{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:48:51Z","timestamp":1778618931749,"version":"3.51.4"},"reference-count":198,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["M1420-01-0145-FEDER-000005"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016218","name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}],"id":[{"id":"10.13039\/100016218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016218","name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}],"id":[{"id":"10.13039\/100016218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016218","name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["M1420-01-0145-FEDER-000005"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005"]}],"id":[{"id":"10.13039\/100016218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Terpenoids are a large class of natural secondary plant metabolites which are highly diverse in structure, formed from isoprene units (C-5), associated with a wide range of biological properties, including antioxidant, antimicrobial, anti-inflammatory, antiallergic, anticancer, antimetastatic, antiangiogenesis, and apoptosis induction, and are considered for potential application in the food, cosmetics, pharmaceutical, and medical industries. In plants, terpenoids exert a variety of basic functions in growth and development. This review gives an overview, highlighting the current knowledge of terpenoids and recent advances in our understanding of the organization, regulation, and diversification of core and specialized terpenoid metabolic pathways and addressing the most important functions of volatile and non-volatile specialized terpenoid metabolites in plants. A comprehensive description of different aspects of plant-derived terpenoids as a sustainable source of bioactive compounds, their biosynthetic pathway, the several biological properties attributed to these secondary metabolites associated with health-promoting effects, and their potential industrial applications in several fields will be provided, and emerging and green extraction methods will also be discussed. In addition, future research perspectives within this framework will be highlighted. Literature selection was carried out using the National Library of Medicine, PubMed, and international reference data for the period from 2010 to 2024 using the keyword \u201cterpenoids\u201d. A total of 177,633 published papers were found, of which 196 original and review papers were included in this review according to the criteria of their scientific reliability, their completeness, and their relevance to the theme considered.<\/jats:p>","DOI":"10.3390\/molecules29163861","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T05:47:11Z","timestamp":1723700831000},"page":"3861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications\u2014A Comprehensive Overview"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e da Engenharia da Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1022","authenticated-orcid":false,"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1467-4332","authenticated-orcid":false,"given":"Rui","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-1175","authenticated-orcid":false,"given":"Cristina V.","family":"Berenguer","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-5348","authenticated-orcid":false,"given":"Jorge A. M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-4286","authenticated-orcid":false,"given":"Paula C.","family":"Castilho","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, NPRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e da Engenharia da Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/B978-0-12-823944-5.00012-0","article-title":"Food Bioactives: The Food Image behind the Curtain of Health Promotion and Prevention against Several Degenerative Diseases","volume":"Volume 72","author":"Adefegha","year":"2022","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1073\/pnas.1812935116","article-title":"Two-Step Pathway for Isoprenoid Synthesis","volume":"116","author":"Chatzivasileiou","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Perreca, E., Rohwer, J., Gonz\u00e1lez-Cabanelas, D., Loreto, F., Schmidt, A., Gershenzon, J., and Wright, L.P. (2020). Effect of Drought on the Methylerythritol 4-Phosphate (MEP) Pathway in the Isoprene Emitting Conifer Picea Glauca. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.546295"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12934-019-1235-5","article-title":"Investigation of the Methylerythritol 4-Phosphate Pathway for Microbial Terpenoid Production through Metabolic Control Analysis","volume":"18","author":"Volke","year":"2019","journal-title":"Microb. Cell Fact."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"17318","DOI":"10.1002\/chem.202002163","article-title":"Germacrene A\u2013A Central Intermediate in Sesquiterpene Biosynthesis","volume":"26","author":"Xu","year":"2020","journal-title":"Chem. Eur. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/tpj.16177","article-title":"Plant Terpene Specialized Metabolism: Complex Networks or Simple Linear Pathways?","volume":"114","author":"Lanier","year":"2023","journal-title":"Plant J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1021\/acs.jafc.6b05386","article-title":"Differential Gene Expression Network in Terpenoid Synthesis of Antrodia Cinnamomea in Mycelia and Fruiting Bodies","volume":"65","author":"Lin","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Boncan, D.A.T., Tsang, S.S.K., Li, C., Lee, I.H.T., Lam, H.M., Chan, T.F., and Hui, J.H.L. (2020). Terpenes and Terpenoids in Plants: Interactions with Environment and Insects. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197382"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/pcp\/pcx123","article-title":"\u201cHidden\u201d Terpenoids in Plants: Their Biosynthesis, Localization and Ecological Roles","volume":"58","author":"Yazaki","year":"2017","journal-title":"Plant Cell Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3897\/biorisk.17.77052","article-title":"Plant Products with Acetylcholinesterase Inhibitory Activity for Insect Control","volume":"2022","author":"Georgiev","year":"2022","journal-title":"BioRisk"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Jankowska, M., Rogalska, J., Wyszkowska, J., and Stankiewicz, M. (2018). Molecular Targets for Components of Essential Oils in the Insect Nervous System\u2014A Review. Molecules, 23.","DOI":"10.3390\/molecules23010034"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/07352680600899973","article-title":"Plant Volatiles: Recent Advances and Future Perspectives","volume":"25","author":"Dudareva","year":"2006","journal-title":"CRC Crit. Rev. Plant Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.actatropica.2016.01.024","article-title":"Plants Traditionally Used as Mosquito Repellents and the Implication for Their Use in Vector Control","volume":"157","author":"Tisgratog","year":"2016","journal-title":"Acta Trop."