{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:07:05Z","timestamp":1773799625653,"version":"3.50.1"},"reference-count":92,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"strategic funding","award":["IDB\/04423\/2020"],"award-info":[{"award-number":["IDB\/04423\/2020"]}]},{"name":"strategic funding","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}]},{"DOI":"10.13039\/501100001871","name":"CIIMAR","doi-asserted-by":"publisher","award":["IDB\/04423\/2020"],"award-info":[{"award-number":["IDB\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"CIIMAR","doi-asserted-by":"publisher","award":["UIDP\/04423\/2020"],"award-info":[{"award-number":["UIDP\/04423\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Within the Cactaceae family, Opuntia comprises the most widespread species, with a recognized importance in human life, including feeding, domestic use as home natural barriers, and as a traditional remedy for diverse diseases and conditions such asthma, edema, and burns. Indeed, scientific reports have stated that these health benefits may be due to various active compounds, particularly polyphenols, which are ubiquitously found in plants and have proven their pharmacological efficiency by displaying antimicrobial, anti-cancer, and anti-inflammatory activities, among others. Opuntia species contain different classes of phenolic compounds that are recognized for their anti-inflammatory potential. Among them, quercetin, isorhamnetin, and kaempferol derivates were reported to greatly contribute to modulate cells\u2019 infiltration and secretion of soluble inflammatory mediators, with key implications in the inflammatory process. In this review, we make a summary of the different classes of phenolic compounds reported in Opuntia species so far and explore their implications in the inflammatory process, reported by in vitro and in vivo bioassays, supporting the use of cactus in folk medicine and valorizing them from the socio-economic point of view.<\/jats:p>","DOI":"10.3390\/molecules27154763","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:17:27Z","timestamp":1658794647000},"page":"4763","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Phenolic Compounds\u2019 Occurrence in Opuntia Species and Their Role in the Inflammatory Process: A Review"],"prefix":"10.3390","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-1049","authenticated-orcid":false,"given":"Walid","family":"Zeghbib","sequence":"first","affiliation":[{"name":"Laboratoire de Biochimie Appliqu\u00e9e, Facult\u00e9 des Sciences de la Nature et de la Vie, Universit\u00e9 de Bejaia, Bejaia 06000, Algeria"},{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]},{"given":"Fares","family":"Boudjouan","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie de l\u2019Environnement, Facult\u00e9 de Technologie, Universit\u00e9 de Bejaia, Bejaia 06000, Algeria"},{"name":"Facult\u00e9 des Sciences de la Nature et de la Vie, Universit\u00e9 de Bejaia, Bejaia 06000, Algeria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-2417","authenticated-orcid":false,"given":"Vitor","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"},{"name":"FCUP\u2014Faculty of Sciences, University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-474X","authenticated-orcid":false,"given":"Graciliana","family":"Lopes","sequence":"additional","affiliation":[{"name":"CIIMAR\u2014Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","unstructured":"S\u00e1enz, C., Berger, H., Rodr\u00edguez-F\u00e9lix, A., Galletti, L., Garc\u00eda, J.C., Sep\u00falveda, E., Varnero, M.T., Garc\u00eda de Cort\u00e1zar, V., Garc\u00eda, R.C., and Arias, E. 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