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The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of \u221220.57, providing physical stability for the nanosystem. NanoLPG demonstrated antioxidant capacity, as shown using the ORAC methodology, and prevented DNA degradation (DNA agarose). Proinflammatory activity was evaluated by quantifying the cytokines TNF-\u03b1, IL-6 and IL-8, with only IL-8 showing a significant increase (p &lt; 0.0001). NanoLPG showed greater inhibition of the tyrosinase and elastase enzymes, involved in the skin aging process, compared to purified lycopene (LPG). In vitro treatment for 24 h with 5.0 \u00b5g\/mL of nanoLPG did not affect the viability of HaCaT cells. The ultrastructure of HaCaT cells demonstrated the maintenance of morphology. This contrasts with endoplasmic reticulum stresses and autophagic vacuoles when treated with LPG after stimulation or not with LPS. Therefore, the use of lycopene in a nanoemulsion may be beneficial in strategies and products associated with skin health.<\/jats:p>","DOI":"10.3390\/molecules28031219","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T01:27:58Z","timestamp":1674782878000},"page":"1219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-3098","authenticated-orcid":false,"given":"S\u00f4nia Nair","family":"B\u00e1o","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Microscopia e Microan\u00e1lise, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"}]},{"given":"Manuela","family":"Machado","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Ana Luisa","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Microscopia e Microan\u00e1lise, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9685-4689","authenticated-orcid":false,"given":"Adma","family":"Melo","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-9993","authenticated-orcid":false,"given":"Sara","family":"Cunha","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"S\u00e9rgio S.","family":"Sousa","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Ana Rita","family":"Malheiro","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9535-368X","authenticated-orcid":false,"given":"Rui","family":"Fernandes","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-3236","authenticated-orcid":false,"given":"Jos\u00e9 Roberto S. A.","family":"Leite","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Morfologia e Imunologia Aplicada, \u00c1rea de Morfologia, Faculdade de Medicina, Universidade de Bras\u00edlia, UnB, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"People & Science Pesquisa, Desenvolvimento e Inova\u00e7\u00e3o Ltda, Bras\u00edlia 70910-900, DF, Brazil"}]},{"given":"Andreanne G.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Morfologia e Imunologia Aplicada, \u00c1rea de Morfologia, Faculdade de Medicina, Universidade de Bras\u00edlia, UnB, Campus Universit\u00e1rio Darcy Ribeiro, Asa Norte, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"People & Science Pesquisa, Desenvolvimento e Inova\u00e7\u00e3o Ltda, Bras\u00edlia 70910-900, DF, Brazil"}]},{"given":"Jo\u00e3o","family":"Relvas","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-135 Porto, Portugal"}]},{"given":"Manuela","family":"Pintado","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.foodres.2019.01.058","article-title":"Edible fruits from Brazilian biodiversity: A review on their sensorial characteristics versus bioactivity as tool to select research","volume":"119","author":"Teixeira","year":"2019","journal-title":"Food Res. 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