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Independently, these materials can be employed in cancer treatment as intelligent drug carriers in chemotherapy, photothermal therapy, and photodynamic therapy; conversely, MOFs can further be used as diagnostic tools in fluorescence imaging, magnetic resonance imaging, computed tomography imaging, and photoacoustic imaging. One essential property of these materials is their great ability to fine-tune their composition toward a specific application by way of a judicious choice of the starting building materials (metal nodes and organic ligands). Moreover, many advancements were made concerning the preparation of these materials, including the ability to downsize the crystallites yielding nanoporous porphyrin MOFs (NMOFs) which are of great interest for clinical treatment and diagnostic theranostic tools. The usage of porphyrins as ligands allows a high degree of multifunctionality. Historically these molecules are well known for their reactive oxygen species formation and strong fluorescence characteristics, and both have proved helpful in cancer treatment and diagnostic tools. The anticipation that porphyrins in MOFs could prompt the resulting materials to multifunctional theranostic platforms is a reality nowadays with a series of remarkable and ground-breaking reports available in the literature. This is particularly remarkable in the last five years, when the scientific community witnessed rapid development in porphyrin MOFs theranostic agents through the development of imaging technologies and treatment strategies for cancer. This manuscript reviews the most relevant recent results and achievements in this particular area of interest in MOF chemistry and application.<\/jats:p>","DOI":"10.3390\/molecules27103111","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"3111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-9736","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Figueira","sequence":"first","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Jo\u00e3o P. C.","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, n\u00b0 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-5645","authenticated-orcid":false,"given":"Filipe A. Almeida","family":"Paz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1166\/jnn.2014.9014","article-title":"Nanoarchitectonics in cancer therapy and imaging diagnosis","volume":"14","author":"Pandey","year":"2014","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.addr.2012.09.006","article-title":"Nanoparticles in cancer therapy and diagnosis","volume":"64","author":"Brigger","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/smll.201000523","article-title":"Engineering nanocomposite materials for cancer therapy","volume":"6","author":"Minelli","year":"2010","journal-title":"Small"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-017-0004-3","article-title":"Controlled drug delivery vehicles for cancer treatment and their performance","volume":"3","author":"Senapati","year":"2018","journal-title":"Signal Transduct Target Ther"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15416","DOI":"10.1002\/chem.202004529","article-title":"Bone Tissue Disorders: Healing Through Coordination Chemistry","volume":"26","author":"Barbosa","year":"2020","journal-title":"Chem. Eur. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1910021","DOI":"10.1002\/adfm.201910021","article-title":"Metal-based nanomaterials in biomedical applications: Antimicrobial activity and cytotoxicity aspects","volume":"30","author":"Makvandi","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2003559","DOI":"10.1002\/adfm.202003559","article-title":"Recent advances of cell membrane-coated nanomaterials for biomedical applications","volume":"30","author":"Liu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.colsurfb.2019.05.008","article-title":"Therapeutic and diagnostic potential of nanomaterials for enhanced biomedical applications","volume":"180","author":"Abdelrahman","year":"2019","journal-title":"Colloids Surf. B"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mattod.2020.10.024","article-title":"Virus meet metal-organic frameworks: A nanoporous solution to a world-sized problem?","volume":"43","author":"Figueira","year":"2021","journal-title":"Mater. Today"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.talanta.2018.02.088","article-title":"Recent biomedical applications of gold nanoparticles: A review","volume":"184","author":"Elahi","year":"2018","journal-title":"Talanta"},{"key":"ref_11","first-page":"1801137","article-title":"Promoting role of MXene nanosheets in biomedical sciences: Therapeutic and biosensing innovations","volume":"8","author":"Soleymaniha","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1039\/C8NH00274F","article-title":"Recent advances in functionalized MnO 2 nanosheets for biosensing and biomedicine applications","volume":"4","author":"Chen","year":"2019","journal-title":"Nanoscale Horiz."