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incidence, a type of skin cancer, has been increasing worldwide. There is a strong need to develop new therapeutic strategies to improve melanoma treatment. Morin is a bioflavonoid with the potential for use in the treatment of cancer, including melanoma. However, therapeutic applications of morin are restrained owing to its low aqueous solubility and limited bioavailability. This work investigates morin hydrate (MH) encapsulation in mesoporous silica nanoparticles (MSNs) to enhance morin bioavailability and consequently increase the antitumor effects in melanoma cells. Spheroidal MSNs with a mean size of 56.3 \u00b1 6.5 nm and a specific surface area of 816 m2\/g were synthesized. MH was successfully loaded (MH-MSN) using the evaporation method, with a loading capacity of 28.3% and loading efficiency of 99.1%. In vitro release studies showed that morin release from MH-MSNs was enhanced at pH 5.2, indicating increased flavonoid solubility. The in vitro cytotoxicity of MH and MH-MSNs on human A375, MNT-1 and SK-MEL-28 melanoma cell lines was investigated. Exposure to MSNs did not affect the cell viability of any of the cell lines tested, suggesting that the nanoparticles are biocompatible. The effect of MH and MH-MSNs on reducing cell viability was time- and concentration-dependent in all melanoma cell lines. The A375 and SK-MEL-28 cell lines were slightly more sensitive than MNT-1 cells in both the MH and MH-MSN treatments. Our findings suggest that MH-MSNs are a promising delivery system for the treatment of melanoma.<\/jats:p>","DOI":"10.3390\/molecules28124776","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T03:18:46Z","timestamp":1686799126000},"page":"4776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Morin Hydrate Encapsulation and Release from Mesoporous Silica Nanoparticles for Melanoma Therapy"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1226-0136","authenticated-orcid":false,"given":"Catarina","family":"Cunha","sequence":"first","affiliation":[{"name":"Department of Biology, CESAM-Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-5744","authenticated-orcid":false,"given":"Diogo","family":"Marinheiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-3160","authenticated-orcid":false,"given":"B\u00e1rbara J. M. L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-0696","authenticated-orcid":false,"given":"Helena","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biology, CESAM-Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-8880","authenticated-orcid":false,"given":"Ana L.","family":"Daniel-da-Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s42247-021-00236-z","article-title":"Silica-Based Nanomaterials as Drug Delivery Tools for Skin Cancer (Melanoma) Treatment","volume":"4","author":"Trinh","year":"2021","journal-title":"Emergent Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.semcancer.2017.10.006","article-title":"Epigenetics of Malignant Melanoma","volume":"51","author":"Moran","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ch\u00e9nais, B. (2022). Transposable Elements and Human Diseases: Mechanisms and Implication in the Response to Environmental Pollutants. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052551"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"de Oliveira, N.F.P., de Souza, B.F., and de Castro Co\u00ealho, M. (2020). UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review. Epigenomes, 4.","DOI":"10.3390\/epigenomes4040023"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pinto, A., Cunha, C., Chaves, R., Butchbach, M.E.R., and Adega, F. (2022). Comprehensive In Silico Analysis of Retrotransposon Insertions within the Survival Motor Neuron Genes Involved in Spinal Muscular Atrophy. Biology, 11.","DOI":"10.21203\/rs.3.rs-1239736\/v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/febs.15722","article-title":"Transposable Element Regulation and Expression in Cancer","volume":"289","author":"Grundy","year":"2022","journal-title":"FEBS J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/CMR.0b013e32832b274e","article-title":"CpG Island Methylation Profiling in Human Melanoma Cell Lines","volume":"19","author":"Tellez","year":"2009","journal-title":"Melanoma Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejca.2022.04.018","article-title":"European Consensus-Based Interdisciplinary Guideline for Melanoma. Part 2: Treatment-Update 2022","volume":"170","author":"Garbe","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/ITT.S134842","article-title":"Melanoma Treatment in Review","volume":"7","author":"Domingues","year":"2018","journal-title":"Immunotargets Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Oliveira Pinho, J., Matias, M., and Gaspar, M.M. (2019). Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma. Nanomaterials, 9.","DOI":"10.3390\/nano9101455"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00432-018-2726-1","article-title":"Melanoma Treatment: From Conventional to Nanotechnology","volume":"144","author":"Mishra","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Beiu, C., Giurcaneanu, C., Grumezescu, A.M., Holban, A.M., Popa, L.G., and Mihai, M.M. (2020). Nanosystems for Improved Targeted Therapies in Melanoma. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020318"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1038\/sj.onc.1206454","article-title":"Apoptosis and Melanoma Chemoresistance","volume":"22","author":"Soengas","year":"2003","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An Overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103409","DOI":"10.1016\/j.drudis.2022.103409","article-title":"Recent Advances in Flavonoid-Based Nanocarriers as an Emerging Drug Delivery Approach for Cancer Chemotherapy","volume":"28","author":"Dewanjee","year":"2023","journal-title":"Drug Discov. Today"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1080\/10408398.2021.1881437","article-title":"Prenylated Flavonoids in Foods and Their Applications on Cancer Prevention","volume":"62","author":"Wen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1258\/ebm.2012.012148","article-title":"Apigenin-Induced Apoptosis in A375 and A549 Cells through Selective Action and Dysfunction of Mitochondria","volume":"237","author":"Das","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/exd.12181","article-title":"Fisetin Inhibits Growth, Induces G2\/M Arrest and Apoptosis of Human Epidermoid Carcinoma A431 Cells: Role of Mitochondrial Membrane Potential Disruption and Consequent Caspases Activation","volume":"22","author":"Pal","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.nano.2014.05.007","article-title":"Excellent Anti-Proliferative and pro-Apoptotic Effects of (\u2212)-Epigallocatechin-3-Gallate Encapsulated in Chitosan Nanoparticles on Human Melanoma Cell Growth Both in Vitro and in Vivo","volume":"10","author":"Siddiqui","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jddst.2019.04.044","article-title":"Synthesis of Luteolin Loaded Zein Nanoparticles for Targeted Cancer Therapy Improving Bioavailability and Efficacy","volume":"52","author":"Shinde","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27471","DOI":"10.18632\/oncotarget.15832","article-title":"Luteolin Inhibits Cell Proliferation and Induces Cell Apoptosis via Down-Regulation of Mitochondrial Membrane Potential in Esophageal Carcinoma Cells EC1 and KYSE450","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mnfr.201500822","article-title":"Molecular Mechanisms of Flavonoids in Melanin Synthesis and the Potential for the Prevention and Treatment of Melanoma","volume":"60","author":"Meyskens","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kopustinskiene, D.M., Jakstas, V., Savickas, A., and Bernatoniene, J. (2020). Flavonoids as Anticancer Agents. Nutrients, 12.","DOI":"10.3390\/nu12020457"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/01635581.2020.1778747","article-title":"Overview of Morin and Its Complementary Role as an Adjuvant for Anticancer Agents","volume":"73","author":"Solairaja","year":"2021","journal-title":"Nutr. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.1002\/ptr.7270","article-title":"The Anticarcinogenic and Anticancer Effects of the Dietary Flavonoid, Morin: Current Status, Challenges, and Future Perspectives","volume":"35","author":"Mottaghi","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12272-019-01158-5","article-title":"Flavonoid Morin Inhibits Proliferation and Induces Apoptosis of Melanoma Cells by Regulating Reactive Oxygen Species, Sp1 and Mcl-1","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jphs.2018.02.003","article-title":"Morin Inhibits Proliferation and Self-Renewal of CD133 + Melanoma Cells by Upregulating MiR-216a","volume":"136","author":"Hu","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1155\/2009\/154321","article-title":"Structural Analysis of DNA and RNA Interactions with Antioxidant Flavonoids","volume":"23","author":"Kanakis","year":"2009","journal-title":"Spectroscopy"},{"key":"ref_35","first-page":"395","article-title":"Morin Inhibits the Growth of Human Leukemia HL-60 Cells via Cell Cycle Arrest and Induction of Apoptosis through Mitochondria Dependent Pathway","volume":"27","author":"Kuo","year":"2007","journal-title":"Anticancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.cbi.2009.11.011","article-title":"Morin Fosters Apoptosis in Experimental Hepatocellular Carcinogenesis Model","volume":"183","author":"Sivaramakrishnan","year":"2010","journal-title":"Chem. Biol. Interact"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.taap.2014.03.008","article-title":"Morin