhazmat.2018.06.070","article-title":"Assessing bioaccumulation behaviour of hydrophobic organic contaminants in a tropical urban catchment","volume":"358","author":"Wang","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_52","unstructured":"(2021, March 27). EU Commission Regulation (EU) No 1259\/2011 of 2 December 2011 Amending Regulation (EC) No 1881\/2006 as Regards Maximum Levels for Dioxins, Dioxin-like PCBs and Non Dioxin-like PCBs in Foodstuffs. Available online: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2011:320:0018:0023:EN:PDF."},{"key":"ref_53","unstructured":"(2021, March 27). EU Commission Regulation (EC) No 178\/2006 of 1 February 2006 Amending Regulation (EC) No 396\/2005 of the European Parliament and of the Council to Establish Annex I Listing the Food and Feed Products to Which Maximum Levels for Pesticide Residues Apply. Available online: https:\/\/www.eurl-pesticides.eu\/userfiles\/file\/EurlALL\/AqcGuiance_SANTE_2019_12682.pdf."},{"key":"ref_54","unstructured":"(2021, March 27). EU Commission Recommendation of 3 March 2014 on the Monitoring of Traces of Brominated Flame Retardants in Food. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX:32006R0178&from=EN."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Contaminants in the Food Chain (2012). Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food. EFSA J., 10, 1\u2013133.","DOI":"10.2903\/j.efsa.2012.2908"},{"key":"ref_56","unstructured":"Chemical Substances Bureau (2021, April 22). 4\u2032-TERT-BUTYL-2\u2032,6\u2032-DIMETHYL-3\u2032,5\u2032-DINITROACETOPHENONE (MUSK KETONE)_Risk Assessment, Available online: https:\/\/echa.europa.eu\/documents\/10162\/c870f3b6-a674-4589-9565-c7a771b5fb5d."},{"key":"ref_57","unstructured":"Chemical Substances Bureau (2021, April 22). 1-(5,6,7,8-TETRAHYDRO-3,5,5,6,8,8-HEXAMETHYL-2-NAPHTHYL)ETHAN-1-ONE (AHTN)-Risk Assessment, Available online: https:\/\/echa.europa.eu\/documents\/10162\/a0da6504-8d8c-49af-8614-fe396c556c43."},{"key":"ref_58","unstructured":"Chemical Substances Bureau (2021, April 22). 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA-\u03b3-2-BENZOPYRAN (1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLIN-DENO[5,6-C]PYRAN-HHCB)-Risk Assessment, Available online: https:\/\/echa.europa.eu\/documents\/10162\/947def3b-bbbf-473b-bc19-3bda7a8da910."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.fct.2016.10.026","article-title":"Risk assessment of methylmercury in five European countries considering the national seafood consumption patterns","volume":"104","author":"Jacobs","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_60","unstructured":"(2020, November 30). Aprova o Regulamento da Pesca por Arte de Arrasto Portaria n.\u00b0 1102-E\/2000 - Di\u00e1rio da Rep\u00fablica n.\u00b0 270\/2000, 2\u00b0 Suplemento, S\u00e9rie I-B de 2000-11-22. Available online: https:\/\/dre.pt\/web\/guest\/legislacao-consolidada\/-\/lc\/106487480\/201804160154\/exportPdf\/maximized\/1\/cacheLevelPage?rp=indice."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.talanta.2013.11.086","article-title":"Analysis of 7 synthetic musks in cream by supported liquid extraction and solid phase extraction followed by GC-MS\/MS","volume":"120","author":"Dong","year":"2014","journal-title":"Talanta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jchromb.2007.08.027","article-title":"SPE\/SPME-GC\/MS approach for measuring musk compounds in serum and breast milk","volume":"858","author":"Kuklenyik","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1021\/jf103899r","article-title":"Organochlorine pesticide residues in strawberries from integrated pest management and organic farming","volume":"59","author":"Fernandes","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chroma.2018.08.025","article-title":"High-throughput analytical method for 265 pesticides and environmental contaminants in meats and poultry by fast low pressure gas chromatography and ultrahigh-performance liquid chromatography tandem mass spectrometry","volume":"1572","author":"Sapozhnikova","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aca.2012.10.034","article-title":"Multi-class, multi-residue analysis of pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and novel flame retardants in fish using fast, low-pressure gas chromatography-tandem mass spectrometry","volume":"758","author":"Sapozhnikova","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/a06-005","article-title":"A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms","volume":"14","author":"Arnot","year":"2006","journal-title":"Environ. Rev."},{"key":"ref_67","unstructured":"U.S. EPA (1991). Technical Support Document for Water Quality-based Toxics Control."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/19\/5774\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:04:08Z","timestamp":1760166248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/19\/5774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":67,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["molecules26195774"],"URL":"https:\/\/doi.org\/10.3390\/molecules26195774","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]}}}