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NaDES were prepared using natural compounds, including lactic acid (Lac), fructose (Fru), and urea (Ur), and were characterized to define their physicochemical properties, including the viscosity, density, surface tension, and refractive index. FTIR and NMR analysis confirmed the presence of intermolecular hydrogen bonding in NaDES. The extracts obtained using these NaDES were characterized to define their composition. Results demonstrated that the extract\u2019s composition differed highly, depending not only on the DES used, but also on the structure and composition of the raw material. Proteins and lipids were mainly present in extracts obtained from mussels, while ash content was highest in the extracts obtained from codfish bones. The biocompatibility of NaDES and the soluble fractions (SF) of the raw materials in NaDES was evaluated, and it was possible to conclude that the soluble ingredients obtained from the raw materials improved the biocompatibility of NaDES.<\/jats:p>","DOI":"10.3390\/molecules27144356","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:51:56Z","timestamp":1657180316000},"page":"4356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lactic Acid-Based Natural Deep Eutectic Solvents to Extract Bioactives from Marine By-Products"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-1649","authenticated-orcid":false,"given":"Maha M.","family":"Abdallah","sequence":"first","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-1761","authenticated-orcid":false,"given":"Martim","family":"Cardeira","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4888-9414","authenticated-orcid":false,"given":"Ana A.","family":"Matias","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"}]},{"given":"Maria Ros\u00e1rio","family":"Bronze","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-2966","authenticated-orcid":false,"given":"Naiara","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2781-901 Oeiras, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"ref_1","unstructured":"Food and Agriculture Organization (2019, August 27). World Fisheries and Aquaculture. Available online: www.fao.org\/publications."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jclepro.2019.05.082","article-title":"Valorization of discarded Marine Eel fish skin for collagen extraction as a 3D printable blue biomaterial for tissue engineering","volume":"230","author":"Govindharaj","year":"2019","journal-title":"J. Clean. Prod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1021\/acsmedchemlett.8b00368","article-title":"Marine Natural Products in Medicinal Chemistry","volume":"9","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Amberg, N., and Fogarassy, C. (2019). Green Consumer Behavior in the Cosmetics Market. Resources, 8.","DOI":"10.3390\/resources8030137"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jsps.2018.02.015","article-title":"Natural products chemistry: The emerging trends and prospective goals","volume":"26","author":"Khan","year":"2018","journal-title":"Saudi Pharm. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"International Natural Product Sciences Taskforce; Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Saxena, P. (2001). Development of Plant-Based Medicines: Conservation, Efficacy and Safety, Kluwer Academic Publishers.","DOI":"10.1007\/978-94-015-9779-1"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0973-7847.120508","article-title":"Natural proteins: Sources, isolation, characterization and applications","volume":"7","author":"Nehete","year":"2013","journal-title":"Pharmacogn. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.peptides.2007.11.018","article-title":"Anti-hypertensive activity of genetically modified soybean seeds accumulating novokinin","volume":"29","author":"Yamada","year":"2008","journal-title":"Peptides"},{"key":"ref_10","first-page":"74","article-title":"Lipids in pharmaceutical and cosmetic preparations","volume":"51","author":"Alvarez","year":"2000","journal-title":"Grasas Aceites"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hoang, H.T., Moon, J.-Y., and Lee, Y.-C. (2021). Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives. Cosmetics, 8.","DOI":"10.3390\/cosmetics8040106"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12154-014-0127-8","article-title":"A review of characterization of tocotrienols from plant oils and foods","volume":"8","author":"Ahsan","year":"2015","journal-title":"J. Chem. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/nu6020466","article-title":"Potential Role of Carotenoids as Antioxidants in Human Health and Disease","volume":"6","author":"Fiedor","year":"2014","journal-title":"Nutrients"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.foodres.2005.10.010","article-title":"Bioactive compounds from marine processing byproducts\u2014A review","volume":"39","author":"Kim","year":"2006","journal-title":"Food Res. Int."