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.indcrop.2014.06.030","article-title":"Acute, Synergistic and Antagonistic Effects of Some Aromatic Compounds on the Spodoptera littoralis Boisd. (Lep., Noctuidae) Larvae","volume":"60","author":"Pavela","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.indcrop.2009.11.005","article-title":"Mode of Inhibition of Acetylcholinesterase by Monoterpenoids and Implications for Pest Control","volume":"31","year":"2010","journal-title":"Ind. Crops Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pestbp.2011.12.002","article-title":"Acetylcholinesterase Inhibition by Nootkatone and Carvacrol in Arthropods","volume":"102","author":"Anderson","year":"2012","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","article-title":"Structure, Function, and Modulation of GABAA Receptors","volume":"287","author":"Sigel","year":"2012","journal-title":"J Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1007\/s00436-016-5106-2","article-title":"Toxicological Evaluation of Essential Oil from the Leaves of Croton Tetradenius (Euphorbiaceae) on Aedes Aegypti and Mus Musculus","volume":"115","author":"Carvalho","year":"2016","journal-title":"Parasitol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OAIP.S20911","article-title":"Review of Octopamine in Insect Nervous Systems","volume":"4","author":"Farooqui","year":"2012","journal-title":"Open Access Insect Physiol."},{"key":"ref_20","unstructured":"Oliveria, M., Silva, S., and da Costa, W. (2020). Terpenoids as Important Bioactive Constituents of Essential Oils. Essential Oils\u2014Bioactive Compounds, New Perspectives and Applications, IntechOpen."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sampaio, L.A., Pina, L.T.S., Serafini, M.R., Tavares, D.d.S., and Guimar\u00e3es, A.G. (2021). Antitumor Effects of Carvacrol and Thymol: A Systematic Review. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.702487"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1007\/s10886-008-9558-4","article-title":"Responses of the Pollinating Wasp Ceratosolen Solmsi Marchali to Odor Variation between Two Floral Stages of Ficus Hispida","volume":"34","author":"Chen","year":"2008","journal-title":"J. Chem. Ecol."},{"key":"ref_23","first-page":"623","article-title":"Defence Mechanisms of Brassicaceae: Implications for Plant-Insect Interactions and Potential for Integrated Pest Management","volume":"2","author":"Ahuja","year":"2009","journal-title":"Sustain. Agric."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1111\/pce.13323","article-title":"Terpenes Associated with Resistance against the Gall Wasp, Leptocybe invasa, in Eucalyptus Grandis","volume":"41","author":"Naidoo","year":"2018","journal-title":"Plant Cell Environ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2307\/1938595","article-title":"Reproductive Interactions Between Sympatric Dalechampia Species: Are Natural Assemblages \u201cRandom\u201d or Organized?","volume":"67","author":"Armbruster","year":"1986","journal-title":"Ecology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s10886-019-01118-9","article-title":"Floral Odors and the Interaction between Pollinating Ceratopogonid Midges and Cacao","volume":"45","author":"Arnold","year":"2019","journal-title":"J. Chem. Ecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2435.2008.01517.x","article-title":"The Sweet Smell of Success: Floral Scent Affects Pollinator Attraction and Seed Fitness in Hesperis matronalis","volume":"23","author":"Majetic","year":"2009","journal-title":"Funct. Ecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/ee\/nvv106","article-title":"Electrophysiological and Behavioral Responses of Chrysopa phyllochroma (Neuroptera: Chrysopidae) to Plant Volatiles","volume":"44","author":"Xu","year":"2015","journal-title":"Environ. Entomol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jplph.2014.08.011","article-title":"Tobacco Overexpressing \u03b2-Ocimene Induces Direct and Indirect Responses against Aphids in Receiver Tomato Plants","volume":"173","author":"Cascone","year":"2015","journal-title":"J. Plant Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Li, H., Li, J., Dong, Y., Hao, H., Ling, Z., Bai, H., Wang, H., Cui, H., and Shi, L. (2019). Time-Series Transcriptome Provides Insights into the Gene Regulation Network Involved in the Volatile Terpenoid Metabolism during the Flower Development of Lavender. BMC Plant Biol., 19.","DOI":"10.1186\/s12870-019-1908-6"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ecoenv.2018.03.033","article-title":"Terpenoid Constituents of Cinnamon and Clove Essential Oils Cause Toxic Effects and Behavior Repellency Response on Granary Weevil, Sitophilus Granarius","volume":"156","author":"Campos","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1021\/acs.jafc.8b00331","article-title":"Geraniol Encapsulated in Chitosan\/Gum Arabic Nanoparticles: A Promising System for Pest Management in Sustainable Agriculture","volume":"66","author":"Campos","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Nazzaro, F., Fratianni, F., Coppola, R., and De Feo, V. (2017). Essential Oils and Antifungal Activity. Pharmaceuticals, 10.","DOI":"10.3390\/ph10040086"},{"key":"ref_34","first-page":"2167-0412","article-title":"Correlation between Plant Secondary Metabolites and Their Antifungal Mechanisms\u2014A Review","volume":"3","author":"Freiesleben","year":"2014","journal-title":"Med. Aromat. Plants"},{"key":"ref_35","first-page":"977","article-title":"Anticandidal Effects of Thymoquinone: Mode of Action Determined by Transmission Electron Microscopy (TEM)","volume":"11","author":"Demirci","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1134\/S0026261716040093","article-title":"Terpenoids with Antifungal Activity Trigger Mitochondrial Dysfunction in Saccharomyces Cerevisiae","volume":"85","author":"Haque","year":"2016","journal-title":"Microbiology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0005-2736(97)00028-X","article-title":"Exploring an Antifungal Target in the Plasma Membrane H+-ATPase of Fungi","volume":"1326","author":"Monk","year":"1997","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Xu, J., Liu, R., Sun, F., An, L., Shang, Z., Kong, L., and Yang, M. (2019). Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida Albicans by Competitively Inhibiting Efflux Pump. Front. Cell Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00211"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3852\/12-012","article-title":"Farnesol Induces Apoptosis-like Phenotype in the Phytopathogenic Fungus Botrytis Cinerea","volume":"105","author":"Cotoras","year":"2013","journal-title":"Mycologia"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Costa-Orlandi, C.B., Sardi, J.C.O., Pitangui, N.S., de Oliveira, H.C., Scorzoni, L., Galeane, M.C., Medina-Alarc\u00f3n, K.P., Melo, W.C.M.A., Marcelino, M.Y., and Braz, J.D. (2017). Fungal Biofilms and Polymicrobial Diseases. J. Fungi, 3.","DOI":"10.3390\/jof3020022"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11046-007-0097-2","article-title":"In Vitro Activity of Eugenol against Candida Albicans Biofilms","volume":"163","author":"He","year":"2007","journal-title":"Mycopathologia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jep.2012.01.045","article-title":"Biofilm Inhibition by Cymbopogon Citratus and Syzygium Aromaticum Essential Oils in the Strains of Candida Albicans","volume":"140","author":"Khan","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5487\/TR.2017.33.2.097","article-title":"Terpenes from Forests and Human Health","volume":"33","author":"Cho","year":"2017","journal-title":"Toxicol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Proshkina, E., Plyusnin, S., Babak, T., Lashmanova, E., Maganova, F., Koval, L., Platonova, E., Shaposhnikov, M., and Moskalev, A. (2020). Terpenoids as Potential Geroprotectors. Antioxidants, 9.","DOI":"10.3390\/antiox9060529"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"100217","DOI":"10.1016\/j.fochx.2022.100217","article-title":"Terpenes and Terpenoids as Main Bioactive Compounds of Essential Oils, Their Roles in Human Health and Potential Application as Natural Food Preservatives","volume":"13","author":"Masyita","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bai, L., Li, J., Li, H., Song, J., Zhou, Y., Lu, R., Liu, B., Pang, Y., Zhang, P., and Chen, J. (2019). Renoprotective Effects of Artemisinin and Hydroxychloroquine Combination Therapy on IgA Nephropathy via Suppressing NF-\u03baB Signaling and NLRP3 Inflammasome Activation by Exosomes in Rats. Biochem. Pharmacol., 169.","DOI":"10.1016\/j.bcp.2019.08.021"},{"key":"ref_47","first-page":"1934578X20903555","article-title":"Advances in Pharmacological Activities of Terpenoids","volume":"15","author":"Yang","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"K\u0142os, P., and Chlubek, D. (2022). Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma. Cancers, 14.","DOI":"10.3390\/cancers14030502"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"111117","DOI":"10.1016\/j.foodres.2022.111117","article-title":"Signaling Pathways and the Potential Anticarcinogenic Effect of Native Brazilian Fruits on Breast Cancer","volume":"155","author":"Reguengo","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Machado, T.Q., Da Fonseca, A.C.C., Duarte, A.B.S., Robbs, B.K., and De Sousa, D.P. (2022). A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/6317201"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105165","DOI":"10.1016\/j.phrs.2020.105165","article-title":"Sesquiterpenes and Their Derivatives-Natural Anticancer Compounds: An Update","volume":"161","author":"Rauf","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_52","first-page":"5301","article-title":"Andrographolide Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Human Melanoma Cells","volume":"15","author":"Liu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Coricovac, D., Dehelean, C.A., Pinzaru, I., Mioc, A., Aburel, O.M., Macasoi, I., Draghici, G.A., Petean, C., Soica, C., and Boruga, M. (2021). Assessment of Betulinic Acid Cytotoxicity and Mitochondrial Metabolism Impairment in a Human Melanoma Cell Line. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094870"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.7150\/jca.45304","article-title":"Borneol Promotes Apoptosis of Human Glioma Cells through Regulating HIF-1a Expression via MTORC1\/EIF4E Pathway","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/1750-3841.14143","article-title":"Natural Borneol Enhances Paclitaxel-Induced Apoptosis of ESCC Cells by Inactivation of the PI3K\/AKT","volume":"83","author":"Meng","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yang, T.Y., Wu, Y.J., Chang, C.I., Chiu, C.C., and Wu, M.L. (2018). The Effect of Bornyl Cis-4-Hydroxycinnamate on Melanoma Cell Apoptosis Is Associated with Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051370"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wu, Y.J., Su, T.R., Chang, C.I., Chen, C.R., Hung, K.F., and Liu, C. (2020). (+)-Bornyl p-Coumarate Extracted from Stem of Piper betle Induced Apoptosis and Autophagy in Melanoma Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103737"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4274\/balkanmedj.galenos.2019.2019.7.117","article-title":"R-(\u2212)-Carvone Attenuated Doxorubicin Induced Cardiotoxicity in Vivo and Potentiated Its Anticancer Toxicity in Vitro","volume":"37","author":"Abbas","year":"2020","journal-title":"Balk. Med. J."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nordin, N., Yeap, S.K., Rahman, H.S., Zamberi, N.R., Abu, N., Mohamad, N.E., How, C.W., Masarudin, M.J., Abdullah, R., and Alitheen, N.B. (2019). In Vitro Cytotoxicity and Anticancer Effects of Citral Nanostructured Lipid Carrier on MDA MBA-231 Human Breast Cancer Cells. Sci. Rep., 9.","DOI":"10.1038\/s41598-018-38214-x"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Est\u00e9vez-Sarmiento, F., Saavedra, E., Ruiz-Est\u00e9vez, M., Le\u00f3n, F., Quintana, J., Brouard, I., and Est\u00e9vez, F. (2020). Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249767"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Abbasifarid, E., Bolhassani, A., Irani, S., and Sotoodehnejadnematalahi, F. (2021). Synergistic Effects of Exosomal Crocin or Curcumin Compounds and HPV L1-E7 Polypeptide Vaccine Construct on Tumor Eradication in C57BL\/6 Mouse Model. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258599"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wu, D., Wang, Z., Lin, M., Shang, Y., Wang, F., Zhou, J.Y., Wang, F., Zhang, X., Luo, X., and Huang, W. (2019). In Vitro and in Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product from Cucumber. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01287"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.7150\/jca.31303","article-title":"Cucurbitacin E Inhibits Cellular Proliferation and Enhances the Chemo-Response in Gastric Cancer by Suppressing AKt Activation","volume":"10","author":"Si","year":"2019","journal-title":"J. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Mun, H., and Townley, H.E. (2021). Mechanism of Action of the Sesquiterpene Compound Helenalin in Rhabdomyosarcoma Cells. Pharmaceuticals, 14.","DOI":"10.3390\/ph14121258"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Jayakumar, T., Liu, C.H., Wu, G.Y., Lee, T.Y., Manubolu, M., Hsieh, C.Y., Yang, C.H., and Sheu, J.R. (2018). Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040939"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ijbiomac.2020.03.132","article-title":"Biocompatible Chitosan-Zinc Oxide Nanocomposite Based Dispersive Micro-Solid Phase Extraction Coupled with HPLC-UV for the Determination of Rosmarinic Acid in the Extracts of Medical Plants and Water Sample","volume":"154","author":"Asfaram","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_67","first-page":"1934578X20961189","article-title":"Myrcene Exhibits Antitumor Activity Against Lung Cancer Cells by Inducing Oxidative Stress and Apoptosis Mechanisms","volume":"15","author":"Bai","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbagen.2018.09.006","article-title":"Myrtenal-Induced V-ATPase Inhibition\u2014A Toxicity Mechanism behind Tumor Cell Death and Suppressed Migration and Invasion in Melanoma","volume":"1863","author":"Martins","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Khusnutdinova, E., Petrova, A., Zileeva, Z., Kuzmina, U., Zainullina, L., Vakhitova, Y., Babkov, D., and Kazakova, O. (2021). Novel A-Ring Chalcone Derivatives of Oleanolic and Ursolic Amides with Anti-Proliferative Effect Mediated through Ros-Triggered Apoptosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189796"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1016\/j.wneu.2018.02.136","article-title":"Thymoquinone Induces Apoptosis in B16-F10 Melanoma Cell Through Inhibition of p-STAT3 and Inhibits Tumor Growth in a Murine Intracerebral Melanoma Model","volume":"114","author":"Hatiboglu","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mc.22795","article-title":"Triptolide Sensitizes Breast Cancer Cells to Doxorubicin through the DNA Damage Response Inhibition","volume":"57","author":"Deng","year":"2018","journal-title":"Mol. Carcinog."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"115497","DOI":"10.1016\/j.taap.2021.115497","article-title":"\u03b1-Phellandrene Exhibits Antinociceptive and Tumor-Reducing Effects in a Mouse Model of Oncologic Pain","volume":"418","author":"Lopes","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Xu, Q., Li, M., Yang, M., Yang, J., Xie, J., Lu, X., Wang, F., and Chen, W. (2018). \u03b1-Pinene Regulates MiR-221 and Induces G2\/M Phase Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells. Biosci. Rep., 38.","DOI":"10.1042\/BSR20180980"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.2174\/1871520621999210104195820","article-title":"Alpha-Terpineol as Antitumor Candidate in Pre-Clinical Studies","volume":"21","author":"Negreiros","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fitote.2019.02.020","article-title":"Therapeutic Potential of Monoterpene \u03b1-Thujone, the Main Compound of Thuja occidentalis L. Essential Oil, against Malignant Glioblastoma Multiforme Cells in Vitro","volume":"134","author":"Catapano","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Bai, Z., Yao, C., Zhu, J., Xie, Y., Ye, X.Y., Bai, R., and Xie, T. (2021). Anti-Tumor Drug Discovery Based on Natural Product \u03b2-Elemene: Anti-Tumor Mechanisms and Structural Modification. Molecules, 26.","DOI":"10.3390\/molecules26061499"},{"key":"ref_77","first-page":"419","article-title":"The Use of SS-Elemene to Enhance Radio Sensitization of A375 Human Melanoma Cells","volume":"21","author":"Balavandi","year":"2020","journal-title":"Cell J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12935-022-02721-9","article-title":"Sesquiterpenoid Lactones as Potential Anti-Cancer Agents: An Update on Molecular Mechanisms and Recent Studies","volume":"22","author":"Dhyani","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1007\/s11033-021-06578-5","article-title":"Anticancer Activity of Monoterpenes: A Systematic Review","volume":"48","author":"Silva","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Alipanah, H., Farjam, M., Zarenezhad, E., Roozitalab, G., and Osanloo, M. (2021). Chitosan Nanoparticles Containing Limonene and Limonene-Rich Essential Oils: Potential Phytotherapy Agents for the Treatment of Melanoma and Breast Cancers. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-021-03362-7"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Abdul Ghani, M.A., Ugusman, A., Latip, J., and Zainalabidin, S. (2023). Role of Terpenophenolics in Modulating Inflammation and Apoptosis in Cardiovascular Diseases: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065339"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Haines, D.D., Cowan, F.M., and Tosaki, A. (2024). Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD). Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116176"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/10520295.2019.1647457","article-title":"Artemisinin Attenuates Doxorubicin Induced Cardiotoxicity and Hepatotoxicity in Rats","volume":"95","author":"Tutun","year":"2020","journal-title":"Biotech. Histochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbrc.2019.07.087","article-title":"Anti-Inflammatory Effect of Artemisinin on Uric Acid-Induced NLRP3 Inflammasome Activation through Blocking Interaction between NLRP3 and NEK7","volume":"517","author":"Kim","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-020-03842-3","article-title":"Artemisinin Suppresses Myocardial Ischemia\u2013Reperfusion Injury via NLRP3 Inflammasome Mechanism","volume":"474","author":"Wang","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3732718","DOI":"10.1155\/2020\/3732718","article-title":"Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1\/Nrf2 Signaling Pathway","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wang, Z., Gao, L., Xiao, L., Kong, L., Shi, H., Tian, X., and Zhao, L. (2018). Bakuchiol Protects against Pathological Cardiac Hypertrophy by Blocking NF-\u039aB Signaling Pathway. Biosci. Rep., 38.","DOI":"10.1042\/BSR20181043"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"106653","DOI":"10.1016\/j.intimp.2020.106653","article-title":"Betulin Alleviates on Myocardial Inflammation in Diabetes Mice via Regulating Siti1\/NLRP3\/NF-\u039aB Pathway","volume":"85","author":"Wen","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1007\/s10753-020-01405-8","article-title":"Betulin Alleviates Myocardial Ischemia\u2013Reperfusion Injury in Rats via Regulating the Siti1\/NLRP3\/NF-\u039aB Signaling Pathway","volume":"44","author":"Yu","year":"2021","journal-title":"Inflammation"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Lee, Y.H., Lim, W., and Sung, M.K. (2018). Carnosic Acid Modulates Increased Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Mice Fed Normal or High-Fat Diets. Nutrients, 10.","DOI":"10.3390\/nu10121984"},{"key":"ref_91","first-page":"3709","article-title":"Carnosic Acid Protects against Pressure Overload-induced Cardiac Remodelling by Inhibiting the AKT\/GSK3\u03b2\/NOX4 Signalling Pathway","volume":"20","author":"Wei","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biopha.2018.07.037","article-title":"Carvedilol (CAR) Combined with Carnosic Acid (CAA) Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Excessive Oxidative Stress, Inflammation, Apoptosis and Autophagy","volume":"109","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"112143","DOI":"10.1016\/j.intimp.2024.112143","article-title":"Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation","volume":"134","author":"Xu","year":"2024","journal-title":"Int. Immunopharm."