{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T22:06:54Z","timestamp":1764540414734,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa de Minas Gerais","award":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"],"award-info":[{"award-number":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"],"award-info":[{"award-number":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"],"award-info":[{"award-number":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"]}]},{"name":"National Institute of Science and Technology in Theranostics and Nanobiotechnology\u2014INCT\u2014Teranano","award":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"],"award-info":[{"award-number":["FAPEMIG\u2014APQ-01087-21","REMITRIBIC, RED-00031-21","APQ-00760-18","303210\/2021-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Prostate Cancer (PCa) is the second leading cause of cancer-related deaths among men worldwide. The treatment of advanced cases is based on chemotherapy, which lacks specificity and efficacy, due to severe side effects and resistance to the traditional drugs. Copper complexes have shown antitumoral efficacy and low toxicity, being considered a promising class of metal-based drugs for the treatment of malignant neoplasms. Thus, the present study aimed to evaluate the cellular effects of a copper(II) complex with 4-fluorophenoxyacetic acid hydrazide and 1,10-phenanthroline (1) on PCa cell lines, as well as the mutagenic\/recombinogenic and anticarcinogenic potential of 1 in Drosophila melanogaster. PNT-2 (non-tumorigenic), LNCaP (hormone-responsive PCa) and PC-3 (androgen-independent PCa) cells were cultured, and cytotoxicity was assessed using the MTT assay. The expression levels of the proliferation markers Ki-67 and Cyclin D1 were analyzed by flow cytometry. Furthermore, the Somatic Mutation and Recombination Test (SMART) and the Epithelial Tumor Test (ETT) were performed. Complex 1 was selective to LNCaP cells, significantly reducing Ki-67 and Cyclin D1 expression levels. Sub-toxic concentrations of complex 1 were defined by the toxicity test in D. melanogaster, and no mutagenic\/recombinogenic\/carcinogenic effects were observed. Anticarcinogenic potential was observed in D. melanogaster, suggesting modulating activity of the complex 1 against Doxorubicin, a drug used as control by its carcinogenic properties. Therefore, complex 1 is a possible starting point for the development of new antitumor agents for the treatment of PCa.<\/jats:p>","DOI":"10.3390\/molecules27207097","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T22:49:46Z","timestamp":1666306186000},"page":"7097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Copper(II) Complex Containing 4-Fluorophenoxyacetic Acid Hydrazide and 1,10-Phenanthroline: A Prostate Cancer Cell-Selective and Low-Toxic Copper(II) Compound"],"prefix":"10.3390","volume":"27","author":[{"given":"Nayara J\u00fania de Souza","family":"Bontempo","sequence":"first","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Drielly Aparecida","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia, Uberlandia 38400-089, Brazil"}]},{"given":"Paula Marynella Alves Pereira","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Deysse Carla Tolentino","family":"Barros","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Dayanne Silva","family":"Borges","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Priscila Capelari","family":"Orsolin","sequence":"additional","affiliation":[{"name":"Laboratory of Cytogenetic and Mutagenesis, Centro Universit\u00e1rio de Patos de Minas, Patos de Minas 38700-207, Brazil"}]},{"given":"Isabella Castro","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Pedro Henrique Alves","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Ricardo Campos","family":"Lino","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Tiago Rodrigues de","family":"Souza","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Luana Munique Sousa","family":"Ramos","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia, Uberlandia 38400-089, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-1658","authenticated-orcid":false,"given":"Samuel Cota","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Uberl\u00e2ndia, Uberlandia 38405-318, Brazil"}]},{"given":"Raoni Pais","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Luiz Ricardo","family":"Goulart Filho","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"given":"Wendell","family":"Guerra","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidade Federal de Uberl\u00e2ndia, Uberlandia 38400-089, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-3194","authenticated-orcid":false,"given":"Robson Jos\u00e9 de","family":"Oliveira J\u00fanior","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-1403","authenticated-orcid":false,"given":"Thaise Gon\u00e7alves de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnologia, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia 38400-902, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41588-020-0708-0","article-title":"Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure","volume":"52","author":"Akdemir","year":"2020","journal-title":"Nat. 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