{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:21:00Z","timestamp":1777710060453,"version":"3.51.4"},"reference-count":394,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CESAM (UIDP\/50017\/2020+UIDB\/50017\/2020+LA\/P\/0094\/2020), LAQV-REQUIMTE","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"CESAM (UIDP\/50017\/2020+UIDB\/50017\/2020+LA\/P\/0094\/2020), LAQV-REQUIMTE","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"CESAM (UIDP\/50017\/2020+UIDB\/50017\/2020+LA\/P\/0094\/2020), LAQV-REQUIMTE","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"CESAM (UIDP\/50017\/2020+UIDB\/50017\/2020+LA\/P\/0094\/2020), LAQV-REQUIMTE","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"CESAM (UIDP\/50017\/2020+UIDB\/50017\/2020+LA\/P\/0094\/2020), LAQV-REQUIMTE","award":["LISBOA-01-0145-FEDER-402-022125"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-402-022125"]}]},{"name":"CICECO-Aveiro Institute of Materials","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"CICECO-Aveiro Institute of Materials","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"CICECO-Aveiro Institute of Materials","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"CICECO-Aveiro Institute of Materials","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"CICECO-Aveiro Institute of Materials","award":["LISBOA-01-0145-FEDER-402-022125"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-402-022125"]}]},{"name":"RNEM, Portuguese Mass Spectrometry Network","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"RNEM, Portuguese Mass Spectrometry Network","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"RNEM, Portuguese Mass Spectrometry Network","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"RNEM, Portuguese Mass Spectrometry Network","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]},{"name":"RNEM, Portuguese Mass Spectrometry Network","award":["LISBOA-01-0145-FEDER-402-022125"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-402-022125"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plant sterols (PS) are cholesterol-like terpenoids widely spread in the kingdom Plantae. Being the target of extensive research for more than a century, PS have topped with evidence of having beneficial effects in healthy subjects and applications in food, cosmetic and pharmaceutical industries. However, many gaps in several fields of PS\u2019s research still hinder their widespread practical applications. In fact, many of the mechanisms associated with PS supplementation and their health benefits are still not fully elucidated. Furthermore, compared to cholesterol data, many complex PS chemical structures still need to be fully characterized, especially in oxidized PS. On the other hand, PS molecules have also been the focus of structural modifications for applications in diverse areas, including not only the above-mentioned but also in e.g., drug delivery systems or alternative matrixes for functional foods and fats. All the identified drawbacks are also superimposed by the need of new PS sources and technologies for their isolation and purification, taking into account increased environmental and sustainability concerns. Accordingly, current and future trends in PS research warrant discussion.<\/jats:p>","DOI":"10.3390\/molecules28186526","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:11:18Z","timestamp":1694423478000},"page":"6526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production"],"prefix":"10.3390","volume":"28","author":[{"given":"Dmitry D.","family":"Evtyugin","sequence":"first","affiliation":[{"name":"CICECO, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"LAQV-REQUIMTE, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6304-5105","authenticated-orcid":false,"given":"Dmitry V.","family":"Evtuguin","sequence":"additional","affiliation":[{"name":"CICECO, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-3850","authenticated-orcid":false,"given":"Susana","family":"Casal","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":false,"given":"Maria Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Centre, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"},{"name":"CESAM, Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF01518263","article-title":"\u00dcber Sitosterin","volume":"18","year":"1897","journal-title":"Monatsh. 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