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ou, S., Lv, J., Peng, L., Zhao, J., and Chi, L. (2016). Carnosol Promotes Endothelial Differentiation under H2O2-Induced Oxidative Stress. Arch. Biol. Sci., 69.","DOI":"10.2298\/ABS160327101O"},{"key":"ref_95","first-page":"54","article-title":"The Effect of Carvacrol on Transcription Levels of Bcl-2 Family Proteins in Hypertrophied Heart of Rats","volume":"22","author":"Sadeghzadeh","year":"2018","journal-title":"Physiol. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","article-title":"Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3","volume":"126","author":"Ye","year":"2020","journal-title":"Circ. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.yrtph.2017.12.021","article-title":"Treatment of \u03b2-Thujaplicin Counteracts Di(2-Ethylhexyl)Phthalate (DEHP)-Exposed Vascular Smooth Muscle Activation, Inflammation and Atherosclerosis Progression","volume":"92","author":"Shih","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2700000","DOI":"10.1155\/2022\/2700000","article-title":"Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3 \u03b2-Mediated Autophagy","volume":"2022","author":"Xiao","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Li, W., Cao, J., Wang, X., Zhang, Y., Sun, Q., Jiang, Y., Yao, J., Li, C., Wang, Y., and Wang, W. (2021). Ferruginol Restores SIRT1-PGC-1\u03b1-Mediated Mitochondrial Biogenesis and Fatty Acid Oxidation for the Treatment of DOX-Induced Cardiotoxicity. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.773834"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/tox.23030","article-title":"Ameliorative Effect of Ferruginol on Isoprenaline Hydrochloride-Induced Myocardial Infarction in Rats","volume":"36","author":"Zhang","year":"2021","journal-title":"Environ. Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/jphp.13361","article-title":"Geniposide in Gardenia Jasminoides Var. Radicans Makino Modulates Blood Pressure via Inhibiting WNK Pathway Mediated by the Estrogen Receptors","volume":"72","author":"Fu","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"106609","DOI":"10.1016\/j.intimp.2020.106609","article-title":"Inhibition of Autophagy by Geniposide Protects against Myocardial Ischemia\/Reperfusion Injury","volume":"85","author":"Luo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"106547","DOI":"10.1016\/j.intimp.2020.106547","article-title":"Geniposide Inhibits NLRP3 Inflammasome Activation via Autophagy in BV-2 Microglial Cells Exposed to Oxygen\u2013Glucose Deprivation\/Reoxygenation","volume":"84","author":"Fu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.freeradbiomed.2020.02.011","article-title":"Geniposide Protects against Sepsis-Induced Myocardial Dysfunction through AMPK\u03b1-Dependent Pathway","volume":"152","author":"Song","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2018.02.044","article-title":"Oridonin Inhibits Vascular Inflammation by Blocking NF-\u03baB and MAPK Activation","volume":"826","author":"Huang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9724520","DOI":"10.1155\/2020\/9724520","article-title":"Oridonin Attenuates Lipopolysaccharide-Induced ROS Accumulation and Inflammation in HK-2 Cells","volume":"2020","author":"Huang","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"172587","DOI":"10.1016\/j.ejphar.2019.172587","article-title":"Beneficial Effects of Oridonin on Myocardial Ischemia\/Reperfusion Injury: Insight Gained by Metabolomic Approaches","volume":"861","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"7395187","DOI":"10.1155\/2020\/7395187","article-title":"Oridonin Attenuates Myocardial Ischemia\/Reperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice","volume":"2020","author":"Lu","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin Is a Covalent NLRP3 Inhibitor with Strong Anti-Inflammasome Activity","volume":"9","author":"He","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12964-019-0366-y","article-title":"Oridonin Protects LPS-Induced Acute Lung Injury by Modulating Nrf2-Mediated Oxidative Stress and Nrf2-Independent NLRP3 and NF-\u039aB Pathways","volume":"17","author":"Yang","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_111","first-page":"1737","article-title":"Retraction Pterostilbene Attenuates Inflammation in Rat Heart Subjected to Ischemia-Reperfusion: Role of TLR4\/NF-\u03baB Signaling Pathway","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Li, J., Zhao, C., Zhu, Q., Wang, Y., Li, G., Li, X., Li, Y., Wu, N., and Ma, C. (2021). Sweroside Protects Against Myocardial Ischemia\u2013Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1\/Nrf2 Axis. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.650368"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Ma, L.Q., Yu, Y., Chen, H., Li, M., Ihsan, A., Tong, H.Y., Huang, X.J., and Gao, Y. (2018). Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01138"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Yang, G., Jang, J.H., Kim, S.W., Han, S.H., Ma, K.H., Jang, J.K., Kang, H.C., Cho, Y.Y., Lee, H.S., and Lee, J.Y. (2020). Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082790"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e04431","DOI":"10.1016\/j.heliyon.2020.e04431","article-title":"Cardioprotective Effect of Thymol against Adrenaline-Induced Myocardial Injury in Rats","volume":"6","author":"Hassan","year":"2020","journal-title":"Heliyon"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Pan, X.C., Liu, Y., Cen, Y.Y., Xiong, Y.L., Li, J.M., Ding, Y.Y., Tong, Y.F., Liu, T., Chen, X.H., and Zhang, H.G. (2019). Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020360"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10787-021-00918-4","article-title":"Phenols and Terpenoids: Natural Products as Inhibitors of NLRP3 Inflammasome in Cardiovascular Diseases","volume":"30","author":"Hua","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 Inflammasome, an Immune-inflammatory Target in Pathogenesis and Treatment of Cardiovascular Diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Montenegro, Z.J.S., \u00c1lvarez-Rivera, G., S\u00e1nchez-Mart\u00ednez, J.D., Gallego, R., Vald\u00e9s, A., Bueno, M., Cifuentes, A., and Ib\u00e1\u00f1ez, E. (2021). Neuroprotective Effect of Terpenoids Recovered from Olive Oil By-Products. Foods, 10.","DOI":"10.3390\/foods10071507"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Xu, B., Bai, L., Chen, L., Tong, R., Feng, Y., and Shi, J. (2022). Terpenoid Natural Products Exert Neuroprotection via the PI3K\/Akt Pathway. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1036506"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Mony, T.J., Elahi, F., Choi, J.W., and Park, S.J. (2022). Neuropharmacological Effects of Terpenoids on Preclinical Animal Models of Psychiatric Disorders: A Review. Antioxidants, 11.","DOI":"10.3390\/antiox11091834"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1055\/a-0953-6738","article-title":"Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids","volume":"85","author":"Palomino","year":"2019","journal-title":"Planta Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.18632\/aging.103121","article-title":"Artesunate Promotes the Proliferation of Neural Stem\/Progenitor cells and Alleviates Ischemia-Reperfusion Injury through PI3K\/Akt\/FOXO3a\/P27kip1 Signaling Pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lfs.2018.07.016","article-title":"Asiatic Acid Protects Differentiated PC12 Cells from A\u03b225\u201335-Induced Apoptosis and Tau Hyperphosphorylation via Regulating PI3K\/Akt\/GSK-3\u03b2 Signaling","volume":"208","author":"Cheng","year":"2018","journal-title":"Life Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s10787-020-00733-3","article-title":"Oral Administration of Centella asiatica (L.) Urb Leave Aqueous Extract Ameliorates Cerebral Oxidative Stress, Inflammation, and Apoptosis in Male Rats with Type-2 Diabetes","volume":"28","author":"Giribabu","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2021.07.029","article-title":"Catalpol Weakens Depressive-like Behavior in Mice with Streptozotocin-Induced Hyperglycemia via PI3K\/AKT\/Nrf2\/HO-1 Signaling Pathway","volume":"473","author":"Wu","year":"2021","journal-title":"Neuroscience"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"306","DOI":"10.21037\/atm.2019.06.25","article-title":"Catalpol May Improve Axonal Growth via Regulating MiR-124 Regulated PI3K\/AKT\/MTOR Pathway in Neurons after Ischemia","volume":"7","author":"Zhu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.intimp.2018.11.029","article-title":"Celastrol Inhibits Microglial Pyroptosis and Attenuates Inflammatory Reaction in Acute Spinal Cord Injury Rats","volume":"66","author":"Dai","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_129","first-page":"1136","article-title":"Geniposide Attenuates Epilepsy Symptoms in a Mouse Model through the PI3K\/Akt\/GSK-3\u03b2 Signaling Pathway","volume":"15","author":"Wei","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1007\/s00213-021-05895-8","article-title":"Geniposide Ameliorates Chronic Unpredictable Mild Stress Induced Depression-like Behavior through Inhibition of Ceramide-PP2A Signaling via the PI3K\/Akt\/GSK3\u03b2 Axis","volume":"238","author":"Wang","year":"2021","journal-title":"Psychopharmacology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s12640-022-00531-5","article-title":"Geniposide Alleviates Neuropathic Pain in CCI Rats by Inhibiting the EGFR\/PI3K\/AKT Pathway and Ca2+ Channels","volume":"40","author":"Zhang","year":"2022","journal-title":"Neurotox. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1159\/000490016","article-title":"By Activating Akt\/ENOS Bilobalide B Inhibits Autophagy and Promotes Angiogenesis Following Focal Cerebral Ischemia Reperfusion","volume":"47","author":"Zheng","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Usuki, T., Yoshimoto, Y., Sato, M., Takenaka, T., Takezawa, R., Yoshida, Y., Satake, M., Suzuki, N., Hashizume, D., and Dzyuba, S.V. (2020). Bilobalide and PC12 Cells: A Structure Activity Relationship Study. Bioorg. Med. Chem., 28.","DOI":"10.1016\/j.bmc.2019.115251"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/aps.2017.149","article-title":"Diterpene Ginkgolides Protect against Cerebral Ischemia\/Reperfusion Damage in Rats by Activating Nrf2 and CREB through PI3K\/Akt Signaling","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12192-019-00977-1","article-title":"Antioxidant Effects of Ginkgolides and Bilobalide against Cerebral Ischemia Injury by Activating the Akt\/Nrf2 Pathway in Vitro and in Vivo","volume":"24","author":"Liu","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"ref_136","first-page":"4417","article-title":"Comparing the Role of Ginkgolide B and Ginkgolide K on Cultured Astrocytes Exposed to Oxygen-glucose Deprivation","volume":"18","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6","DOI":"10.21037\/atm.2019.12.35","article-title":"Echinocystic Acid Provides a Neuroprotective Effect via the PI3K\/AKT Pathway in Intracerebral Haemorrhage Mice","volume":"8","author":"Chen","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Park, J.Y., Amarsanaa, K., Cui, Y., Lee, J.H., Wu, J., Yang, Y.S., Eun, S.Y., and Jung, S.C. (2019). Methyl Lucidone Exhibits Neuroprotective Effects on Glutamate-Induced Oxidative Stress in HT-22 Cells via Nrf-2\/HO-1 Signaling. Appl. Biol. Chem., 62.","DOI":"10.1186\/s13765-019-0474-9"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"8817309","DOI":"10.1155\/2021\/8817309","article-title":"Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-like Effect on Mouse Model of Maternal Separation Stress","volume":"2021","author":"Lorigooini","year":"2021","journal-title":"Behav. Neurol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s11033-019-04801-y","article-title":"Lycopene Protects against T-BHP-Induced Neuronal Oxidative Damage and Apoptosis via Activation of the PI3K\/Akt Pathway","volume":"46","author":"Huang","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1002\/jcb.28677","article-title":"Platycodin D Protects Cortical Neurons against Oxygen-Glucose Deprivation\/Reperfusion in Neonatal Hypoxic-Ischemic Encephalopathy","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/1673-5374.314321","article-title":"Polygalasaponin F Protects Hippocampal Neurons against Glutamate-Induced Cytotoxicity","volume":"17","author":"Sun","year":"2022","journal-title":"Neural. Regen. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/bcpt.13408","article-title":"Polygalasaponin F Inhibits Neuronal Apoptosis Induced by Oxygen-Glucose Deprivation and Reoxygenation through the PI3K\/Akt Pathway","volume":"127","author":"Xie","year":"2020","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1403572","DOI":"10.1155\/2020\/1403572","article-title":"In Vitro Evaluation of the Neuroprotective Effect of Panax Notoginseng Saponins by Activating the EGFR\/PI3K\/AKT Pathway","volume":"2020","author":"Wu","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s11064-018-2538-3","article-title":"Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-MTOR\/JNK Pathway in Neonatal Cerebral Hypoxic-Ischemic Brain Injury","volume":"43","author":"Tu","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"104977","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104977","article-title":"Alpha-Pinene Exerts Neuroprotective Effects via Anti-Inflammatory and Anti-Apoptotic Mechanisms in a Rat Model of Focal Cerebral Ischemia-Reperfusion","volume":"29","author":"Khoshnazar","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/01480545.2014.919585","article-title":"Linalool as a Neuroprotective Agent against Acrylamide-Induced Neurotoxicity in Wistar Rats","volume":"38","author":"Mehri","year":"2015","journal-title":"Drug Chem Toxicol"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Weston-Green, K., Clunas, H., and Jimenez Naranjo, C. (2021). A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.583211"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1039\/D0FO02809F","article-title":"In Vitro Neuroprotective Potential of Terpenes from Industrial Orange Juice by-Products","volume":"12","author":"Bueno","year":"2021","journal-title":"Food Funct."