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Regional Development Fund (FEDER)","award":["UIDB\/00690\/2020"],"award-info":[{"award-number":["UIDB\/00690\/2020"]}]},{"name":"European Regional Development Fund (FEDER)","award":["UIDP\/00690\/2020"],"award-info":[{"award-number":["UIDP\/00690\/2020"]}]},{"name":"European Regional Development Fund (FEDER)","award":["UIDB\/05757\/2020"],"award-info":[{"award-number":["UIDB\/05757\/2020"]}]},{"name":"European Regional Development Fund (FEDER)","award":["UIDP\/05757\/2020"],"award-info":[{"award-number":["UIDP\/05757\/2020"]}]},{"name":"European Regional Development Fund (FEDER)","award":["LA\/P\/0007\/2021"],"award-info":[{"award-number":["LA\/P\/0007\/2021"]}]},{"name":"European Regional Development Fund (FEDER)","award":["CEECIND\/01011\/2018"],"award-info":[{"award-number":["CEECIND\/01011\/2018"]}]},{"name":"European Regional Development Fund (FEDER)","award":["2020.08092.BD"],"award-info":[{"award-number":["2020.08092.BD"]}]},{"name":"European Regional Development Fund (FEDER)","award":["FJC20120-045405-I"],"award-info":[{"award-number":["FJC20120-045405-I"]}]},{"name":"European Regional Development Fund (FEDER)","award":["POCI-01-0247-FEDER-046112"],"award-info":[{"award-number":["POCI-01-0247-FEDER-046112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aromatic plants are a remarkable source of natural products. Aloysia citrodora Pal\u00e1u (Verbenaceae), commonly known as lemon verbena, is a relevant source of essential oils with potential applications due to its lemony scent and bioactive properties. Studies carried out on this species have focused on the volatile composition of the essential oil obtained by Clevenger hydrodistillation (CHD), with little information available on alternative extraction methodologies or the biological properties of the oil. Therefore, this work aimed to compare the volatile composition, antioxidant activity, cytotoxicity, anti-inflammatory and antibacterial activities of the essential oil extracted by conventional hydrodistillation by Clevenger (CHD) and Microwave-Assisted Hydrodistillation (MAHD). Significant differences (p &lt; 0.05) were observed for some compounds, including the two major ones, geranial (18.7\u201321.1%) and neral (15.3\u201316.2%). Better antioxidant activity was exhibited by the MAHD essential oil in DPPH radical scavenging and reducing power assays, while no differences were observed in the cellular antioxidant assay. The MADH essential oil also presented higher inhibition against four tumoral cell lines and exhibited lower cytotoxicity in non-tumoral cells as compared with Clevenger-extracted essential oil. In contrast, the latter showed higher anti-inflammatory activity. Both essential oils were able to inhibit the growth of eleven out of the fifteen bacterial strains tested.<\/jats:p>","DOI":"10.3390\/molecules28114528","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T02:18:29Z","timestamp":1685931509000},"page":"4528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Volatile Compounds and Biological Activity of the Essential Oil of Aloysia citrodora Pal\u00e1u: Comparison of Hydrodistillation and Microwave-Assisted Hydrodistillation"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-6401","authenticated-orcid":false,"given":"Rafael M.","family":"Sprea","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"}]},{"given":"Lu\u00eds H. M.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-3833","authenticated-orcid":false,"given":"T\u00e2nia C. S. P.","family":"Pires","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":false,"given":"Ricardo C.","family":"Calhelha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-2029","authenticated-orcid":false,"given":"Pedro Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"},{"name":"Research Center in Digitalization and Intelligent Robotics (CeDRI), Instituto Polit\u00e9cnico de Bragan\u00e7a, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-7303","authenticated-orcid":false,"given":"Joana S.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Braganc\u0327a, Campus de Santa Apol\u00f3nia, 5300-253 Braganc\u0327a, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sharmeen, J.B., Mahomoodally, F.M., Zengin, G., and Maggi, F. (2021). Essential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals. Molecules, 26.","DOI":"10.3390\/molecules26030666"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fmicb.2012.00012","article-title":"Essential Oils in Food Preservation: Mode of Action, Synergies, and Interactions with Food Matrix Components","volume":"3","author":"Hyldgaard","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Maggi, F., and Benelli, G. (2018). Mosquito-Borne Diseases: Implications for Public Health, Springer.","DOI":"10.1007\/978-3-319-94075-5"},{"key":"ref_4","unstructured":"WFO (2023, March 17). World Flora Online. Available online: http:\/\/www.worldfloraonline.org\/taxon\/wfo-0000950712."