{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:53:57Z","timestamp":1760151237193,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RAS, Regione Autonoma Sardegna","award":["RASSR79857"],"award-info":[{"award-number":["RASSR79857"]}]},{"name":"University of Cagliari and Fondazione di Sardegna","award":["CUP F72F20000240007 (2019)"],"award-info":[{"award-number":["CUP F72F20000240007 (2019)"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UIDB\/00100\/2020        UIDP\/00100\/2020       LA\/P\/0056\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020        UIDP\/00100\/2020       LA\/P\/0056\/2020"]}]},{"name":"COST (European Cooperation in Science and Technology)","award":["COST Action CA18202, NECTAR"],"award-info":[{"award-number":["COST Action CA18202, NECTAR"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric\u2013spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.<\/jats:p>","DOI":"10.3390\/molecules27051555","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:48:33Z","timestamp":1645994913000},"page":"1555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-8311","authenticated-orcid":false,"given":"Rosita","family":"Cappai","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Vita e dell\u2019Ambiente, Universit\u00e0 di Cagliari, 09042 Monserrato-Cagliari, Italy"}]},{"given":"Alessandra","family":"Fantasia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita e dell\u2019Ambiente, Universit\u00e0 di Cagliari, 09042 Monserrato-Cagliari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-0231","authenticated-orcid":false,"given":"Guido","family":"Crisponi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita e dell\u2019Ambiente, Universit\u00e0 di Cagliari, 09042 Monserrato-Cagliari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-5966","authenticated-orcid":false,"given":"Eugenio","family":"Garribba","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Universit\u00e0 di Sassari, Viale San Pietro, 07100 Sassari, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4069-9368","authenticated-orcid":false,"given":"M. Am\u00e9lia","family":"Santos","sequence":"additional","affiliation":[{"name":"Centro de Quimica Estrutural, Institute of Molecular Sciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-1988","authenticated-orcid":false,"given":"Valeria Marina","family":"Nurchi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita e dell\u2019Ambiente, Universit\u00e0 di Cagliari, 09042 Monserrato-Cagliari, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","first-page":"24","article-title":"Vanadium compounds in medicine","volume":"301\u2013302","author":"Etcheverry","year":"2015","journal-title":"Coord. Chem. 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