},{"key":"ref_15","unstructured":"Food and Agriculture Organization (FAO) (2020). The State of World Fisheries and Aquaculture 2020. brief, FAO."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1021\/cr300162p","article-title":"Deep Eutectic Solvents (DESs) and Their Applications","volume":"114","author":"Smith","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1039\/c2cs35178a","article-title":"Deep eutectic solvents: Syntheses, properties and applications","volume":"41","author":"Zhang","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1021\/acs.chemrev.0c00385","article-title":"Deep Eutectic Solvents: A Review of Fundamentals and Applications","volume":"121","author":"Hansen","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kalhor, P., and Ghandi, K. (2019). Deep eutectic solvents for pretreatment, extraction, and catalysis of biomass and food waste. Molecules, 24.","DOI":"10.3390\/molecules24224012"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1039\/b210714g","article-title":"Novel solvent properties of choline chloride\/urea mixtures","volume":"1","author":"Abbott","year":"2003","journal-title":"Chem. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1021\/ja048266j","article-title":"Deep Eutectic Solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids","volume":"126","author":"Abbott","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mineng.2015.09.026","article-title":"The application of deep eutectic solvent ionic liquids for environmentally-friendly dissolution and recovery of precious metals","volume":"87","author":"Jenkin","year":"2016","journal-title":"Miner. Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1021\/ac400432p","article-title":"Natural deep eutectic solvents as a new extraction media for phenolic metabolites in Carthamus tinctorius L.","volume":"85","author":"Dai","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cjche.2019.01.012","article-title":"Separation of light hydrocarbons with ionic liquids: A review","volume":"27","author":"Huang","year":"2019","journal-title":"Chinese J. Chem. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1021\/np400051w","article-title":"Ionic Liquids and Deep Eutectic Solvents in Natural Products Research: Mixtures of Solids as Extraction Solvents","volume":"76","author":"Dai","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/ntrev-2016-0106","article-title":"Deep eutectic solvents as versatile media for the synthesis of noble metal nanomaterials","volume":"6","author":"Lee","year":"2017","journal-title":"Nanotechnol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.fluid.2013.06.050","article-title":"Prediction of refractive index and density of deep eutectic solvents using atomic contributions","volume":"354","author":"Shahbaz","year":"2013","journal-title":"Fluid Phase Equilib."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/cphc.200500489","article-title":"Design of Improved Deep Eutectic Solvents Using Hole Theory","volume":"7","author":"Abbott","year":"2006","journal-title":"ChemPhysChem"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"012014","DOI":"10.1088\/1742-6596\/1764\/1\/012014","article-title":"Potency of Deep Euteutic Solvent as an Alternative Solvent on Pretreatment Process of Lignocellulosic Biomass: Review","volume":"1764","author":"Sumiati","year":"2021","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1515\/gps-2019-0003","article-title":"Use of deep eutectic solvents as catalyst: A mini-review","volume":"8","author":"Arlkaya","year":"2019","journal-title":"Green Process. Synth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.carbpol.2018.07.078","article-title":"Deep eutectic solvents for polysaccharides processing. A review","volume":"200","author":"Zdanowicz","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2017.05.012","article-title":"New horizons in the extraction of bioactive compounds using deep eutectic solvents: A review","volume":"979","author":"Hayyan","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1039\/c3an02235h","article-title":"Deep eutectic solvents as novel extraction media for protein partitioning","volume":"139","author":"Zeng","year":"2014","journal-title":"Analyst"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1007\/s13399-020-00753-7","article-title":"Choline chloride\u2013based deep eutectic solvents (Ch-DESs) as promising green solvents for phenolic compounds extraction from bioresources: State-of-the-art, prospects, and challenges","volume":"12","author":"Lu","year":"2020","journal-title":"Biomass Convers. Biorefinery"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1021\/acssuschemeng.7b01378","article-title":"Ecofriendly Mechanochemical Extraction of Bioactive Compounds from Plants with Deep Eutectic