{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:32:26Z","timestamp":1778232746590,"version":"3.51.4"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, I.P,","award":["UID\/Multi\/04349\/2019"],"award-info":[{"award-number":["UID\/Multi\/04349\/2019"]}]},{"name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, I.P,","award":["LISBOA-01-0145-FEDER-022096"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-022096"]}]},{"name":"FCT, Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, I.P,","award":["PRT\/BD\/154845\/2023"],"award-info":[{"award-number":["PRT\/BD\/154845\/2023"]}]},{"name":"PhD doctoral","award":["UID\/Multi\/04349\/2019"],"award-info":[{"award-number":["UID\/Multi\/04349\/2019"]}]},{"name":"PhD doctoral","award":["LISBOA-01-0145-FEDER-022096"],"award-info":[{"award-number":["LISBOA-01-0145-FEDER-022096"]}]},{"name":"PhD doctoral","award":["PRT\/BD\/154845\/2023"],"award-info":[{"award-number":["PRT\/BD\/154845\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction\u2013precipitation (MR\/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating\u2019s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1\/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. M\u00f6ssbauer spectroscopy indicated that samples obtained from MR\/P consist of approximately 11\u201313% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33\u201345%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1\/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.<\/jats:p>","DOI":"10.3390\/molecules29081824","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:52:37Z","timestamp":1713351157000},"page":"1824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1493-5950","authenticated-orcid":false,"given":"Vital Cruvinel","family":"Ferreira-Filho","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]},{"given":"Beatriz","family":"Morais","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-9875","authenticated-orcid":false,"given":"Bruno J. C.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-4099","authenticated-orcid":false,"given":"Jo\u00e3o Carlos","family":"Waerenborgh","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-187X","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Carmezim","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural-CQE, DEQ, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"ESTSet\u00fabal, CDP2T, Instituto Polit\u00e9cnico de Set\u00fabal, 2910-761 Set\u00fabal, Portugal"}]},{"given":"Csilla No\u00e9mi","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, Rue Charles Sadron, 45071 Orl\u00e9ans, CEDEX 2, France"}]},{"given":"Sandra","family":"M\u00eame","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, Rue Charles Sadron, 45071 Orl\u00e9ans, CEDEX 2, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-4379","authenticated-orcid":false,"given":"Sara","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Centre de Biophysique Mol\u00e9culaire, CNRS, UPR 4301, Universit\u00e9 d\u2019Orl\u00e9ans, Rue Charles Sadron, 45071 Orl\u00e9ans, CEDEX 2, France"}]},{"given":"Daniel","family":"Jaque","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica de Materiales, Universidad Autonoma de Madrid, Avda. Francisco Tom\u00e1s y Valiente 7, 28049 Madrid, Spain"}]},{"given":"C\u00e9lia T.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica Aplicada, Universidad Autonoma de Madrid, Avda. Francisco Tom\u00e1s y Valiente 7, 28049 Madrid, Spain"}]},{"given":"Maria Paula Cabral","family":"Campello","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-0039","authenticated-orcid":false,"given":"Laura C. J.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias e Tecnologias Nucleares, Departamento Engenharia Ci\u00eancias Nucleares, Instituto Superior T\u00e9cnico, Universidade de Lisboa, EN10, km 139,7, 2695-066 Bobadela, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref_1","first-page":"85","article-title":"Incident cardiovascular disease among adults with cancer: A population-based cohort study","volume":"4","author":"Paterson","year":"2022","journal-title":"J. Am. Coll. Cardiol. Cardio Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. 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