Ameliorates Chemically Induced Liver Fibrosis in Vivo and Inhibits Stellate Cell Proliferation in Vitro by Suppressing Wnt\/\u03b2-Catenin Signaling","volume":"277","author":"MadanKumar","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.biopha.2016.10.001","article-title":"Anticancer Effects of Morin-7-Sulphate Sodium, a Flavonoid Derivative, in Mouse Melanoma Cells","volume":"84","author":"Li","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/ijms16010645","article-title":"Morin, a Flavonoid from Moraceae, Induces Apoptosis by Induction of BAD Protein in Human Leukemic Cells","volume":"16","author":"Park","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1158\/1078-0432.CCR-06-2394","article-title":"Morin (3, 5, 7, 2\u2032, 4\u2032-Pentahydroxyflavone) Abolishes Nuclear Factor-\u039aB Activation Induced by Various Carcinogens and Inflammatory Stimuli, Leading to Suppression of Nuclear Factor-\u039aB\u2013Regulated Gene Expression and up-Regulation of Apoptosis","volume":"13","author":"Manna","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.3892\/ijo.2015.2967","article-title":"The Flavonoid Morin from Moraceae Induces Apoptosis by Modulation of Bcl-2 Family Members and Fas Receptor in HCT 116 Cells","volume":"46","author":"Hyun","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.biopha.2018.02.035","article-title":"Molecular Chemoprevention by Morin\u2014A Plant Flavonoid That Targets Nuclear Factor Kappa B in Experimental Colon Cancer","volume":"100","author":"Sharma","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijo.2016.3546","article-title":"Combination Treatment with Flavonoid Morin and Telomerase Inhibitor MST-312 Reduces Cancer Stem Cell Traits by Targeting STAT3 and Telomerase","volume":"49","author":"Chung","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejps.2018.12.011","article-title":"Mechanisms of Poor Oral Bioavailability of Flavonoid Morin in Rats: From Physicochemical to Biopharmaceutical Evaluations","volume":"128","author":"Li","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2012.09.008","article-title":"Mesoporous Systems for Poorly Soluble Drugs","volume":"453","author":"Xu","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104988","DOI":"10.1016\/j.chemphyslip.2020.104988","article-title":"Morin Hydrate Loaded Solid Lipid Nanoparticles: Characterization, Stability, Anticancer Activity, and Bioavailability","volume":"233","author":"Karamchedu","year":"2020","journal-title":"Chem. Phys. Lipids"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/07373937.2018.1488261","article-title":"Influence of Novel Carrier Soluplus\u00ae on Aqueous Stability, Oral Bioavailability, and Anticancer Activity of Morin Hydrate","volume":"37","author":"Kulkarni","year":"2019","journal-title":"Dry. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nogueira, J., Soares, S.F., Amorim, C.O., Amaral, J.S., Silva, C., Martel, F., Trindade, T., and Daniel-da-Silva, A.L. (2020). Magnetic Driven Nanocarriers for PH-Responsive Doxorubicin Release in Cancer Therapy. Molecules, 25.","DOI":"10.3390\/molecules25020333"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1002\/jps.24548","article-title":"Orally Administered Chitosan-Coated Polycaprolactone Nanoparticles Containing Curcumin Attenuate Metastatic Melanoma in the Lungs","volume":"104","author":"Mazzarino","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Martau, G.A., Mihai, M., and Vodnar, D.C. (2019). The Use of Chitosan, Alginate, and Pectin in the Biomedical and Food Sector-Biocompatibility, Bioadhesiveness, and Biodegradability. Polymers, 11.","DOI":"10.3390\/polym11111837"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"P\u0103duraru, D.N., Ion, D., Niculescu, A.-G., Mu\u0219at, F., Andronic, O., Grumezescu, A.M., and Bolocan, A. (2022). Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020435"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1039\/D1NA00036E","article-title":"Carbon Dots for Cancer Nanomedicine: A Bright Future","volume":"3","author":"Bayda","year":"2021","journal-title":"Nanoscale Adv."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1039\/C3RA44257H","article-title":"Mesoporous Silica Nanoparticles Enhance the Cytotoxicity of Curcumin","volume":"4","author":"Jambhrunkar","year":"2014","journal-title":"RSC Adv."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kong, Z.L., Kuo, H.P., Johnson, A., Wu, L.C., and Chang, K.L.B. (2019). Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20122918"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.msec.2016.03.011","article-title":"Curcumin-Loaded Silica-Based Mesoporous Materials: Synthesis, Characterization and Cytotoxic Properties against Cancer Cells","volume":"63","author":"Bollu","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s13346-019-00640-3","article-title":"Mesoporous Silica Nanoparticles, a Safe Option for Silymarin Delivery: Preparation, Characterization, and in Vivo Evaluation","volume":"9","author":"Nasr","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Marinheiro, D., Ferreira, B., Oskoei, P., Oliveira, H., and Daniel-da-Silva, A. (2021). Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy. Materials, 14.","DOI":"10.3390\/ma14061382"},{"key":"ref_58","unstructured":"Zieli\u0144ska, A., Pereira, I., Antunes, S., Veiga, F.J., Santos, A.C., Nowak, I., Silva, A.M., and Souto, E.B. (2018). Design of Nanostructures for Theranostics Applications, Elsevier."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1172\/JCI45600","article-title":"Multimodal Silica Nanoparticles Are Effective Cancer-Targeted Probes in a Model of Human Melanoma","volume":"121","author":"Benezra","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41578-021-00385-x","article-title":"Clinical Translation of Silica Nanoparticles","volume":"6","author":"Janjua","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ejpb.2016.08.020","article-title":"Ordered Mesoporous Silica to Enhance the Bioavailability of Poorly Water-Soluble Drugs: Proof of Concept in Man","volume":"108","author":"Bukara","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.biomaterials.2010.10.035","article-title":"Single and Repeated Dose Toxicity of Mesoporous Hollow Silica Nanoparticles in Intravenously Exposed Mice","volume":"32","author":"Liu","year":"2011","journal-title":"Biomaterials"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/smll.201001459","article-title":"In Vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation","volume":"7","author":"He","year":"2011","journal-title":"Small"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/ar3000986","article-title":"Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility","volume":"46","author":"Tarn","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref_65","unstructured":"Deswal, B., Kapoor, S., and Roy, A. (2021). Nanomedicine for Cancer Diagnosis and Therapy, Springer."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Arriagada, F., Correa, O., G\u00fcnther, G., Nonell, S., Mura, F., Olea-Azar, C., and Morales, J. (2016). Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164507"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101198","DOI":"10.1016\/j.mtcomm.2020.101198","article-title":"Antioxidant Activity and Modified Release Profiles of Morin and Hesperetin Flavonoids Loaded in Mg- or Ag-Modified SBA-16 Carriers","volume":"24","author":"Trendafilova","year":"2020","journal-title":"Mater. Today Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1111\/jocd.15273","article-title":"Characteristics and in Vitro Anti Skin Aging Activity and UV Radiation Protection of Morin Loaded in Niosomes","volume":"21","author":"Mohamadi","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s11051-022-05552-x","article-title":"Morin-Loaded Nanoceria as an Efficient Nanoformulation for Increased Antioxidant and Antibacterial Efficacy","volume":"24","author":"Thakur","year":"2022","journal-title":"J. Nanoparticle Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"109976","DOI":"10.1016\/j.inoche.2022.109976","article-title":"Folic Acid-Functionalized Cerium Oxide Nanoparticles as Smart Nanocarrier for PH-Responsive and Targeted Delivery of Morin in Breast Cancer Therapy","volume":"145","author":"Thakur","year":"2022","journal-title":"Inorg. Chem. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/ja910846q","article-title":"Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity","volume":"132","author":"Lin","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.eng.2018.06.001","article-title":"Progress in the Physisorption Characterization of Nanoporous Gas Storage Materials","volume":"4","author":"Cychosz","year":"2018","journal-title":"Engineering"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cej.2007.07.078","article-title":"Studies on MCM-41 Mesoporous Silica for Drug Delivery: Effect of Particle Morphology and Amine Functionalization","volume":"137","author":"Manzano","year":"2008","journal-title":"Chem. Eng. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jcis.2008.01.035","article-title":"Rheological Behavior of Thermoreversible \u03ba-Carrageenan\/Nanosilica Gels","volume":"320","author":"Pinto","year":"2008","journal-title":"J. Colloid Interface Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vibspec.2012.10.006","article-title":"Interpretation of the IR and Raman Spectra of Morin by Density Functional Theory and Comparative Analysis","volume":"64","year":"2013","journal-title":"Vib. Spectrosc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/IJN.S73971","article-title":"Preparation, in Vitro and in Vivo Evaluation of Polymeric Nanoparticles Based on Hyaluronic Acid-Poly(Butyl Cyanoacrylate) and D-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate for Tumor-Targeted Delivery of Morin Hydrate","volume":"10","author":"Zhou","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.2174\/1385272822666180827125651","article-title":"Phase Change Materials Based on Mesoporous Silica","volume":"22","author":"Mitran","year":"2019","journal-title":"Curr. Org. