{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:01:22Z","timestamp":1764784882891,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Researcher Development Project of Khon Kaen University","award":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"],"award-info":[{"award-number":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"]}]},{"name":"Thailand Research Fund","award":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"],"award-info":[{"award-number":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"]}]},{"name":"Thailand Science Research and Innovation","award":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"],"award-info":[{"award-number":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"]}]},{"name":"FCT-Foundation for Science and Technology of Portugal","award":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"],"award-info":[{"award-number":["RDG5520030","161860","UIDB\/04423\/2020","UIDP\/04423\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The present study describes investigation of the effects of the bark resin extract of Garcinia nigrolineata (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract G. nigrolineata. Moreover, the prenylated xanthones viz. cowagarcinone C, cowaxanthone, \u03b1-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymusxanthones A, 7-O-methylgarcinone E, and cowagarcinone A, isolated from the bark resin of G. nigrolineata, were assayed for their inhibitory activities against \u03b2-amyloid (A\u03b2) aggregation and monoamine oxidase enzymes (MAOs).<\/jats:p>","DOI":"10.3390\/molecules27093014","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"3014","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of the Bark Resin Extract of Garcinia nigrolineata on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and \u03b2-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-0670","authenticated-orcid":false,"given":"Charinya","family":"Khamphukdee","sequence":"first","affiliation":[{"name":"Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"given":"Ibrahim","family":"Turkmani","sequence":"additional","affiliation":[{"name":"ICBAS-Instituo de Ci\u00eancias Biom\u00e9dicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-4984","authenticated-orcid":false,"given":"Yutthana","family":"Chotritthirong","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"given":"Yaowared","family":"Chulikhit","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-6090","authenticated-orcid":false,"given":"Chantana","family":"Boonyarat","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-0106","authenticated-orcid":false,"given":"Nazim","family":"Sekeroglu","sequence":"additional","affiliation":[{"name":"Phytotherapy, Medicinal and Aromatic Plants Application & Research Center and Biology Department, Faculty of Arts and Science, Gaziantep University, 27310 Gaziantep, Turkey"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica & QOPNA, Universidade de Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Orawan","family":"Monthakantirat","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-1061","authenticated-orcid":false,"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[{"name":"ICBAS-Instituo de Ci\u00eancias Biom\u00e9dicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16271","DOI":"10.1038\/s41598-021-95850-6","article-title":"Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats","volume":"11","author":"Izadi","year":"2021","journal-title":"Sci. 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