{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:21:29Z","timestamp":1762161689936,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","award":["ALPO"],"award-info":[{"award-number":["ALPO"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Foreign Affairs","award":["YP Fellowship"],"award-info":[{"award-number":["YP Fellowship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cyclodextrins (CDs) are cyclic oligosaccharides used in many fields. Grafting polymers onto CDs enables new structures and applications to be obtained. Polylactide (PLA) is a biobased, biocompatible aliphatic polyester that can be grafted onto CDs by -OH-initiated ring-opening polymerization. Using 4-dimethylaminopyridine (DMAP) as an organocatalyst, a quantitative functionalization is reached on native \u03b1-, \u03b2-, \u03b3- and 2,3-dimethyl- \u03b2-cyclodextrins. Narrow molecular weight distributions are obtained with the native CDs (dispersity &lt; 1.1). The DMAP\/\u03b2-CD combination is used as a case study, and the formation of an inclusion complex (1\/1) is shown for the first time in the literature, which is fully characterized by NMR. The inclusion of DMAP into the cavity occurs via the secondary rim of the \u03b2-CD and the association constant (Ka) is estimated to be 88.2 M\u22121. Its use as an initiator for ring-opening polymerization leads to a partial functionalization efficiency, and thus a more hydrophilic \u03b2-CD-PLA conjugate than that obtained starting from native \u03b2-CD. Polymerization results including also the use of the adamantane\/\u03b2-CD inclusion complex as an initiator suggest that inclusion of the DMAP catalyst into the CD may not occur during polymerization reactions. Rac-lactide does not form an inclusion complex with \u03b2-CD.<\/jats:p>","DOI":"10.3390\/molecules27031083","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T20:38:40Z","timestamp":1644179920000},"page":"1083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cyclodextrins Initiated Ring-Opening Polymerization of Lactide Using 4-Dimethylaminopyridine (DMAP) as Catalyst: Study of DMAP\/\u03b2-CD Inclusion Complex and Access to New Structures"],"prefix":"10.3390","volume":"27","author":[{"given":"Julie","family":"Meimoun","sequence":"first","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-7951","authenticated-orcid":false,"given":"Yupin","family":"Phuphuak","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"},{"name":"Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand"}]},{"given":"Remi","family":"Miyamachi","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"}]},{"given":"Yong","family":"Miao","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-0621","authenticated-orcid":false,"given":"Marc","family":"Bria","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, INRA, Centrale Lille, ENSCL, Univ. Artois, FR 2638\u2014IMEC\u2014Institut Michel-Eug\u00e8ne Chevreul, P\u00f4le RMN, F-59000 Lille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-6868","authenticated-orcid":false,"given":"Cyril","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-62300 Lens, France"}]},{"given":"Guilherme","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"},{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-208X","authenticated-orcid":false,"given":"Andreia","family":"Valente","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-9608","authenticated-orcid":false,"given":"Audrey","family":"Favrelle-Huret","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-9116","authenticated-orcid":false,"given":"Philippe","family":"Zinck","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181\u2014UCCS\u2014Unit\u00e9 de Catalyse et Chimie du Solide, F-59000 Lille, France"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dodziuk, H. (2006). Front matter. Cyclodextrins and Their Complexes, Wiley-VCH Verlag GmbH & Co. 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