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1080\/0972060X.2022.2130015","article-title":"Chemical Composition and Biological Activity of Lemon Verbena (Lippia citriodora) Essential Oil\u2014A Review","volume":"25","author":"Majewska","year":"2022","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jep.2018.04.021","article-title":"Aloysia Citrodora Pal\u00e1u (Lemon verbena): A Review of Phytochemistry and Pharmacology","volume":"222","author":"Bahramsoltani","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","first-page":"182","article-title":"Influence of Different Drying Methods on Drying Period, Essential Oil Content and Composition of Lippia Citriodora Kunth","volume":"2","author":"Ebadi","year":"2015","journal-title":"J. Appl. Res. Med. Aromat. Plants"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.scp.2018.03.002","article-title":"Extraction of Essential Oils from Damask Rose Using Green and Conventional Techniques: Microwave and Ohmic Assisted Hydrodistillation versus Hydrodistillation","volume":"8","author":"Manouchehri","year":"2018","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.foodres.2018.06.036","article-title":"Extraction of Bioactive Compounds and Essential Oils from Mediterranean Herbs by Conventional and Green Innovative Techniques: A Review","volume":"113","author":"Giacometti","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104999","DOI":"10.1016\/j.ultsonch.2020.104999","article-title":"Extraction of Bioactive Compounds from Defatted Passion Fruit Bagasse (Passiflora edulis sp.) Applying Pressurized Liquids Assisted by Ultrasound","volume":"64","author":"Meireles","year":"2020","journal-title":"Ultrason. Sonochemistry"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Malik, S. (2019). Essential Oil Research: Trends in Biosynthesis, Analytics, Industrial Applications and Biotechnological Production, Springer International Publishing.","DOI":"10.1007\/978-3-030-16546-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/10412905.2021.1936666","article-title":"Effect of Distillation Methods on the Leaf Essential Oil of Some Citrus Cultivars","volume":"33","author":"Sulzbach","year":"2021","journal-title":"J. Essent. Oil Res."},{"key":"ref_13","unstructured":"Adams, R.P. (2017). Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry, Allured Publishing."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10412905.2005.9698835","article-title":"Composition of the Essential Oils from Flowers and Leaves of Vervain [ Aloysia Triphylla (L\u2019Herit.) Britton] Grown in Portugal","volume":"17","author":"Vicente","year":"2005","journal-title":"J. Essent. Oil Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.fct.2011.04.012","article-title":"Evaluation of the Antioxidant and Antiproliferative Potential of Bioflavors","volume":"49","author":"Bicas","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/0972060X.2013.854494","article-title":"Chemical Profile of the Volatile Oil of Lemon Verbena (Aloysia Citriodora Pal\u00e1u) Growing in Jordan","volume":"16","author":"Hudaib","year":"2013","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/10412905.1996.9700698","article-title":"Composition of the Essential Oil of Aloysia Triphylla (L\u2019Herit.) Britton Grown in Turkey","volume":"8","author":"Kirimer","year":"1996","journal-title":"J. Essent. Oil Res."},{"key":"ref_18","first-page":"1","article-title":"Chemical Composition and Cytotoxic and Antibacterial Activities of the Essential Oil of Aloysia Citriodora Palau Grown in Morocco","volume":"2017","author":"Oukerrou","year":"2017","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.1021\/jf0708387","article-title":"Identification of the Genotype from the Content and Composition of the Essential Oil of Lemon Verbena (Aloysia Citriodora Palau)","volume":"55","author":"Gil","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bse.2017.07.003","article-title":"Essential Oil Chemotypes of Aloysia citrodora (Verbenaceae) in Northwestern Argentina","volume":"74","author":"Elechosa","year":"2017","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/cbdv.201100416","article-title":"Northwestern Argentina: A Center of Genetic Diversity of Lemon Verbena (Aloysia citriodora Pal\u00e1u, Verbenaceae)","volume":"10","author":"Molina","year":"2013","journal-title":"Chem. Biodivers."