{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:38:27Z","timestamp":1763059107134,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CICECO-Aveiro Institute of Materials","award":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"],"award-info":[{"award-number":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"]}]},{"name":"national funds through the FCT\/MCTES (PIDDAC)","award":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"],"award-info":[{"award-number":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"]}]},{"name":"Research Excellence Initiative of the University of Silesia in Katowice and Doctoral School Financial Source","award":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"],"award-info":[{"award-number":["UIDP\/50011\/2020","UIDB\/50011\/2020","LA\/P\/0006\/2020","ZFIN 00001022 (IDB)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nowadays, drug delivery systems (DDSs) are gaining more and more attention. Conducting polymers (CPs) are efficiently used for DDS construction as such systems can be used in therapy. In this research, a well-known CP, polypyrrole (PPy), was synthesized in the presence of the polysaccharide heparin (HEP) and chlorpromazine (CPZ) using sodium dodecyl sulfate (SDS) as electrolyte on a steel substrate. The obtained results demonstrate the successful incorporation of CPZ and HEP into the polymer matrix, with the deposited films maintaining stable electrochemical parameters across multiple doping\/dedoping cycles. Surface roughness, estimated via AFM analysis, revealed a correlation with layer thickness\u2014decreasing for thinner layers and increasing for thicker ones. Moreover, SEM images revealed a change in the morphology of PPy films when PPy is electropolymerized in the presence of CPZ and HEP, while FTIR confirmed the presence of CPZ and HEP within PPy. Due to its lower molecular mass compared to HEP, CPZ was readily integrated into the thin polymer matrix during deposition, with diffusion being unimpeded, as opposed to films with greater thickness. Finally, the resulting system exhibited the ability to release CPZ, enabling a dosing range of 10 mg to 20 mg per day, effectively covering the therapeutic concentration range.<\/jats:p>","DOI":"10.3390\/molecules29071531","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T06:33:16Z","timestamp":1711693996000},"page":"1531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chlorpromazine\u2013Polypyrrole Drug Delivery System Tailored for Neurological Application"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-7738","authenticated-orcid":false,"given":"Sara","family":"Krawczyk","sequence":"first","affiliation":[{"name":"Department of Science and Technology, Institute of Materials Engineering, Doctoral School, University of Silesia, Bankowa 14, 40-007 Katowice, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-0490","authenticated-orcid":false,"given":"Sylwia","family":"Golba","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Institute of Materials Engineering, Bankowa 14, 40-007 Katowice, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9530-6963","authenticated-orcid":false,"given":"Cristina","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramic Engineering, Centre for Research in Ceramics and Composite Materials (CICECO), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-4641","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Tedim","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramic Engineering, Centre for Research in Ceramics and Composite Materials (CICECO), University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1257700","DOI":"10.3389\/fphar.2023.1257700","article-title":"Drug repurposing for Alzheimer\u2019s disease from 2012\u20132022\u2014A 10-year literature review","volume":"14","author":"Grabowska","year":"2023","journal-title":"Front. 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