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Nevertheless, many of the commercial biocides, such as Econea\u00ae (tralopyril), are toxic in marine environments. For that reason, it is of extreme importance that new efficient AF compounds that do not cause any harm to non-target organisms and humans are designed. In this study, we measured the half-maximal inhibitory concentration (IC50) of a promising nature-inspired AF compound, a triazolyl glycosylated chalcone (compound 1), in an immortalized human retinal pigment epithelial cell line (hTERT-RPE-1) and compared the results with the commercial biocide Econea\u00ae. We also investigated the effects of these biocides on the cellular lipidome following an acute (24 h) exposure using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF\/MS). Our results showed that compound 1 did not affect viability in hTERT-RPE-1 cells at low concentrations (1 \u03bcM), in contrast to Econea\u00ae, which caused a 40% reduction in cell viability. In total, 71 lipids were found to be regulated upon exposure to 10 \u00b5M of both compounds. Interestingly, both compounds induced changes in lipids involved in cell death, membrane modeling, lipid storage, and oxidative stress, but often in opposing directions. In general, Econea\u00ae exposure was associated with an increase in lipid concentrations, while compound 1 exposure resulted in lipid depletion. Our study showed that exposure to human cells at sublethal Econea\u00ae concentrations results in the modulation of several lipids that are linked to cell death and survival.<\/jats:p>","DOI":"10.3390\/molecules27165247","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T22:53:30Z","timestamp":1660776810000},"page":"5247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Tralopyril and Triazolyl Glycosylated Chalcone in Human Retinal Cells\u2019 Lipidome"],"prefix":"10.3390","volume":"27","author":[{"given":"C\u00e1tia","family":"Vilas-Boas","sequence":"first","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\/CIMAR\u2014Interdisciplinary Center for Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"}]},{"given":"Logan","family":"Running","sequence":"additional","affiliation":[{"name":"Chemistry Department, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-7598","authenticated-orcid":false,"given":"Daniela","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\/CIMAR\u2014Interdisciplinary Center for Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-1779","authenticated-orcid":false,"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\/CIMAR\u2014Interdisciplinary Center for Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-8532","authenticated-orcid":false,"given":"Marta","family":"Correia-da-Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"CIIMAR\/CIMAR\u2014Interdisciplinary Center for Marine and Environmental Research, University of Porto, 4450-208 Matosinhos, Portugal"}]},{"given":"Gunes Ekin","family":"Atilla-Gokcumen","sequence":"additional","affiliation":[{"name":"Chemistry Department, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-7713","authenticated-orcid":false,"given":"Diana S.","family":"Aga","sequence":"additional","affiliation":[{"name":"Chemistry Department, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","first-page":"3179","article-title":"Occurrence, effects and environmental risk of antifouling biocides (EU PT21): Are marine ecosystems threatened?","volume":"52","author":"Figueiredo","year":"2021","journal-title":"Crit. 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