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.biopha.2016.12.104","article-title":"Biological Properties of Citral and Its Potential Protective Effects against Cytotoxicity Caused by Aspirin in the IEC-6 Cells","volume":"87","author":"Bouzenna","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_23","first-page":"295","article-title":"Approach to Determination a Structure\u2014Antioxidant Activity Relationship of Selected Common Terpenoids Evaluated by ABTS \u2022+ Radical Cation Assay","volume":"13","author":"Ciesla","year":"2018","journal-title":"Nat. Prod. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.foodchem.2017.04.036","article-title":"Explaining the Antioxidant Activity of Some Common Non-Phenolic Components of Essential Oils","volume":"232","author":"Baschieri","year":"2017","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.3390\/molecules200711808","article-title":"The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene \u03b2-Caryophyllene from the Essential Oil of Aquilaria Crassna","volume":"20","author":"Dahham","year":"2015","journal-title":"Molecules"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jsfa.6744","article-title":"Antioxidant Effects of the Monoterpenes Carvacrol, Thymol and Sabinene Hydrate on Chemical and Sensory Stability of Roasted Sunflower Seeds","volume":"95","author":"Quiroga","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.procbio.2017.10.020","article-title":"Extraction of Essential Oil from Aloysia Citriodora Palau Leaves Using Continuous and Pulsed Ultrasound: Kinetics, Antioxidant Activity and Antimicrobial Properties","volume":"65","author":"Hashemi","year":"2018","journal-title":"Process Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.29252\/jhehp.5.2.7","article-title":"The Antibacterial and Antioxidant Effects of Clove (Syzygium Aromaticum) and Lemon Verbena (Aloysia Citriodora) Essential Oils","volume":"5","author":"Hosseini","year":"2019","journal-title":"J. Hum. Environ. Health Promot."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Carocho, M., Heleno, S.A., and Barros, L. (2023). Natural Secondary Metabolites: From Nature, Through Science, to Industry, Springer International Publishing.","DOI":"10.1007\/978-3-031-18587-8"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/039463200902200426","article-title":"Verbena Officinalis Essential Oil and Its Component Citral as Apoptotic-Inducing Agent in Chronic Lymphocytic Leukemia","volume":"22","author":"Minervini","year":"2009","journal-title":"Int. J. Immunopathol. Pharm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1055\/s-2005-864146","article-title":"Citral Is a New Inducer of Caspase-3 in Tumor Cell Lines","volume":"71","author":"Dudai","year":"2005","journal-title":"Planta Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1002\/ptr.7125","article-title":"Anticancer Activity of Limonene: A Systematic Review of Target Signaling Pathways","volume":"35","author":"Carvalho","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_33","first-page":"1934578X2096118","article-title":"Myrcene Exhibits Antitumor Activity Against Lung Cancer Cells by Inducing Oxidative Stress and Apoptosis Mechanisms","volume":"15","author":"Bai","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3892\/ijo.2016.3427","article-title":"The Antitumor Effects of Geraniol: Modulation of Cancer Hallmark Pathways (Review)","volume":"48","author":"Cho","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"702487","DOI":"10.3389\/fphar.2021.702487","article-title":"Antitumor Effects of Carvacrol and Thymol: A Systematic Review","volume":"12","author":"Sampaio","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9765","DOI":"10.3748\/wjg.v22.i44.9765","article-title":"Anticancer Effect of Linalool via Cancer-Specific Hydroxyl Radical Generation in Human Colon Cancer","volume":"22","author":"Iwasaki","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1540\/jsmr.46.309","article-title":"Spasmolytic and Anti-Inflammatory Effects of Aloysia Triphylla and Citral, In Vitro and In Vivo Studies","volume":"46","author":"Ortiz","year":"2010","journal-title":"J. Smooth Muscle Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jff.2015.09.034","article-title":"Anti-Inflammatory Activity of Neral and Geranial Isolated from Fruits of Litsea Cubeba Lour","volume":"19","author":"Liao","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e01162019","DOI":"10.1590\/2175-7860202172041","article-title":"Anti-Mycobacterial