{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:29:39Z","timestamp":1774772979089,"version":"3.50.1"},"reference-count":326,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Polysaccharides are complex macromolecules long regarded as energetic storage resources or as components of plant and fungal cell walls. They have also been described as plant mucilages or microbial exopolysaccharides. The development of glycosciences has led to a partial and difficult deciphering of their other biological functions in living organisms. The objectives of glycobiochemistry and glycobiology are currently to correlate some structural features of polysaccharides with some biological responses in the producing organisms or in another one. In this context, the literature focusing on bioactive polysaccharides has increased exponentially during the last two decades, being sometimes very optimistic for some new applications of bioactive polysaccharides, notably in the medical field. Therefore, this review aims to examine bioactive polysaccharide, taking a critical look of the different biological activities reported by authors and the reality of the market. It focuses also on the chemical, biochemical, enzymatic, and physical modifications of these biopolymers to optimize their potential as bioactive agents.<\/jats:p>","DOI":"10.3390\/molecules26237068","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:01:11Z","timestamp":1638309671000},"page":"7068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bioactive Carbohydrate Polymers\u2014Between Myth and Reality"],"prefix":"10.3390","volume":"26","author":[{"given":"Maroua","family":"Drira","sequence":"first","affiliation":[{"name":"Laboratoire de Biotechnologies des Plantes Appliqu\u00e9es \u00e0 l\u2019Am\u00e9lioration des Cultures, Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, Sfax 3038, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-1519","authenticated-orcid":false,"given":"Faiez","family":"Hentati","sequence":"additional","affiliation":[{"name":"INRAE, URAFPA, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8997","authenticated-orcid":false,"given":"Olga","family":"Babich","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}]},{"given":"Stanislas","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}]},{"given":"Viktoria","family":"Larina","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-2604","authenticated-orcid":false,"given":"Sana","family":"Sharifian","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas 74576, Iran"}]},{"given":"Ahmad","family":"Homaei","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas 74576, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-5444","authenticated-orcid":false,"given":"Imen","family":"Fendri","sequence":"additional","affiliation":[{"name":"Laboratoire de Biotechnologies des Plantes Appliqu\u00e9es \u00e0 l\u2019Am\u00e9lioration des Cultures, Facult\u00e9 des Sciences de Sfax, Universit\u00e9 de Sfax, Sfax 3038, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-1864","authenticated-orcid":false,"given":"Marco","family":"Lemos","sequence":"additional","affiliation":[{"name":"MARE\u2013Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-641 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-9400","authenticated-orcid":false,"given":"Carina","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"MARE\u2013Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-641 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-3736","authenticated-orcid":false,"given":"Rafael","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"MARE\u2013Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-641 Peniche, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-0523","authenticated-orcid":false,"given":"Slim","family":"Abdelkafi","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Enzymatique et Microbiologie, Equipe de Biotechnologie des Algues, Ecole Nationale d\u2019Ing\u00e9nieurs de Sfax, Universit\u00e9 de Sfax, Sfax 3038, Tunisia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-4549","authenticated-orcid":false,"given":"Philippe","family":"Michaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, CNRS, Clermont Auvergne INP, Institut Pascal, F-63000 Clermont-Ferrand, France"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hentati, F., Tounsi, L., Djomdi, D., Pierre, G., Delattre, C., Ursu, A.V., and Michaud, P. 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