Solvents","volume":"5","author":"Wang","year":"2017","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.msec.2012.08.014","article-title":"Extraction and characterisation of apatite- and tricalcium phosphate-based materials from cod fish bones","volume":"33","author":"Piccirillo","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1016\/j.msec.2013.04.003","article-title":"Extraction of high added value biological compounds from sardine, sardine-type fish and mackerel canning residues\u2014A review","volume":"33","author":"Ferraro","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_38","first-page":"123","article-title":"Sustainable alternatives for by-products derived from industrial mussel processing: A critical review","volume":"40","author":"Vergara","year":"2021","journal-title":"Waste Manag. Res. J. Sustain. Circ. Econ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"116441","DOI":"10.1016\/j.carbpol.2020.116441","article-title":"Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: Extraction and purification methods","volume":"243","author":"Abdallah","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2215\/CJN.04020318","article-title":"Urea for the Treatment of Hyponatremia","volume":"13","author":"Tandukar","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/pgmj.47.552.654","article-title":"Fructose in medicine","volume":"47","author":"Huttunen","year":"1971","journal-title":"Postgrad. Med. J."},{"key":"ref_42","first-page":"2","article-title":"L-Lactic Acid-A Safe Antimicrobial for Home-and Personal Care Formulations","volume":"141","author":"Boomsma","year":"2015","journal-title":"SOFW-J."},{"key":"ref_43","first-page":"8048","article-title":"Investigation of inhibitive action of urea-Zn2+ system in the corrosion control of carbon steel in sea water","volume":"3","author":"Manivannan","year":"2011","journal-title":"Int. J. Eng. Sci. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"29702","DOI":"10.1039\/C4RA02030H","article-title":"An insight into the extraction of transition metal ions by picolinamides associated with intramolecular hydrogen bonding and rotational isomerization","volume":"4","author":"Li","year":"2014","journal-title":"RSC Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13643","DOI":"10.3390\/molecules190913643","article-title":"1H-NMR as a structural and analytical tool of intra- and intermolecular hydrogen bonds of phenol-containing natural products and model compounds","volume":"19","author":"Charisiadis","year":"2014","journal-title":"Molecules"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ejpb.2017.02.003","article-title":"A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: Solubility and permeability studies","volume":"114","author":"Duarte","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Abdallah, M.M., M\u00fcller, S., de Castilla, A.G., Gurikov, P., Matias, A., Bronze, M., and Fern\u00e1ndez, N. (2021). Physicochemical Characterization and Simulation of the Solid\u2013Liquid Equilibrium Phase Diagram of Terpene-Based Eutectic Solvent Systems. Molecules, 26.","DOI":"10.3390\/molecules26061801"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111916","DOI":"10.1016\/j.molliq.2019.111916","article-title":"Deep eutectic solvents based highly efficient extractive desulfurization of fuels\u2014Eco-friendly approach","volume":"296","author":"Boczkaj","year":"2019","journal-title":"J. Mol. Liq."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.molliq.2016.02.062","article-title":"Thermal and physical properties of (Choline chloride + urea + l-arginine) deep eutectic solvents","volume":"218","author":"Chemat","year":"2016","journal-title":"J. Mol. Liq."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11814-015-0134-7","article-title":"Characteristics and intermolecular interaction of eutectic binary mixtures: Reline and Glyceline","volume":"33","author":"Mjalli","year":"2016","journal-title":"Korean J. Chem. Eng."},{"key":"ref_51","unstructured":"Bonem, J.M. (2018). Chemical Projects Scale Up, Elsevier."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jtice.2012.01.007","article-title":"Densities and refractive indices of the deep eutectic solvents (choline chloride+ethylene glycol or glycerol) and their aqueous mixtures at the temperature ranging from 298.15 to 333.15K","volume":"43","author":"Leron","year":"2012","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113110","DOI":"10.1016\/j.molliq.2020.113110","article-title":"Experimental and predicted physicochemical properties of monopropanolamine-based deep eutectic solvents","volume":"309","author":"Nowosielski","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1002\/chem.200601738","article-title":"Eutectic-Based Ionic Liquids with Metal-Containing Anions and Cations","volume":"13","author":"Abbott","year":"2007","journal-title":"Chem. Eur. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molliq.2017.06.024","article-title":"The study on temperature dependence of viscosity and surface tension of several Phosphonium-based deep eutectic solvents","volume":"241","author":"Ghaedi","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12741","DOI":"10.1021\/acs.iecr.9b00867","article-title":"Surface Tension of 50 Deep Eutectic Solvents: Effect of Hydrogen-Bonding Donors, Hydrogen-Bonding Acceptors, Other Solvents, and Temperature","volume":"58","author":"Chen","year":"2019","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/aic.690170503","article-title":"The effect of surface phenomena on a solvent extraction process","volume":"17","author":"McFerrin","year":"1971","journal-title":"AIChE J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jcis.2007.06.003","article-title":"Surface tensions of imidazolium based ionic liquids: Anion, cation, temperature and water effect","volume":"314","author":"Freire","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Dong, Y., Yan, W., Zhang, X.-D., Dai Z., Y., and Zhang, Y.Q. (2021). Steam Explosion-Assisted Extraction of Protein from Fish Backbones and Effect of Enzymatic Hydrolysis on the Extracts. Foods, 10.","DOI":"10.3390\/foods10081942"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cbpb.2006.11.020","article-title":"Chemical composition, mineral content and amino acid and lipid profiles in bones from various fish species","volume":"146","author":"Toppe","year":"2007","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.foodchem.2014.12.062","article-title":"Seasonal and geographical variations in the biochemical composition of the blue mussel (Mytilus edulis L.) from Ireland","volume":"177","author":"Grienke","year":"2015","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Trilaksani, W., Riyanto, B., and Wahyuningsih, T. (2019). Characterization and Antioxidant Activity of Hyaluronan from Vitreous Humor of Yellowfin Tuna Eye (Thunnus albacares). J. Pengolah. Has. Perikan. Indones., 22.","DOI":"10.17844\/jphpi.v22i3.29126"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/foods11030342","article-title":"Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems","volume":"11","author":"Abdallah","year":"2022","journal-title":"Foods."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/toxins7020593","article-title":"Dual Effects Exerted in Vitro by Micromolar Concentrations of Deoxynivalenol on Undifferentiated Caco-2 Cells","volume":"7","author":"Manda","year":"2015","journal-title":"Toxins"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.tiv.2015.06.020","article-title":"Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol","volume":"29","author":"Ramos","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxlet.2006.04.010","article-title":"Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay","volume":"166","author":"Bony","year":"2006","journal-title":"Toxicol. Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ffj.3425","article-title":"Application of natural deep eutectic solvents for the \u201cgreen\u201dextraction of vanillin from vanilla pods","volume":"33","author":"Mustafa","year":"2018","journal-title":"Flavour Fragr. J."},{"key":"ref_68","first-page":"120","article-title":"Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants","volume":"3","author":"Bakirtzi","year":"2016","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1007\/s10811-018-1481-7","article-title":"Production of protein extracts from Swedish red, green, and brown seaweeds, Porphyra umbilicalis K\u00fctzing, Ulva lactuca Linnaeus, and Saccharina latissima (Linnaeus) J. V. Lamouroux using three different methods","volume":"30","author":"Harrysson","year":"2018","journal-title":"J. Appl. Phycol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0955-2863(99)00014-5","article-title":"Nutritional value of proteins from edible seaweed Palmaria palmata (dulse)","volume":"10","author":"Fleurence","year":"1999","journal-title":"J. Nutr. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10811-005-1641-4","article-title":"An evaluation of methods for extraction and quantification of protein from marine macro- and microalgae","volume":"17","author":"Barbarino","year":"2005","journal-title":"J. Appl. Phycol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1023\/A:1012533316609","article-title":"Intestinal Cell Culture Models: Applications in Toxicology and Pharmacology","volume":"17","author":"Sambruy","year":"2001","journal-title":"Cell Biol. Toxicol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.supflu.2010.06.005","article-title":"Processing cherries (Prunus avium) using supercritical fluid technology. Part 1: Recovery of extract fractions rich in bioactive compounds","volume":"55","author":"Serra","year":"2010","journal-title":"J. Supercrit. 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