and Immunomodulatory Activity of n-Hexane Fraction and Spathulenol from Ocotea notata Leaves","volume":"72","author":"Calixto","year":"2021","journal-title":"Rodrigu\u00e9sia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2017.08.030","article-title":"Antioxidant, Anti-Inflammatory, Antiproliferative and Antimycobacterial Activities of the Essential Oil of Psidium Guineense Sw. and Spathulenol","volume":"210","author":"Moreira","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s10787-022-00960-w","article-title":"Pharmacological Evaluation of Anti-Arthritic Potential of Terpinen-4-Ol Using in Vitro and in Vivo Assays","volume":"30","author":"Aslam","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s000110050639","article-title":"Terpinen-4-Ol, the Main Component of the Essential Oil of Melaleuca Alternifolia (Tea Tree Oil), Suppresses Inflammatory Mediator Production by Activated Human Monocytes","volume":"49","author":"Hart","year":"2000","journal-title":"Inflamm. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1055\/s-0035-1546169","article-title":"Gamma-Terpinene Modulates Acute Inflammatory Response in Mice","volume":"81","author":"Piuvezam","year":"2015","journal-title":"Planta Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.jss.2012.10.050","article-title":"Anti-Inflammatory Effects of Linalool in RAW 264.7 Macrophages and Lipopolysaccharide-Induced Lung Injury Model","volume":"180","author":"Huo","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1078\/094471102321621322","article-title":"Anti-Inflammatory Activity of Linalool and Linalyl Acetate Constituents of Essential Oils","volume":"9","author":"Peana","year":"2002","journal-title":"Phytomedicine"},{"key":"ref_46","first-page":"83","article-title":"Growth Inhibition and Morphological Alterations of Staphylococcus Aureus Caused by the Essential Oil of Aloysia Triphylla","volume":"14","author":"Oliva","year":"2015","journal-title":"Bolet\u00edn Latinoam. Y Del Caribe De Plantas Med. Y Arom\u00e1ticas"},{"key":"ref_47","unstructured":"Rezig, L., Sadaa, M., Trabelsi, N., Tammar, S., Limam, H., Rebey, I.B., Smaoui, A., Sghaier, G., Re, G.D., and Ksouri, R. (2019). Chemical Composition, Antioxidant and Antimicrobial Activities of Aloysia triphylla L. essential oils and methanolic extract. Ital. J. Food Sci., 31."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Spr\u00e9a, R.M., Fernandes, \u00c2., Finimundy, T.C., Pereira, C., Alves, M.J., Calhelha, R.C., Canan, C., Barros, L., Amaral, J.S., and Ferreira, I.C.F.R. (2020). Lovage (Levisticum Officinale W.D.J. Koch) Roots: A Source of Bioactive Compounds towards a Circular Economy. Resources, 9.","DOI":"10.3390\/resources9070081"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1021\/jf0715166","article-title":"Cellular Antioxidant Activity (CAA) Assay for Assessing Antioxidants, Foods, and Dietary Supplements","volume":"55","author":"Wolfe","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1016\/j.ejmech.2011.09.029","article-title":"Anti-Hepatocellular Carcinoma Activity Using Human HepG2 Cells and Hepatotoxicity of 6-Substituted Methyl 3-Aminothieno[3,2-b]Pyridine-2-Carboxylate Derivatives: In Vitro Evaluation, Cell Cycle Analysis and QSAR Studies","volume":"46","author":"Abreu","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1039\/C8FO01910J","article-title":"Calluna Vulgaris (L.) Hull: Chemical Characterization, Evaluation of Its Bioactive Properties and Effect on the Vaginal Microbiota","volume":"10","author":"Mandim","year":"2019","journal-title":"Food Funct."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.foodchem.2017.08.010","article-title":"Antioxidant and Antimicrobial Properties of Dried Portuguese Apple Variety (Malus Domestica Borkh. Cv Bravo de Esmolfe)","volume":"240","author":"Pires","year":"2018","journal-title":"Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and Variable Selection via the Elastic Net","volume":"67","author":"Zou","year":"2005","journal-title":"J. R. Stat. Soc. Ser. B (Stat. Methodol.)"},{"key":"ref_54","first-page":"2825","article-title":"Scikit-Learn: Machine Learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/11\/4528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:48:20Z","timestamp":1760125700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/11\/4528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["molecules28114528"],"URL":"https:\/\/doi.org\/10.3390\/molecules28114528","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]}}}