{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T17:50:20Z","timestamp":1775325020406,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Human Genetics, Polish Academy of Sciences","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}]},{"name":"Institute of Human Genetics, Polish Academy of Sciences","award":["INNOMED\/I\/11\/NCBR\/2014"],"award-info":[{"award-number":["INNOMED\/I\/11\/NCBR\/2014"]}]},{"name":"Institute of Human Genetics, Polish Academy of Sciences","award":["2020.04729.BD"],"award-info":[{"award-number":["2020.04729.BD"]}]},{"name":"National Science Centre within the MINIATURA 4","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}]},{"name":"National Science Centre within the MINIATURA 4","award":["INNOMED\/I\/11\/NCBR\/2014"],"award-info":[{"award-number":["INNOMED\/I\/11\/NCBR\/2014"]}]},{"name":"National Science Centre within the MINIATURA 4","award":["2020.04729.BD"],"award-info":[{"award-number":["2020.04729.BD"]}]},{"name":"START 2021 Program of the Foundation for Polish Science (FNP)","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}]},{"name":"START 2021 Program of the Foundation for Polish Science (FNP)","award":["INNOMED\/I\/11\/NCBR\/2014"],"award-info":[{"award-number":["INNOMED\/I\/11\/NCBR\/2014"]}]},{"name":"START 2021 Program of the Foundation for Polish Science (FNP)","award":["2020.04729.BD"],"award-info":[{"award-number":["2020.04729.BD"]}]},{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"publisher","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"publisher","award":["INNOMED\/I\/11\/NCBR\/2014"],"award-info":[{"award-number":["INNOMED\/I\/11\/NCBR\/2014"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"publisher","award":["2020.04729.BD"],"award-info":[{"award-number":["2020.04729.BD"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["2020\/04\/X\/ST5\/00789"],"award-info":[{"award-number":["2020\/04\/X\/ST5\/00789"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["INNOMED\/I\/11\/NCBR\/2014"],"award-info":[{"award-number":["INNOMED\/I\/11\/NCBR\/2014"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","award":["2020.04729.BD"],"award-info":[{"award-number":["2020.04729.BD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) are receiving increasing interest as an approach to encapsulate natural extracts to increase the physicochemical stability of bioactives. Cannabis extract-derived cannabidiol (CBD) has potent therapeutic properties, including anti-inflammatory, antioxidant, and neuroprotective properties. In this work, physicochemical characterization was carried out after producing Compritol-based nanoparticles (cSLN or cNLC) loaded with CBD. Then, the determination of the encapsulation efficiency (EE), loading capacity (LC), particle size (Z-Ave), polydispersity index (PDI), and zeta potential were performed. Additionally, the viscoelastic profiles and differential scanning calorimetry (DSC) patterns were recorded. As a result, CBD-loaded SLN showed a mean particle size of 217.2 \u00b1 6.5 nm, PDI of 0.273 \u00b1 0.023, and EE of about 74%, while CBD-loaded NLC showed Z-Ave of 158.3 \u00b1 6.6 nm, PDI of 0.325 \u00b1 0.016, and EE of about 70%. The rheological analysis showed that the loss modulus for both lipid nanoparticle formulations was higher than the storage modulus over the applied frequency range of 10 Hz, demonstrating that they are more elastic than viscous. The crystallinity profiles of both CBD-cSLN (90.41%) and CBD-cNLC (40.18%) were determined. It may justify the obtained encapsulation parameters while corroborating the liquid-like character demonstrated in the rheological analysis. Scanning electron microscopy (SEM) study confirmed the morphology and shape of the developed nanoparticles. The work has proven that the solid nature and morphology of cSLN\/cNLC strengthen these particles\u2019 potential to modify the CBD delivery profile for several biomedical applications.<\/jats:p>","DOI":"10.3390\/molecules28062875","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T02:35:26Z","timestamp":1679538926000},"page":"2875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Phytocannabinoids: Chromatographic Screening of Cannabinoids and Loading into Lipid Nanoparticles"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-1377","authenticated-orcid":false,"given":"Aleksandra","family":"Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Strzeszy\u0144ska 32, 60-479 Poznan, Poland"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Raquel","family":"da Ana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Joel","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8251","authenticated-orcid":false,"given":"Milena","family":"Szalata","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, National Research Institute, Wojska Polskiego 71B, 60-630 Poznan, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-2991","authenticated-orcid":false,"given":"Karolina","family":"Wielgus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27\/33, 60-572 Poznan, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8537-0948","authenticated-orcid":false,"given":"Faezeh","family":"Fathi","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira No. 280, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6596","authenticated-orcid":false,"given":"M. Beatriz P. P.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira No. 280, 4050-313 Porto, Portugal"}]},{"given":"Rafa\u0142","family":"Staszewski","sequence":"additional","affiliation":[{"name":"Department of Hypertension Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}]},{"given":"Jacek","family":"Karczewski","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland"},{"name":"Department of Gastroenterology, Dietetics and Internal Diseases, H. Swiecicki University Hospital, Poznan University of Medical Sciences, 60-355 Poznan, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/17425247.2020.1727883","article-title":"SLN and NLC for topical, dermal, and transdermal drug delivery","volume":"17","author":"Souto","year":"2020","journal-title":"Expert Opin. 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Sci., 21.","DOI":"10.3390\/ijms21041449"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2875\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:00:57Z","timestamp":1760122857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/6\/2875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["molecules28062875"],"URL":"https:\/\/doi.org\/10.3390\/molecules28062875","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}