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Simon, J., Flahaut, E., and Golzio, M. (2019). Overview of Carbon Nanotubes for Biomedical Applications. Materials, 12.","DOI":"10.3390\/ma12040624"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Saliev, T. (2019). The Advances in Biomedical Applications of Carbon Nanotubes. C, 5.","DOI":"10.3390\/c5020029"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1900440","DOI":"10.1002\/smtd.201900440","article-title":"Recent advances in multifunctional graphitic nanocapsules for Raman detection, imaging, and therapy","volume":"4","author":"Liu","year":"2020","journal-title":"Small Methods"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2002046","DOI":"10.1002\/adfm.202002046","article-title":"2D covalent organic frameworks for biomedical applications","volume":"30","author":"Bhunia","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"110673","DOI":"10.1016\/j.micromeso.2020.110673","article-title":"Recent advances in surface engineering of porous silicon nanomaterials for biomedical applications","volume":"310","author":"Jung","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Aflori, M. (2021). Smart Nanomaterials for Biomedical Applications\u2014A Review. Nanomaterials, 11.","DOI":"10.3390\/nano11020396"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cclet.2019.11.036","article-title":"Metal-organic framework-based nanomaterials for biomedical applications","volume":"31","author":"Zhang","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1021\/acs.cgd.8b01444","article-title":"Mesoporous Metal\u2013Organic Frameworks as Effective Nucleating Agents in Protein Crystallography","volume":"19","author":"Leite","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"214262","DOI":"10.1016\/j.ccr.2021.214262","article-title":"Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment","volume":"451","author":"Mallakpour","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1021\/acsami.1c01089","article-title":"Metal\u2013Organic Frameworks for Drug Delivery: A Design Perspective","volume":"13","author":"Lawson","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ccr.2018.07.016","article-title":"Beyond pristine metal-organic frameworks: Preparation and application of nanostructured, nanosized, and analogous MOFs","volume":"376","author":"Khan","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccr.2019.02.033","article-title":"Metal-organic framework nanosheets: Preparation and applications","volume":"388","author":"Li","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100743","DOI":"10.1016\/j.pmatsci.2020.100743","article-title":"MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives","volume":"117","author":"Bieniek","year":"2021","journal-title":"Prog. Mater Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1039\/D0CS00883D","article-title":"Metal\u2013organic frameworks: A future toolbox for biomedicine?","volume":"49","author":"Mendes","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1707365","DOI":"10.1002\/adma.201707365","article-title":"Nanoparticles of metal-organic frameworks: On the road to in vivo efficacy in biomedicine","volume":"30","author":"Mielcarek","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41401-020-0414-6","article-title":"Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy","volume":"41","author":"Zhong","year":"2020","journal-title":"Acta Pharmacologica Sinica"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Cai, M., Chen, G., Qin, L., Qu, C., Dong, X., Ni, J., and Yin, X. (2020). Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12030232"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Saeb, M.R., Rabiee, N., Mozafari, M., Verpoort, F., Voskressensky, L.G., and Luque, R. (2021). Metal-Organic Frameworks (MOFs) for Cancer Therapy. Materials, 14.","DOI":"10.3390\/ma14237277"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"119707","DOI":"10.1016\/j.biomaterials.2019.119707","article-title":"Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy","volume":"232","author":"Rabiee","year":"2020","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s42004-021-00484-4","article-title":"Physical properties of porphyrin-based crystalline metal\u2014organic frameworks","volume":"4","author":"Rajasree","year":"2021","journal-title":"Commun. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Figueira, F., and Paz, F.A.A. (2021). Porphyrin MOF-Derived Porous Carbons: Preparation and Applications. C, 7.","DOI":"10.3390\/c7020047"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"162992","DOI":"10.1016\/j.jallcom.2021.162992","article-title":"Boosting the photocatalytic activity of Ti-MOF via emerging with metal phthalocyanine to degrade hazard textile pigments","volume":"896","author":"Abdelhameed","year":"2022","journal-title":"J. Alloys Compd."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tsolekile, N., Nelana, S., and Oluwafemi, O.S. (2019). Porphyrin as Diagnostic and Therapeutic Agent. Molecules, 24.","DOI":"10.3390\/molecules24142669"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1142\/S1088424619501049","article-title":"Synthesis and characterization of novel 5-monocarbohydrate-10,20-bis-aryl-porphyrins","volume":"24","author":"Figueira","year":"2019","journal-title":"J. Porphyrins Phthalocyanines"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1039\/C9DT00378A","article-title":"Copper-phthalocyanine coordination polymer as a reusable catechol oxidase biomimetic catalyst","volume":"48","author":"Castro","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fphy.2015.00023","article-title":"Emerging applications of porphyrins in photomedicine","volume":"3","author":"Huang","year":"2015","journal-title":"Front. Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"109136","DOI":"10.1016\/j.dyepig.2021.109136","article-title":"Porphyrin-based compounds and their applications in materials and medicine","volume":"188","author":"Shi","year":"2021","journal-title":"Dyes Pigm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1142\/S1088424611003653","article-title":"Silica nanoparticles functionalized with porphyrins and analogs for biomedical studies","volume":"15","author":"Figueira","year":"2011","journal-title":"J. Porphyrins Phthalocyanines"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1142\/S1088424616300135","article-title":"Synthesis and anion binding properties of porphyrins and related compounds","volume":"20","author":"Figueira","year":"2016","journal-title":"J. Porphyrins Phthalocyanines"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Montaseri, H., Kruger, C.A., and Abrahamse, H. (2020). Recent Advances in Porphyrin-Based Inorganic Nanoparticles for Cancer Treatment. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093358"},{"key":"ref_43","first-page":"625","article-title":"Nanoporous metal organic frameworks as hybrid polymer\u2013metal composites for drug delivery and biomedical applications","volume":"22","author":"Beg","year":"2017","journal-title":"Drug Discov."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"12394","DOI":"10.1039\/C5NR07849K","article-title":"Porphyrin-loaded nanoparticles for cancer theranostics","volume":"8","author":"Zhou","year":"2016","journal-title":"Nanoscale"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.poly.2018.11.022","article-title":"Porphyrinic coordination polymer-type materials as heterogeneous catalysts in catechol oxidation","volume":"158","author":"Castro","year":"2019","journal-title":"Polyhedron"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1002\/viw2.20","article-title":"Metal-organic framework-based cancer theranostic nanoplatforms","volume":"1","author":"Yang","year":"2020","journal-title":"View"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ccr.2017.09.002","article-title":"Metalloporphyrin nanoparticles: Coordinating diverse theranostic functions","volume":"379","author":"Shao","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.trechm.2020.01.003","article-title":"Catalytic porphyrin framework compounds","volume":"2","author":"Feng","year":"2020","journal-title":"Trends in Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ccr.2014.10.001","article-title":"Photochemical hydrogen generation with porphyrin-based systems","volume":"304","author":"Ladomenou","year":"2015","journal-title":"Coord. Chem. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"213410","DOI":"10.1016\/j.ccr.2020.213410","article-title":"Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy","volume":"420","author":"Tian","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pereira, C.F., Sim\u00f5es, M.M., Tom\u00e9, J.P., and Almeida Paz, F.A. (2016). Porphyrin-based metal-organic frameworks as heterogeneous catalysts in oxidation reactions. Molecules, 21.","DOI":"10.3390\/molecules21101348"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Qi, Z.-L., Cheng, Y.-H., Xu, Z., and Chen, M.-L. (2020). Recent advances in porphyrin-based materials for metal ions detection. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165839"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1021\/acs.chemrev.9b00685","article-title":"Metal\u2013Organic Frameworks in Heterogeneous Catalysis: Recent Progress, New Trends, and Future Perspectives","volume":"120","author":"Bavykina","year":"2020","journal-title":"Chem. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12951-021-01037-6","article-title":"Molecularly engineered carrier-free co-delivery nanoassembly for self-sensitized photothermal cancer therapy","volume":"19","author":"Shan","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Algorri, J.F., Ochoa, M., Rold\u00e1n-Varona, P., Rodr\u00edguez-Cobo, L., and L\u00f3pez-Higuera, J.M. (2021). Photodynamic Therapy: A Compendium of Latest Reviews. Cancers, 13.","DOI":"10.3390\/cancers13174447"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","article-title":"Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Algorri, J.F., Ochoa, M., Rold\u00e1n-Varona, P., Rodr\u00edguez-Cobo, L., and L\u00f3pez-Higuera, J.M. (2021). Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review. Cancers, 13.","DOI":"10.3390\/cancers13143484"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fonc.2020.00597","article-title":"Susceptibility and Resistance Mechanisms during Photodynamic Therapy of Melanoma","volume":"10","author":"Li","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"81591","DOI":"10.18632\/oncotarget.20189","article-title":"Porphyrin photosensitizers in photodynamic therapy and its applications","volume":"8","author":"Kou","year":"2017","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/cmdc.202000353","article-title":"Porphyrin-Based Metal-Organic Framework Compounds as Promising Nanomedicines in Photodynamic Therapy","volume":"15","author":"Yu","year":"2020","journal-title":"ChemMedChem"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Doughty, A.C.V., Hoover, A.R., Layton, E., Murray, C.K., Howard, E.W., and Chen, W.R. (2019). Nanomaterial Applications in Photothermal Therapy for Cancer. Materials, 12.","DOI":"10.3390\/ma12050779"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1021\/acsapm.0c00704","article-title":"Polymer-Based Nanomaterials for Noninvasive Cancer Photothermal Therapy","volume":"2","author":"Yu","year":"2020","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"102205","DOI":"10.1016\/j.pdpdt.2021.102205","article-title":"A review of advanced nanoformulations in phototherapy for cancer therapeutics","volume":"33","author":"Hak","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1900471","DOI":"10.1002\/advs.201900471","article-title":"Plasmonic photothermal nanoparticles for biomedical applications","volume":"6","author":"Kim","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1606134","DOI":"10.1002\/adma.201606134","article-title":"Metal\u2013organic framework (MOF)-based drug\/cargo delivery and cancer therapy","volume":"29","author":"Wu","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"213945","DOI":"10.1016\/j.ccr.2021.213945","article-title":"Recent advances in porphyrin-based MOFs for cancer therapy and diagnosis therapy","volume":"439","author":"Wang","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1002\/anie.201909880","article-title":"Porphyrin-Based Metal\u2013Organic Frameworks for Biomedical Applications","volume":"60","author":"Chen","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41467-018-04703-w","article-title":"Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jmir.2011.10.001","article-title":"Radiotherapy Treatment Review: A Prospective Evaluation of Concordance between Clinical Specialist Radiation Therapist and Radiation Oncologist in Patient Assessments","volume":"43","author":"Lee","year":"2012","journal-title":"J. Med. Imaging Radiat. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.copbio.2007.01.003","article-title":"Fluorescence imaging in vivo: Recent advances","volume":"18","author":"Rao","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14789","DOI":"10.1021\/jacs.0c07022","article-title":"Advanced fluorescence imaging technology in the near-infrared-II window for biomedical applications","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1021\/acs.bioconjchem.9b00231","article-title":"Porphyrin-based nanomedicines for cancer treatment","volume":"30","author":"Xue","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/cjoc.202000410","article-title":"Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo","volume":"39","author":"Liu","year":"2021","journal-title":"Chin. J. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jceh.2015.08.001","article-title":"Magnetic Resonance Imaging: Principles and Techniques: Lessons for Clinicians","volume":"5","author":"Grover","year":"2015","journal-title":"J Clin Exp Hepatol"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mrrev.2015.02.002","article-title":"Magnetic resonance imaging (MRI): A review of genetic damage investigations","volume":"764","author":"Vijayalaxmi","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"214069","DOI":"10.1016\/j.ccr.2021.214069","article-title":"Mn(III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy","volume":"445","author":"Geraldes","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Imran, M., Ramzan, M., Qureshi, A.K., Khan, M.A., and Tariq, M. (2018). Emerging Applications of Porphyrins and Metalloporphyrins in Biomedicine and Diagnostic Magnetic Resonance Imaging. Biosensors, 8.","DOI":"10.3390\/bios8040095"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ccr.2016.11.011","article-title":"Metal coordinated pyrrole-based macrocycles as contrast agents for magnetic resonance imaging technologies: Synthesis and applications","volume":"333","author":"Calvete","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"ref_79","first-page":"279ct","article-title":"Computed Tomography: A Technical Review","volume":"89","author":"Seeram","year":"2018","journal-title":"Radiol. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/cr200358s","article-title":"X-ray-Computed Tomography Contrast Agents","volume":"113","author":"Lusic","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.2217\/nnm-2020-0125","article-title":"Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications","volume":"15","author":"Fathi","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1098\/rsfs.2011.0028","article-title":"Biomedical photoacoustic imaging","volume":"1","author":"Beard","year":"2011","journal-title":"Interface Focus"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cocis.2019.02.014","article-title":"Nanodiamonds for advanced optical bioimaging and beyond","volume":"39","author":"Prabhakar","year":"2019","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/ja208256u","article-title":"Template-Directed Synthesis of Nets Based upon Octahemioctahedral Cages That Encapsulate Catalytically Active Metalloporphyrins","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1039\/C5CC03028E","article-title":"A porphyrin photosensitized metal\u2013organic framework for cancer cell apoptosis and caspase responsive theranostics","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1021\/acs.chemmater.8b03043","article-title":"Nanoscale Mixed-Component Metal\u2013Organic Frameworks with Photosensitizer Spatial-Arrangement-Dependent Photochemistry for Multimodal-Imaging-Guided Photothermal Therapy","volume":"30","author":"Zheng","year":"2018","journal-title":"Chem. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"119792","DOI":"10.1016\/j.biomaterials.2020.119792","article-title":"Integration of metal-organic framework with a photoactive porous-organic polymer for interface enhanced phototherapy","volume":"235","author":"Zheng","year":"2020","journal-title":"Biomaterials"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1603459","DOI":"10.1002\/smll.201603459","article-title":"Fluorescent Imaging-Guided Chemotherapy-and-Photodynamic Dual Therapy with Nanoscale Porphyrin Metal\u2013Organic Framework","volume":"13","author":"Liu","year":"2017","journal-title":"Small"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1039\/C8SC02210K","article-title":"ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy","volume":"9","author":"Liu","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/IJN.S177880","article-title":"Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: Fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma","volume":"14","author":"Chen","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"41946","DOI":"10.1021\/acsami.9b15083","article-title":"Mn\u2013Porphyrin-Based Metal\u2013Organic Framework with High Longitudinal Relaxivity for Magnetic Resonance Imaging Guidance and Oxygen Self-Supplementing Photodynamic Therapy","volume":"11","author":"He","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"28390","DOI":"10.1021\/acsami.8b09680","article-title":"Theranostic Mn-Porphyrin Metal\u2013Organic Frameworks for Magnetic Resonance Imaging-Guided Nitric Oxide and Photothermal Synergistic Therapy","volume":"10","author":"Zhang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/2211738507666190429111306","article-title":"Controlled Delivery of Nitric Oxide for Cancer Therapy","volume":"7","author":"Alimoradi","year":"2019","journal-title":"Pharm Nanotechnol"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1039\/C9NH00021F","article-title":"Porphyrin\u2013palladium hydride MOF nanoparticles for tumor-targeting photoacoustic imaging-guided hydrogenothermal cancer therapy","volume":"4","author":"Zhou","year":"2019","journal-title":"Nanoscale Horiz."