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Maitra, U., Stephen, C., and Ciesla, L.M. (2022). Drug Discovery from Natural Products\u2014Old Problems and Novel Solutions for the Treatment of Neurodegenerative Diseases. J. Pharm. Biomed. Anal., 210.","DOI":"10.1016\/j.jpba.2021.114553"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Wojtunik-Kulesza, K.A., Kasprzak, K., Oniszczuk, T., and Oniszczuk, A. (2019). Natural Monoterpenes: Much More than Only a Scent. Chem. Biodivers., 16.","DOI":"10.1002\/cbdv.201900434"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jconrel.2020.11.021","article-title":"Neurodegenerative Diseases and Effective Drug Delivery: A Review of Challenges and Novel Therapeutics","volume":"330","author":"Akhtar","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.3390\/molecules17033524","article-title":"Terpenoids as Potential Anti-Alzheimer\u2019s Disease Therapeutics","volume":"17","author":"Yoo","year":"2012","journal-title":"Molecules"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1021\/acsomega.2c03291","article-title":"Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases","volume":"7","author":"Marino","year":"2022","journal-title":"ACS Omega"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Dehelean, C.A., Marcovici, I., Soica, C., Mioc, M., Coricovac, D., Iurciuc, S., Cretu, O.M., and Pinzaru, I. (2021). Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy. Molecules, 26.","DOI":"10.3390\/molecules26041109"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Zhu, L., and Chen, L. (2019). Progress in Research on Paclitaxel and Tumor Immunotherapy. Cell Mol. Biol. Lett., 24.","DOI":"10.1186\/s11658-019-0164-y"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Jiang, Z., Jacob, J.A., Loganathachetti, D.S., Nainangu, P., and Chen, B. (2017). \u03b2-Elemene: Mechanistic Studies on Cancer Cell Interaction and Its Chemosensitization Effect. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00105"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11936-021-00953-y","article-title":"Managing Cancer Patients and Survivors with Advanced Heart Failure","volume":"23","author":"Nijst","year":"2021","journal-title":"Curr. Treat Options Cardiovasc. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1001\/jama.2022.2350","article-title":"Acute Cholecystitis A Review","volume":"327","author":"Gallaher","year":"2022","journal-title":"JAMA Netw."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Mukhtar, Y.M., Adu-Frimpong, M., Xu, X., and Yu, J. (2018). Biochemical Significance of Limonene and Its Metabolites: Future Prospects for Designing and Developing Highly Potent Anticancer Drugs. Biosci. Rep., 38.","DOI":"10.1042\/BSR20181253"},{"key":"ref_162","unstructured":"Costain, W., and Laprairie, R.B. (2018). The United Chemicals of Cannabis: Beneficial effects of Cannabis phytochemicals on the brain and cognition. Recent Advances in Cannabinoid Research, InTechOpen."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13020-021-00489-0","article-title":"Anti-Malarial Drug: The Emerging Role of Artemisinin and Its Derivatives in Liver Disease Treatment","volume":"16","author":"Xiong","year":"2021","journal-title":"Chin. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41467-018-06221-1","article-title":"Artemisinin Kills Malaria Parasites by Damaging Proteins and Inhibiting the Proteasome","volume":"9","author":"Bridgford","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Fan, M., Yuan, S., Li, L., Zheng, J., Zhao, D., Wang, C., Wang, H., Liu, X., and Liu, J. (2023). Application of Terpenoid Compounds in Food and Pharmaceutical Products. Fermentation, 9.","DOI":"10.3390\/fermentation9020119"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00425-018-3056-x","article-title":"Terpenes and Isoprenoids: A Wealth of Compounds for Global Use","volume":"249","author":"Tetali","year":"2019","journal-title":"Planta"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Shahidi, F., and De Camargo, A.C. (2016). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101745"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/bjd.15080","article-title":"Molecular Evidence That Oral Supplementation with Lycopene or Lutein Protects Human Skin against Ultraviolet Radiation: Results from a Double-Blinded, Placebo-Controlled, Crossover Study","volume":"176","author":"Marini","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10937404.2013.769418","article-title":"Safety Evaluation and Risk Assessment of D-Limonene","volume":"16","author":"Kim","year":"2013","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"110487","DOI":"10.1016\/j.foodres.2021.110487","article-title":"Genetic Engineering of Yeast, Filamentous Fungi and Bacteria for Terpene Production and Applications in Food Industry","volume":"147","author":"Liang","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Guti\u00e9rrez-Del-r\u00edo, I., L\u00f3pez-Ib\u00e1\u00f1ez, S., Magad\u00e1n-Corpas, P., Fern\u00e1ndez-Calleja, L., P\u00e9rez-Valero, \u00c1., Tu\u00f1\u00f3n-Granda, M., Migu\u00e9lez, E.M., Villar, C.J., and Lomb\u00f3, F. (2021). Terpenoids and Polyphenols as Natural Antioxidant Agents in Food Preservation. Antioxidants, 10.","DOI":"10.3390\/antiox10081264"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s11696-018-0516-5","article-title":"Comparison of the Oxidative Stability of Soybean and Sunflower Oils Enriched with Herbal Plant Extracts","volume":"72","year":"2018","journal-title":"Chem. Pap."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1002\/jsfa.7568","article-title":"Oregano (Lippia Graveolens) Essential Oil Added within Pectin Edible Coatings Prevents Fungal Decay and Increases the Antioxidant Capacity of Treated Tomatoes","volume":"96","author":"Moctezuma","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Kutyna, D.R., and Borneman, A.R. (2018). Heterologous Production of Flavour and Aroma Compounds in Saccharomyces Cerevisiae. Genes, 9.","DOI":"10.3390\/genes9070326"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1134\/S1061934821030151","article-title":"Comparison of Headspace, Hydrodistillation and Pressurized Liquid Extraction of Terpenes and Terpenoids from Food Matrices\u2014Qualitative and Quantitative Analysis","volume":"76","author":"Triaux","year":"2021","journal-title":"J. Anal. Chem."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Zhang, C., and Hong, K. (2020). Production of Terpenoids by Synthetic Biology Approaches. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00347"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Isidore, E., Karim, H., and Ioannou, I. (2021). Extraction of Phenolic Compounds and Terpenes from Cannabis Sativa l. By-Products: From Conventional to Intensified Processes. Antioxidants, 10.","DOI":"10.3390\/antiox10060942"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"111268","DOI":"10.1016\/j.foodres.2022.111268","article-title":"A Review of Ultrasound-Assisted Extraction for Plant Bioactive Compounds: Phenolics, Flavonoids, Thymols, Saponins and Proteins","volume":"157","author":"Yusoff","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Llorente, D., Ca\u00f1ada-Barcala, A., \u00c1lvarez-Torrellas, S., \u00c1gueda, V.I., Garc\u00eda, J., and Larriba, M. (2020). A Review of the Use of Eutectic Solvents, Terpenes and Terpenoids in Liquid\u2013Liquid Extraction Processes. Processes, 8.","DOI":"10.3390\/pr8101220"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Awad, A.M., Kumar, P., Ismail-Fitry, M.R., Jusoh, S., Ab Aziz, M.F., and Sazili, A.Q. (2021). Green Extraction of Bioactive Compounds from Plant Biomass and Their Application in Meat as Natural Antioxidant. Antioxidants, 10.","DOI":"10.3390\/antiox10091465"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"100242","DOI":"10.1016\/j.fochx.2022.100242","article-title":"Neuroprotective Potential of Terpenoid-Rich Extracts from Orange Juice by-Products Obtained by Pressurized Liquid Extraction","volume":"13","author":"Gallego","year":"2022","journal-title":"Food Chem. X"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"134885","DOI":"10.1016\/j.foodchem.2022.134885","article-title":"Effects of Pressurized Liquid Extraction with Dimethyl Sulfoxide on the Recovery of Carotenoids and Other Dietary Valuable Compounds from the Microalgae Spirulina, Chlorella and Phaeodactylum tricornutum","volume":"405","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"11425","DOI":"10.1021\/acs.analchem.9b02844","article-title":"Tandem Mass Spectrometric Quantification of 93 Terpenoids in Cannabis Using Static Headspace Injections","volume":"91","author":"Shapira","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Deng, H., He, R., Huang, R., Pang, C., Ma, Y., Xia, H., Liang, D., Liao, L., Xiong, B., and Wang, X. (2022). Optimization of a Static Headspace GC-MS Method and Its Application in Metabolic Fingerprinting of the Leaf Volatiles of 42 Citrus Cultivars. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.1050289"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Lamberti, L., Grillo, G., Gallina, L., Carnaroglio, D., Chemat, F., and Cravotto, G. (2021). Microwave-Assisted Hydrodistillation of Hop (Humulus lupulus L.) Terpenes: A Pilot-Scale Study. Foods, 10.","DOI":"10.3390\/foods10112726"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fbp.2020.06.015","article-title":"Conventional versus Microwave-Assisted Hydrodistillation of Sage Herbal Dust: Kinetics Modeling and Physico-Chemical Properties of Essential Oil","volume":"123","author":"Radivojac","year":"2020","journal-title":"Food Bioprod. Process."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"117355","DOI":"10.1016\/j.indcrop.2023.117355","article-title":"Recovery of Essential Oils from the Withered Flowers of Magnolia Soulangeana Soul.-Bod. by Microwave-Assisted Hydrodistillation with Uniform Heating and Its New Application in the Hypolipidemic Field","volume":"204","author":"Peng","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"114034","DOI":"10.1016\/j.indcrop.2021.114034","article-title":"Stabilisation of Lavender Essential Oil Extracted by Microwave-Assisted Hydrodistillation: Characteristics of Starch and Soy Protein-Based Microemulsions","volume":"172","author":"Berber","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"127724","DOI":"10.1016\/j.foodchem.2020.127724","article-title":"Antioxidant and Enzyme-Inhibitory Activity of Peppermint Extracts and Essential Oils Obtained by Conventional and Emerging Extraction Techniques","volume":"338","author":"Zengin","year":"2021","journal-title":"Food Chem."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"de Andrade Lima, M., Kestekoglou, I., Charalampopoulos, D., and Chatzifragkou, A. (2019). Supercritical Fluid Extraction of Carotenoids from Vegetable Waste Matrices. Molecules, 24.","DOI":"10.3390\/molecules24030466"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"104574","DOI":"10.1016\/j.supflu.2019.104574","article-title":"Valorisation of Mango Peel: Proximate Composition, Supercritical Fluid Extraction of Carotenoids, and Application as an Antioxidant Additive for an Edible Oil","volume":"152","author":"Vargas","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.supflu.2019.01.013","article-title":"Selective Extraction of Bioactive Compounds from Annatto Seeds by Sequential Supercritical CO2 Process","volume":"150","author":"Vardanega","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.supflu.2018.11.006","article-title":"Extraction from Leaves of Piper Klotzschianum Using Supercritical Carbon Dioxide and Co-Solvents","volume":"147","author":"Lima","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"132192","DOI":"10.1016\/j.foodchem.2022.132192","article-title":"Selective Extraction of Oxygenated Terpene in Caraway (Carum carvi L.) Using Subcritical Water Extraction (SWE) Technique","volume":"381","author":"Kim","year":"2022","journal-title":"Food Chem."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Spinozzi, E., Ferrati, M., Lo Giudice, D., Felicioni, E., Petrelli, R., Benelli, G., Maggi, F., and Cespi, M. (2023). Microwave-Assisted Hydrodistillation of the Insecticidal Essential Oil from Carlina Acaulis: A Fractional Factorial Design Optimization Study. Plants, 12.","DOI":"10.3390\/plants12030622"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"110746","DOI":"10.1016\/j.foodres.2021.110746","article-title":"Supercritical Fluid Extraction (SCFE) as Green Extraction Technology for High-Value Metabolites of Algae, Its Potential Trends in Food and Human Health","volume":"150","author":"Singh","year":"2021","journal-title":"Food Res. Internat."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"C\u00e2mara, J.S., Perestrelo, R., Berenguer, C.V., Andrade, C.F.P., Gomes, T.M., Olayanju, B., Kabir, A., Rocha, C.M.R., Teixeira, J.A., and Pereira, J.A.M. (2022). Green Extraction Techniques as Advanced Sample Preparation Approaches in Biological, Food, and Environmental Matrices: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092953"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tifs.2020.01.014","article-title":"Recent Advances in Subcritical Water and Supercritical Carbon Dioxide Extraction of Bioactive Compounds from Plant Materials","volume":"97","author":"Essien","year":"2020","journal-title":"Trends Food Sci. Technol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/16\/3861\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:36:59Z","timestamp":1760110619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/16\/3861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,15]]},"references-count":198,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["molecules29163861"],"URL":"https:\/\/doi.org\/10.3390\/molecules29163861","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,15]]}}}