{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:50:07Z","timestamp":1760147407297,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FINEP","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"]}]},{"name":"CAPES","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"]}]},{"name":"FAPEMIG","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"]}]},{"name":"Barretos Cancer Hospital","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"]}]},{"name":"FINEP","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013-FPXII-BIOPLAT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>(1) Background: Malignant gliomas are aggressive tumors characterized by fast cellular growth and highly invasive properties. Despite all biological and clinical advances in therapy, the standard treatment remains essentially palliative. Therefore, searching for alternative therapies that minimize adverse symptoms and improve glioblastoma patients\u2019 outcomes is imperative. Natural products represent an essential source in the discovery of such new drugs. Plants from the cerrado biome have been receiving increased attention due to the presence of secondary metabolites with significant therapeutic potential. (2) Aim: This study provides data on the cytotoxic potential of 13 leaf extracts obtained from plants of 5 families (Anacardiaceae, Annonaceae, Fabaceae, Melastomataceae e Siparunaceae) found in the Brazilian cerrado biome on a panel of 5 glioma cell lines and one normal astrocyte. (3) Methods: The effect of crude extracts on cell viability was evaluated by MTS assay. Mass spectrometry (ESI FT-ICR MS) was performed to identify the secondary metabolites classes presented in the crude extracts and partitions. (4) Results: Our results revealed the cytotoxic potential of Melastomataceae species Miconia cuspidata, Miconia albicans, and Miconia chamissois. Additionally, comparing the four partitions obtained from M. chamissois crude extract indicates that the chloroform partition had the greatest cytotoxic activity against the glioma cell lines. The partitions also showed a mean IC50 close to chemotherapy, temozolomide; nevertheless, lower toxicity against normal astrocytes. Analysis of secondary metabolites classes presented in these crude extracts and partitions indicates the presence of phenolic compounds. (5) Conclusions: These findings highlight M. chamissois chloroform partition as a promising component and may guide the search for the development of additional new anticancer therapies.<\/jats:p>","DOI":"10.3390\/molecules28031394","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T01:53:54Z","timestamp":1675302834000},"page":"1394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5919-5242","authenticated-orcid":false,"given":"Viviane A. O.","family":"Silva","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"},{"name":"Department of Pathology, School of Medicine of the Federal University of Bahia, Salvador 40170-110, Brazil"},{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ\/BA), Salvador 40296-710, Brazil"}]},{"given":"Marcela N.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-138X","authenticated-orcid":false,"given":"Izabela N. F.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-6980","authenticated-orcid":false,"given":"Patrik da Silva","family":"Vital","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-3768","authenticated-orcid":false,"given":"Ana Laura V.","family":"Alves","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-2082","authenticated-orcid":false,"given":"Adriane F.","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"given":"Giovanna B.","family":"Longato","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"},{"name":"Research Laboratory in Cellular and Molecular Biology of Tumors and Bioactive Compounds, San Francisco University, Bragan\u00e7a Paulista, S\u00e3o Paulo 12916-900, Brazil"}]},{"given":"Adriana C.","family":"Carloni","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"}]},{"given":"Bruno G.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Petroleomic and Forensic Laboratory, Chemistry Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}]},{"given":"Fernanda E.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Petroleomic and Forensic Laboratory, Chemistry Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}]},{"given":"Wanderson","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Petroleomic and Forensic Laboratory, Chemistry Department, Federal University of Esp\u00edrito Santo, Vit\u00f3ria 29075-910, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-1696","authenticated-orcid":false,"given":"Allisson R.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Ituiutaba Unit, Department of Agrarian and Natural Sciences (DECAN), State University of Minas Gerais (UEMG), Divinopolis 38302-192, Brazil"}]},{"given":"Arali A. C.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Ituiutaba Unit, Department of Agrarian and Natural Sciences (DECAN), State University of Minas Gerais (UEMG), Divinopolis 38302-192, Brazil"}]},{"given":"Lohanna S. F. M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology, Federal University of S\u00e3o Jo\u00e3o del Rei\u2014CCO\/UFSJ, Divin\u00f3polis 35501-296, Brazil"}]},{"given":"Alessandra A. M.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology, Federal University of S\u00e3o Jo\u00e3o del Rei\u2014CCO\/UFSJ, Divin\u00f3polis 35501-296, Brazil"}]},{"given":"Stephanie C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology, Federal University of S\u00e3o Jo\u00e3o del Rei\u2014CCO\/UFSJ, Divin\u00f3polis 35501-296, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4743","authenticated-orcid":false,"given":"Rosy Iara Maciel A.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology, Federal University of S\u00e3o Jo\u00e3o del Rei\u2014CCO\/UFSJ, Divin\u00f3polis 35501-296, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":false,"given":"Rui M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, S\u00e3o Paulo 14784-400, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41582-022-00679-w","article-title":"Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours","volume":"18","author":"Horbinski","year":"2022","journal-title":"Nat. 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