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Mitran, R.-A., Ioni\u0163\u01ce, S., Lincu, D., Berger, D., and Matei, C. (2021). A Review of Composite Phase Change Materials Based on Porous Silica Nanomaterials for Latent Heat Storage Applications. Molecules, 26.","DOI":"10.3390\/molecules26010241"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1080\/03639045.2020.1776318","article-title":"Amorphous Nano Morin Outperforms Native Molecule in Anticancer Activity and Oral Bioavailability","volume":"46","author":"Jangid","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1021\/acs.molpharmaceut.5b00863","article-title":"Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion","volume":"13","author":"Harmon","year":"2016","journal-title":"Mol. Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1021\/jo802716v","article-title":"Acidity of Hydroxyl Groups: An Overlooked Influence on Antiradical Properties of Flavonoids","volume":"74","author":"Musialik","year":"2009","journal-title":"J. Org. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molliq.2016.11.036","article-title":"Structure-Solubility Relationships and Thermodynamic Aspects of Solubility of Some Flavonoids in the Solvents Modeling Biological Media","volume":"225","author":"Zhang","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"28836","DOI":"10.1039\/C8RA04139C","article-title":"Determination of Solubility, Stability and Degradation Kinetics of Morin Hydrate in Physiological Solutions","volume":"8","author":"Jangid","year":"2018","journal-title":"RSC Adv."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and Comparison of Dissolution Profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-3659(87)90035-6","article-title":"A Simple Equation for Description of Solute Release II. Fickian and Anomalous Release from Swellable Devices","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxlet.2013.09.012","article-title":"Strategic Formulation of Apigenin-Loaded PLGA Nanoparticles for Intracellular Trafficking, DNA Targeting and Improved Therapeutic Effects in Skin Melanoma in Vitro","volume":"223","author":"Das","year":"2013","journal-title":"Toxicol. Lett."},{"key":"ref_87","first-page":"585","article-title":"Nitric Oxide Triggers Apoptosis in A375 Human Melanoma Cells Treated with Capsaicin and Resveratrol","volume":"5","author":"Kim","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Salvador, D., Bastos, V., and Oliveira, H. (2021). Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010035"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s11095-021-03043-7","article-title":"Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells","volume":"38","author":"Palliyage","year":"2021","journal-title":"Pharm. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1158\/1940-6207.CAPR-12-0425","article-title":"Direct Targeting of MEK1\/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth","volume":"6","author":"Lee","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Militaru, I.V., Rus, A.A., Munteanu, C.V.A., Manica, G., and Petrescu, S.M. (2023). New Panel of Biomarkers to Discriminate between Amelanotic and Melanotic Metastatic Melanoma. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1061832"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bbcan.2016.10.002","article-title":"Guidelines for the Selection of Functional Assays to Evaluate the Hallmarks of Cancer","volume":"1866","author":"Sukumar","year":"2016","journal-title":"Biochim. Et Biophys. Acta (BBA)-Rev. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biomaterials.2009.09.060","article-title":"The Effect of the Shape of Mesoporous Silica Nanoparticles on Cellular Uptake and Cell Function","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2014.11.022","article-title":"Mesoporous Silica as Topical Nanocarriers for Quercetin: Characterization and in Vitro Studies","volume":"89","author":"Sapino","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"854096","DOI":"10.1100\/2012\/854096","article-title":"Evaluation of Melanogenesis in A-375 Cells in the Presence of DMSO and Analysis of Pyrolytic Profile of Isolated Melanin","volume":"2012","author":"Chodurek","year":"2012","journal-title":"Sci. World J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.15419\/bmrat.v7i7.614","article-title":"Comparative Cytotoxic Effects of Methanol, Ethanol and DMSO on Human Cancer Cell Lines","volume":"7","author":"Nguyen","year":"2020","journal-title":"Biomed. Res. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fphar.2018.00429","article-title":"The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells","volume":"9","author":"Mioc","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1167\/iovs.06-1304","article-title":"Responses of Human Lens Epithelial Cells to Quercetin and DMSO","volume":"48","author":"Cao","year":"2007","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/21691401.2018.1423991","article-title":"Development of Fisetin-Loaded Folate Functionalized Pluronic Micelles for Breast Cancer Targeting","volume":"46","author":"Pawar","year":"2018","journal-title":"Artif. Cells Nanomed Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"111719","DOI":"10.1016\/j.msec.2020.111719","article-title":"Delivery of Apigenin-Loaded Magnetic Fe2O3\/Fe3O4@mSiO2 Nanocomposites to A549 Cells and Their Antitumor Mechanism","volume":"120","author":"Liu","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_102","first-page":"2306","article-title":"Development of Genistein-PEGylated Silica Hybrid Nanomaterials with Enhanced Antioxidant and Antiproliferative Properties on HT29 Human Colon Cancer Cells","volume":"10","author":"Pool","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/02652048.2020.1740804","article-title":"Synthesis and Characterisation of Chitosan-Encapsulated Genistein: Its Anti-Proliferative and Anti-Angiogenic Activities","volume":"37","author":"Rahmani","year":"2020","journal-title":"J. Microencapsul."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.bbagen.2016.07.001","article-title":"Targeted Delivery of Quercetin Loaded Mesoporous Silica Nanoparticles to the Breast Cancer Cells","volume":"1860","author":"Sarkar","year":"2016","journal-title":"Biochim. Et Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3892\/ijo.2014.2535","article-title":"Morin, a Flavonoid from Moraceae, Suppresses Growth and Invasion of the Highly Metastatic Breast Cancer Cell Line MDA-MB-231 Partly through Suppression of the Akt Pathway","volume":"45","author":"Jin","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s43440-021-00272-w","article-title":"Cell Cycle Arrest-Mediated Cell Death by Morin in MDA-MB-231 Triple-Negative Breast Cancer Cells","volume":"73","author":"Maharjan","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fphar.2017.00640","article-title":"Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect","volume":"8","author":"Sithara","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"111832","DOI":"10.1016\/j.jinorgbio.2022.111832","article-title":"Hydrophilic Bis-MPA Hyperbranched Dendritic Scaffolds as Nanocarriers of a Fully Characterized Flavonoid Morin-Zn(II) Complex for Anticancer Applications","volume":"232","author":"Halevas","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.colsurfb.2018.11.073","article-title":"Designing of Fatty Acid-Surfactant Conjugate Based Nanomicelles of Morin Hydrate for Simultaneously Enhancing Anticancer Activity and Oral Bioavailability","volume":"175","author":"Jangid","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cbi.2014.09.025","article-title":"Synthesis and Characterisation of Morin Reduced Gold Nanoparticles and Its Cytotoxicity in MCF-7 Cells","volume":"224","author":"Kondath","year":"2014","journal-title":"Chem Biol. Interact."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s11671-020-03297-x","article-title":"Designing Aptamer-Gold Nanoparticle-Loaded PH-Sensitive Liposomes Encapsulate Morin for Treating Cancer","volume":"15","author":"Ding","year":"2020","journal-title":"Nanoscale Res. Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"101415","DOI":"10.1039\/C6RA20441D","article-title":"Solubility Enhancement of Morin and Epicatechin through Encapsulation in an Albumin Based Nanoparticulate System and Their Anticancer Activity against the MDA-MB-468 Breast Cancer Cell Line","volume":"6","author":"Ghosh","year":"2016","journal-title":"RSC Adv."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1021\/acsomega.1c06956","article-title":"Nanoencapsulation as a Promising Platform for the Delivery of the Morin-Cu(II) Complex: Antibacterial and Anticancer Potential","volume":"7","author":"Ghosh","year":"2022","journal-title":"ACS Omega"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.1021\/ja211035w","article-title":"Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles","volume":"134","author":"Pan","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/bjc.1987.190","article-title":"A Study of Some Variables in a Tetrazolium Dye (MTT) Based Assay for Cell Growth and Chemosensitivity","volume":"56","author":"Twentyman","year":"1987","journal-title":"Br. J. 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