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.2147\/IJN.S267321","article-title":"Multifunctional Hf\/Mn-TCPP metal-organic framework nanoparticles for triple-modality imaging-guided PTT\/RT synergistic cancer therapy","volume":"15","author":"Bao","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1039\/D0CC07903K","article-title":"Defect-engineered porphyrinic metal\u2013organic framework nanoparticles for targeted multimodal cancer phototheranostics","volume":"57","author":"Wang","year":"2021","journal-title":"Chem. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"120782","DOI":"10.1016\/j.biomaterials.2021.120782","article-title":"A near infrared ratiometric platform based \u03c0-extended porphyrin metal-organic framework for O2 imaging and cancer therapy","volume":"272","author":"Xie","year":"2021","journal-title":"Biomaterials"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.smaim.2022.01.006","article-title":"Application of organic frame materials in cancer therapy through regulation of tumor microenvironment","volume":"3","author":"Yao","year":"2022","journal-title":"Smart Mater. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1021\/acsnano.9b00300","article-title":"A Mn(III)-Sealed Metal\u2013Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics","volume":"13","author":"Wan","year":"2019","journal-title":"ACS Nano"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1039\/C9CC01957J","article-title":"GSH-activated MRI-guided enhanced photodynamic- and chemo-combination therapy with a MnO2-coated porphyrin metal organic framework","volume":"55","author":"Tian","year":"2019","journal-title":"Chem. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1705451","DOI":"10.1002\/adfm.201705451","article-title":"Porphyrinic Metal\u2013Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic\/Photothermal\/Chemotherapy of Tumor","volume":"28","author":"Zeng","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"44153","DOI":"10.1038\/srep44153","article-title":"Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/cmdc.202000562","article-title":"Gold-Nanoparticle-Decorated Metal-Organic Frameworks for Anticancer Therapy","volume":"15","author":"Dhakshinamoorthy","year":"2020","journal-title":"ChemMedChem"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"841316","DOI":"10.3389\/fchem.2022.841316","article-title":"Recent Development of MOF-Based Photothermal Agent for Tumor Ablation","volume":"10","author":"Yin","year":"2022","journal-title":"Front. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1039\/C7TB02818K","article-title":"Albumin\/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: Targeting tumor hypoxia by carbonic anhydrase IX inhibition and T1\u2013T2 dual mode MRI guided photodynamic\/photothermal therapy","volume":"6","author":"Zhu","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1002\/adma.201503648","article-title":"Ultrathin 2D metal\u2013organic framework nanosheets","volume":"27","author":"Zhao","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10331","DOI":"10.1021\/jacs.0c04442","article-title":"Micron-Sized Ultrathin Metal\u2013Organic Framework Sheet","volume":"142","author":"Zhao","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"26651","DOI":"10.1021\/acsami.1c05234","article-title":"Porphyrin-Containing MOFs and COFs as Heterogeneous Photosensitizers for Singlet Oxygen-Based Antimicrobial Nanodevices","volume":"13","author":"Schlachter","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"111599","DOI":"10.1016\/j.jinorgbio.2021.111599","article-title":"Recent advances in Cu(II)\/Cu(I)-MOFs based nano-platforms for developing new nano-medicines","volume":"225","author":"Sun","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"15131","DOI":"10.1002\/chem.201800556","article-title":"Two-dimensional metal-organic framework nanosheets: A rapidly growing class of versatile nanomaterials for gas separation, MALDI-TOF matrix and biomimetic applications","volume":"24","author":"Xu","year":"2018","journal-title":"Chem. Eur. J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s12274-018-2242-2","article-title":"Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy","volume":"12","author":"Zhu","year":"2019","journal-title":"Nano Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1039\/C7DT01146F","article-title":"Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters","volume":"46","author":"Morais","year":"2017","journal-title":"Dalton Trans."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/10\/3111\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:09:54Z","timestamp":1760137794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/27\/10\/3111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":112,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["molecules27103111"],"URL":"https:\/\/doi.org\/10.3390\/molecules27103111","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]}}}