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Portugal","award":["422893\/2021-8"],"award-info":[{"award-number":["422893\/2021-8"]}]},{"name":"FCT, Portugal","award":["317282\/2021-2"],"award-info":[{"award-number":["317282\/2021-2"]}]},{"name":"FCT, Portugal","award":["88887.582123\/2020-00"],"award-info":[{"award-number":["88887.582123\/2020-00"]}]},{"name":"FCT, Portugal","award":["UID\/QUI\/00313\/2020"],"award-info":[{"award-number":["UID\/QUI\/00313\/2020"]}]},{"name":"FCT, Portugal","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"FCT, Portugal","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"FCT, Portugal","award":["IMS-LA\/P\/0056\/2020UIDB\/00100\/2020"],"award-info":[{"award-number":["IMS-LA\/P\/0056\/2020UIDB\/00100\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Coamorphous formation in binary systems of valsartan (Val) with 4,4\u2032-bipyridine (Bipy) and trimethoprim (Tri) was investigated for mixtures with a mole fraction of 0.16~0.86 of valsartan and evaluated in terms of the glass transition temperature. The glass transition of the systems had a behavior outside the values predicted by the Gordon\u2013Taylor equation, showing that Val-Bipy (hydrogen bonding between the components) had a lower deviation and Val-Tri (ionic bonding between the components) had a higher deviation. Mixtures of compositions 2:1 Val-Bipy and 1:1 Val-Tri were selected for further investigation and verified to be stable, as no crystallization was observed during subsequent heating and cooling programs. For these systems, the effective activation energy during glass transition was evaluated. Compared to pure valsartan, the system with the lower glass transition temperature (Val-Bipy) presented the highest effective activation energy, and the system with the higher glass transition temperature (Val-Tri) presented a lower effective activation energy. The results presented a good correlation between the data obtained from two different techniques to determine the fragility and effective activation energy: non-isothermal kinetic analysis by DSC and TSDC.<\/jats:p>","DOI":"10.3390\/molecules28176240","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:42:20Z","timestamp":1692952940000},"page":"6240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coamorphous Systems of Valsartan: Thermal Analysis Contribution to Evaluate Intermolecular Interactions Effects on the Structural Relaxation"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-241X","authenticated-orcid":false,"given":"Bruno","family":"Ekawa","sequence":"first","affiliation":[{"name":"Institute of Chemistry, S\u00e3o Paulo State University (UNESP), Araraquara 14801-970, Brazil"},{"name":"Coimbra Chemistry Center, Institute of Molecular Sciences, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-1306","authenticated-orcid":false,"given":"Herm\u00ednio P.","family":"Diogo","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1263-9034","authenticated-orcid":false,"given":"Ricardo A. E.","family":"Castro","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Center, Institute of Molecular Sciences, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-2111","authenticated-orcid":false,"given":"Fl\u00e1vio J.","family":"Caires","sequence":"additional","affiliation":[{"name":"School of Sciences, S\u00e3o Paulo State University (UNESP), Bauru 17033-360, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-7721","authenticated-orcid":false,"given":"M. Ermelinda S.","family":"Eus\u00e9bio","sequence":"additional","affiliation":[{"name":"Coimbra Chemistry Center, Institute of Molecular Sciences, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1021\/acs.jcim.8b00364","article-title":"Trans and Cis Conformations of the Antihypertensive Drug Valsartan Respectively Lock the Inactive and Ac-tive-like States of Angiotensin II Type 1 Receptor: A Molecular Dynamics Study","volume":"58","author":"Wang","year":"2018","journal-title":"J. Chem. Inf. Model."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, X.J., Zhang, Y., and Wang, X.Z. (2020). Study on Co-Crystallization of LCZ696 Using In Situ ATR-FTIR and Imaging. 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